DE942928T1 - Impfstoffzubereitung bestehend aus untereinheiten des respiratorischen synzytialvirus (rsv) - Google Patents
Impfstoffzubereitung bestehend aus untereinheiten des respiratorischen synzytialvirus (rsv)Info
- Publication number
- DE942928T1 DE942928T1 DE0942928T DE97930274T DE942928T1 DE 942928 T1 DE942928 T1 DE 942928T1 DE 0942928 T DE0942928 T DE 0942928T DE 97930274 T DE97930274 T DE 97930274T DE 942928 T1 DE942928 T1 DE 942928T1
- Authority
- DE
- Germany
- Prior art keywords
- protein
- virus
- rsv
- respiratory
- synvial
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 241000700605 Viruses Species 0.000 title abstract 2
- 230000000241 respiratory effect Effects 0.000 title 1
- 229960005486 vaccine Drugs 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 abstract 6
- 102000004169 proteins and genes Human genes 0.000 abstract 6
- 241000725643 Respiratory syncytial virus Species 0.000 abstract 3
- 230000002163 immunogen Effects 0.000 abstract 2
- 239000011159 matrix material Substances 0.000 abstract 2
- 108010068327 4-hydroxyphenylpyruvate dioxygenase Proteins 0.000 abstract 1
- 108091006027 G proteins Proteins 0.000 abstract 1
- 108091000058 GTP-Binding Proteins 0.000 abstract 1
- 101710085938 Matrix protein Proteins 0.000 abstract 1
- 101710127721 Membrane protein Proteins 0.000 abstract 1
- 206010061603 Respiratory syncytial virus infection Diseases 0.000 abstract 1
- 238000010171 animal model Methods 0.000 abstract 1
- 239000003599 detergent Substances 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 238000000605 extraction Methods 0.000 abstract 1
- 230000004927 fusion Effects 0.000 abstract 1
- 229910052588 hydroxylapatite Inorganic materials 0.000 abstract 1
- 238000005342 ion exchange Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 abstract 1
- 208000030925 respiratory syncytial virus infectious disease Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/155—Paramyxoviridae, e.g. parainfluenza virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/04—Drugs for disorders of the respiratory system for throat disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56983—Viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55577—Saponins; Quil A; QS21; ISCOMS
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
- C12N2760/18521—Viruses as such, e.g. new isolates, mutants or their genomic sequences
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
- C12N2760/18522—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
- C12N2760/18534—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
- C12N2760/18551—Methods of production or purification of viral material
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Mycology (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cell Biology (AREA)
- Physics & Mathematics (AREA)
- General Engineering & Computer Science (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Food Science & Technology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/679,060 US6020182A (en) | 1996-07-12 | 1996-07-12 | Subunit respiratory syncytial virus vaccine preparation |
| PCT/CA1997/000497 WO1998002457A1 (en) | 1996-07-12 | 1997-07-11 | Subunit respiratory syncytial virus vaccine preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE942928T1 true DE942928T1 (de) | 2000-03-02 |
Family
ID=24725423
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE0942928T Pending DE942928T1 (de) | 1996-07-12 | 1997-07-11 | Impfstoffzubereitung bestehend aus untereinheiten des respiratorischen synzytialvirus (rsv) |
