DK0424168T3 - Polymerkomplekser af en type, som reagerer på sukkerarter - Google Patents

Polymerkomplekser af en type, som reagerer på sukkerarter

Info

Publication number
DK0424168T3
DK0424168T3 DK90311485.8T DK90311485T DK0424168T3 DK 0424168 T3 DK0424168 T3 DK 0424168T3 DK 90311485 T DK90311485 T DK 90311485T DK 0424168 T3 DK0424168 T3 DK 0424168T3
Authority
DK
Denmark
Prior art keywords
sugars
respond
polymer complexes
complexes
polymer
Prior art date
Application number
DK90311485.8T
Other languages
Danish (da)
English (en)
Inventor
Tsuyoshi Miyazaki
Yoshishige Murata
Daijiro Shiino
Kazunori Waki
Yasuhisa Sakurai
Teruo Okano
Kazunori Kataoka
Yoshiyuki Koyama
Masayuki Yokoyama
Shigeru Kitano
Original Assignee
Nippon Oils & Fats Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP02241192A external-priority patent/JP3087293B2/ja
Priority claimed from JP2241191A external-priority patent/JP2874309B2/ja
Application filed by Nippon Oils & Fats Co Ltd filed Critical Nippon Oils & Fats Co Ltd
Application granted granted Critical
Publication of DK0424168T3 publication Critical patent/DK0424168T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Medicinal Preparation (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK90311485.8T 1989-10-19 1990-10-19 Polymerkomplekser af en type, som reagerer på sukkerarter DK0424168T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP27021589 1989-10-19
JP02241192A JP3087293B2 (ja) 1990-09-13 1990-09-13 糖応答型高分子複合体
JP2241191A JP2874309B2 (ja) 1990-09-13 1990-09-13 糖応答性高分子複合体

Publications (1)

Publication Number Publication Date
DK0424168T3 true DK0424168T3 (da) 1993-12-13

Family

ID=27332917

Family Applications (1)

Application Number Title Priority Date Filing Date
DK90311485.8T DK0424168T3 (da) 1989-10-19 1990-10-19 Polymerkomplekser af en type, som reagerer på sukkerarter

Country Status (8)

