GR990300042T1 - Subunit respiratory syncytial virus vaccine preparation - Google Patents
Subunit respiratory syncytial virus vaccine preparationInfo
- Publication number
- GR990300042T1 GR990300042T1 GR990300042T GR990300042T GR990300042T1 GR 990300042 T1 GR990300042 T1 GR 990300042T1 GR 990300042 T GR990300042 T GR 990300042T GR 990300042 T GR990300042 T GR 990300042T GR 990300042 T1 GR990300042 T1 GR 990300042T1
- Authority
- GR
- Greece
- Prior art keywords
- respiratory syncytial
- protein
- syncytial virus
- virus vaccine
- vaccine preparation
- Prior art date
Links
- 241000725643 Respiratory syncytial virus Species 0.000 title abstract 4
- 229960005486 vaccine Drugs 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 abstract 6
- 102000004169 proteins and genes Human genes 0.000 abstract 6
- 230000002163 immunogen Effects 0.000 abstract 2
- 239000011159 matrix material Substances 0.000 abstract 2
- 108010068327 4-hydroxyphenylpyruvate dioxygenase Proteins 0.000 abstract 1
- 108091006027 G proteins Proteins 0.000 abstract 1
- 108091000058 GTP-Binding Proteins 0.000 abstract 1
- 101710085938 Matrix protein Proteins 0.000 abstract 1
- 101710127721 Membrane protein Proteins 0.000 abstract 1
- 206010061603 Respiratory syncytial virus infection Diseases 0.000 abstract 1
- 241000700605 Viruses Species 0.000 abstract 1
- 238000010171 animal model Methods 0.000 abstract 1
- 239000003599 detergent Substances 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 238000000605 extraction Methods 0.000 abstract 1
- 230000004927 fusion Effects 0.000 abstract 1
- 229910052588 hydroxylapatite Inorganic materials 0.000 abstract 1
- 238000005342 ion exchange Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 abstract 1
- 208000030925 respiratory syncytial virus infectious disease Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/155—Paramyxoviridae, e.g. parainfluenza virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/04—Drugs for disorders of the respiratory system for throat disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56983—Viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55577—Saponins; Quil A; QS21; ISCOMS
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
- C12N2760/18521—Viruses as such, e.g. new isolates, mutants or their genomic sequences
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
- C12N2760/18522—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
- C12N2760/18534—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
- C12N2760/18551—Methods of production or purification of viral material
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Microbiology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Zoology (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Tropical Medicine & Parasitology (AREA)
- Oncology (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/679,060 US6020182A (en) | 1996-07-12 | 1996-07-12 | Subunit respiratory syncytial virus vaccine preparation |
| PCT/CA1997/000497 WO1998002457A1 (en) | 1996-07-12 | 1997-07-11 | Subunit respiratory syncytial virus vaccine preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GR990300042T1 true GR990300042T1 (en) | 2000-01-31 |
Family
ID=24725423
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GR990300042T GR990300042T1 (en) | 1996-07-12 | 1997-07-11 | Subunit respiratory syncytial virus vaccine preparation |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US6020182A (el) |
| EP (2) | EP1477494A1 (el) |
| JP (1) | JP2000501418A (el) |
| CN (1) | CN1145639C (el) |
| AT (1) | ATE282633T1 (el) |
| AU (1) | AU716378B2 (el) |
| BR (1) | BR9712970A (el) |
| CA (1) | CA2259594C (el) |
| DE (2) | DE942928T1 (el) |
| ES (1) | ES2141065T5 (el) |
| GR (1) | GR990300042T1 (el) |
| HK (1) | HK1022704A1 (el) |
| NZ (1) | NZ334115A (el) |
