DE69925250D1 - Aktivatoren der kalium-kanäle - Google Patents

Aktivatoren der kalium-kanäle

Info

Publication number
DE69925250D1
DE69925250D1 DE69925250T DE69925250T DE69925250D1 DE 69925250 D1 DE69925250 D1 DE 69925250D1 DE 69925250 T DE69925250 T DE 69925250T DE 69925250 T DE69925250 T DE 69925250T DE 69925250 D1 DE69925250 D1 DE 69925250D1
Authority
DE
Germany
Prior art keywords
substituted
amino
aryl
pharmaceutical composition
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69925250T
Other languages
English (en)
Other versions
DE69925250T2 (de
Inventor
Mitsushi Tanaka
Masami Tsuda
Ayatsugu Nakamura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nippon Shinyaku Co Ltd
Original Assignee
Nippon Shinyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Shinyaku Co Ltd filed Critical Nippon Shinyaku Co Ltd
Publication of DE69925250D1 publication Critical patent/DE69925250D1/de
Application granted granted Critical
Publication of DE69925250T2 publication Critical patent/DE69925250T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C07D207/40—2,5-Pyrrolidine-diones
    • C07D207/416—2,5-Pyrrolidine-diones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Bakery Products And Manufacturing Methods Therefor (AREA)
  • Detergent Compositions (AREA)
DE69925250T 1998-01-14 1999-01-13 Aktivatoren der kalium-kanäle Expired - Fee Related DE69925250T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP561398 1998-01-14
JP561398 1998-01-14
JP5088898 1998-03-03
JP5088898 1998-03-03
PCT/JP1999/000103 WO1999036068A1 (fr) 1998-01-14 1999-01-13 Activateurs des canaux de potassium

Publications (2)

Publication Number Publication Date
DE69925250D1 true DE69925250D1 (de) 2005-06-16
DE69925250T2 DE69925250T2 (de) 2006-02-23

Family

ID=26339581

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69925250T Expired - Fee Related DE69925250T2 (de) 1998-01-14 1999-01-13 Aktivatoren der kalium-kanäle

Country Status (10)

Country Link
US (1) US6353016B1 (de)
EP (1) EP1057485B1 (de)
KR (1) KR20010034114A (de)
CN (1) CN1162151C (de)
AT (1) ATE295166T1 (de)
AU (1) AU1890299A (de)
CA (1) CA2316853A1 (de)
DE (1) DE69925250T2 (de)
RU (1) RU2204390C2 (de)
WO (1) WO1999036068A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2277416C2 (ru) * 2000-03-21 2006-06-10 Ниппон Синяку Ко., Лтд. Препараты для перорального введения с замедленным высвобождением
EP1303502A2 (de) * 2000-07-06 2003-04-23 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES Tetrahydrobenzothiazol-analoge als neuroprotektive mittel
TWI239952B (en) * 2001-03-14 2005-09-21 Nippon Shinyaku Co Ltd Stable crystals of pyrrole compound
CA2537746A1 (en) * 2003-09-04 2005-03-17 Poseidon Pharmaceuticals A/S Erg channel openers for the treatment of cardiac arrhythmias
JP4703649B2 (ja) * 2004-07-30 2011-06-15 エグゼリクシス， インコーポレイテッド 薬学的因子としてのピロール誘導体
US8278466B2 (en) 2008-04-28 2012-10-02 Janssen Pharmaceutica Nv Benzocycloheptane and benzoxepine derivatives
GB201107176D0 (en) * 2011-04-28 2011-06-15 Cxr Biosciences Ltd Pyrrolnitrin derivatives