| DE69731659T Expired - Lifetime DE69731659T3 (de) | 1996-07-12 | 1997-07-11 | Impfstoffzubereitung bestehend aus untereinheiten des respiratorischen synzytialvirus (rsv) |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69731659T Expired - Lifetime DE69731659T3 (de) | 1996-07-12 | 1997-07-11 | Impfstoffzubereitung bestehend aus untereinheiten des respiratorischen synzytialvirus (rsv) |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US6020182A (de) |
| EP (2) | EP1477494A1 (de) |
| JP (1) | JP2000501418A (de) |
| CN (1) | CN1145639C (de) |
| AT (1) | ATE282633T1 (de) |
| AU (1) | AU716378B2 (de) |
| BR (1) | BR9712970A (de) |
| CA (1) | CA2259594C (de) |
| DE (2) | DE942928T1 (de) |
| ES (1) | ES2141065T5 (de) |
| GR (1) | GR990300042T1 (de) |
| HK (1) | HK1022704A1 (de) |
| NZ (1) | NZ334115A (de) |
| RU (1) | RU2243234C2 (de) |
| WO (1) | WO1998002457A1 (de) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020136739A1 (en) * | 1996-07-12 | 2002-09-26 | Cates George A. | Subunit respiratory syncytial virus preparation |
| US6020182A (en) * | 1996-07-12 | 2000-02-01 | Connaught Laboratories Limited | Subunit respiratory syncytial virus vaccine preparation |
| US6017694A (en) * | 1997-12-19 | 2000-01-25 | American Cyanamid Company | Methods of screening for modulators of respiratory syncytial virus matrix protein interaction |
| NZ512980A (en) * | 1998-12-17 | 2003-07-25 | Aventis Pasteur | Multivalent immunogenic composition containing RSV subunit composition and influenza virus preparation |
| GB9909077D0 (en) * | 1999-04-20 | 1999-06-16 | Smithkline Beecham Biolog | Novel compositions |
| WO2001006429A1 (en) * | 1999-07-15 | 2001-01-25 | Shea Robert S | Method of sequencing chronic disease testing, reporting and evaluation |
| DE60136334D1 (en) | 2000-02-02 | 2008-12-11 | Us Health | Cd40-ligand als adjuvant für respiratorisches syncytialvirus-impfstoff |
| FR2806912B1 (fr) * | 2000-04-04 | 2004-07-23 | Fond Mondiale Rech Et Preventi | UTILISATION DE PROTEINES gp120 ET gp160 MODIFIEES DANS LA BOUCLE V3 DU VIH-1 POUR LA PREPARATION DE COMPOSITIONS VACCINALES ET FORMULATIONS LES CONTENANT |
| US20040022800A1 (en) * | 2000-07-31 | 2004-02-05 | Mark Parrington | Respiratory syncytial virus vaccine |
| CA2418939A1 (en) * | 2000-08-07 | 2002-02-14 | Aventis Pasteur Limited | Stabilization of immunogens derived from paramyxoviruses |
| AU2002224416A1 (en) * | 2000-10-18 | 2002-04-29 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services, Centers For Disease Control And Prevention | Compositions and methods for modulating RSV infection and immunity |
| EP1441762A1 (de) | 2001-09-28 | 2004-08-04 | University Of South Florida | Rsv genexpressions impstoff |
| CA2436972A1 (en) * | 2001-12-20 | 2003-07-03 | Aventis Pasteur Limited | Immunogenic compositions comprising an antigen and a purified m protein from respiratory syncytial virus |
| US7354908B2 (en) | 2002-04-30 | 2008-04-08 | University Of South Florida | Materials and methods for prevention and treatment of RNA viral diseases |
| US7595303B1 (en) | 2002-09-05 | 2009-09-29 | University Of South Florida | Genetic adjuvants for immunotherapy |
| WO2004083397A2 (en) * | 2003-03-18 | 2004-09-30 | Wyeth Holdings Corporation | Process for increasing rsv surface glycoprotein yields using a mutant strain of rsv |
| CA2703667C (en) * | 2007-10-25 | 2015-12-29 | Lawrence M. Kauvar | Anti-rsv g protein antibodies |
| ES2713864T3 (es) | 2008-06-05 | 2019-05-24 | Ablynx Nv | Secuencias de aminoácidos dirigidas contra proteínas de la envuelta de un virus y polipéptidos que comprenden las mismas para el tratamiento de enfermedades virales |
| DK3067064T3 (da) * | 2008-12-09 | 2020-06-08 | Novavax Inc | Modificerede rsv-f-proteiner og fremgangsmåder til anvendelse deraf |
