DK0474509T3 - Fremgangsmåde til oprensning af blandinger omfattende ibuprofen - Google Patents

Fremgangsmåde til oprensning af blandinger omfattende ibuprofen

Info

Publication number
DK0474509T3
DK0474509T3 DK91308177.4T DK91308177T DK0474509T3 DK 0474509 T3 DK0474509 T3 DK 0474509T3 DK 91308177 T DK91308177 T DK 91308177T DK 0474509 T3 DK0474509 T3 DK 0474509T3
Authority
DK
Denmark
Prior art keywords
ibuprofen
crystallization
mixture
purifying
reaction product
Prior art date
Application number
DK91308177.4T
Other languages
Danish (da)
English (en)
Inventor
Debra A Ryan
Edward G Zey
Thomas H Shockley
Gary L Moss
Original Assignee
Hoechst Celanese Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Celanese Corp filed Critical Hoechst Celanese Corp
Application granted granted Critical
Publication of DK0474509T3 publication Critical patent/DK0474509T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/42—Separation; Purification; Stabilisation; Use of additives
    • C07C51/43—Separation; Purification; Stabilisation; Use of additives by change of the physical state, e.g. crystallisation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK91308177.4T 1990-09-06 1991-09-06 Fremgangsmåde til oprensning af blandinger omfattende ibuprofen DK0474509T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/579,427 US5151551A (en) 1990-09-06 1990-09-06 Method for purification of ibuprofen comprising mixtures

Publications (1)

Publication Number Publication Date
DK0474509T3 true DK0474509T3 (da) 1997-05-12

Family

ID=24316864

Family Applications (1)

Application Number Title Priority Date Filing Date
DK91308177.4T DK0474509T3 (da) 1990-09-06 1991-09-06 Fremgangsmåde til oprensning af blandinger omfattende ibuprofen

Country Status (10)

Country Link
US (1) US5151551A (de)
EP (1) EP0474509B1 (de)
AT (1) ATE149995T1 (de)
BR (1) BR9103858A (de)
CA (1) CA2050709C (de)
DE (1) DE69125073T2 (de)
DK (1) DK0474509T3 (de)
ES (1) ES2100212T3 (de)
GR (1) GR3022805T3 (de)
MX (1) MX9100983A (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5300301A (en) * 1992-12-02 1994-04-05 Hoechst Celanese Corporation Isolation of ibuprofen from tablets
WO2004096747A1 (en) * 2003-04-28 2004-11-11 Basf Aktiengesellschaft Process for the separation of palladium catalyst from crude reaction mixtures of aryl acetic acids obtained by carbonylation
WO2015163832A1 (en) 2014-04-25 2015-10-29 Pharmacti̇ve İlaç Sanayi̇ Ve Ti̇caret A.Ş. An ibuprofen and famotidine combined composition having improved stability
CN112433016A (zh) * 2020-12-11 2021-03-02 青岛科技大学 检测重排酯含量的液相色谱分析方法
CN114195633A (zh) * 2021-12-24 2022-03-18 浙江新和成股份有限公司 一种布洛芬杂质f的合成方法
CN115286501A (zh) * 2022-08-10 2022-11-04 浙江新和成股份有限公司 一种布洛芬结晶母液的综合利用方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2646792C2 (de) * 1975-10-23 1985-05-09 Mitsubishi Petrochemical Co., Ltd., Tokio/Tokyo Verfahren zur Herstellung einer α-(arylsubstituierten)-Propionsäure und/oder eines Esters derselben
US4476248A (en) * 1983-02-28 1984-10-09 The Upjohn Company Crystallization of ibuprofen
US4694100A (en) * 1984-07-14 1987-09-15 Nippon Petrochemicals Company, Ltd. Method for producing α-(p-isobutylphenyl)propionic acid or its alkyl esters
CA1286316C (en) * 1986-02-08 1991-07-16 Isoo Shimizu Method for refining 2-(aryl substituted)-propionic acid or its salt
JPH064560B2 (ja) * 1986-02-08 1994-01-19 日本石油化学株式会社 ２−（ｐ−イソブチルフエニル）プロピオン酸またはその塩の回収方法
JPH0657670B2 (ja) * 1986-06-14 1994-08-03 日本石油化学株式会社 粗イブプロフエンの精製方法
US4981995A (en) * 1987-03-20 1991-01-01 Varadaraj Elango Method for producing ibuprofen
DE3802619C1 (de) * 1988-01-29 1989-09-07 Hoechst Ag, 6230 Frankfurt, De
JPH02152945A (ja) * 1988-12-02 1990-06-12 Daicel Chem Ind Ltd ２−（４−ヒドロキシフェノキシ）プロピオン酸エステルの精製法

Also Published As

Publication number Publication date
EP0474509A3 (en) 1993-07-07
CA2050709A1 (en) 1992-03-07
CA2050709C (en) 2002-08-20
BR9103858A (pt) 1992-05-26
US5151551A (en) 1992-09-29
DE69125073D1 (de) 1997-04-17
DE69125073T2 (de) 1997-06-19
MX9100983A (es) 1992-05-04
EP0474509A2 (de) 1992-03-11
ATE149995T1 (de) 1997-03-15
EP0474509B1 (de) 1997-03-12
ES2100212T3 (es) 1997-06-16
GR3022805T3 (en) 1997-06-30

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