DK0458823T3 - Fremgangsmåde til fremstilling af enantiomerisk rene polysubstituerede 1,4-dihydropridiner - Google Patents

Fremgangsmåde til fremstilling af enantiomerisk rene polysubstituerede 1,4-dihydropridiner

Info

Publication number
DK0458823T3
DK0458823T3 DK90903015.7T DK90903015T DK0458823T3 DK 0458823 T3 DK0458823 T3 DK 0458823T3 DK 90903015 T DK90903015 T DK 90903015T DK 0458823 T3 DK0458823 T3 DK 0458823T3
Authority
DK
Denmark
Prior art keywords
dihydropyridines
enantiomerically pure
dihydropridines
polysubstituted
preparation
Prior art date
Application number
DK90903015.7T
Other languages
Danish (da)
English (en)
Inventor
Carmelo A Gandolfi
Marco Frigerio
Carlo Riva
Andrea Zaliani
Giorgio Long
Domenico Roberto Di
Original Assignee
Boehringer Mannheim Italia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim Italia filed Critical Boehringer Mannheim Italia
Application granted granted Critical
Publication of DK0458823T3 publication Critical patent/DK0458823T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Treatments Of Macromolecular Shaped Articles (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK90903015.7T 1989-02-17 1990-02-15 Fremgangsmåde til fremstilling af enantiomerisk rene polysubstituerede 1,4-dihydropridiner DK0458823T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT8919477A IT1230752B (it) 1989-02-17 1989-02-17 Processo per la preparazione di 1,4 diidropiridine polisostituite in forma enantiomericamente pura.

Publications (1)

Publication Number Publication Date
DK0458823T3 true DK0458823T3 (da) 1994-02-21

Family

ID=11158352

Family Applications (1)

Application Number Title Priority Date Filing Date
DK90903015.7T DK0458823T3 (da) 1989-02-17 1990-02-15 Fremgangsmåde til fremstilling af enantiomerisk rene polysubstituerede 1,4-dihydropridiner

Country Status (17)

Country Link
US (1) US5245039A (no)
EP (2) EP0383320A1 (no)
JP (1) JPH04505610A (no)
KR (1) KR0155557B1 (no)
AT (1) ATE95813T1 (no)
AU (1) AU630928B2 (no)
CA (1) CA2047741A1 (no)
DE (1) DE69003936T2 (no)
DK (1) DK0458823T3 (no)
ES (1) ES2060144T3 (no)
FI (1) FI95371C (no)
HU (1) HUT62270A (no)
IE (1) IE66498B1 (no)
IT (1) IT1230752B (no)
NO (1) NO177186C (no)
RU (1) RU2069658C1 (no)
WO (1) WO1990009376A1 (no)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5571827A (en) * 1990-03-13 1996-11-05 Sepracor Inc. Methods and compositions for treating hypertension, angina and other disorders using optically pure s(-) nitrendipine
US5834496A (en) * 1991-12-02 1998-11-10 Sepracor, Inc. Methods for treating hypertension using optically pure S(-) felodipine
EP0661971A1 (en) * 1991-12-02 1995-07-12 Sepracor, Inc. Methods and compositions for treating hypertension, angina, and other disorders using optically pure s(-) felodipine
ES2055653B1 (es) * 1992-09-22 1995-03-01 Elmuquimica Farm Sl Procedimiento de obtencion del 2,6-dimetil-4-(3-nitrofenil)-1,4-dihidropiridin-3,5-dicarboxilato de 3-isopropil-5-(2-metoxi)etil.
ES2055655B1 (es) * 1992-09-22 1995-03-01 Elmuquimica Farm Sl Procedimiento de obtencion de 2,6-dimetil-4-(2-nitrofenil)-1,4-dihidropiridin-3,5-dicarboxilato de 3-isobutil-5-metil.
ES2055654B1 (es) * 1992-09-22 1995-03-01 Elmuquimica Farm Sl Procedimiento de obtencion de 2,6-dimetil-4-(3-nitrofenil)-1,4-dihidropiridin-3,5-dicarboxilato de 3-etil-5-metil.
ES2055652B1 (es) * 1992-09-22 1995-03-01 Elmuquimica Farm Sl Procedimiento de obtencion de 2,6-dimetil-4-(2,3-diclorofenil)-1,4-dihidropiridin-3,5-dicarboxilato de 3-etil-5-metil.
GB9405833D0 (en) * 1994-03-24 1994-05-11 Pfizer Ltd Separation of the enantiomers of amlodipine
FR2719585B1 (fr) * 1994-05-05 1996-08-02 Lafon Labor Procédé d'obtention de 1,4-dihydropyridines optiquement pures.
US5554621A (en) * 1995-06-07 1996-09-10 Bristol-Myers Squibb Company Dihydropyridine NPY antagonists: nitrogen heterocyclic derivatives
ITMI20012434A1 (it) 2001-11-20 2003-05-20 Dompe Spa Acidi 2-aril-propionici e composizioni farmaceutiche che li contengono

