MXPA04000201A - Metodo y aparato para preparar particulas. - Google Patents
Metodo y aparato para preparar particulas.Info
- Publication number
- MXPA04000201A MXPA04000201A MXPA04000201A MXPA04000201A MXPA04000201A MX PA04000201 A MXPA04000201 A MX PA04000201A MX PA04000201 A MXPA04000201 A MX PA04000201A MX PA04000201 A MXPA04000201 A MX PA04000201A MX PA04000201 A MXPA04000201 A MX PA04000201A
- Authority
- MX
- Mexico
- Prior art keywords
- solvent
- fluid
- substance
- vessel
- sonic
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
- B01J2/02—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
- B01J2/04—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops in a gaseous medium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
Abstract
Se describe un metodo para preparar una sustancia objetivo en forma de particulas, que comprende introducir a un recipiente de formacion de particulas, a traves de primeros y segundos medios de entrada de fluido separados, respectivamente, (a) una "solucion/suspension objetivo" de la sustancia en un vehiculo fluido y (b) un antisolvente de fluido comprimido y permitir que el antisolvente extraiga el vehiculo para formar particulas de la sustancia, en donde el fluido antisolvente tiene una velocidad sonica, casi sonica o supersonica a medida que entra al recipiente y en donde el antisolvente y la solucion/suspension objetivo entran al recipiente en diferentes sitios y se encuentran corriente abajo (en la direccion del flujo del antisolvente) de los segundos medios de entrada del fluido. Tambien se proporciona un aparato para uso en tal metodo.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0117696.5A GB0117696D0 (en) | 2001-07-20 | 2001-07-20 | Particle information |
GBGB0208742.7A GB0208742D0 (en) | 2002-04-17 | 2002-04-17 | Particulate materials |
PCT/GB2002/003296 WO2003008082A1 (en) | 2001-07-20 | 2002-07-17 | Method and apparatus for preparing particles |
Publications (1)
Publication Number | Publication Date |
---|---|
MXPA04000201A true MXPA04000201A (es) | 2004-03-18 |
Family
ID=26246332
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MXPA04000201A MXPA04000201A (es) | 2001-07-20 | 2002-07-17 | Metodo y aparato para preparar particulas. |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP1409123B1 (es) |
JP (1) | JP4369227B2 (es) |
KR (1) | KR20040018466A (es) |
AU (1) | AU2002314390B2 (es) |
CA (1) | CA2454331C (es) |
GB (1) | GB2381214B (es) |
MX (1) | MXPA04000201A (es) |
TW (1) | TW586963B (es) |
WO (1) | WO2003008082A1 (es) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0027357D0 (en) | 2000-11-09 | 2000-12-27 | Bradford Particle Design Plc | Particle formation methods and their products |
ES2223034T3 (es) | 2001-02-26 | 2005-02-16 | Dompe S.P.A. | Aparato y metodo para la formacion de particulas micronicas y submicronicas. |
GB0208742D0 (en) | 2002-04-17 | 2002-05-29 | Bradford Particle Design Ltd | Particulate materials |
GB2405334B (en) * | 2002-04-17 | 2006-02-15 | Nektar Therapeutics Uk Ltd | Particulate materials |
US9339459B2 (en) | 2003-04-24 | 2016-05-17 | Nektar Therapeutics | Particulate materials |
GB0300338D0 (en) * | 2003-01-08 | 2003-02-05 | Bradford Particle Design Ltd | Particle formation |
GB0300339D0 (en) * | 2003-01-08 | 2003-02-05 | Bradford Particle Design Ltd | Particle formation |
EP1624862B1 (en) | 2003-05-08 | 2014-12-31 | Nektar Therapeutics | Particulate materials |
WO2005049192A1 (en) * | 2003-10-30 | 2005-06-02 | Laboratoires Serono S.A. | Process and apparatus for cooling and atomizing liquid or pasty-like substances |
SE0303476D0 (sv) * | 2003-12-22 | 2003-12-22 | Censdelivery Ab | Device, method and use for the formation of small particles |