| HUE035773T2 (en) * | 2009-06-05 | 2018-05-28 | Ablynx Nv | Trivalent human airway giant cell virus (hrsv) nanotubes for preventing and / or treating respiratory infections |
| US20120164176A1 (en) * | 2009-07-15 | 2012-06-28 | Kurt Swanson | Rsv f protein compositions amd methods for making same |
| NZ599148A (en) * | 2009-10-06 | 2014-08-29 | Medimmune Ltd | Rsv-specific binding molecule |
| BR112012015596B1 (pt) * | 2009-12-23 | 2021-06-01 | Sanofi Pasteur | Processo de cultura de células aderentes |
| CN102199198A (zh) * | 2011-03-28 | 2011-09-28 | 北京交通大学 | 人呼吸道合胞病毒f蛋白的纯化方法 |
| KR102435054B1 (ko) | 2012-08-01 | 2022-08-22 | 버베리안 노딕 에이/에스 | 재조합 변형된 백시니아 바이러스 앙카라(ankara) (mva) 호흡기 신시티알 바이러스(rsv) 백신 |
| CN112851766A (zh) | 2013-03-13 | 2021-05-28 | 美国政府(由卫生和人类服务部的部长所代表) | 融合前rsv f蛋白和其用途 |
| US9738689B2 (en) | 2013-03-13 | 2017-08-22 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Prefusion RSV F proteins and their use |
| JP6479305B2 (ja) | 2013-07-12 | 2019-03-06 | 株式会社Ｕｍｎファーマ | ウイルス様粒子の精製方法 |
| EP3076999B1 (de) * | 2013-12-02 | 2020-01-22 | The U.S.A. as represented by the Secretary, Department of Health and Human Services | Rekombinante fragmente des g proteins des respiratorischen synzytial-virus |
| RU2746280C1 (ru) * | 2020-08-03 | 2021-04-12 | Федеральное государственное бюджетное научное учреждение "Федеральный исследовательский центр фундаментальной и трансляционной медицины" (ФИЦ ФТМ) | Штамм респираторно-синцитиального вируса RSV/Novosibirsk/66Hl/2018 для использования в диагностике респираторно-синцитиальной вирусной инфекции и исследования эффективности противовирусных препаратов in vitro |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3689622T2 (de) * | 1986-01-14 | 1994-06-16 | Univ North Carolina | Impfstoffe gegen menschliche respiratorische viren. |
| GB8914968D0 (en) * | 1989-06-29 | 1989-08-23 | Connaught Lab | Production of virus and purification of viral envelope proteins for vaccine use |
| DK0705109T4 (da) * | 1993-05-25 | 2004-05-10 | Wyeth Corp | Adjuvanser til vacciner mod respiratorisk syncytialvirus |
| US20030072774A1 (en) | 1994-06-10 | 2003-04-17 | Diane M. Gajewczyk | Proteinaceous adjuvants |
| US6020182A (en) * | 1996-07-12 | 2000-02-01 | Connaught Laboratories Limited | Subunit respiratory syncytial virus vaccine preparation |
-
1996
- 1996-07-12 US US08/679,060 patent/US6020182A/en not_active Expired - Lifetime
-
1997
- 1997-07-11 US US09/214,605 patent/US6309649B1/en not_active Expired - Fee Related
- 1997-07-11 JP JP10505475A patent/JP2000501418A/ja active Pending
- 1997-07-11 BR BR9712970-4A patent/BR9712970A/pt not_active Application Discontinuation
- 1997-07-11 CN CNB97197862XA patent/CN1145639C/zh not_active Expired - Fee Related
- 1997-07-11 DE DE0942928T patent/DE942928T1/de active Pending
- 1997-07-11 WO PCT/CA1997/000497 patent/WO1998002457A1/en active IP Right Grant
- 1997-07-11 CA CA002259594A patent/CA2259594C/en not_active Expired - Lifetime
- 1997-07-11 DE DE69731659T patent/DE69731659T3/de not_active Expired - Lifetime
- 1997-07-11 GR GR990300042T patent/GR990300042T1/el unknown
- 1997-07-11 AU AU34311/97A patent/AU716378B2/en not_active Ceased
- 1997-07-11 EP EP04018160A patent/EP1477494A1/de not_active Withdrawn
- 1997-07-11 ES ES97930274T patent/ES2141065T5/es not_active Expired - Lifetime
- 1997-07-11 RU RU99102812/13A patent/RU2243234C2/ru not_active IP Right Cessation
- 1997-07-11 NZ NZ334115A patent/NZ334115A/en not_active IP Right Cessation
- 1997-07-11 AT AT97930274T patent/ATE282633T1/de active
- 1997-07-11 EP EP97930274A patent/EP0942928B2/de not_active Expired - Lifetime
-
2000
