MXPA04000201A - Metodo y aparato para preparar particulas. - Google Patents

Metodo y aparato para preparar particulas.

Info

Publication number
MXPA04000201A
MXPA04000201A MXPA04000201A MXPA04000201A MXPA04000201A MX PA04000201 A MXPA04000201 A MX PA04000201A MX PA04000201 A MXPA04000201 A MX PA04000201A MX PA04000201 A MXPA04000201 A MX PA04000201A MX PA04000201 A MXPA04000201 A MX PA04000201A
Authority
MX
Mexico
Prior art keywords
solvent
fluid
substance
vessel
sonic
Prior art date
Application number
MXPA04000201A
Other languages
English (en)
Inventor
Palakodaty Srinivas
Original Assignee
Nektar Therapeutics Uk Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB0117696.5A external-priority patent/GB0117696D0/en
Priority claimed from GBGB0208742.7A external-priority patent/GB0208742D0/en
Application filed by Nektar Therapeutics Uk Ltd filed Critical Nektar Therapeutics Uk Ltd
Publication of MXPA04000201A publication Critical patent/MXPA04000201A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/02—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
    • B01J2/04—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops in a gaseous medium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Medicinal Preparation (AREA)

Abstract

Se describe un metodo para preparar una sustancia objetivo en forma de particulas, que comprende introducir a un recipiente de formacion de particulas, a traves de primeros y segundos medios de entrada de fluido separados, respectivamente, (a) una "solucion/suspension objetivo" de la sustancia en un vehiculo fluido y (b) un antisolvente de fluido comprimido y permitir que el antisolvente extraiga el vehiculo para formar particulas de la sustancia, en donde el fluido antisolvente tiene una velocidad sonica, casi sonica o supersonica a medida que entra al recipiente y en donde el antisolvente y la solucion/suspension objetivo entran al recipiente en diferentes sitios y se encuentran corriente abajo (en la direccion del flujo del antisolvente) de los segundos medios de entrada del fluido. Tambien se proporciona un aparato para uso en tal metodo.
MXPA04000201A 2001-07-20 2002-07-17 Metodo y aparato para preparar particulas. MXPA04000201A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0117696.5A GB0117696D0 (en) 2001-07-20 2001-07-20 Particle information
GBGB0208742.7A GB0208742D0 (en) 2002-04-17 2002-04-17 Particulate materials
PCT/GB2002/003296 WO2003008082A1 (en) 2001-07-20 2002-07-17 Method and apparatus for preparing particles

Publications (1)

Publication Number Publication Date
MXPA04000201A true MXPA04000201A (es) 2004-03-18

Family

ID=26246332

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA04000201A MXPA04000201A (es) 2001-07-20 2002-07-17 Metodo y aparato para preparar particulas.

Country Status (9)