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3447169A1 (de) * 1984-12-22 1986-07-03 Bayer Ag, 5090 Leverkusen Optisch aktive nitrodihydropyridine, verfahren zur herstellung und ihre verwendung in arzneimitteln
HU199796B (en) * 1985-08-06 1990-03-28 Boehringer Biochemia Srl Process for producing 2-thiomethyl-substituted-1,4-dihydropyridines and pharmaceutical compositions comprising such compounds
EP0225175A3 (en) * 1985-11-28 1988-12-28 FISONS plc Dihydropyridine derivatives, processes for their preparation and pharmaceutical compositions thereof
US4920225A (en) * 1986-12-22 1990-04-24 Laboratoires Syntex S.A. Resolution of 1,4-dihydropyridine derivatives
US4994461A (en) * 1987-03-27 1991-02-19 Byk Gulden Lomberg Chemische Fabrik Gmbh 1,4-dihydropyridine enantiomers
WO1988007531A1 (en) * 1987-03-27 1988-10-06 Byk Gulden Lomberg Chemische Fabrik Gmbh New optically active compounds

Also Published As

Publication number Publication date
AU5090490A (en) 1990-09-05
EP0383320A1 (en) 1990-08-22
WO1990009376A1 (en) 1990-08-23
FI913861A0 (fi) 1991-08-15
KR0155557B1 (ko) 1998-11-16
KR910700234A (ko) 1991-03-14
IE66498B1 (en) 1996-01-10
US5245039A (en) 1993-09-14
CA2047741A1 (en) 1990-08-18
RU2069658C1 (ru) 1996-11-27
DE69003936D1 (de) 1993-11-18
NO177186C (no) 1995-08-02
ES2060144T3 (es) 1994-11-16
FI95371B (fi) 1995-10-13
HUT62270A (en) 1993-04-28
IT1230752B (it) 1991-10-29
DE69003936T2 (de) 1994-03-31
JPH04505610A (ja) 1992-10-01
ATE95813T1 (de) 1993-10-15
AU630928B2 (en) 1992-11-12
FI95371C (fi) 1996-01-25
IT8919477A0 (it) 1989-02-17
IE900584L (en) 1990-08-17
EP0458823B1 (en) 1993-10-13
NO913188L (no) 1991-08-15
NO177186B (no) 1995-04-24
NO913188D0 (no) 1991-08-15
EP0458823A1 (en) 1991-12-04

Similar Documents

Publication Publication Date Title
DK0458823T3 (da) Fremgangsmåde til fremstilling af enantiomerisk rene polysubstituerede 1,4-dihydropridiner
DE68928956D1 (de) Verfahren zur Herstellung von optisch aktivem 1,3-Butanediol
DK369284A (da) Aprotininhomologe med andre aminosyrer i stilling 15 i stedet for lysin, fremgangsmaade til fremstilling heraf samt deres anvendelse som laegemiddel
DE68916754D1 (de) Verfahren zur Herstellung von optisch aktiver 3-Hydroxybuttersäure.
PT92603A (pt) Processo de producao de factor de crescimento transformante, quimerico,beta
DE69009237T2 (de) Verfahren zur Herstellung von optisch aktiven Estern der 6-t-Butoxy-3,5-dihydroxyhexansäure.
DE3683512D1 (de) Verfahren zur optischen isomerisierung von optisch aktiver aminosaeure und verfahren zur herstellung von optisch aktiver aminosaeure.
NO177500C (no) Fremgangsmåte til fremstilling av en terapeutisk aktiv hirudinvariant
FR2614790B1 (fr) Nouvelle composition ophtalmologique a base d'acide eicosapeutaenoique
PT91006A (pt) Processo para a preparacao de um novo sal de estroncio
DE68926417T2 (de) Verfahren zur herstellung von optisch aktiven 2-hydroxysäureabkömmlingen
HUT44126A (en) Herbicide composition containing pyridine-monocarboxylic acid derivative with sulfur-containing group at the 5th position as active component and process for producing the active component
ATE95244T1 (de) Verfahren zur herstellung von l-phosphinothricin.
AT375940B (de) Verfahren zur herstellung neuer 10-halogen-14-oxo-15-hydroxy-e-homoeburnane (3 alpha,17 alpha) sowie deren epimeren, optisch aktiven antipoden und physiologisch vertraeglichen saeureadditionssalze
PT87091A (pt) Process for preparing 3(5)-cyano-1h-pyrazole-4-carboxylic acid esters
DE69033833D1 (de) Verfahren zur Herstellung von Butantetracarbonsäure
DK149592C (da) Analogifremgangsmaade til fremstilling af racemiske eller optisk aktive1,1-disubstituerede octahydro-indolo(2,3-a)quinoliziner eller farmaceutisk acceptable syreadditionssalte deraf
DE68920265T2 (de) Verfahren zur Enantiomerentrennung von Cis-3-amino-4-[2-(2-furyl)vinyl]-1-methoxycarbonylmethyl-azetidin-2-on und deren Di-p-Toluoyl-Weinsäuresalze.
ATA18878A (de) Verfahren zur herstellung von (1,1-dithienyl- -(3-propen-(1)-yl-(3))-(1-phenyl-1-hydroxyproyl -(2))-amin und dessen saeureadditionssalzen und optisch aktiven isomeren
IL90333A0 (en) Process for the racemization of optically active d-2-n-phenacetyl-amino-4-methyl-phosphinobutyric acid
ES2089327T3 (es) Procedimiento e intermediarios para la preparacion de un agente antivirico que contiene un grupo ciclobutilo.
HUT47232A (en) Process for the racemization of optically active chrysanthemic acid derivatives
DE68928788T2 (de) Verfahren zur Herstellung von optisch aktiven 3,4-Dihydroxybuttersäurederivaten
DE3851942D1 (de) Verfahren zur Herstellung von optisch aktiver alpha-Isopropyl-p-chlorophenylessigsäure.
DE68924482T2 (de) Verfahren zur herstellung optisch aktiver 2-hydroxy-4-phenyl-3-butensäure.