WO2001023541A3 - Compositions and methods for altering gene expression - Google Patents
Compositions and methods for altering gene expression Download PDFInfo
- Publication number
- WO2001023541A3 WO2001023541A3 PCT/US2000/027065 US0027065W WO0123541A3 WO 2001023541 A3 WO2001023541 A3 WO 2001023541A3 US 0027065 W US0027065 W US 0027065W WO 0123541 A3 WO0123541 A3 WO 0123541A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- methods
- compositions
- gene expression
- altering gene
- target gene
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 3
- 230000014509 gene expression Effects 0.000 title abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 108091029865 Exogenous DNA Proteins 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 238000003780 insertion Methods 0.000 abstract 1
- 230000037431 insertion Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
- C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
- C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
- C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/60—Vectors containing traps for, e.g. exons, promoters
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/42—Vector systems having a special element relevant for transcription being an intron or intervening sequence for splicing and/or stability of RNA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/44—Vectors comprising a special translation-regulating system being a specific part of the splice mechanism, e.g. donor, acceptor
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Mycology (AREA)
- Environmental Sciences (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Animal Husbandry (AREA)
- Biodiversity & Conservation Biology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Materials For Medical Uses (AREA)
Abstract
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP00967217A EP1220928A2 (en) | 1999-09-30 | 2000-10-02 | Compositions and methods for altering gene expression |
JP2001526924A JP2003510072A (en) | 1999-09-30 | 2000-10-02 | Compositions and methods for altering gene expression |
CA002385162A CA2385162A1 (en) | 1999-09-30 | 2000-10-02 | Compositions and methods for altering gene expression |
AU77448/00A AU7744800A (en) | 1999-09-30 | 2000-10-02 | Compositions and methods for altering gene expression |
MXPA02003232A MXPA02003232A (en) | 1999-09-30 | 2000-10-02 | Compositions and methods for altering gene expression. |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US15695399P | 1999-09-30 | 1999-09-30 | |
US60/156,953 | 1999-09-30 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2001023541A2 WO2001023541A2 (en) | 2001-04-05 |
WO2001023541A3 true WO2001023541A3 (en) | 2002-01-17 |
Family
ID=22561777
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2000/027065 WO2001023541A2 (en) | 1999-09-30 | 2000-10-02 | Compositions and methods for altering gene expression |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP1220928A2 (en) |
JP (1) | JP2003510072A (en) |
AU (1) | AU7744800A (en) |
CA (1) | CA2385162A1 (en) |
MX (1) | MXPA02003232A (en) |
WO (1) | WO2001023541A2 (en) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6902890B1 (en) | 1999-11-04 | 2005-06-07 | Diadexus, Inc. | Method of diagnosing monitoring, staging, imaging and treating cancer |
US7879540B1 (en) | 2000-08-24 | 2011-02-01 | Promega Corporation | Synthetic nucleic acid molecule compositions and methods of preparation |
AU2012227227B2 (en) * | 2001-12-21 | 2015-05-07 | Immerge Biotherapeutics, Inc. | Knockout swine and methods for making the same |
JP2005514016A (en) * | 2001-12-21 | 2005-05-19 | ザ キュレイターズ オブ ザ ユニバーシティ オブ ミズーリ | Knockout pig and method for producing the same |
EP1534819B1 (en) | 2002-08-21 | 2009-12-09 | Revivicor, Inc. | Porcine animals lacking any expression of functional alpha 1,3 galactosyltransferase |
US8106251B2 (en) | 2002-08-21 | 2012-01-31 | Revivicor, Inc. | Tissue products derived from porcine animals lacking any expression of functional alpha 1,3 galactosyltransferase |
AU2003290689A1 (en) | 2002-11-08 | 2004-06-03 | Kyowa Hakko Kirin Co., Ltd. | Transgenic ungulates having reduced prion protein activity and uses thereof |
