DE69922173D1 - Verfahren zur herstellung von teilchen - Google Patents

Verfahren zur herstellung von teilchen

Info

Publication number
DE69922173D1
DE69922173D1 DE69922173T DE69922173T DE69922173D1 DE 69922173 D1 DE69922173 D1 DE 69922173D1 DE 69922173 T DE69922173 T DE 69922173T DE 69922173 T DE69922173 T DE 69922173T DE 69922173 D1 DE69922173 D1 DE 69922173D1
Authority
DE
Germany
Prior art keywords
fluid
suspension
solution
substance
inlet means
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69922173T
Other languages
English (en)
Other versions
DE69922173T2 (de
Inventor
Hermiz Hanna
Gwynfor Owen Humphreys
Richard Storey
Boris Shekunov
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nektar Therapeutics
Original Assignee
Nektar Therapeutics UK Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nektar Therapeutics UK Ltd filed Critical Nektar Therapeutics UK Ltd
Publication of DE69922173D1 publication Critical patent/DE69922173D1/de
Application granted granted Critical
Publication of DE69922173T2 publication Critical patent/DE69922173T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/24—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C07C233/25—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/04—Solvent extraction of solutions which are liquid
    • B01D11/0403—Solvent extraction of solutions which are liquid with a supercritical fluid
    • B01D11/0411—Solvent extraction of solutions which are liquid with a supercritical fluid the supercritical fluid acting as solvent for the solvent and as anti-solvent for the solute, e.g. formation of particles from solutions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/02—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
    • B01J2/04—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops in a gaseous medium
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/54—Improvements relating to the production of bulk chemicals using solvents, e.g. supercritical solvents or ionic liquids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Extraction Or Liquid Replacement (AREA)
  • Medicinal Preparation (AREA)
  • Glanulating (AREA)
  • Devices And Processes Conducted In The Presence Of Fluids And Solid Particles (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
DE69922173T 1998-03-02 1999-02-26 Verfahren zur herstellung von teilchen Expired - Lifetime DE69922173T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9804379.7A GB9804379D0 (en) 1998-03-02 1998-03-02 Method of particle formation
GB9804379 1998-03-02
PCT/GB1999/000587 WO1999044733A1 (en) 1998-03-02 1999-02-26 Method of particle formation

Publications (2)

Publication Number Publication Date
DE69922173D1 true DE69922173D1 (de) 2004-12-30
DE69922173T2 DE69922173T2 (de) 2005-12-01

Family

ID=10827831

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69922173T Expired - Lifetime DE69922173T2 (de) 1998-03-02 1999-02-26 Verfahren zur herstellung von teilchen

Country Status (11)

