DE69923584T2 - Antivirale zusammensetzungen welche propylenglykol und isopropyl-alkansäureester enthalten - Google Patents
Antivirale zusammensetzungen welche propylenglykol und isopropyl-alkansäureester enthalten Download PDFInfo
- Publication number
- DE69923584T2 DE69923584T2 DE69923584T DE69923584T DE69923584T2 DE 69923584 T2 DE69923584 T2 DE 69923584T2 DE 69923584 T DE69923584 T DE 69923584T DE 69923584 T DE69923584 T DE 69923584T DE 69923584 T2 DE69923584 T2 DE 69923584T2
- Authority
- DE
- Germany
- Prior art keywords
- composition
- propylene glycol
- composition according
- antiviral
- isopropyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000000203 mixture Substances 0.000 title claims description 110
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- 230000000840 anti-viral effect Effects 0.000 title claims description 19
- 150000002148 esters Chemical class 0.000 title claims description 15
- 239000002253 acid Substances 0.000 title claims description 12
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 claims description 30
- 229960000890 hydrocortisone Drugs 0.000 claims description 15
- JNTOCHDNEULJHD-UHFFFAOYSA-N Penciclovir Chemical compound N1C(N)=NC(=O)C2=C1N(CCC(CO)CO)C=N2 JNTOCHDNEULJHD-UHFFFAOYSA-N 0.000 claims description 12
- 229960004150 aciclovir Drugs 0.000 claims description 12
- MKUXAQIIEYXACX-UHFFFAOYSA-N aciclovir Chemical compound N1C(N)=NC(=O)C2=C1N(COCCO)C=N2 MKUXAQIIEYXACX-UHFFFAOYSA-N 0.000 claims description 11
- 229960001179 penciclovir Drugs 0.000 claims description 11
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- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims description 4
- 238000002360 preparation method Methods 0.000 claims description 4
- 208000029433 Herpesviridae infectious disease Diseases 0.000 claims description 3
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 3
- SCBFBAWJWLXVHS-UHFFFAOYSA-N 2-amino-9-[4-hydroxy-2-(hydroxymethyl)butyl]-3h-purin-6-one Chemical compound N1C(N)=NC(=O)C2=C1N(CC(CO)CCO)C=N2 SCBFBAWJWLXVHS-UHFFFAOYSA-N 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
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- TUNFSRHWOTWDNC-UHFFFAOYSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCCC(O)=O TUNFSRHWOTWDNC-UHFFFAOYSA-N 0.000 claims description 2
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- MDCGTBRYRLWFJI-WDCKKOMHSA-N 2-amino-9-(2-hydroxyethoxymethyl)-3h-purin-6-one;(8s,9s,10r,11s,13s,14s,17r)-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1h-cyclopenta[a]phenanthren-3-one Chemical compound N1C(N)=NC(=O)C2=C1N(COCCO)C=N2.O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 MDCGTBRYRLWFJI-WDCKKOMHSA-N 0.000 description 2
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- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical class OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 description 1
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- QMMJWQMCMRUYTG-UHFFFAOYSA-N 1,2,4,5-tetrachloro-3-(trifluoromethyl)benzene Chemical compound FC(F)(F)C1=C(Cl)C(Cl)=CC(Cl)=C1Cl QMMJWQMCMRUYTG-UHFFFAOYSA-N 0.000 description 1
- NZJXADCEESMBPW-UHFFFAOYSA-N 1-methylsulfinyldecane Chemical compound CCCCCCCCCCS(C)=O NZJXADCEESMBPW-UHFFFAOYSA-N 0.000 description 1
- LGEZTMRIZWCDLW-UHFFFAOYSA-N 14-methylpentadecyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCCCCCCCCCCCCC(C)C LGEZTMRIZWCDLW-UHFFFAOYSA-N 0.000 description 1
- PWVUXRBUUYZMKM-UHFFFAOYSA-N 2-(2-hydroxyethoxy)ethyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCOCCO PWVUXRBUUYZMKM-UHFFFAOYSA-N 0.000 description 1
- SFAAOBGYWOUHLU-UHFFFAOYSA-N 2-ethylhexyl hexadecanoate Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(CC)CCCC SFAAOBGYWOUHLU-UHFFFAOYSA-N 0.000 description 1
- HBTAOSGHCXUEKI-UHFFFAOYSA-N 4-chloro-n,n-dimethyl-3-nitrobenzenesulfonamide Chemical compound CN(C)S(=O)(=O)C1=CC=C(Cl)C([N+]([O-])=O)=C1 HBTAOSGHCXUEKI-UHFFFAOYSA-N 0.000 description 1