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0548680B1 (de) * 1991-12-26 1998-02-25 Mitsubishi Chemical Corporation Beta-Oxo-Beta-Benzenepropanthioamidderivate
JP3439249B2 (ja) * 1993-11-18 2003-08-25 三和生薬株式会社 新規なピロール型化合物及び発毛・育毛促進剤
US5998459A (en) * 1995-06-07 1999-12-07 Nippon Shinyaku Co Ltd Pyrrole derivatives and medicinal composition
AU702887B2 (en) * 1995-10-31 1999-03-11 Merck & Co., Inc. Substituted pyridyl pyrroles, compositions containing such compounds and methods of use
WO1998002430A1 (en) * 1996-07-11 1998-01-22 Pfizer Pharmaceuticals Inc. Pyridylpyrrole compounds useful as interleukin- and tnf antagonists
WO1999061016A1 (en) * 1998-05-27 1999-12-02 Nippon Shinyaku Co., Ltd. Cyclooxygenase-2 inhibitors

Also Published As

Publication number Publication date
KR20010034114A (ko) 2001-04-25
CN1162151C (zh) 2004-08-18
EP1057485A1 (de) 2000-12-06
CN1288377A (zh) 2001-03-21
RU2204390C2 (ru) 2003-05-20
CA2316853A1 (en) 1999-07-22
AU1890299A (en) 1999-08-02
EP1057485A4 (de) 2001-05-09
EP1057485B1 (de) 2005-05-11
WO1999036068A1 (fr) 1999-07-22
US6353016B1 (en) 2002-03-05
DE69925250T2 (de) 2006-02-23
ATE295166T1 (de) 2005-05-15

Similar Documents

Publication Publication Date Title
BRPI0213243B8 (pt) composto heterocíclico aromático contendo um anel oxazol, tiazol ou imidazol, ou um sal farmaceuticamente aceitável do mesmo, e, composição farmacêutica
EA200400893A1 (ru) N-арил-2-оксазолидинон-5-карбоксамиды, их производные и их применение в качестве антибактериальных средств
EA200100755A1 (ru) 4-оксо-1,4-дигидро-3-хинолинкарбоксамиды как антивирусные агенты
DE69514367T2 (de) Substituierte amidderivate
FI950309A0 (fi) Proliiniamidijohdannaisia
EA200200938A1 (ru) Фармацевтические композиции, содержащие производные азетидина, новые производные азетидина и их получение
ATE260103T1 (de) Ortho-anthranilamide derivate als antikoagulantien
ATE260255T1 (de) 5-oxo-pyrrolidine-2-carbonsäure- hydroxamidderivate
DK0976748T3 (da) Pyrrolidinderivater med phospholispase A2-hæmmende aktivitet
EA200201071A1 (ru) Циклопентилзамещенные производные глутарамида в качестве ингибиторов нейтральной эндопептидазы
PT784054E (pt) Derivados de tetraidroquinoxalinadiona 1,2,3,4 e sua utilizacao como antagonistas do receptor glutamato
ATE266039T1 (de) Hiv-protease inhibitoren
DE69414019D1 (de) Bicyclische Stichstoff enthaltende Derivate als Prolyl-Endopeptidase Inhibitoren
DE69925250D1 (de) Aktivatoren der kalium-kanäle
AU579872B2 (en) 2-amino-4-substituted oxazolines
ES2091489T3 (es) Derivados de imidazol y composiciones farmaceuticas que los contienen.
ES2155655T3 (es) Compuestos de benzotiofeno, usos y formulaciones de los mismos.
AR019438A1 (es) Compuesto derivado de piperazina, usos del mismo y metodos para su fabricacion
EA200401099A1 (ru) Производные гетероциклического амида
EP0900566A4 (de) Neuartige tripeptidvebindungen und arzneimittel gegen aids
ES2183500T3 (es) Nuevos compuestos y composiciones farmaceuticas que los contienen.
EA200301062A1 (ru) Фармацевтические комбинации на основе производных пиридоиндолона и противораковых агентов
EA200500028A1 (ru) Новые соединения 3-(4-оксо-4h-хромен-2-ил)-(1h)-хинолин-4-она, способ их получения и фармацевтические композиции, которые их содержат
EA200200379A3 (ru) Новые соединения пиримидин-4-она, способ их получения и содержащие их фармацевтические композиции
ATE70716T1 (de) Stabile, injizierbare, antiemetische zusammensetzungen.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee