DE69934407D1 - Leberstammzellen - Google Patents

Leberstammzellen

Info

Publication number
DE69934407D1
DE69934407D1 DE69934407T DE69934407T DE69934407D1 DE 69934407 D1 DE69934407 D1 DE 69934407D1 DE 69934407 T DE69934407 T DE 69934407T DE 69934407 T DE69934407 T DE 69934407T DE 69934407 D1 DE69934407 D1 DE 69934407D1
Authority
DE
Germany
Prior art keywords
stem cells
liver stem
cells
stem cell
cell
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69934407T
Other languages
English (en)
Other versions
DE69934407T2 (de
Inventor
A Faris
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rhode Island Hospital
Original Assignee
Rhode Island Hospital
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhode Island Hospital filed Critical Rhode Island Hospital
Publication of DE69934407D1 publication Critical patent/DE69934407D1/de
Application granted granted Critical
Publication of DE69934407T2 publication Critical patent/DE69934407T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/067—Hepatocytes
    • C12N5/0672—Stem cells; Progenitor cells; Precursor cells; Oval cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Developmental Biology & Embryology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cell Biology (AREA)
  • Public Health (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE69934407T 1998-07-10 1999-07-08 Leberstammzellen Expired - Lifetime DE69934407T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/113,774 US6129911A (en) 1998-07-10 1998-07-10 Liver stem cell
US113774 1998-07-10
PCT/US1999/015625 WO2000003001A1 (en) 1998-07-10 1999-07-08 Liver stem cell

Publications (2)

Publication Number Publication Date
DE69934407D1 true DE69934407D1 (de) 2007-01-25
DE69934407T2 DE69934407T2 (de) 2007-09-27

Family

ID=22351445

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69934407T Expired - Lifetime DE69934407T2 (de) 1998-07-10 1999-07-08 Leberstammzellen

Country Status (9)

Country Link
US (1) US6129911A (de)
EP (1) EP1097193B1 (de)
JP (1) JP4610083B2 (de)
AT (1) ATE348148T1 (de)
AU (1) AU5095699A (de)
CA (1) CA2336958A1 (de)
DE (1) DE69934407T2 (de)
DK (1) DK1097193T3 (de)
WO (1) WO2000003001A1 (de)