- 2000-03-21 HK HK00101725A patent/HK1022704A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ES2141065T3 (es) | 2005-05-01 |
| US6309649B1 (en) | 2001-10-30 |
| WO1998002457A1 (en) | 1998-01-22 |
| AU3431197A (en) | 1998-02-09 |
| CN1230197A (zh) | 1999-09-29 |
| DE69731659T3 (de) | 2009-06-18 |
| JP2000501418A (ja) | 2000-02-08 |
| NZ334115A (en) | 2000-06-23 |
| EP0942928B2 (de) | 2008-08-13 |
| ES2141065T1 (es) | 2000-03-16 |
| DE69731659T2 (de) | 2006-03-02 |
| CN1145639C (zh) | 2004-04-14 |
| ATE282633T1 (de) | 2004-12-15 |
| GR990300042T1 (en) | 2000-01-31 |
| AU716378B2 (en) | 2000-02-24 |
| RU2243234C2 (ru) | 2004-12-27 |
| BR9712970A (pt) | 2001-08-28 |
| US6020182A (en) | 2000-02-01 |
| CA2259594A1 (en) | 1998-01-22 |
| EP0942928A1 (de) | 1999-09-22 |
| HK1022704A1 (en) | 2000-08-18 |
| DE69731659D1 (de) | 2004-12-23 |
| CA2259594C (en) | 2003-11-11 |
| EP0942928B1 (de) | 2004-11-17 |
| EP1477494A1 (de) | 2004-11-17 |
| ES2141065T5 (es) | 2009-02-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE942928T1 (de) | Impfstoffzubereitung bestehend aus untereinheiten des respiratorischen synzytialvirus (rsv) | |
| DE69637914D1 (de) | Impstoff gegen den für atemwegs- und reproduktionserkrankungen beim schwein verantwortlichen virus | |
| DK1382348T3 (da) | Polynukleotidvaccineformulering, især til behandling af bovin luftvejssygdom | |
| ATE163682T1 (de) | Respiratorisches syncytiales virus, impstoffe | |
| PL375407A1 (en) | Vaccine composition | |
| PL331202A1 (en) | Polynucleotidic vaccine composition for treating horses' diseases | |
| CY1107146T1 (el) | Μεθοδοι για προληψη και θεραπεια ασθενειας alzheimer (ad) | |
| BR9506047A (pt) | Partículas montadas de um virus de planta vacina para proteção contra patógenos humanos ou animais vacina de virus de animal fragmento de cdna de proteína de revestimento de cpmv vetor transcrito de rna e processo para proteger animais (incluíndo humanos) contra patógenos | |
| DK162883A (da) | N-glucosylerede carboxylsyreamidderivater, fremgangsmaade til fremstilling heraf samt deres anvendelse til paavirkning af organismens egen forsvarsmekanisme | |
| ATE371373T1 (de) | Durch polynukleinsäuren vom reproduktiven und respiratorischen syndromvirus des schweines kodierte proteine | |
| HK1068282A1 (en) | Method for the preparation of a pharmaceutical composition comprising 5-aminosalicyclic acid for usein treatment of ulcerative colitis and crohn's di sease | |
| CA2399172A1 (en) | Cold-adapted equine influenza viruses | |
| AU9215101A (en) | Vaccines containing ribavirin and methods of use thereof | |
| DE69937269D1 (de) | Bioaktive Peptide, ihre Verwendung und Verfahren zu ihre Herstellung | |
| DE69323921T2 (de) | Mutante des Respiratory-syncytial-Virus (RS-Virus) und eine eine solche Mutante enthaltende pharmazeutische Zusammensetzung | |
| PT1015595E (pt) | Peptidos derivados da proteina de ligacao (g) do virus sincicial respiratorio | |
| WO2003022878A3 (en) | Subunit respiratory syncytial virus vaccine preparation | |
| CA2181590A1 (en) | Peptomers with enhanced immunogenicity | |
| WO1999014345A3 (de) | Arzneimittel zur therapie einer manifesten lyme-borreliose | |
| BR9815496A (pt) | Vacinas de ácido nucléico que codificam proteìna gde vìrus sincicial respiratório | |
| RU93048174A (ru) | Авирулентная вакцина против бешенства и способ ее получения | |
| EA200200743A1 (ru) | Рекомбинантное ослабление вируса репродуктивного и респираторного синдрома свиней (prrsv) | |
| WO2002009749A3 (en) | Respiratory syncytial virus vaccine | |
| PL353349A1 (en) | Method for isolating and purifying grass pollen allergens | |
| GB2283974A (en) | Allatostatins and their use |