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- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 1
- CTKXFMQHOOWWEB-UHFFFAOYSA-N Ethylene oxide/propylene oxide copolymer Chemical compound CCCOC(C)COCCO CTKXFMQHOOWWEB-UHFFFAOYSA-N 0.000 description 1
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- 229920002675 Polyoxyl Polymers 0.000 description 1
- MLHOXUWWKVQEJB-UHFFFAOYSA-N Propyleneglycol diacetate Chemical class CC(=O)OC(C)COC(C)=O MLHOXUWWKVQEJB-UHFFFAOYSA-N 0.000 description 1
- 206010039509 Scab Diseases 0.000 description 1
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical group [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 1
- BCKXLBQYZLBQEK-KVVVOXFISA-M Sodium oleate Chemical compound [Na+].CCCCCCCC\C=C/CCCCCCCC([O-])=O BCKXLBQYZLBQEK-KVVVOXFISA-M 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
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- 230000003111 delayed effect Effects 0.000 description 1
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- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- UGMCXQCYOVCMTB-UHFFFAOYSA-K dihydroxy(stearato)aluminium Chemical compound CCCCCCCCCCCCCCCCCC(=O)O[Al](O)O UGMCXQCYOVCMTB-UHFFFAOYSA-K 0.000 description 1
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- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
- 125000005908 glyceryl ester group Chemical group 0.000 description 1
- UBHWBODXJBSFLH-UHFFFAOYSA-N hexadecan-1-ol;octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO.CCCCCCCCCCCCCCCCCCO UBHWBODXJBSFLH-UHFFFAOYSA-N 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
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- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 229940049964 oleate Drugs 0.000 description 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
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- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- RYYKJJJTJZKILX-UHFFFAOYSA-M sodium octadecanoate Chemical compound [Na+].CCCCCCCCCCCCCCCCCC([O-])=O RYYKJJJTJZKILX-UHFFFAOYSA-M 0.000 description 1
- 229940080350 sodium stearate Drugs 0.000 description 1
- 229940045902 sodium stearyl fumarate Drugs 0.000 description 1
- 229960000776 sodium tetradecyl sulfate Drugs 0.000 description 1
- UPUIQOIQVMNQAP-UHFFFAOYSA-M sodium;tetradecyl sulfate Chemical compound [Na+].CCCCCCCCCCCCCCOS([O-])(=O)=O UPUIQOIQVMNQAP-UHFFFAOYSA-M 0.000 description 1
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- 239000000516 sunscreening agent Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 description 1
- 229940099259 vaseline Drugs 0.000 description 1
- XOOUIPVCVHRTMJ-UHFFFAOYSA-L zinc stearate Chemical compound [Zn+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O XOOUIPVCVHRTMJ-UHFFFAOYSA-L 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Dermatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9803929 | 1998-11-18 | ||
| SE9803929A SE9803929D0 (sv) | 1998-11-18 | 1998-11-18 | Antiviral formulation |
| PCT/SE1999/002043 WO2000029027A1 (en) | 1998-11-18 | 1999-11-12 | Antiviral formulations comprising propylene glycol and an isopropyl alkanoic acid ester |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69923584D1 DE69923584D1 (de) | 2005-03-10 |
| DE69923584T2 true DE69923584T2 (de) | 2006-03-23 |
Family
ID=20413320
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69923584T Expired - Lifetime DE69923584T2 (de) | 1998-11-18 | 1999-11-12 | Antivirale zusammensetzungen welche propylenglykol und isopropyl-alkansäureester enthalten |
Country Status (21)
| Country | Link |
|---|---|
| EP (1) | EP1131104B1 (enExample) |
| JP (2) | JP2002529520A (enExample) |
| KR (1) | KR100608963B1 (enExample) |
| CN (1) | CN1160128C (enExample) |
| AR (1) | AR023705A1 (enExample) |
| AT (1) | ATE288283T1 (enExample) |
| AU (1) | AU772435B2 (enExample) |
| CA (1) | CA2351463C (enExample) |
| DE (1) | DE69923584T2 (enExample) |
| DK (1) | DK1131104T3 (enExample) |
| EG (1) | EG23853A (enExample) |