Families Citing this family (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6872389B1 (en) * 1999-07-08 2005-03-29 Rhode Island Hospital Liver stem cell
US20020187133A1 (en) * 1999-10-01 2002-12-12 Hiroshi Kubota Methods of isolating bipotent hepatic progenitor cells
US7456017B2 (en) * 1999-10-01 2008-11-25 University Of North Carolina At Chapel Hill Processes for clonal growth of hepatic progenitor cells
CA2397927A1 (en) * 2000-01-19 2001-07-26 University Of North Carolina At Chapel Hill Liver tissue source
JP2003531124A (ja) * 2000-04-13 2003-10-21 ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム 胃腸臓器に幹細胞および／またはその子孫を移植することによる障害の治療
US6458589B1 (en) * 2000-04-27 2002-10-01 Geron Corporation Hepatocyte lineage cells derived from pluripotent stem cells
US7473555B2 (en) 2000-04-27 2009-01-06 Geron Corporation Protocols for making hepatocytes from embryonic stem cells
US7282366B2 (en) 2000-04-27 2007-10-16 Geron Corporation Hepatocytes for therapy and drug screening made from embryonic stem cells
US7256042B2 (en) 2000-04-27 2007-08-14 Geron Corporation Process for making hepatocytes from pluripotent stem cells
WO2001096866A1 (en) 2000-06-14 2001-12-20 Vistagen, Inc. Toxicity typing using liver stem cells
ATE510905T1 (de) * 2000-10-03 2011-06-15 Univ North Carolina Verfahren zur isolierung von bipotenten lebervorläuferzellen
US7838292B1 (en) 2001-03-29 2010-11-23 University Of Louisville Research Foundation, Inc. Methods for obtaining adult human olfactory progenitor cells
US7211404B2 (en) * 2001-06-22 2007-05-01 Stem Cells, Inc. Liver engrafting cells, assays, and uses thereof
US20050064587A1 (en) * 2001-09-07 2005-03-24 Lawrence Rosenberg Pancreatic small cells and uses thereof
CA2461290C (en) 2001-09-24 2014-11-25 Sangamo Biosciences, Inc. Modulation of stem cells using zinc finger proteins
WO2003078588A2 (en) * 2002-03-15 2003-09-25 University Of North Carolina At Chapel Hill Primitive and proximal hepatic stem cells
EP1496110B1 (de) 2002-03-25 2012-05-09 Hiroshima Industrial Promotion Organization Verfahren zur vermehrung menschlicher hepatozyten und verfahren zur gewinnung menschlicher hepatozyten
US20040042997A1 (en) * 2002-09-03 2004-03-04 Donnie Rudd Method of regenerating human tissue
US20040076620A1 (en) * 2002-09-03 2004-04-22 Donnie Rudd Method of repairing primate mammalian tissue
US20040043009A1 (en) * 2002-09-03 2004-03-04 Donnie Rudd Method of repairing primate mammalian tissue
US20040076605A1 (en) * 2002-09-03 2004-04-22 Donnie Rudd Method of regenerating human tissue
CN1894234A (zh) 2003-03-25 2007-01-10 武田药品工业株式会社 二肽基肽酶抑制剂
JP2007511467A (ja) 2003-05-14 2007-05-10 タケダ サン ディエゴ インコーポレイテッド ジペプチジルペプチダーゼインヒビター
US7723344B2 (en) 2003-08-13 2010-05-25 Takeda San Diego, Inc. Dipeptidyl peptidase inhibitors
US7169926B1 (en) 2003-08-13 2007-01-30 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
US7678909B1 (en) 2003-08-13 2010-03-16 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
EP1947173A3 (de) 2003-09-02 2008-07-30 Regenetech, Inc. VERFAHREN ZUR PREPARaTION VON EXPANDIERTEN PRIMATENSÄUGER BLUTZELLEN
EP1699777B1 (de) 2003-09-08 2012-12-12 Takeda Pharmaceutical Company Limited Dipeptidylpeptidase-hemmer
US7732446B1 (en) 2004-03-11 2010-06-08 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
CN102134230B (zh) 2004-03-15 2019-06-28 武田药品工业株式会社 二肽基肽酶抑制剂
US7687638B2 (en) 2004-06-04 2010-03-30 Takeda San Diego, Inc. Dipeptidyl peptidase inhibitors
KR100563297B1 (ko) * 2004-06-16 2006-03-27 시 명 김 골프공 이송장치
US7456019B2 (en) 2004-06-30 2008-11-25 Regenetech, Inc. Three-dimensional cell to tissue development process
WO2006019965A2 (en) 2004-07-16 2006-02-23 Takeda San Diego, Inc. Dipeptidyl peptidase inhibitors
CN101014855A (zh) * 2004-08-20 2007-08-08 第一化学药品株式会社 药物在人体中的肝代谢和肝功能的预测方法
EP1828192B1 (de) 2004-12-21 2014-12-03 Takeda Pharmaceutical Company Limited Dipeptidylpeptidasehemmer
WO2006126219A1 (en) 2005-05-26 2006-11-30 Fresenius Medical Care Deutschland G.M.B.H. Liver progenitor cells