Country Link
US (1) US5478575A (fr)
EP (1) EP0424168B1 (fr)
KR (1) KR930001305B1 (fr)
AU (1) AU628674B2 (fr)
CA (1) CA2027930C (fr)
DE (1) DE69003068T2 (fr)
DK (1) DK0424168T3 (fr)
TW (1) TW218353B (fr)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997037680A1 (fr) * 1996-04-05 1997-10-16 The Board Of Trustees Of The University Of Illinois Complexes macromoleculaires pour administration de medicaments
US5935599A (en) * 1996-10-28 1999-08-10 The Board Of Trustees Of The University Of Illinois Polymer-associated liposomes for drug delivery and method of manufacturing the same
US7316999B2 (en) * 2000-06-02 2008-01-08 Novo Nordisk A/S Glucose dependent release of insulin from glucose sensing insulin derivatives
AU2001263775A1 (en) * 2000-06-02 2001-12-11 Novo-Nordisk A/S Glucose dependent release of insulin from glucose sensing insulin derivatives
US6417237B1 (en) 2000-06-08 2002-07-09 The Board Of Trustees Of The University Of Illinois Macromolecular drug complexes and compositions containing the same
KR100431536B1 (ko) * 2001-02-14 2004-05-20 박상규 ｐＨ변화를 이용한 식품 품질 식별표시계
JP5052736B2 (ja) * 2001-05-30 2012-10-17 中外製薬株式会社 タンパク質製剤
AU2002349295A1 (en) * 2001-12-02 2003-06-17 Novo Nordisk A/S Glucose dependant release of insulin from glucose sensing insulin derivatives
US7317000B2 (en) 2001-12-02 2008-01-08 Novo Nordisk A/S Glucose-dependent insulins
GB0305587D0 (en) * 2003-03-11 2003-04-16 Smart Holograms Ltd Sensor
CA2575431A1 (fr) * 2004-07-30 2006-02-02 Basf Ag Derives d'acide boronique polymeriques et utilisation dans la fabrication du papier
CA2507121A1 (fr) * 2005-05-12 2006-11-12 Le Groupe Lysac Inc. Complexes de galactomannan hydrophobes utilises comme polymeres superabsorbants
GB0519169D0 (en) * 2005-09-21 2005-10-26 Leuven K U Res & Dev Novel anti-viral strategy
ES2553154T3 (es) * 2006-05-09 2015-12-04 Novo Nordisk A/S Derivado de la insulina
JP5550338B2 (ja) * 2006-07-31 2014-07-16 ノボ・ノルデイスク・エー／エス ペグ化持続型インスリン
CN101541830A (zh) * 2006-09-22 2009-09-23 诺沃-诺迪斯克有限公司 蛋白酶抗性的胰岛素类似物
ES2563038T3 (es) * 2007-04-30 2016-03-10 Novo Nordisk A/S Método para secar una composición proteica, una composición proteica seca y una composición farmacéutica que comprende la proteína seca
JP5675347B2 (ja) * 2007-06-01 2015-02-25 ノボ・ノルデイスク・エー／エス 安定した非水性薬学的組成物
ES2618073T3 (es) * 2008-03-14 2017-06-20 Novo Nordisk A/S Análogos de insulina estabilizados frente a proteasas
EP2910571B1 (fr) 2008-03-18 2016-10-05 Novo Nordisk A/S Analogues de l'insuline acylés, stabilisés à la protéase
AU2010208381A1 (en) 2009-01-28 2011-08-04 Smartcells, Inc. Exogenously triggered controlled release materials and uses thereof
SG173117A1 (en) 2009-01-28 2011-08-29 Smartcells Inc Crystalline insulin-conjugates
WO2010088286A1 (fr) 2009-01-28 2010-08-05 Smartcells, Inc. Conjugués synthétiques et leurs utilisations
MA33064B1 (fr) 2009-01-28 2012-02-01 Smartcells Inc Systemes à base de conjugués pour administration contrôlée de médicaments
WO2010107519A1 (fr) 2009-03-20 2010-09-23 Smartcells, Inc. Conjugués fonctionnalisés aux extrémités et leurs utilisations
EP2408470A4 (fr) 2009-03-20 2012-08-29 Smartcells Inc Conjugués d'insulines non déposées solubles et leurs utilisations
WO2011000823A1 (fr) 2009-06-30 2011-01-06 Novo Nordisk A/S Dérivés de l'insuline
EP2582741B1 (fr) 2010-06-18 2016-07-27 Universiteit Twente Polymères borés
JP2013541500A (ja) 2010-07-28 2013-11-14 スマートセルズ・インコーポレイテツド 組換えレクチン、結合部位修飾レクチンおよびそれらの用途
WO2012015692A2 (fr) 2010-07-28 2012-02-02 Smartcells, Inc. Polypeptides d'insuline exprimés de façon recombinante et utilisations de ceux-ci
US8933207B2 (en) 2010-07-28 2015-01-13 Smartcells, Inc. Drug-ligand conjugates, synthesis thereof, and intermediates thereto
CA2870313A1 (fr) 2012-04-11 2013-10-17 Novo Nordisk A/S Formulations a base d'insuline
WO2013168136A1 (fr) * 2012-05-11 2013-11-14 Schlumberger Technology B.V. Épaississement de fluides
JP6364067B2 (ja) 2013-04-05 2018-07-25 ノボ・ノルデイスク・エー／エス 薬剤送達装置の投与記録装置
MX366852B (es) 2013-10-04 2019-07-25 Merck Sharp & Dohme Conjugados de insulina sensibles a glucosa.
WO2015052088A1 (fr) 2013-10-07 2015-04-16 Novo Nordisk A/S Nouveau dérivé d'un analogue de l'insuline
CN105153347B (zh) * 2015-08-11 2017-07-07 台州学院 糖响应的单分散聚合物空心微球的制备方法
EP3393641B1 (fr) * 2015-12-22 2020-04-29 DDP Specialty Electronic Materials US 8, LLC Procédé de polymérisation en suspension de gouttelettes distribuées dans un milieu aqueux
MX2019006463A (es) 2016-12-16 2019-08-14 Novo Nordisk As Composiciones farmaceuticas que contienen insulina.
WO2018223114A1 (fr) * 2017-06-02 2018-12-06 North Carolina State University Compositions sensibles au glucose pour l'administration de médicament
CN107556509B (zh) * 2017-08-28 2020-07-14 上海第二工业大学 一种二维光子晶体葡萄糖传感薄膜的制备方法
JP7254792B2 (ja) 2017-11-09 2023-04-10 ノヴォ ノルディスク アー／エス グルコース感受性アルブミン結合誘導体
CN108102004B (zh) * 2018-01-03 2020-02-14 温州医科大学附属第二医院、温州医科大学附属育英儿童医院 一种葡聚糖聚合物、聚合物胶束和药物载体系统
CN110452390B (zh) * 2018-05-03 2021-04-06 清华大学深圳研究生院 一种胰岛素智能给药制剂
EP3586876A1 (fr) 2018-06-21 2020-01-01 Gubra ApS Hormones peptidiques sensibles au glucose
TW202112397A (zh) * 2019-03-29 2021-04-01 丹麥商諾佛．儂迪克股份有限公司 葡萄糖敏感型胰島素衍生物
CN110483691B (zh) * 2019-09-25 2021-11-09 安徽大学 一种三元共聚物交联剂及其在扩散渗析专用阳离子膜制备中的应用
CN115975224B (zh) * 2023-03-16 2023-08-08 四川大学 一种pH/ROS双响应的组织粘附载药水凝胶及其制备方法和应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0110879A1 (fr) * 1982-05-26 1984-06-20 The Children's Medical Center Corporation Composes informateurs
IT1173459B (it) * 1984-03-22 1987-06-24 Sirac Spa Resine boroniche stabili ad elevato potere assorbente selettivo
IT1215406B (it) * 1987-04-03 1990-02-08 Sirac Spa Resine boroniche stabili di elevato poytere assorbente selettivo.
IT1215407B (it) * 1987-04-03 1990-02-08 Sirac Spa Resine boroniche di elevato potere assorbente selettivo.

