DE69922688D1 - Zusammensetzungen aus einem 5ht1b/1d agonisten und einem selektiven cox-2 hemmer zur behandlung von migräne - Google Patents
Zusammensetzungen aus einem 5ht1b/1d agonisten und einem selektiven cox-2 hemmer zur behandlung von migräneInfo
- Publication number
- DE69922688D1 DE69922688D1 DE69922688T DE69922688T DE69922688D1 DE 69922688 D1 DE69922688 D1 DE 69922688D1 DE 69922688 T DE69922688 T DE 69922688T DE 69922688 T DE69922688 T DE 69922688T DE 69922688 D1 DE69922688 D1 DE 69922688D1
- Authority
- DE
- Germany
- Prior art keywords
- migraine
- agonist
- treatment
- inhibitor
- 5ht1b
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10660598P | 1998-11-02 | 1998-11-02 | |
US106605P | 1998-11-02 | ||
PCT/US1999/025388 WO2000025779A1 (en) | 1998-11-02 | 1999-10-29 | Method of treating migraines and pharmaceutical compositions |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69922688D1 true DE69922688D1 (de) | 2005-01-20 |
DE69922688T2 DE69922688T2 (de) | 2005-12-01 |
Family
ID=22312313
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69922688T Expired - Lifetime DE69922688T2 (de) | 1998-11-02 | 1999-10-29 | Zusammensetzungen aus einem 5ht1b/1d agonisten und einem selektiven cox-2 hemmer zur behandlung von migräne |
Country Status (9)
Country | Link |
---|---|
US (3) | US6384034B2 (de) |
EP (1) | EP1126841B1 (de) |
JP (1) | JP2002528498A (de) |
AT (1) | ATE284691T1 (de) |
AU (1) | AU759307B2 (de) |
CA (1) | CA2348979A1 (de) |
DE (1) | DE69922688T2 (de) |
ES (1) | ES2234324T3 (de) |
WO (1) | WO2000025779A1 (de) |
Families Citing this family (114)
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US6642268B2 (en) | 1994-09-13 | 2003-11-04 | G.D. Searle & Co. | Combination therapy employing ileal bile acid transport inhibiting benzothipines and HMG Co-A reductase inhibitors |
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ES2234324T3 (es) * | 1998-11-02 | 2005-06-16 | MERCK & CO., INC. | Combinaciones de un agonista 5ht1b/1d y un inhibidor selectivo de cox-2 para el tratamiento de la migraña. |
WO2000048583A2 (en) * | 1999-02-19 | 2000-08-24 | Pozen Inc. | Formulation of 5-ht agonists with nsaids, especially cox-2 inhibitors, for treating migraine |
CO5190664A1 (es) | 1999-06-30 | 2002-08-29 | Pfizer Prod Inc | Terapia de combinacion para el tratamiento de migrana administracion de un receptor 5ht, cafeina y un inhibidor de ciclooxigenasa-2 |
EP1150959B1 (de) * | 1999-12-08 | 2008-02-27 | Pharmacia Corporation | Celecoxib in festkörperform mit erhöhter bioverfügbarkeit |
AR035642A1 (es) * | 2000-05-26 | 2004-06-23 | Pharmacia Corp | Uso de una composicion de celecoxib para el alivio rapido del dolor |
WO2001091856A2 (en) * | 2000-06-01 | 2001-12-06 | Pharmacia Corporation | Use of cox2 inhibitors for treating skin injury from exposure to ultraviolet radiation |
AU2001285334A1 (en) * | 2000-08-29 | 2002-03-13 | Peter Van Patten | Combination for the treatment of migraine comprising a cyclooxygenase-2 inhibitor and acetylsalicylic acid |
US6579898B2 (en) * | 2001-03-01 | 2003-06-17 | Pfizer Inc. | Compositions having improved bioavailability |
JP2004532871A (ja) * | 2001-05-31 | 2004-10-28 | ファルマシア・コーポレーション | 皮膚浸透性シクロオキシゲナーゼ−2選択的阻害組成物 |
US20030013753A1 (en) * | 2001-06-05 | 2003-01-16 | Ronald Aung-Din | Transdermal migraine therapy |