SI1942898T2 (sl) 2005-09-14 2014-08-29 Takeda Pharmaceutical Company Limited Dipeptidil-peptidazni inhibitorji za zdravljenje diabetesa
PE20070622A1 (es) * 2005-09-14 2007-08-22 Takeda Pharmaceutical Administracion de inhibidores de dipeptidil peptidasa
CN102675221A (zh) 2005-09-16 2012-09-19 武田药品工业株式会社 用于制备嘧啶二酮衍生物的方法中的中间体
US20080009442A1 (en) 2005-12-06 2008-01-10 Institute For Human Genetics And Biochemistry Therapeutic use for alpha1 proteinase inhibitor in hematopoiesis
EP2422799A3 (de) 2006-03-07 2013-03-06 Geeta Shroff Zusammensetzungen enhaltend menschliche embryonale Stammzellen und ihre Derivate, Verwendung davon und Verfahren zur ihrer Vorbereitung
WO2007112347A1 (en) 2006-03-28 2007-10-04 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
GB2453074B (en) * 2006-06-02 2011-06-22 Geron Corp Differentiation of primate pluripotent cells to hepatocyte-lineage cells
US20100068187A1 (en) * 2006-08-31 2010-03-18 Roisen Fred J Transcription factors for differentiation of adult human olfactory progenitor cells
US8324383B2 (en) 2006-09-13 2012-12-04 Takeda Pharmaceutical Company Limited Methods of making polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile
TW200838536A (en) 2006-11-29 2008-10-01 Takeda Pharmaceutical Polymorphs of succinate salt of 2-[6-(3-amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethy]-4-fluor-benzonitrile and methods of use therefor
US8093236B2 (en) 2007-03-13 2012-01-10 Takeda Pharmaceuticals Company Limited Weekly administration of dipeptidyl peptidase inhibitors
US20100291042A1 (en) 2007-05-03 2010-11-18 The Brigham And Women's Hospital, Inc. Multipotent stem cells and uses thereof
US8574567B2 (en) * 2007-05-03 2013-11-05 The Brigham And Women's Hospital, Inc. Multipotent stem cells and uses thereof
US20100144140A1 (en) * 2008-12-10 2010-06-10 Novellus Systems, Inc. Methods for depositing tungsten films having low resistivity for gapfill applications
US20100329986A1 (en) * 2009-01-06 2010-12-30 Greenbaum Linda E Adult Hepatic Progenitor Cells and Methods of Use Thereof
DK2561078T3 (en) 2010-04-23 2019-01-14 Cold Spring Harbor Laboratory NEW STRUCTURALLY DESIGNED SHRNAs
AU2015205872B2 (en) * 2010-05-07 2017-07-06 University Of North Carolina At Chapel Hill Method of engrafting cells from solid tissues
SG10201503582YA (en) * 2010-05-07 2015-06-29 Univ North Carolina Method of engrafting cells from solid tissues
WO2012048275A2 (en) 2010-10-08 2012-04-12 Caridianbct, Inc. Configurable methods and systems of growing and harvesting cells in a hollow fiber bioreactor system
WO2015028577A1 (en) * 2013-08-28 2015-03-05 Promethera Biosciences S.A./N.V. Method for producing adult liver progenitor cells
CN105793411B (zh) 2013-11-16 2018-04-17 泰尔茂比司特公司 生物反应器中的细胞扩增
ES2941686T3 (es) 2013-12-16 2023-05-24 Fresenius Medical Care Deutschland Gmbh Estructuras de células similares a islotes pancreáticos y un método para prepararlas
EP3613841B1 (de) 2014-03-25 2022-04-20 Terumo BCT, Inc. Passives ersetzen von medien
BR112017003996A2 (pt) 2014-08-28 2017-12-12 Promethera Biosciences S A /N V ?método para produção de células progenitoras de fígado adultas?
US20160090569A1 (en) 2014-09-26 2016-03-31 Terumo Bct, Inc. Scheduled Feed
WO2016179481A1 (en) 2015-05-07 2016-11-10 Cardelli James Allen Cancer treatment via repositioned tricyclic anti-depressant-like drugs as anti-cancer agents and new combinations of such drugs
WO2017004592A1 (en) 2015-07-02 2017-01-05 Terumo Bct, Inc. Cell growth with mechanical stimuli
EP3464565A4 (de) 2016-05-25 2020-01-01 Terumo BCT, Inc. Zellexpansion
US11104874B2 (en) 2016-06-07 2021-08-31 Terumo Bct, Inc. Coating a bioreactor
US11685883B2 (en) 2016-06-07 2023-06-27 Terumo Bct, Inc. Methods and systems for coating a cell growth surface
US11624046B2 (en) 2017-03-31 2023-04-11 Terumo Bct, Inc. Cell expansion
JP7393945B2 (ja) 2017-03-31 2023-12-07 テルモ ビーシーティー、インコーポレーテッド 細胞増殖