Also Published As

Publication number Publication date
US5478575A (en) 1995-12-26
DE69003068D1 (de) 1993-10-07
AU6475490A (en) 1991-07-11
EP0424168A1 (fr) 1991-04-24
KR910007545A (ko) 1991-05-30
DE69003068T2 (de) 1993-12-16
CA2027930A1 (fr) 1991-04-20
EP0424168B1 (fr) 1993-09-01
KR930001305B1 (ko) 1993-02-25
AU628674B2 (en) 1992-09-17
CA2027930C (fr) 1998-06-30
TW218353B (fr) 1994-01-01

Similar Documents

Publication Publication Date Title
DK0424168T3 (da) Polymerkomplekser af en type, som reagerer på sukkerarter
FI870614A (fi) Haerdbara blandningar, vilka innehaoller n-sulfonylaminosulfoniumsalter som kationiskt verksamma katalysatorer.
FI874125A0 (fi) Tvaettmedelskompositioner, vilka innehaoller polyalkylenglykol-iminodiaettiksyra som stoedsubstans.
FI913215A0 (fi) Additionspolymeriseringskatalysator, som aktiveras medelst oxidering.
DE68904101D1 (de) Polymerzusammensetzungen.
FI883175A0 (fi) Displayfoersett elektroniskt maolspel, som sjaelv raeknar poaeng.
FI893557A0 (fi) Polyestrar, som innehaoller en eterbrygga.
FI900125A0 (fi) Positivt arbetande straolningskaenslig blandning innehaollande en flerfunktionell a-diazo-b-ketoester, foerfarande foer dess framstaellning och staolningskaensligt registreringsmaterial som innehaoller denna blandning.
FI903028A0 (fi) Polymerbaserade blandningskompositioner, som innehaoller destrukturerad staerkelse.
DE59004206D1 (de) Cellulosische Membranen.
FI891411A (fi) Neopentylesterderivat, foerfarande foer deras framstaellning och deras anvaendning som laekemedel.
FI905020A0 (fi) Orala kompositioner, som innehaoller monoperoxisyror.
FI896346A0 (fi) Organiska, svavelhaltiga foereningar foer anvaendning i positiva, elektrostatiska, vaetskeformiga framkallningsmedel.
FI890098A0 (fi) Pyrazol- och indazolpyridinaminer, foerfarande foer deras framstaellning och deras anvaendning som laekemedel.
FI920080A0 (fi) Kulfaongare, som uppstannar kulor.
DE68914047D1 (de) Polymer-Zusammensetzungen.
DE3750645D1 (de) Räumliche, optische logische Anordnung.
FI903792A0 (fi) Nickel-kopparskaerstenkonverter, i vilken anvaends kvaeveanrikad blaestring.
FI891409A0 (fi) Dietylenglykolmonoestrar, foerfaranden foer deras framstaellning och deras framstaellning och deras anvaendning som laekemedel.
FI903774A0 (fi) Ogarvade, biologiskt stabila skinn i fuktig form.
DE3750720D1 (de) Transparentes, hochschlagfestes Blockkopolymer.
FI902177A0 (fi) Kompositioner som innehaoller elastomerer och icke-karboniserade, metaller innehaollande komplex.
FI882610A (fi) Bett, speciellt kniv- eller saxbett foer skaerande verktyg.
NO885331D0 (no) Ispropp som tunnel-luke.
FI884176A0 (fi) Foerbaettringar i spickbleck, spikblecksfoerband och- konstruktioner.