DK0475352T3 - 3-(1H-Indazol-3-yl)-4-pyridinaminer, fremgangsmåde og mellemprodukter til deres fremstilling og deres anvendelse som lægemidler - Google Patents
3-(1H-Indazol-3-yl)-4-pyridinaminer, fremgangsmåde og mellemprodukter til deres fremstilling og deres anvendelse som lægemidlerInfo
- Publication number
- DK0475352T3 DK0475352T3 DK91115280.9T DK91115280T DK0475352T3 DK 0475352 T3 DK0475352 T3 DK 0475352T3 DK 91115280 T DK91115280 T DK 91115280T DK 0475352 T3 DK0475352 T3 DK 0475352T3
- Authority
- DK
- Denmark
- Prior art keywords
- hydrogen
- loweralkyl
- pyridinamines
- indazol
- intermediates
- Prior art date
Links
- 239000000543 intermediate Substances 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- JYMZOGPPXKPHNM-UHFFFAOYSA-N 3-(1h-indazol-3-yl)pyridin-4-amine Chemical class NC1=CC=NC=C1C1=NNC2=CC=CC=C12 JYMZOGPPXKPHNM-UHFFFAOYSA-N 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 150000002431 hydrogen Chemical group 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- NETLQOUGNOSTNN-UHFFFAOYSA-N 4-(2h-indazol-3-yl)-3h-pyridin-4-amine Chemical class N1N=C2C=CC=CC2=C1C1(N)CC=NC=C1 NETLQOUGNOSTNN-UHFFFAOYSA-N 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 229940035676 analgesics Drugs 0.000 abstract 1
- 239000000730 antalgic agent Substances 0.000 abstract 1
- 239000002260 anti-inflammatory agent Substances 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- -1 loweralkyl Chemical group 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 230000003287 optical effect Effects 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 208000017520 skin disease Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/73—Unsubstituted amino or imino radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/579,751 US5051430A (en) | 1990-09-10 | 1990-09-10 | 3-(1H-indazol-3-yl)-4-pyridinamines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0475352T3 true DK0475352T3 (da) | 1995-10-16 |
Family
ID=24318208
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK91115280.9T DK0475352T3 (da) | 1990-09-10 | 1991-09-10 | 3-(1H-Indazol-3-yl)-4-pyridinaminer, fremgangsmåde og mellemprodukter til deres fremstilling og deres anvendelse som lægemidler |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US5051430A (cs) |
| EP (1) | EP0475352B1 (cs) |
| JP (1) | JP3042915B2 (cs) |
| KR (1) | KR100203236B1 (cs) |
| AT (1) | ATE123493T1 (cs) |
| AU (1) | AU640590B2 (cs) |
| CA (1) | CA2050875C (cs) |
| CZ (1) | CZ280883B6 (cs) |
| DE (1) | DE69110219T2 (cs) |
| DK (1) | DK0475352T3 (cs) |
| ES (1) | ES2074618T3 (cs) |
| FI (1) | FI914219A7 (cs) |
| HU (1) | HUT59126A (cs) |
| IE (1) | IE67442B1 (cs) |
| IL (1) | IL99434A (cs) |
| NO (1) | NO913543L (cs) |
| NZ (1) | NZ239692A (cs) |
| PL (1) | PL295728A1 (cs) |
| PT (1) | PT98911B (cs) |
| ZA (1) | ZA917141B (cs) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0435222A3 (en) * | 1989-12-27 | 1991-12-11 | Hoechst-Roussel Pharmaceuticals Incorporated | Aminopyridinylmethanols and aminomethylpyridinamines and related compounds, a process for their preparation and their use as medicaments |
| US7211594B2 (en) | 2000-07-31 | 2007-05-01 | Signal Pharmaceuticals, Llc | Indazole compounds and compositions thereof as JNK inhibitors and for the treatment of diseases associated therewith |