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5367057A (en) * 1991-04-02 1994-11-22 The Trustees Of Princeton University Tyrosine kinase receptor flk-2 and fragments thereof
JPH07501206A (ja) * 1991-08-07 1995-02-09 イェシバ・ユニバーシティ 前駆肝細胞の増殖
US5460964A (en) * 1992-04-03 1995-10-24 Regents Of The University Of Minnesota Method for culturing hematopoietic cells
CA2146747C (en) * 1992-10-09 2006-12-19 Brian A. Naughton Liver reserve cells
US5532156A (en) * 1993-10-08 1996-07-02 The United States Of America As Represented By The Secretary Of Agriculture Hepatocyte cell line derived from the epiblast of pig blastocysts
US5861313A (en) * 1995-06-07 1999-01-19 Ontogeny, Inc. Method of isolating bile duct progenitor cells

Also Published As

Publication number Publication date
WO2000003001A1 (en) 2000-01-20
CA2336958A1 (en) 2000-01-20
JP2002520015A (ja) 2002-07-09
US6129911A (en) 2000-10-10
EP1097193A1 (de) 2001-05-09
ATE348148T1 (de) 2007-01-15
EP1097193B1 (de) 2006-12-13
DK1097193T3 (da) 2007-04-23
DE69934407T2 (de) 2007-09-27
JP4610083B2 (ja) 2011-01-12
AU5095699A (en) 2000-02-01

Similar Documents

Publication Publication Date Title
ATE348148T1 (de) Leberstammzellen
EP1100870A4 (de) Verbesserung der herzfunktion durch transplantation mesenchymaler stammzellen
DK1272616T3 (da) Humane, pancreatiske, epitelstamfaderceller og fremgangsmåder til isolation og anvendelse deraf
WO2000047720A3 (en) Pancreatic progenitor cells, methods and uses related thereto
DE60332157D1 (de) Expansion erneuerbarer stammzellpopulationen
AU4302101A (en) Prognostic testing of organs intended for transplantation
DK0920491T3 (da) Immortaliserede cellelinier til virusvækst
DK0780469T3 (da) Udødeliggjorte cellelinier stammende fra normalt menneskeligt hudvæv og serumfrit vækstmedium til dyrkning af sådanne
NO20062709L (no) Stamceller som er egnet for transplantasjon, fremstilling derav og farmasoytiske preperater omfattende nevnte stamceller
IL141308A0 (en) Methods, instruments and materials for chondrocyte cell transplantation
ITRM20030376A0 (it) Procedimento per l'isolamento e l'espansione di cellule staminali cardiache da biopsia.
DE69433822D1 (de) Humane epithelzellinien der leber
WO2004016726A3 (en) Methods and compositions for extending the life span and increasing the stress resistance of cells and organisms
WO2006031926A3 (en) Methods for the isolation and expansion of cord blood derived t regulatory cells
NO975557L (no) Immortalisering og dissimortalisering av celler
WO2000015764A3 (en) Propagation and/or derivation of embryonic stem cells
DK0971679T3 (da) Fremgangsmåde til opformering af hår
TR199802503A3 (tr) Endojen gen aktivasyonu için hücrelerin optimizasyonu.
WO2001023541A3 (en) Compositions and methods for altering gene expression
DK1131408T3 (da) Celler, dyrkningsmetoder og deres anvendelse ved autolog transplantationsbehandling
DK1589807T3 (da) Transgene ananasplanter med modificerede carotenoidniveauer og fremgangsmåder til deres fremstilling
AU2003209297A1 (en) Methods and compositions for preserving the viability of photoreceptor cells
AU2003247270A1 (en) Methods of mixing large numbers of heterologous genes
WO2004044127A3 (en) Stem cell populations
DK1343369T3 (da) Konservering af celler

Legal Events

Date Code Title Description
8364 No opposition during term of opposition