| ES (1) | ES2233104T3 (enExample) |
| HK (1) | HK1042440B (enExample) |
| IL (2) | IL142702A0 (enExample) |
| MY (1) | MY122397A (enExample) |
| NZ (1) | NZ511832A (enExample) |
| PT (1) | PT1131104E (enExample) |
| SE (1) | SE9803929D0 (enExample) |
| TW (1) | TW589191B (enExample) |
| WO (1) | WO2000029027A1 (enExample) |
| ZA (1) | ZA200103335B (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100956369B1 (ko) * | 2001-11-19 | 2010-05-10 | 메디진 아게 | 바이러스성 피부 질환 및 종양 질환 치료용 약제 |
| ZA200602544B (en) | 2003-10-09 | 2007-06-27 | Medigene Ag | The use of a polyphenol for the treatment of a cancerous or pre-cancerous lesion of the skin |
| JP4972062B2 (ja) * | 2008-03-17 | 2012-07-11 | メディヴィル・アクチエボラーグ | 抗ウイルス製剤 |
| ES2955089T3 (es) * | 2018-08-17 | 2023-11-28 | Ilko Ilac Sanayi Ve Ticaret Anonim Sirketi | Composición tópica estable en fase que comprende aciclovir e hidrocortisona |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW438585B (en) * | 1995-02-06 | 2001-06-07 | Astra Ab | Pharmaceutical compositions for topical administration for prophylaxis and/or treatment of herpesvirus infections |
| US5760096A (en) * | 1996-10-18 | 1998-06-02 | Thornfeldt; Carl R. | Potent penetration enhancers |
-
1998
- 1998-11-18 SE SE9803929A patent/SE9803929D0/xx unknown
-
1999
- 1999-11-12 AU AU14364/00A patent/AU772435B2/en not_active Expired
- 1999-11-12 NZ NZ511832A patent/NZ511832A/en not_active IP Right Cessation
- 1999-11-12 EP EP99972109A patent/EP1131104B1/en not_active Expired - Lifetime
- 1999-11-12 DE DE69923584T patent/DE69923584T2/de not_active Expired - Lifetime
- 1999-11-12 HK HK02104279.2A patent/HK1042440B/zh not_active IP Right Cessation
- 1999-11-12 PT PT99972109T patent/PT1131104E/pt unknown
- 1999-11-12 CN CNB998133825A patent/CN1160128C/zh not_active Expired - Lifetime
- 1999-11-12 CA CA002351463A patent/CA2351463C/en not_active Expired - Lifetime
- 1999-11-12 ES ES99972109T patent/ES2233104T3/es not_active Expired - Lifetime
- 1999-11-12 JP JP2000582073A patent/JP2002529520A/ja active Pending
- 1999-11-12 IL IL14270299A patent/IL142702A0/xx active IP Right Grant
- 1999-11-12 KR KR1020017006232A patent/KR100608963B1/ko not_active Expired - Fee Related
- 1999-11-12 DK DK99972109T patent/DK1131104T3/da active
- 1999-11-12 AT AT99972109T patent/ATE288283T1/de active
- 1999-11-12 WO PCT/SE1999/002043 patent/WO2000029027A1/en not_active Ceased
- 1999-11-15 TW TW088119865A patent/TW589191B/zh not_active IP Right Cessation
- 1999-11-16 MY MYPI99004979A patent/MY122397A/en unknown
- 1999-11-16 EG EG146899A patent/EG23853A/xx active
- 1999-11-17 AR ARP990105846A patent/AR023705A1/es active IP Right Grant
-
2001
- 2001-04-19 IL IL142702A patent/IL142702A/en not_active IP Right Cessation
- 2001-04-24 ZA ZA200103335A patent/ZA200103335B/en unknown
-
2011
- 2011-04-11 JP JP2011087438A patent/JP5420583B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| HK1042440A1 (en) | 2002-08-16 |
| EG23853A (en) | 2007-11-06 |
| AU1436400A (en) | 2000-06-05 |
| AU772435B2 (en) | 2004-04-29 |
| TW589191B (en) | 2004-06-01 |
| CN1326364A (zh) | 2001-12-12 |
| DK1131104T3 (da) | 2005-03-14 |
| ES2233104T3 (es) | 2005-06-01 |
| IL142702A (en) | 2006-07-05 |
| HK1042440B (zh) | 2005-04-29 |
| EP1131104B1 (en) | 2005-02-02 |
| ZA200103335B (en) | 2002-07-24 |
| MY122397A (en) | 2006-04-29 |
| NZ511832A (en) | 2003-09-26 |
| ATE288283T1 (de) | 2005-02-15 |
| CN1160128C (zh) | 2004-08-04 |
| CA2351463C (en) | 2009-10-13 |
| JP2002529520A (ja) | 2002-09-10 |
| IL142702A0 (en) | 2002-03-10 |
| KR20010075720A (ko) | 2001-08-09 |
| PT1131104E (pt) | 2005-03-31 |
| EP1131104A1 (en) | 2001-09-12 |
| WO2000029027A1 (en) | 2000-05-25 |
| JP5420583B2 (ja) | 2014-02-19 |
| SE9803929D0 (sv) | 1998-11-18 |
| CA2351463A1 (en) | 2000-05-25 |
| AR023705A1 (es) | 2002-09-04 |
| JP2011157392A (ja) | 2011-08-18 |
| KR100608963B1 (ko) | 2006-08-09 |
| DE69923584D1 (de) | 2005-03-10 |
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