ES2051723T3 - Procedimiento para preparar tetrahidroaminoquinolinoles heterociclicos condensados. - Google Patents

Procedimiento para preparar tetrahidroaminoquinolinoles heterociclicos condensados.

Info

Publication number
ES2051723T3
ES2051723T3 ES87117031T ES87117031T ES2051723T3 ES 2051723 T3 ES2051723 T3 ES 2051723T3 ES 87117031 T ES87117031 T ES 87117031T ES 87117031 T ES87117031 T ES 87117031T ES 2051723 T3 ES2051723 T3 ES 2051723T3
Authority
ES
Spain
Prior art keywords
tetrahydroaminokinolinols
cyclic
procedure
loweralkyl
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES87117031T
Other languages
English (en)
Inventor
Gregory Michael Shutske
Kevin J Kapples
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Hoechst Roussel Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Roussel Pharmaceuticals Inc filed Critical Hoechst Roussel Pharmaceuticals Inc
Application granted granted Critical
Publication of ES2051723T3 publication Critical patent/ES2051723T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Abstract

SE LOGRAN COMPUESTOS DE FORMULA (I) SIENDO R4 ALQUILO INFERIOR Y SIENDO R5 HIDROGENO O ALQUILO INFERIOR, Z ES (III), N ES 1,2 O 3, R1 Y R2 SON CADA UNO INDEPENDIENTEMENTE HIDROGENO, ALQUILO INFERIOR O ALQUILO INFERIOR ARILO, Y R3 ES HIDROGENO O ALQUILO INFERIOR A CONDICION DE QUE CUANDO =X-Y ES = N-N-R4, N ES 2 O 3, R1 ES HIDROGENO Y R2 ES HIDROGENO O ALQUILO INFERIOR Y Z NO SEA C=0. ESTOS COMPUESTOS SON DE UTILIDAD PARA MEJORAR LA MEMORIA Y EN EL TRATAMIENTO DELA ENFERMEDAD DE ALZHEIMER.
ES87117031T 1986-11-24 1987-11-19 Procedimiento para preparar tetrahidroaminoquinolinoles heterociclicos condensados. Expired - Lifetime ES2051723T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/934,038 US4753950A (en) 1986-11-24 1986-11-24 Fused heterocyclic tetrahydroaminoquinolinols and related compounds

Publications (1)

Publication Number Publication Date
ES2051723T3 true ES2051723T3 (es) 1994-07-01

Family

ID=25464855

Family Applications (1)

Application Number Title Priority Date Filing Date
ES87117031T Expired - Lifetime ES2051723T3 (es) 1986-11-24 1987-11-19 Procedimiento para preparar tetrahidroaminoquinolinoles heterociclicos condensados.

Country Status (17)

Country Link
US (1) US4753950A (es)
EP (1) EP0273176B1 (es)
JP (1) JPS63141980A (es)
KR (1) KR880006203A (es)
AT (1) ATE77625T1 (es)
AU (1) AU604786B2 (es)
DE (1) DE3780015T2 (es)
DK (1) DK613687A (es)
ES (1) ES2051723T3 (es)
FI (1) FI875145A (es)
GR (1) GR3005461T3 (es)
IL (1) IL84564A (es)
NO (1) NO167863C (es)
NZ (1) NZ222640A (es)
PH (1) PH25317A (es)
PT (1) PT86197B (es)
ZA (1) ZA878763B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4851536A (en) * 1987-05-07 1989-07-25 American Home Products Corporation Cyclohexylquinolines as inhibitors of interleukin 1
IL87861A0 (en) * 1987-10-05 1989-03-31 Pfizer 4-aminopyridine derivatives
US5202440A (en) * 1987-10-05 1993-04-13 Pfizer Inc. Certain 9-amino-2-(or 4)-oxa 1,2,3,4-tetrahydro- or 1,2,3,4,5,6,7,8-octahydro-acridines
US5008853A (en) 1987-12-02 1991-04-16 Xerox Corporation Representation of collaborative multi-user activities relative to shared structured data objects in a networked workstation environment
US4985430A (en) 1987-12-03 1991-01-15 Mitsubishi Kasei Corporation 9-acylamino-tetrahydroacridine derivatives and memory enhancing agent containing said derivative as active ingredient
US4916135A (en) * 1989-05-08 1990-04-10 Hoechst Roussel Pharmaceuticals Inc. N-heteroaryl-4-quinolinamines
CA2029497C (en) * 1989-11-08 2002-06-04 Kunihiro Ninomiya (Deceased) 4-acylaminopyridine derivative
US5608067A (en) * 1993-12-09 1997-03-04 Afonso; Adriano 4-substituted pyrazoloquinoline derivatives
US5786480A (en) * 1994-04-28 1998-07-28 Schering Corporation 4-substituted pyrazoloquinoline derivatives
KR101953366B1 (ko) 2018-12-26 2019-02-28 정종문 침향을 포함하는 기억력 및 인지능력을 향상시키는 기능성 건강식품 및 이의 제조방법

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8329531D0 (en) * 1983-11-04 1983-12-07 Ici America Inc Pyrazolopyridine cycloalkanones
EP0179383B1 (en) * 1984-10-25 1991-05-29 Hoechst-Roussel Pharmaceuticals Incorporated 9-amino-1,2,3,4-tetrahydroacridin-1-ol and related compounds, a process for their preparation and their use as medicaments
IL87861A0 (en) * 1987-10-05 1989-03-31 Pfizer 4-aminopyridine derivatives

Also Published As

Publication number Publication date
KR880006203A (ko) 1988-07-22
NO874872D0 (no) 1987-11-23
DK613687A (da) 1988-05-25
AU604786B2 (en) 1991-01-03
IL84564A0 (en) 1988-04-29
ATE77625T1 (de) 1992-07-15
DE3780015T2 (de) 1993-01-21
US4753950A (en) 1988-06-28
ZA878763B (en) 1988-05-19
DK613687D0 (da) 1987-11-23
PH25317A (en) 1991-04-30
FI875145A0 (fi) 1987-11-20
NO167863B (no) 1991-09-09
NO167863C (no) 1991-12-18
PT86197A (en) 1987-12-01
DE3780015D1 (de) 1992-07-30
PT86197B (pt) 1990-11-07
AU8148387A (en) 1988-05-26
JPS63141980A (ja) 1988-06-14
GR3005461T3 (es) 1993-05-24
EP0273176B1 (en) 1992-06-24
NZ222640A (en) 1990-10-26
FI875145A (fi) 1988-05-25
IL84564A (en) 1993-03-15
NO874872L (no) 1988-05-25
EP0273176A3 (en) 1988-07-20
EP0273176A2 (en) 1988-07-06

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