DK0452390T3 - Halogensubstituerede aminotetraliner - Google Patents

Halogensubstituerede aminotetraliner

Info

Publication number
DK0452390T3
DK0452390T3 DK90901708.9T DK90901708T DK0452390T3 DK 0452390 T3 DK0452390 T3 DK 0452390T3 DK 90901708 T DK90901708 T DK 90901708T DK 0452390 T3 DK0452390 T3 DK 0452390T3
Authority
DK
Denmark
Prior art keywords
halogen
alkyl
hydrogen
thiophene
cycloalkyl
Prior art date
Application number
DK90901708.9T
Other languages
Danish (da)
English (en)
Inventor
Per Arvid Emil Carlsson
Hakan Vilhelm Wikstrom
Kjell Anders Ivan Svensson
Bengt Ronny Andersson
Agneta Barbro Ekman
Nils Peter Stjernlof
Nils Arne Svensson
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Application granted granted Critical
Publication of DK0452390T3 publication Critical patent/DK0452390T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/74Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/26Psychostimulants, e.g. nicotine, cocaine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00Compounds containing amino groups bound to a carbon skeleton
    • C07C211/33Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C211/39Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton
    • C07C211/41Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton containing condensed ring systems
    • C07C211/42Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton containing condensed ring systems with six-membered aromatic rings being part of the condensed ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/02Systems containing only non-condensed rings with a three-membered ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00Systems containing two condensed rings
    • C07C2602/02Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
DK90901708.9T 1989-01-09 1990-01-03 Halogensubstituerede aminotetraliner DK0452390T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US29516989A 1989-01-09 1989-01-09

Publications (1)

Publication Number Publication Date
DK0452390T3 true DK0452390T3 (da) 1995-04-03

Family

ID=23136530

Family Applications (1)

Application Number Title Priority Date Filing Date
DK90901708.9T DK0452390T3 (da) 1989-01-09 1990-01-03 Halogensubstituerede aminotetraliner

Country Status (9)

Country Link
EP (1) EP0452390B1 (de)
JP (1) JP2868897B2 (de)
KR (1) KR910700225A (de)
AT (1) ATE113271T1 (de)
AU (1) AU4844290A (de)
CA (1) CA2026775C (de)
DE (1) DE69013672T2 (de)
DK (1) DK0452390T3 (de)
WO (1) WO1990007490A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5177112A (en) * 1983-01-03 1993-01-05 Whitby Research, Inc. Substituted 2-aminotetralins
FR2633617B1 (fr) * 1988-07-04 1991-02-08 Adir Nouveaux derives du benzocycloheptene, leur procede de preparation et les compositions pharmaceutiques les renfermant
IL114715A (en) * 1989-02-27 1997-01-10 Lilly Co Eli Intermediate compounds for ring-substituted 2-amino-1, 2, 3, 4-tetrahydronaphthalenes and 3-aminochromanes
SE8901889D0 (sv) * 1989-05-26 1989-05-26 Astra Ab Novel 8-substituted-2-aminotetralines
ES2123500T3 (es) * 1989-05-31 1999-01-16 Upjohn Co Derivados de 8-heterociclil-2-aminotetralina activos sobre el sistema nervioso central.
SE8904127D0 (sv) * 1989-12-07 1989-12-07 Astra Ab New biocyclic amino-substituted compounds
FR2669821A1 (fr) * 1990-12-04 1992-06-05 Sanofi Sa Utilisation de phenylethanolaminotetralines pour la preparation de medicaments destines au traitement de la depression.
DE69422044T2 (de) * 1993-08-06 2000-05-31 Upjohn Co 2-aminoindane als selektive dopamin-d3-liganden
WO1996015099A1 (en) * 1994-11-09 1996-05-23 Novo Nordisk A/S Heterocyclic compounds, their preparation and use
DK0807101T3 (da) * 1995-02-01 2001-09-10 Upjohn Co 2-Aminoindaner som selektive dopamin-D3-ligander
AU2006335174B2 (en) * 2006-01-06 2012-09-06 Sunovion Pharmaceuticals Inc. Tetralone-based monoamine reuptake inhibitors