Country Link
EP (1) EP1060008B1 (de)
JP (1) JP4593777B2 (de)
AT (1) ATE283110T1 (de)
AU (1) AU753115B2 (de)
CA (1) CA2321741C (de)
DE (1) DE69922173T2 (de)
ES (1) ES2232158T3 (de)
GB (2) GB9804379D0 (de)
MX (1) MXPA00008428A (de)
WO (1) WO1999044733A1 (de)
ZA (1) ZA991667B (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1198593C (zh) 1999-06-09 2005-04-27 罗伯特·E·希弗斯 超临界流体辅助的喷雾和鼓泡干燥
GB9915975D0 (en) * 1999-07-07 1999-09-08 Bradford Particle Design Ltd Method for the formation of particles
GB0027357D0 (en) 2000-11-09 2000-12-27 Bradford Particle Design Plc Particle formation methods and their products
AUPR197000A0 (en) 2000-12-08 2001-01-11 Unisearch Limited Synthesis of small particles
AU2002221320B2 (en) * 2000-12-08 2006-06-15 The University Of Sydney Synthesis of small particles
GB0102075D0 (en) 2001-01-26 2001-03-14 Astrazeneca Ab Process
WO2003006223A1 (en) 2001-07-10 2003-01-23 University Technology Corporation Devices and methods for the production of particles
GB0208742D0 (en) 2002-04-17 2002-05-29 Bradford Particle Design Ltd Particulate materials
GB0126716D0 (en) * 2001-11-07 2002-01-02 Advanced Phytonics Ltd Method for the production of particles
EP1624862B1 (de) 2003-05-08 2014-12-31 Nektar Therapeutics Teilchenförmige materialien
WO2007009164A1 (en) 2005-07-15 2007-01-25 Eiffel Technologies Limited Method of particle formation
JP4705691B2 (ja) 2006-10-11 2011-06-22 クリティテック・インコーポレイテッド 使用のための容器に小さい医薬粒子を沈殿させるための方法
EP2425820B1 (de) 2007-02-11 2015-04-08 MAP Pharmaceuticals Inc Verfahren zur therapeutischen Verabreichung von DHE zur schnellen Linderung von Migräne bei gleichzeitiger Minimierung von Nebenwirkungsprofilen
CN101918123B (zh) * 2007-12-07 2013-12-18 X喷雾微粒公司 生产微粒的方法与装置
US8323615B2 (en) * 2008-08-20 2012-12-04 Baxter International Inc. Methods of processing multi-phasic dispersions
US8323685B2 (en) 2008-08-20 2012-12-04 Baxter International Inc. Methods of processing compositions containing microparticles
US8367427B2 (en) 2008-08-20 2013-02-05 Baxter International Inc. Methods of processing compositions containing microparticles
MX350838B (es) 2011-02-11 2017-09-18 Grain Proc Corporation * Composicion de sal.
GB201402556D0 (en) 2014-02-13 2014-04-02 Crystec Ltd Improvements relating to inhalable particles
JP7304043B2 (ja) 2015-07-22 2023-07-06 アナベックス ライフ サイエンシズ コーポレイション テトラヒドロ－ｎ，ｎ－ジメチル－２，２－ジフェニル－３－フランメタンアミンヒドロクロリドの結晶形態、かかる形態の作製方法およびその薬学的組成物
CN111530103B (zh) * 2020-05-08 2021-08-31 福建蓝烟新材料有限公司 一种超临界喷雾干燥方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9313642D0 (en) * 1993-07-01 1993-08-18 Glaxo Group Ltd Method and apparatus for the formation of particles
SI9400079B (sl) * 1994-02-15 2003-02-28 Dr. Weidner Eckhard, Dipl. Ing. Postopek in naprava za pridobivanje in frakcioniranje majhnih delcev iz raztopin nasičenih s plinom
GB9413202D0 (en) * 1994-06-30 1994-08-24 Univ Bradford Method and apparatus for the formation of particles
JP3986086B2 (ja) * 1996-03-01 2007-10-03 ザ ユニバーシティ オブ カンザス 近臨界および超臨界反溶媒を用いる粒子析出方法および被覆方法
GB9703673D0 (en) * 1997-02-21 1997-04-09 Bradford Particle Design Ltd Method and apparatus for the formation of particles
US6228394B1 (en) * 1997-10-14 2001-05-08 Boehringer Ingelheim Pharmaceuticals, Inc. Supercritical fluid extraction of mould lubricant from hard shell capsules

Also Published As

Publication number Publication date
JP4593777B2 (ja) 2010-12-08
GB2334900A (en) 1999-09-08
CA2321741C (en) 2007-10-30
CA2321741A1 (en) 1999-09-10
AU3260199A (en) 1999-09-20
ZA991667B (en) 1999-11-16
GB2334900B (en) 2000-04-19
MXPA00008428A (es) 2003-04-25
AU753115B2 (en) 2002-10-10
ES2232158T3 (es) 2005-05-16
WO1999044733A1 (en) 1999-09-10
ATE283110T1 (de) 2004-12-15
DE69922173T2 (de) 2005-12-01
EP1060008A1 (de) 2000-12-20
JP2002505182A (ja) 2002-02-19
EP1060008B1 (de) 2004-11-24
GB9804379D0 (en) 1998-04-22
GB9904658D0 (en) 1999-04-21

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