FI95371B - Menetelmä ja välituotteet enantiomeerisesti puhtaiden polysubstituoitujen 1,4-dihydropyridiinien valmistamiseksi - Google Patents
Menetelmä ja välituotteet enantiomeerisesti puhtaiden polysubstituoitujen 1,4-dihydropyridiinien valmistamiseksiInfo
- Publication number
- FI95371B FI95371B FI913861A FI913861A FI95371B FI 95371 B FI95371 B FI 95371B FI 913861 A FI913861 A FI 913861A FI 913861 A FI913861 A FI 913861A FI 95371 B FI95371 B FI 95371B
- Authority
- FI
- Finland
- Prior art keywords
- dihydropyridines
- enantiomerically pure
- polysubstituted
- intermediates
- preparation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Plural Heterocyclic Compounds (AREA)
- Treatments Of Macromolecular Shaped Articles (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT1947789 | 1989-02-17 | ||
IT8919477A IT1230752B (it) | 1989-02-17 | 1989-02-17 | Processo per la preparazione di 1,4 diidropiridine polisostituite in forma enantiomericamente pura. |
PCT/EP1990/000243 WO1990009376A1 (en) | 1989-02-17 | 1990-02-15 | A process for preparation of enantiomerically pure polysubstituted 1,4-dihydropyridines |
EP9000243 | 1990-02-15 |
Publications (3)
Publication Number | Publication Date |
---|---|
FI913861A0 FI913861A0 (fi) | 1991-08-15 |
FI95371B true FI95371B (fi) | 1995-10-13 |
FI95371C FI95371C (fi) | 1996-01-25 |
Family
ID=11158352
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI913861A FI95371C (fi) | 1989-02-17 | 1991-08-15 | Menetelmä ja välituotteet enantiomeerisesti puhtaiden polysubstituoitujen 1,4-dihydropyridiinien valmistamiseksi |
Country Status (17)
Country | Link |
---|---|
US (1) | US5245039A (fi) |
EP (2) | EP0458823B1 (fi) |
JP (1) | JPH04505610A (fi) |
KR (1) | KR0155557B1 (fi) |
AT (1) | ATE95813T1 (fi) |
AU (1) | AU630928B2 (fi) |
CA (1) | CA2047741A1 (fi) |
DE (1) | DE69003936T2 (fi) |
DK (1) | DK0458823T3 (fi) |
ES (1) | ES2060144T3 (fi) |
FI (1) | FI95371C (fi) |
HU (1) | HUT62270A (fi) |
IE (1) | IE66498B1 (fi) |
IT (1) | IT1230752B (fi) |
NO (1) | NO177186C (fi) |
RU (1) | RU2069658C1 (fi) |
WO (1) | WO1990009376A1 (fi) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5571827A (en) * | 1990-03-13 | 1996-11-05 | Sepracor Inc. | Methods and compositions for treating hypertension, angina and other disorders using optically pure s(-) nitrendipine |
US5834496A (en) * | 1991-12-02 | 1998-11-10 | Sepracor, Inc. | Methods for treating hypertension using optically pure S(-) felodipine |
CA2125149A1 (en) * | 1991-12-02 | 1993-06-10 | James W. Young | Methods and compositions for treating hypertension, angina, and other disorders using optically pure s(-) felodipine |
ES2055652B1 (es) * | 1992-09-22 | 1995-03-01 | Elmuquimica Farm Sl | Procedimiento de obtencion de 2,6-dimetil-4-(2,3-diclorofenil)-1,4-dihidropiridin-3,5-dicarboxilato de 3-etil-5-metil. |
ES2055653B1 (es) * | 1992-09-22 | 1995-03-01 | Elmuquimica Farm Sl | Procedimiento de obtencion del 2,6-dimetil-4-(3-nitrofenil)-1,4-dihidropiridin-3,5-dicarboxilato de 3-isopropil-5-(2-metoxi)etil. |
ES2055654B1 (es) * | 1992-09-22 | 1995-03-01 | Elmuquimica Farm Sl | Procedimiento de obtencion de 2,6-dimetil-4-(3-nitrofenil)-1,4-dihidropiridin-3,5-dicarboxilato de 3-etil-5-metil. |
ES2055655B1 (es) * | 1992-09-22 | 1995-03-01 | Elmuquimica Farm Sl | Procedimiento de obtencion de 2,6-dimetil-4-(2-nitrofenil)-1,4-dihidropiridin-3,5-dicarboxilato de 3-isobutil-5-metil. |
GB9405833D0 (en) * | 1994-03-24 | 1994-05-11 | Pfizer Ltd | Separation of the enantiomers of amlodipine |
FR2719585B1 (fr) * | 1994-05-05 | 1996-08-02 | Lafon Labor | Procédé d'obtention de 1,4-dihydropyridines optiquement pures. |