Country Link
EP (1) EP1409123B1 (es)
JP (1) JP4369227B2 (es)
KR (1) KR20040018466A (es)
AU (1) AU2002314390B2 (es)
CA (1) CA2454331C (es)
GB (1) GB2381214B (es)
MX (1) MXPA04000201A (es)
TW (1) TW586963B (es)
WO (1) WO2003008082A1 (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0027357D0 (en) 2000-11-09 2000-12-27 Bradford Particle Design Plc Particle formation methods and their products
EP1363726B1 (en) 2001-02-26 2004-09-01 Dompé S.P.A. Apparatus and method for micron and submicron particle formation
GB0208742D0 (en) 2002-04-17 2002-05-29 Bradford Particle Design Ltd Particulate materials
GB2405334B (en) * 2002-04-17 2006-02-15 Nektar Therapeutics Uk Ltd Particulate materials
US9339459B2 (en) 2003-04-24 2016-05-17 Nektar Therapeutics Particulate materials
GB0300338D0 (en) * 2003-01-08 2003-02-05 Bradford Particle Design Ltd Particle formation
GB0300339D0 (en) * 2003-01-08 2003-02-05 Bradford Particle Design Ltd Particle formation
EP1624862B1 (en) 2003-05-08 2014-12-31 Nektar Therapeutics Particulate materials
ES2392433T3 (es) * 2003-10-30 2012-12-10 Merck Serono Sa Procedimiento y aparato para enfriar y atomizar sustancias líquidas o pastosas
SE0303476D0 (sv) 2003-12-22 2003-12-22 Censdelivery Ab Device, method and use for the formation of small particles
US20060062848A1 (en) * 2004-09-17 2006-03-23 Nektar Therapeutics Uk Limited Formulation comprising itraconazole
WO2007009164A1 (en) 2005-07-15 2007-01-25 Eiffel Technologies Limited Method of particle formation
GB0605360D0 (en) * 2006-03-16 2006-04-26 Dupont Teijin Films Us Ltd Method of manufacture
SG172700A1 (en) * 2006-04-28 2011-07-28 Schering Corp Process for the precipitation and isolation of 6,6-dimethyl-3-aza-bicyclo [3.1.0] hexane-amide compounds by controlled precipitation and pharmaceutical formulations containing same
US8420122B2 (en) 2006-04-28 2013-04-16 Merck Sharp & Dohme Corp. Process for the precipitation and isolation of 6,6-dimethyl-3-aza-bicyclo [3.1.0] hexane-amide compounds by controlled precipitation and pharmaceutical formulations containing same
EP2125938A2 (en) * 2007-01-26 2009-12-02 Isp Investments Inc. Formulation process method to produce spray dried products
GB0702402D0 (en) 2007-02-08 2007-03-21 Thar Pharmaceuticals Inc Method of creating crystalline substances
CA2677838C (en) 2007-02-11 2017-08-01 Map Pharmaceuticals, Inc. Method of therapeutic administration of dhe to enable rapid relief of migraine while minimizing side effect profile
ES2336524B1 (es) * 2007-10-17 2011-02-14 Activery Biotech, S.L. Procedimiento para la preparacion de particulas.
EP2229233B1 (en) 2007-12-07 2019-10-09 XSpray Pharma AB (publ) Method for the production of particles
MX350838B (es) 2011-02-11 2017-09-18 Grain Proc Corporation * Composicion de sal.
GB201402556D0 (en) 2014-02-13 2014-04-02 Crystec Ltd Improvements relating to inhalable particles
EP3325456A4 (en) 2015-07-22 2019-01-23 Anavex Life Sciences Corp. CRYSTAL FORMS OF TETRA-HYDRO-N, N-DIMETHYL-2,2-DIPHENYL-3-FURANOMETHANAMINE HYDROCHLORIDE, METHOD FOR THE PREPARATION OF SUCH FORMS, AND THEIR PHARMACEUTICAL COMPOSITIONS
CN112881652B (zh) * 2021-01-27 2024-06-04 武汉工程大学 超临界co2注入页岩储层焦耳-汤姆逊效应试验模拟装置

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB203794A (en) * 1922-06-15 1923-09-17 Alfred Charles Prior Improvements in or relating to agitators and mixing devices
US3894851A (en) * 1972-02-07 1975-07-15 Midwest Research Inst Removal of particulate matter with supersonic droplets
DD203688B1 (de) * 1982-02-25 1987-09-16 Fotochem Werke Berlin Veb Vorrichtung zur mischung von additiven mit suspensionen oder loesungen
JPS62201629A (ja) * 1986-02-28 1987-09-05 Kao Corp 噴霧造粒方法
JPH06323712A (ja) * 1993-04-20 1994-11-25 E I Du Pont De Nemours & Co 霧化した極低温液滴の閉じ込め帯域を用いて凍結粒子を製造する方法および装置
GB9313642D0 (en) * 1993-07-01 1993-08-18 Glaxo Group Ltd Method and apparatus for the formation of particles
WO1997005994A1 (en) * 1995-08-04 1997-02-20 Microcoating Technologies Inc Chemical vapor deposition and powder formation using thermal spray with near supercritical and supercritical fluid solutions
US5874029A (en) * 1996-10-09 1999-02-23 The University Of Kansas Methods for particle micronization and nanonization by recrystallization from organic solutions sprayed into a compressed antisolvent
JP3986086B2 (ja) * 1996-03-01 2007-10-03 ザ ユニバーシティ オブ カンザス 近臨界および超臨界反溶媒を用いる粒子析出方法および被覆方法
SE9901059L (sv) * 1999-03-22 2000-09-23 Johan Carlfors Metod för framställning av partiklar
CH694686A5 (it) * 2000-03-04 2005-06-15 Eco2 Sa Prodotto di micronizzazione di sostanze farmaceutiche.
FR2815540B1 (fr) * 2000-10-19 2005-06-10 Separex Sa Procede de fabrication de tres fines particules constituees d'un principe insere dans une molecule hote
EP1363726B1 (en) 2001-02-26 2004-09-01 Dompé S.P.A. Apparatus and method for micron and submicron particle formation

Also Published As

Publication number Publication date
GB2381214A (en) 2003-04-30
AU2002314390B2 (en) 2007-11-22
EP1409123A1 (en) 2004-04-21
EP1409123B1 (en) 2015-11-04
CA2454331A1 (en) 2003-01-30
GB2381214B (en) 2004-01-21
JP4369227B2 (ja) 2009-11-18
GB0216565D0 (en) 2002-08-28
TW586963B (en) 2004-05-11
CA2454331C (en) 2011-05-24
WO2003008082A1 (en) 2003-01-30
JP2004534648A (ja) 2004-11-18
KR20040018466A (ko) 2004-03-03

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