DK0410278T3 - Reninhæmmende aminooligohydroxyderivater - Google Patents

Reninhæmmende aminooligohydroxyderivater

Info

Publication number
DK0410278T3
DK0410278T3 DK90113712.5T DK90113712T DK0410278T3 DK 0410278 T3 DK0410278 T3 DK 0410278T3 DK 90113712 T DK90113712 T DK 90113712T DK 0410278 T3 DK0410278 T3 DK 0410278T3
Authority
DK
Denmark
Prior art keywords
oligohydroxy
derivatives
pure
inhibiting amino
inhibiting
Prior art date
Application number
DK90113712.5T
Other languages
Danish (da)
English (en)
Inventor
Hansjoerg Dr Urbach
Adalbert Dr Wagner
Heinz-Werner Dr Kleemann
Dieter Dr Ruppert
Wolfgang Dr Linz
Werner Dr Dr Kramer
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE3924506A external-priority patent/DE3924506A1/de
Priority claimed from DE19893932817 external-priority patent/DE3932817A1/de
Application filed by Hoechst Ag filed Critical Hoechst Ag
Application granted granted Critical
Publication of DK0410278T3 publication Critical patent/DK0410278T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/04Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C235/06Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06008Dipeptides with the first amino acid being neutral
    • C07K5/06078Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06139Dipeptides with the first amino acid being heterocyclic

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Hydrogenated Pyridines (AREA)
  • Saccharide Compounds (AREA)
  • Solid Fuels And Fuel-Associated Substances (AREA)
  • Preventing Corrosion Or Incrustation Of Metals (AREA)
  • Footwear And Its Accessory, Manufacturing Method And Apparatuses (AREA)
DK90113712.5T 1989-07-25 1990-07-18 Reninhæmmende aminooligohydroxyderivater DK0410278T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3924506A DE3924506A1 (de) 1989-07-25 1989-07-25 Renin-hemmende aminooligohydroxy-derivate
DE19893932817 DE3932817A1 (de) 1989-09-30 1989-09-30 Renin-hemmende aminooligohydroxy-derivate

Publications (1)

Publication Number Publication Date
DK0410278T3 true DK0410278T3 (da) 1994-05-24

Family

ID=25883333

Family Applications (1)

Application Number Title Priority Date Filing Date
DK90113712.5T DK0410278T3 (da) 1989-07-25 1990-07-18 Reninhæmmende aminooligohydroxyderivater

Country Status (20)

Country Link
EP (1) EP0410278B1 (pt)
JP (1) JPH0366652A (pt)
KR (1) KR910002776A (pt)
CN (1) CN1049164A (pt)
AT (1) ATE100463T1 (pt)
AU (1) AU639246B2 (pt)
CA (1) CA2021822A1 (pt)
CS (1) CS368890A3 (pt)
DE (1) DE59004292D1 (pt)
DK (1) DK0410278T3 (pt)
ES (1) ES2062214T3 (pt)
FI (1) FI903701A0 (pt)
HU (1) HU205140B (pt)
IE (1) IE902686A1 (pt)
IL (1) IL95166A0 (pt)
MA (1) MA21913A1 (pt)
NO (1) NO903291L (pt)
NZ (1) NZ234608A (pt)
PL (1) PL286188A1 (pt)
PT (1) PT94798A (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW209870B (pt) * 1990-01-18 1993-07-21 Pfizer
IE68045B1 (en) * 1990-05-11 1996-05-15 Abbott Lab Renin inhibitors
JPH06500561A (ja) * 1990-08-24 1994-01-20 ジ・アップジョン・カンパニー 遷移状態模擬体としてのアミノポリオール含有ペプチド
EP0483403A1 (en) * 1990-10-31 1992-05-06 Hoechst Aktiengesellschaft Derivatives of amino acids as inhibitors of renin, methods for their preparation, medicaments containing them and their use
CA2404644A1 (en) * 2000-04-10 2001-10-18 Yuichi Ishida Modulators of prorenin activity

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK34086A (da) * 1985-01-23 1986-07-24 Abbott Lab Peptidylaminodioler
NZ218937A (en) * 1986-01-16 1990-03-27 Abbott Lab Functionalised peptidyl aminodiols and -triols as renin inhibitors and pharmaceutical compositions
US4863905A (en) * 1987-02-04 1989-09-05 Warner-Lambert Company Renin inhibitors II

Also Published As

Publication number Publication date
CN1049164A (zh) 1991-02-13
CA2021822A1 (en) 1991-01-26
KR910002776A (ko) 1991-02-26
PT94798A (pt) 1991-03-20
HU205140B (en) 1992-03-30
HUT55033A (en) 1991-04-29
AU5971990A (en) 1991-01-31
NZ234608A (en) 1991-12-23
ES2062214T3 (es) 1994-12-16
HU904582D0 (en) 1990-12-28
NO903291D0 (no) 1990-07-24
NO903291L (no) 1991-01-28
EP0410278A1 (de) 1991-01-30
PL286188A1 (en) 1991-04-22
AU639246B2 (en) 1993-07-22
DE59004292D1 (de) 1994-03-03
IL95166A0 (en) 1991-06-10
ATE100463T1 (de) 1994-02-15
FI903701A0 (fi) 1990-07-23
MA21913A1 (fr) 1991-04-01
CS368890A3 (en) 1992-02-19
EP0410278B1 (de) 1994-01-19
IE902686A1 (en) 1991-02-27
JPH0366652A (ja) 1991-03-22

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