US5554621A (en) * | 1995-06-07 | 1996-09-10 | Bristol-Myers Squibb Company | Dihydropyridine NPY antagonists: nitrogen heterocyclic derivatives |
ITMI20012434A1 (it) | 2001-11-20 | 2003-05-20 | Dompe Spa | Acidi 2-aril-propionici e composizioni farmaceutiche che li contengono |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3447169A1 (de) * | 1984-12-22 | 1986-07-03 | Bayer Ag, 5090 Leverkusen | Optisch aktive nitrodihydropyridine, verfahren zur herstellung und ihre verwendung in arzneimitteln |
WO1987000836A1 (en) * | 1985-08-06 | 1987-02-12 | Boehringer Biochemia Robin S.P.A. | Pharmaceutically active 2-thiomethyl-substituted-1,4-dihydropyridines |
EP0225175A3 (en) * | 1985-11-28 | 1988-12-28 | FISONS plc | Dihydropyridine derivatives, processes for their preparation and pharmaceutical compositions thereof |
US4920225A (en) * | 1986-12-22 | 1990-04-24 | Laboratoires Syntex S.A. | Resolution of 1,4-dihydropyridine derivatives |
EP0296316B1 (de) * | 1987-03-27 | 1993-09-01 | Byk Gulden Lomberg Chemische Fabrik GmbH | 1,4-Dihydropyridin-Enantiomere |
AU1541188A (en) * | 1987-03-27 | 1988-11-02 | Byk Gulden Lomberg Chemische Fabrik Gmbh | New optically active compounds |
-
1989
- 1989-02-17 IT IT8919477A patent/IT1230752B/it active
-
1990
- 1990-02-15 AU AU50904/90A patent/AU630928B2/en not_active Ceased
- 1990-02-15 CA CA002047741A patent/CA2047741A1/en not_active Abandoned
- 1990-02-15 DE DE90903015T patent/DE69003936T2/de not_active Expired - Fee Related
- 1990-02-15 EP EP90903015A patent/EP0458823B1/en not_active Expired - Lifetime
- 1990-02-15 RU SU905001680A patent/RU2069658C1/ru active
- 1990-02-15 AT AT90903015T patent/ATE95813T1/de not_active IP Right Cessation
- 1990-02-15 EP EP90102951A patent/EP0383320A1/en not_active Withdrawn
- 1990-02-15 HU HU901962A patent/HUT62270A/hu unknown
- 1990-02-15 KR KR1019900702275A patent/KR0155557B1/ko not_active IP Right Cessation
- 1990-02-15 JP JP2503175A patent/JPH04505610A/ja active Pending
- 1990-02-15 ES ES90903015T patent/ES2060144T3/es not_active Expired - Lifetime
- 1990-02-15 US US07/743,415 patent/US5245039A/en not_active Expired - Fee Related
- 1990-02-15 WO PCT/EP1990/000243 patent/WO1990009376A1/en active IP Right Grant
- 1990-02-15 DK DK90903015.7T patent/DK0458823T3/da active
- 1990-02-16 IE IE58490A patent/IE66498B1/en not_active IP Right Cessation
-
1991
- 1991-08-15 NO NO913188A patent/NO177186C/no unknown
- 1991-08-15 FI FI913861A patent/FI95371C/fi not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EP0383320A1 (en) | 1990-08-22 |
HUT62270A (en) | 1993-04-28 |
NO177186C (no) | 1995-08-02 |
NO177186B (no) | 1995-04-24 |
FI913861A0 (fi) | 1991-08-15 |
AU5090490A (en) | 1990-09-05 |
ES2060144T3 (es) | 1994-11-16 |
AU630928B2 (en) | 1992-11-12 |
IE900584L (en) | 1990-08-17 |
WO1990009376A1 (en) | 1990-08-23 |
KR910700234A (ko) | 1991-03-14 |
FI95371C (fi) | 1996-01-25 |
DE69003936T2 (de) | 1994-03-31 |
RU2069658C1 (ru) | 1996-11-27 |
EP0458823B1 (en) | 1993-10-13 |
NO913188L (no) | 1991-08-15 |
JPH04505610A (ja) | 1992-10-01 |
DK0458823T3 (da) | 1994-02-21 |
IT8919477A0 (it) | 1989-02-17 |
KR0155557B1 (ko) | 1998-11-16 |
IE66498B1 (en) | 1996-01-10 |
ATE95813T1 (de) | 1993-10-15 |
DE69003936D1 (de) | 1993-11-18 |
US5245039A (en) | 1993-09-14 |
EP0458823A1 (en) | 1991-12-04 |
NO913188D0 (no) | 1991-08-15 |
IT1230752B (it) | 1991-10-29 |
CA2047741A1 (en) | 1990-08-18 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
BB | Publication of examined application | ||
MM | Patent lapsed |