| US6897231B2 (en) | 2000-07-31 | 2005-05-24 | Signal Pharmaceuticals, Inc. | Indazole derivatives as JNK inhibitors and compositions and methods related thereto |
| WO2002083648A1 (en) | 2001-04-16 | 2002-10-24 | Eisai Co., Ltd. | Novel 1h-indazole compound |
| JP2007526324A (ja) * | 2004-03-02 | 2007-09-13 | スミスクライン・ビーチャム・コーポレイション | Ａｋｔ活性のある阻害剤 |
| CN101213191B (zh) * | 2005-03-30 | 2011-08-24 | （株）大熊制药 | 抗真菌三唑衍生物 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU198036B (en) * | 1983-08-22 | 1989-07-28 | Hoechst Roussel Pharma | Process for production of derivatives of 3-piperidil-/1h/-indasole and medical preparatives containing them |
-
1990
- 1990-09-10 US US07/579,751 patent/US5051430A/en not_active Expired - Fee Related
-
1991
- 1991-09-06 CA CA002050875A patent/CA2050875C/en not_active Expired - Fee Related
- 1991-09-06 FI FI914219A patent/FI914219A7/fi not_active Application Discontinuation
- 1991-09-06 IL IL9943491A patent/IL99434A/en unknown
- 1991-09-06 NZ NZ239692A patent/NZ239692A/en unknown
- 1991-09-09 HU HU912901A patent/HUT59126A/hu unknown
- 1991-09-09 NO NO91913543A patent/NO913543L/no unknown
- 1991-09-09 PT PT98911A patent/PT98911B/pt not_active IP Right Cessation
- 1991-09-09 AU AU83716/91A patent/AU640590B2/en not_active Expired - Fee Related
- 1991-09-09 ZA ZA917141A patent/ZA917141B/xx unknown
- 1991-09-09 PL PL29572891A patent/PL295728A1/xx unknown
- 1991-09-09 IE IE315791A patent/IE67442B1/en not_active IP Right Cessation
- 1991-09-09 JP JP3227982A patent/JP3042915B2/ja not_active Expired - Lifetime
- 1991-09-09 CZ CS912776A patent/CZ280883B6/cs not_active IP Right Cessation
- 1991-09-10 DK DK91115280.9T patent/DK0475352T3/da active
- 1991-09-10 EP EP91115280A patent/EP0475352B1/en not_active Expired - Lifetime
- 1991-09-10 ES ES91115280T patent/ES2074618T3/es not_active Expired - Lifetime
- 1991-09-10 AT AT91115280T patent/ATE123493T1/de not_active IP Right Cessation
- 1991-09-10 DE DE69110219T patent/DE69110219T2/de not_active Expired - Fee Related
- 1991-09-10 KR KR1019910015736A patent/KR100203236B1/ko not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| PT98911A (pt) | 1992-07-31 |
| CA2050875A1 (en) | 1992-03-11 |
| PL295728A1 (en) | 1993-05-04 |
| ES2074618T3 (es) | 1995-09-16 |
| KR920006346A (ko) | 1992-04-27 |
| EP0475352A1 (en) | 1992-03-18 |
| JP3042915B2 (ja) | 2000-05-22 |
| JPH04247079A (ja) | 1992-09-03 |
| ATE123493T1 (de) | 1995-06-15 |
| IE67442B1 (en) | 1996-04-03 |
| FI914219A7 (fi) | 1992-03-11 |
| CS277691A3 (en) | 1992-04-15 |
| ZA917141B (en) | 1992-04-29 |
| HU912901D0 (en) | 1992-01-28 |
| AU640590B2 (en) | 1993-08-26 |
| HUT59126A (en) | 1992-04-28 |
| NO913543D0 (no) | 1991-09-09 |
| US5051430A (en) | 1991-09-24 |
| AU8371691A (en) | 1992-03-12 |
| NO913543L (no) | 1992-03-11 |
| DE69110219T2 (de) | 1995-11-09 |
| EP0475352B1 (en) | 1995-06-07 |
| IL99434A0 (en) | 1992-08-18 |
| CA2050875C (en) | 2002-07-16 |
| IE913157A1 (en) | 1992-03-11 |
| IL99434A (en) | 1995-08-31 |
| FI914219A0 (fi) | 1991-09-06 |
| NZ239692A (en) | 1994-01-26 |
| KR100203236B1 (ko) | 1999-06-15 |
| DE69110219D1 (de) | 1995-07-13 |
| CZ280883B6 (cs) | 1996-04-17 |
| PT98911B (pt) | 1999-02-26 |
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