DK0412466T3 - Fremgangsmåde til fremstilling af en stabil faktor VIII - Google Patents

Fremgangsmåde til fremstilling af en stabil faktor VIII

Info

Publication number
DK0412466T3
DK0412466T3 DK90115005.2T DK90115005T DK0412466T3 DK 0412466 T3 DK0412466 T3 DK 0412466T3 DK 90115005 T DK90115005 T DK 90115005T DK 0412466 T3 DK0412466 T3 DK 0412466T3
Authority
DK
Denmark
Prior art keywords
factor viii
producing
stable factor
stable
adsorptions
Prior art date
Application number
DK90115005.2T
Other languages
English (en)
Inventor
Gerhardt Kumpe
Klaus Wellner
Norbert Dr Prof Heimburger
Karl-Heinz Wenz
Original Assignee
Behringwerke Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Behringwerke Ag filed Critical Behringwerke Ag
Application granted granted Critical
Publication of DK0412466T3 publication Critical patent/DK0412466T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/16—Blood plasma; Blood serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Biotechnology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
DK90115005.2T 1989-08-07 1990-08-04 Fremgangsmåde til fremstilling af en stabil faktor VIII DK0412466T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3926034A DE3926034C3 (de) 1989-08-07 1989-08-07 Verfahren zur Herstellung eines stabilen Faktors VIII

Publications (1)

Publication Number Publication Date
DK0412466T3 true DK0412466T3 (da) 1994-05-24

Family

ID=6386638

Family Applications (1)

Application Number Title Priority Date Filing Date
DK90115005.2T DK0412466T3 (da) 1989-08-07 1990-08-04 Fremgangsmåde til fremstilling af en stabil faktor VIII

Country Status (12)

Country Link
US (1) US5424401A (da)
EP (1) EP0412466B1 (da)
JP (1) JP3180957B2 (da)
KR (1) KR0174262B1 (da)
AT (1) ATE101041T1 (da)
AU (1) AU635298B2 (da)
CA (1) CA2022650C (da)
DE (2) DE3926034C3 (da)
DK (1) DK0412466T3 (da)
ES (1) ES2062222T3 (da)
IE (1) IE63919B1 (da)
PT (1) PT94917B (da)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4111393A1 (de) * 1991-04-09 1992-10-15 Behringwerke Ag Stabilisierte faktor viii-praeparationen
SE9403915D0 (sv) * 1994-11-14 1994-11-14 Annelie Almstedt Process A
US5659017A (en) * 1995-11-07 1997-08-19 Alpha Therapeutic Corporation Anion exchange process for the purification of Factor VIII
US6057164A (en) * 1996-03-08 2000-05-02 Octapharma Ag Process for testing suitability of protein fractions containing factor VIII
JP5149470B2 (ja) 1999-02-22 2013-02-20 バクスター・インターナショナル・インコーポレイテッド 新規のアルブミンを含有していない第ｖｉｉｉ因子処方物
NZ593190A (en) 2008-11-07 2013-01-25 Baxter Int Factor viii formulations
AU2015207472B2 (en) * 2014-01-20 2018-11-22 Octapharma Ag A process for manufacturing factor VIII having an improved ratio of FVIII:C/FVIII:Ag

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE713764A (da) * 1967-05-01 1968-09-16 Baxter Travenol Lab
JPS52125609A (en) * 1976-04-09 1977-10-21 Green Cross Corp:The Purification of agglutination factor viii
CA1054052A (en) * 1976-08-14 1979-05-08 Edward Shanbrom Simplified method for preparation of high yield, high purity factor viii concentrate
DE2902158A1 (de) * 1979-01-20 1980-07-31 Biotest Serum Institut Gmbh Verfahren zur herstellung von fibrinogen, einem die gerinnungsfaktoren ii, vii, ix und x enthaltenden prothrombinkomplex, antithrombin iii und einer loesung von lagerstabilen serumproteinen
US4305870A (en) * 1979-01-31 1981-12-15 Immuno Aktiengesellschaft Fur Chemisch-Medizinische Produkte Intravenous plasma derivatives and their production
DE2916711A1 (de) * 1979-04-25 1980-11-06 Behringwerke Ag Blutgerinnungsfaktoren und verfahren zu ihrer herstellung
SE448945B (sv) * 1979-12-20 1987-03-30 Blombaeck E G B Forfarande for rening och /eller koncentrering av faktor viii-komplexet
US4361509A (en) * 1981-12-14 1982-11-30 Scripps Clinic And Research Foundation Ultrapurification of factor VIII using monoclonal antibodies
US4495175A (en) * 1982-08-05 1985-01-22 University Of Rochester Preparation of highly purified human antihemophilic factor
DE3432083A1 (de) * 1984-08-31 1986-03-06 Behringwerke Ag, 3550 Marburg Pasteurisierte, isoagglutininfreie faktor viii-praeparation und verfahren zu ihrer herstellung
US4743680A (en) * 1985-02-01 1988-05-10 New York University Method for purifying antihemophilic factor
CA1293941C (en) * 1985-11-08 1992-01-07 Maria Erlinda Co-Sarno Method for preparing antihemophilic factor (ahf) by cold precipitation and for improving solubility of recovered ahf product
JPS63108000A (ja) * 1986-05-15 1988-05-12 Green Cross Corp:The 第８因子の精製方法
FR2632309B1 (fr) * 1988-06-07 1990-08-24 Lille Transfusion Sanguine Procede de purification par voie chromatographique de proteines, notamment de facteur viii, et les produits obtenus
FR2681867B1 (fr) * 1991-09-26 1993-12-31 Pasteur Merieux Serums Vaccins Procede de purification du facteur viii et preparations obtenues.

Also Published As

Publication number Publication date
DE59004488D1 (de) 1994-03-17
DE3926034C3 (de) 1996-11-21
US5424401A (en) 1995-06-13
IE63919B1 (en) 1995-06-14
KR910004208A (ko) 1991-03-28
CA2022650A1 (en) 1991-02-08
EP0412466A2 (de) 1991-02-13
AU6015090A (en) 1991-02-07
IE902817A1 (en) 1991-02-27
CA2022650C (en) 2001-06-05
ATE101041T1 (de) 1994-02-15
JPH03148294A (ja) 1991-06-25
PT94917A (pt) 1991-04-18
EP0412466A3 (en) 1991-09-18
ES2062222T3 (es) 1994-12-16
PT94917B (pt) 1997-05-28
EP0412466B1 (de) 1994-02-02
DE3926034C2 (da) 1992-06-04
KR0174262B1 (ko) 1999-02-18
DE3926034A1 (de) 1991-02-14
AU635298B2 (en) 1993-03-18
JP3180957B2 (ja) 2001-07-03

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