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1518652A1 (de) * 1965-05-29 1969-04-10 Albert Ag Chem Werke Verfahren zur Herstellung von pharmazeutisch wirksamen Derivaten des 2-Aminoindans
DE2803582A1 (de) * 1978-01-27 1979-08-02 Sandoz Ag Neue tetralinderivate, ihre herstellung und verwendung
US4192888A (en) * 1978-04-10 1980-03-11 Smithkline Corporation Pharmaceutical compositions and method of inhibiting phenylethanolamine N-methyltransferase
SE8004002L (sv) * 1980-05-29 1981-11-30 Arvidsson Folke Lars Erik Terapeutiskt anvendbara tetralinderivat
US4320148A (en) * 1980-11-24 1982-03-16 Smithkline Corporation 2-Aminotetralin compounds, pharmaceutical compositions and method of producing central alpha1 agonist activity
DE3719924A1 (de) * 1986-12-22 1988-06-30 Bayer Ag 8-substituierte 2-aminotetraline

Also Published As

Publication number Publication date
DE69013672T2 (de) 1995-03-30
CA2026775C (en) 1998-04-07
DE69013672D1 (de) 1994-12-01
CA2026775A1 (en) 1990-07-10
KR910700225A (ko) 1991-03-14
WO1990007490A1 (en) 1990-07-12
JPH04502620A (ja) 1992-05-14
AU4844290A (en) 1990-08-01
EP0452390A1 (de) 1991-10-23
ATE113271T1 (de) 1994-11-15
JP2868897B2 (ja) 1999-03-10
EP0452390B1 (de) 1994-10-26

Similar Documents

Publication Publication Date Title
DK0452390T3 (da) Halogensubstituerede aminotetraliner
ES2062009T4 (es) Agentes antifungicos derivados de triazol
ES2029812T3 (es) Un procedimiento para preparar alfa-alquil-4-amino-3-quinolina-metanoles y 1-(4-aralquilamino-3-quinolil)alcanonas.
BR9106905A (pt) Analogos de anel condensado de heterociclos nao aromaticos contendo nitrogenio
DK0494978T3 (da) Heterocycliske forbindelser
DK0497564T3 (da) Benzamider
ATE404539T1 (de) Kondensierte pyridinderivate
SE7906722L (sv) Merkaptoacylderivat av substituerade proliner
NZ334600A (en) Thienopyrimidines inhibiting phosphodiesterase V for treating cardiovascular disease and impotency
NO174549C (no) Analogifremgangsmåte for fremstilling av terapeutisk aktive, asymmetrisk substituerte, heterocykliske forbindelser
ES2113368T3 (es) Antagonistas de serotonina.
DK0592439T3 (da) Aminosulfonylcarbamater
ES2032749T3 (es) Acidos oxoftalazinil-aceticos heterociclicos.
KR900700088A (ko) 치료용으로 유용한 테트랄린 유도체
NO305287B1 (no) AMPA antagonister
ATE116289T1 (de) Ringsubstituierte 2-amino-1,2,3,4-tetrahydro- naphthaline und 3-aminochromane.
DE69010285D1 (de) Als Spasmolytica geeignete Dibenzothiazepin-Derivate.
MX9205374A (es) Piridinil-amino-1h-indoles, 1h-indazoles, 2h-indazoles, benzo(b)tiofenos y 1,2-benzo-isotiazoles sustituidos, un procedimiento para su preparacion y su utilizacion como medicamentos.
ES2051723T3 (es) Procedimiento para preparar tetrahidroaminoquinolinoles heterociclicos condensados.
ATE124697T1 (de) Azabicyclische derivate mit affinität am muskarine rezeptor.
DE3765206D1 (de) Substituierte 2-aminotetraline.
ES2064533T3 (es) Acido(1,2,3,4-tetrahidro-9-acridinimino)-ciclohexanocarboxilico y compuestos relacionados, un procedimiento para su preparacion y su uso como medicamentos.
KR920004383A (ko) 3-(1,2-벤즈이속사졸-3-일)-4-피리딘아민 및 유도체
ES2096800T3 (es) Benzo(b)tiofen-3-il-piperazinas, un procedimiento para su preparacion y su uso como medicamentos.
MX25922A (es) Pirido (3,4-b) pirrolo (1,2-e)(1,4,5)oxadiazepinasy compuestos analogos relacionados un procedimiento para su preparacion y su uso como medicamentos