EP1685148A2 (en) | 2003-11-05 | 2006-08-02 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | PORCINE ISOGLOBOSIDE 3 SYNTHASE PROTEIN, cDNA, GENOMIC ORGANIZATION, AND REGULATORY REGION |
US7420099B2 (en) | 2004-04-22 | 2008-09-02 | Kirin Holdings Kabushiki Kaisha | Transgenic animals and uses thereof |
AU2005243169A1 (en) | 2004-05-07 | 2005-11-24 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Porcine Forssman synthetase protein, cDNA, genomic organization, and regulatory region |
US7728118B2 (en) | 2004-09-17 | 2010-06-01 | Promega Corporation | Synthetic nucleic acid molecule compositions and methods of preparation |
EP2208783A1 (en) * | 2004-12-22 | 2010-07-21 | Chugai Seiyaku Kabushiki Kaisha | Method of producing an antibody using a cell in which the function of fucose transporter is inhibited |
GB0909660D0 (en) * | 2009-06-04 | 2009-07-22 | Gene Bridges Gmbh | Method of altering nucleic acids |
WO2013163346A1 (en) * | 2012-04-25 | 2013-10-31 | The Regents Of The University Of California | Synthetic promoter for modulating gene expression |
KR102210310B1 (en) | 2014-03-03 | 2021-02-01 | 트린세오 유럽 게엠베하 | Styrenic composition containing long fibers |
US11246299B2 (en) | 2015-03-04 | 2022-02-15 | Pormedtec Co., Ltd. | Disease model pig exhibiting stable phenotype, and production method thereof |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1995028412A1 (en) * | 1994-04-13 | 1995-10-26 | Biotransplant, Inc. | α(1,3) GALACTOSYLTRANSFERASE NEGATIVE SWINE |
US5464764A (en) * | 1989-08-22 | 1995-11-07 | University Of Utah Research Foundation | Positive-negative selection methods and vectors |
US5627058A (en) * | 1990-05-14 | 1997-05-06 | Massachusetts Institute Of Technology | Retrovirus promoter-trap vectors |
US5916810A (en) * | 1993-01-05 | 1999-06-29 | Jarvik; Jonathan W. | Method for producing tagged genes transcripts and proteins |
WO1999061604A2 (en) * | 1998-05-22 | 1999-12-02 | Japan Science And Technology Corporation | A vector for gene trap, and a method for gene trapping by using the vector |
WO2001030992A2 (en) * | 1999-10-22 | 2001-05-03 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | α1-3 GALACTOSYLTRANSFERASE GENE AND PROMOTER |
-
2000
- 2000-10-02 CA CA002385162A patent/CA2385162A1/en not_active Abandoned
- 2000-10-02 AU AU77448/00A patent/AU7744800A/en not_active Abandoned
- 2000-10-02 EP EP00967217A patent/EP1220928A2/en not_active Withdrawn
- 2000-10-02 JP JP2001526924A patent/JP2003510072A/en not_active Withdrawn
- 2000-10-02 MX MXPA02003232A patent/MXPA02003232A/en unknown
- 2000-10-02 WO PCT/US2000/027065 patent/WO2001023541A2/en active Search and Examination
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5464764A (en) * | 1989-08-22 | 1995-11-07 | University Of Utah Research Foundation | Positive-negative selection methods and vectors |
US5627058A (en) * | 1990-05-14 | 1997-05-06 | Massachusetts Institute Of Technology | Retrovirus promoter-trap vectors |
US5916810A (en) * | 1993-01-05 | 1999-06-29 | Jarvik; Jonathan W. | Method for producing tagged genes transcripts and proteins |
WO1995028412A1 (en) * | 1994-04-13 | 1995-10-26 | Biotransplant, Inc. | α(1,3) GALACTOSYLTRANSFERASE NEGATIVE SWINE |
WO1999061604A2 (en) * | 1998-05-22 | 1999-12-02 | Japan Science And Technology Corporation | A vector for gene trap, and a method for gene trapping by using the vector |
WO2001030992A2 (en) * | 1999-10-22 | 2001-05-03 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | α1-3 GALACTOSYLTRANSFERASE GENE AND PROMOTER |
Non-Patent Citations (2)
Title |
---|
HOOPES C.W. & PLATT J.L.: "A molecular epidemiological probe for pig microchimerism", TRANSPLANTATION (BALTIMORE), vol. 64, no. 2, 1997, pages 347 - 350, XP000982842 * |
KARAPLIS ET AL: "Gene targeting", PRINCIPLES OF BONE BIOLOGY,XX,XX, 1996, pages 1189 - 1201, XP002090123 * |
Also Published As
Publication number | Publication date |
---|---|
AU7744800A (en) | 2001-04-30 |
CA2385162A1 (en) | 2001-04-05 |
JP2003510072A (en) | 2003-03-18 |
MXPA02003232A (en) | 2003-09-22 |
WO2001023541A2 (en) | 2001-04-05 |
EP1220928A2 (en) | 2002-07-10 |
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