| RU (1) | RU2243234C2 (el) |
| WO (1) | WO1998002457A1 (el) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6020182A (en) * | 1996-07-12 | 2000-02-01 | Connaught Laboratories Limited | Subunit respiratory syncytial virus vaccine preparation |
| US20020136739A1 (en) * | 1996-07-12 | 2002-09-26 | Cates George A. | Subunit respiratory syncytial virus preparation |
| US6017694A (en) * | 1997-12-19 | 2000-01-25 | American Cyanamid Company | Methods of screening for modulators of respiratory syncytial virus matrix protein interaction |
| CA2355270A1 (en) * | 1998-12-17 | 2000-06-22 | Aventis Pasteur Limited | Multivalent immunogenic composition containing rsv subunit composition and influenza virus preparation |
| GB9909077D0 (en) * | 1999-04-20 | 1999-06-16 | Smithkline Beecham Biolog | Novel compositions |
| WO2001006429A1 (en) * | 1999-07-15 | 2001-01-25 | Shea Robert S | Method of sequencing chronic disease testing, reporting and evaluation |
| EP1255560B1 (en) * | 2000-02-02 | 2008-10-29 | UNITED STATES GOVERNMENT as represented by THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES, CENTERS FOR DISEASE | Cd40 ligand adjuvant for respiratory syncytial virus vaccine |
| FR2806912B1 (fr) * | 2000-04-04 | 2004-07-23 | Fond Mondiale Rech Et Preventi | UTILISATION DE PROTEINES gp120 ET gp160 MODIFIEES DANS LA BOUCLE V3 DU VIH-1 POUR LA PREPARATION DE COMPOSITIONS VACCINALES ET FORMULATIONS LES CONTENANT |
| WO2002009749A2 (en) * | 2000-07-31 | 2002-02-07 | Aventis Pasteur Limited | Respiratory syncytial virus vaccine |
| US20040052800A1 (en) * | 2000-08-07 | 2004-03-18 | Bruce Carpick | Stabilization of immunogens derived from paramyxoviruses |
| DE60136381D1 (de) * | 2000-10-18 | 2008-12-11 | Us Gov Health & Human Serv | Zusammensetzungen und verfahren zur modulierung von rsv-infektionen und -immunität |
| US7118888B2 (en) | 2001-09-28 | 2006-10-10 | University Of South Florida Board Of Trustees | Gene expression vaccine |
| AU2002350342A1 (en) * | 2001-12-20 | 2003-07-09 | Aventis Pasteur Limited | Immunogenic compositions comprising an antigen and a purified m protein from respiratory syncytial virus |
| CA2484251C (en) | 2002-04-30 | 2015-06-23 | University Of South Florida | Materials and methods for inhibition of respiratory syncytial virus infection |
| US7595303B1 (en) | 2002-09-05 | 2009-09-29 | University Of South Florida | Genetic adjuvants for immunotherapy |
| CA2518924C (en) * | 2003-03-18 | 2016-06-07 | Wyeth Holdings Corporation | Process for increasing rsv surface glycoprotein yields using a mutant strain of rsv |
| US7736648B2 (en) * | 2007-10-25 | 2010-06-15 | Trellis Bioscience, Inc. | Anti-RSV G protein antibodies |
| SI2285408T1 (sl) | 2008-06-05 | 2019-02-28 | Ablynx N.V. | Aminokislinska zaporedja usmerjena proti proteinom ovojnicam virusa in polipeptidi, ki zaporedja vsebujejo za zdravljenje virusnih bolezni |
| WO2010077717A1 (en) * | 2008-12-09 | 2010-07-08 | Novavax, Inc. | Modified rsv f proteins and methods of their use |
| HUE035773T2 (en) * | 2009-06-05 | 2018-05-28 | Ablynx Nv | Trivalent human airway giant cell virus (hrsv) nanotubes for preventing and / or treating respiratory infections |
| EP3988115A3 (en) * | 2009-07-15 | 2022-08-17 | GlaxoSmithKline Biologicals S.A. | Rsv f protein compositions and methods for making same |
| AU2009353693B2 (en) * | 2009-10-06 | 2016-07-21 | Medimmune Ltd | RSV-specific binding molecule |
| RU2612154C2 (ru) * | 2009-12-23 | 2017-03-02 | Санофи Пастер | Способ культивирования адгезионных клеток |
| CN102199198A (zh) * | 2011-03-28 | 2011-09-28 | 北京交通大学 | 人呼吸道合胞病毒f蛋白的纯化方法 |
| KR20220119527A (ko) | 2012-08-01 | 2022-08-29 | 버베리안 노딕 에이/에스 | 재조합 변형된 백시니아 바이러스 앙카라(ankara) (mva) 호흡기 신시티알 바이러스(rsv) 백신 |
| CN112851766A (zh) * | 2013-03-13 | 2021-05-28 | 美国政府(由卫生和人类服务部的部长所代表) | 融合前rsv f蛋白和其用途 |