US8329734B2 (en) * | 2009-07-27 | 2012-12-11 | Afgin Pharma Llc | Topical therapy for migraine |
DE10129320A1 (de) | 2001-06-19 | 2003-04-10 | Norbert Mueller | Verwendung von COX-2 Inhibitoren zur Behandlung von Schizophrenie, wahnhaften Störungen, affektiven Störungen oder Ticstörungen |
US20030181462A1 (en) * | 2001-08-17 | 2003-09-25 | Boehringer Ingelheim Pharma Kg | Use of BIBN4096 in combination with other antimigraine drugs for the treatment of migraine |
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DE10238723A1 (de) | 2002-08-23 | 2004-03-11 | Bayer Ag | Phenyl-substituierte Pyrazolyprimidine |
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US20090252791A1 (en) * | 2008-04-02 | 2009-10-08 | Venkata Nookaraju Sreedharala | Pharmaceutical compositions comprising a triptan and a nonsteroidal anti-inflammatory drug |
UA105362C2 (en) * | 2008-04-02 | 2014-05-12 | Бьорингер Ингельхайм Интернациональ Гмбх | 1-heterocyclyl-1, 5-dihydro-pyrazolo [3, 4-d] pyrimidin-4-one derivatives and their use as pde9a modulators |
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DE19542281C2 (de) | 1995-11-14 | 1997-12-04 | Boehringer Ingelheim Kg | Verwendung von Epinastin für die Behandlung der Migräne |
ES2311571T3 (es) * | 1996-04-12 | 2009-02-16 | G.D. Searle Llc | Derivados de bencenosulfonamida sustituidos como profarmacos de inhibidores de cox-2. |
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AU3993899A (en) * | 1998-05-18 | 1999-12-06 | Merck & Co., Inc. | Method for treating or preventing chronic nonbacterial prostatitis and prostatodynia |
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WO2000048583A2 (en) | 1999-02-19 | 2000-08-24 | Pozen Inc. | Formulation of 5-ht agonists with nsaids, especially cox-2 inhibitors, for treating migraine |
CN1349423A (zh) * | 1999-03-01 | 2002-05-15 | 奥索-麦克尼尔药品公司 | 包含曲马多物质和选择性cox-2抑制剂药物的组合物 |
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-
1999
- 1999-10-29 ES ES99960171T patent/ES2234324T3/es not_active Expired - Lifetime
- 1999-10-29 CA CA002348979A patent/CA2348979A1/en not_active Abandoned
- 1999-10-29 JP JP2000579220A patent/JP2002528498A/ja active Pending
- 1999-10-29 DE DE69922688T patent/DE69922688T2/de not_active Expired - Lifetime
- 1999-10-29 WO PCT/US1999/025388 patent/WO2000025779A1/en active IP Right Grant
- 1999-10-29 AU AU17098/00A patent/AU759307B2/en not_active Ceased
- 1999-10-29 AT AT99960171T patent/ATE284691T1/de not_active IP Right Cessation
- 1999-10-29 EP EP99960171A patent/EP1126841B1/de not_active Expired - Lifetime
-
2001
- 2001-08-22 US US09/934,823 patent/US6384034B2/en not_active Expired - Fee Related
-
2002
- 2002-03-26 US US10/106,845 patent/US20020177617A1/en not_active Abandoned
-
2006
- 2006-03-10 US US11/372,694 patent/US20060194855A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
WO2000025779A1 (en) | 2000-05-11 |
ES2234324T3 (es) | 2005-06-16 |
DE69922688T2 (de) | 2005-12-01 |
EP1126841A4 (de) | 2002-06-12 |
AU1709800A (en) | 2000-05-22 |
AU759307B2 (en) | 2003-04-10 |
US20020177617A1 (en) | 2002-11-28 |
US20060194855A1 (en) | 2006-08-31 |
CA2348979A1 (en) | 2000-05-11 |
JP2002528498A (ja) | 2002-09-03 |
US6384034B2 (en) | 2002-05-07 |
ATE284691T1 (de) | 2005-01-15 |
EP1126841A1 (de) | 2001-08-29 |
EP1126841B1 (de) | 2004-12-15 |
US20020016348A1 (en) | 2002-02-07 |
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