| US9738689B2 (en) | 2013-03-13 | 2017-08-22 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Prefusion RSV F proteins and their use |
| JP6479305B2 (ja) * | 2013-07-12 | 2019-03-06 | 株式会社Ｕｍｎファーマ | ウイルス様粒子の精製方法 |
| WO2015084838A1 (en) * | 2013-12-02 | 2015-06-11 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Recombinant respiratory syncytial virus g protein fragments |
| RU2746280C1 (ru) * | 2020-08-03 | 2021-04-12 | Федеральное государственное бюджетное научное учреждение "Федеральный исследовательский центр фундаментальной и трансляционной медицины" (ФИЦ ФТМ) | Штамм респираторно-синцитиального вируса RSV/Novosibirsk/66Hl/2018 для использования в диагностике респираторно-синцитиальной вирусной инфекции и исследования эффективности противовирусных препаратов in vitro |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU605476B2 (en) * | 1986-01-14 | 1991-01-17 | University Of North Carolina, The | Vaccines for human respiratory virus |
| GB8914968D0 (en) * | 1989-06-29 | 1989-08-23 | Connaught Lab | Production of virus and purification of viral envelope proteins for vaccine use |
| US5723130A (en) * | 1993-05-25 | 1998-03-03 | Hancock; Gerald E. | Adjuvants for vaccines against respiratory syncytial virus |
| US20030072774A1 (en) | 1994-06-10 | 2003-04-17 | Diane M. Gajewczyk | Proteinaceous adjuvants |
| US6020182A (en) * | 1996-07-12 | 2000-02-01 | Connaught Laboratories Limited | Subunit respiratory syncytial virus vaccine preparation |
-
1996
- 1996-07-12 US US08/679,060 patent/US6020182A/en not_active Expired - Lifetime
-
1997
- 1997-07-11 US US09/214,605 patent/US6309649B1/en not_active Expired - Fee Related
- 1997-07-11 WO PCT/CA1997/000497 patent/WO1998002457A1/en active IP Right Grant
- 1997-07-11 BR BR9712970-4A patent/BR9712970A/pt not_active Application Discontinuation
- 1997-07-11 RU RU99102812/13A patent/RU2243234C2/ru not_active IP Right Cessation
- 1997-07-11 CN CNB97197862XA patent/CN1145639C/zh not_active Expired - Fee Related
- 1997-07-11 EP EP04018160A patent/EP1477494A1/en not_active Withdrawn
- 1997-07-11 AU AU34311/97A patent/AU716378B2/en not_active Ceased
- 1997-07-11 NZ NZ334115A patent/NZ334115A/en not_active IP Right Cessation
- 1997-07-11 DE DE0942928T patent/DE942928T1/de active Pending
- 1997-07-11 AT AT97930274T patent/ATE282633T1/de active
- 1997-07-11 CA CA002259594A patent/CA2259594C/en not_active Expired - Lifetime
- 1997-07-11 JP JP10505475A patent/JP2000501418A/ja active Pending
- 1997-07-11 GR GR990300042T patent/GR990300042T1/el unknown
- 1997-07-11 ES ES97930274T patent/ES2141065T5/es not_active Expired - Lifetime
- 1997-07-11 DE DE69731659T patent/DE69731659T3/de not_active Expired - Lifetime
- 1997-07-11 EP EP97930274A patent/EP0942928B2/en not_active Expired - Lifetime
-
2000
- 2000-03-21 HK HK00101725A patent/HK1022704A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP0942928B2 (en) | 2008-08-13 |
| CN1230197A (zh) | 1999-09-29 |
| RU2243234C2 (ru) | 2004-12-27 |
| ES2141065T3 (es) | 2005-05-01 |
| WO1998002457A1 (en) | 1998-01-22 |
| ATE282633T1 (de) | 2004-12-15 |
| EP0942928A1 (en) | 1999-09-22 |
| EP1477494A1 (en) | 2004-11-17 |
| EP0942928B1 (en) | 2004-11-17 |
| CA2259594C (en) | 2003-11-11 |
| DE69731659T2 (de) | 2006-03-02 |
| CA2259594A1 (en) | 1998-01-22 |
| JP2000501418A (ja) | 2000-02-08 |
| US6020182A (en) | 2000-02-01 |
| DE942928T1 (de) | 2000-03-02 |
| HK1022704A1 (en) | 2000-08-18 |
| AU716378B2 (en) | 2000-02-24 |
| CN1145639C (zh) | 2004-04-14 |
| DE69731659D1 (de) | 2004-12-23 |
| ES2141065T1 (es) | 2000-03-16 |
| AU3431197A (en) | 1998-02-09 |
| ES2141065T5 (es) | 2009-02-16 |
| BR9712970A (pt) | 2001-08-28 |
| US6309649B1 (en) | 2001-10-30 |
| DE69731659T3 (de) | 2009-06-18 |
| NZ334115A (en) | 2000-06-23 |
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