WO2006034080A2 (en) * | 2004-09-17 | 2006-03-30 | Nektar Therapeutics | Formulation comprising itraconazole |
EP1904219A4 (en) | 2005-07-15 | 2011-07-27 | Map Pharmaceuticals Inc | METHOD FOR FORMING PARTICLES |
GB0605360D0 (en) * | 2006-03-16 | 2006-04-26 | Dupont Teijin Films Us Ltd | Method of manufacture |
JP5592647B2 (ja) * | 2006-04-28 | 2014-09-17 | メルク・シャープ・アンド・ドーム・コーポレーション | 制御された析出による6,6−ジメチル−3−アザ−ビシクロ[3.1.0]ヘキサン−アミド化合物の析出および単離のための方法、ならびにこれを含む医薬処方物 |
US8420122B2 (en) | 2006-04-28 | 2013-04-16 | Merck Sharp & Dohme Corp. | Process for the precipitation and isolation of 6,6-dimethyl-3-aza-bicyclo [3.1.0] hexane-amide compounds by controlled precipitation and pharmaceutical formulations containing same |
US10189957B2 (en) * | 2007-01-26 | 2019-01-29 | Isp Investments Llc | Formulation process method to produce spray dried products |
GB0702402D0 (en) | 2007-02-08 | 2007-03-21 | Thar Pharmaceuticals Inc | Method of creating crystalline substances |
EP2425819A1 (en) | 2007-02-11 | 2012-03-07 | MAP Pharmaceuticals Inc | Method of therapeutic administration of dhe to enable rapid relief of migraine while minimizing side effect profile |
ES2336524B1 (es) * | 2007-10-17 | 2011-02-14 | Activery Biotech, S.L. | Procedimiento para la preparacion de particulas. |
CN101918123B (zh) | 2007-12-07 | 2013-12-18 | X喷雾微粒公司 | 生产微粒的方法与装置 |
US9808030B2 (en) | 2011-02-11 | 2017-11-07 | Grain Processing Corporation | Salt composition |
GB201402556D0 (en) | 2014-02-13 | 2014-04-02 | Crystec Ltd | Improvements relating to inhalable particles |
CA2986349A1 (en) | 2015-07-22 | 2017-01-26 | Anavex Life Sciences Corp. | Crystal forms of tetrahydro-n,n-dimethyl-2,2-diphenyl-3-furanmethanamine hydrochloride, processes of making such forms, and their pharmaceutical compositions |
CN112881652A (zh) * | 2021-01-27 | 2021-06-01 | 武汉工程大学 | 超临界co2注入页岩储层焦耳-汤姆逊效应试验模拟装置 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB203794A (en) * | 1922-06-15 | 1923-09-17 | Alfred Charles Prior | Improvements in or relating to agitators and mixing devices |
US3894851A (en) * | 1972-02-07 | 1975-07-15 | Midwest Research Inst | Removal of particulate matter with supersonic droplets |
DD203688B1 (de) * | 1982-02-25 | 1987-09-16 | Fotochem Werke Berlin Veb | Vorrichtung zur mischung von additiven mit suspensionen oder loesungen |
JPS62201629A (ja) * | 1986-02-28 | 1987-09-05 | Kao Corp | 噴霧造粒方法 |
JPH06323712A (ja) * | 1993-04-20 | 1994-11-25 | E I Du Pont De Nemours & Co | 霧化した極低温液滴の閉じ込め帯域を用いて凍結粒子を製造する方法および装置 |
GB9313642D0 (en) * | 1993-07-01 | 1993-08-18 | Glaxo Group Ltd | Method and apparatus for the formation of particles |
US5997956A (en) * | 1995-08-04 | 1999-12-07 | Microcoating Technologies | Chemical vapor deposition and powder formation using thermal spray with near supercritical and supercritical fluid solutions |
US5874029A (en) * | 1996-10-09 | 1999-02-23 | The University Of Kansas | Methods for particle micronization and nanonization by recrystallization from organic solutions sprayed into a compressed antisolvent |
WO1997031691A1 (en) * | 1996-03-01 | 1997-09-04 | The University Of Kansas | Methods and apparatus for particle precipitation and coating using near-critical and supercritical antisolvents |
SE9901059L (sv) * | 1999-03-22 | 2000-09-23 | Johan Carlfors | Metod för framställning av partiklar |
CH694686A5 (it) * | 2000-03-04 | 2005-06-15 | Eco2 Sa | Prodotto di micronizzazione di sostanze farmaceutiche. |
FR2815540B1 (fr) * | 2000-10-19 | 2005-06-10 | Separex Sa | Procede de fabrication de tres fines particules constituees d'un principe insere dans une molecule hote |
ES2223034T3 (es) | 2001-02-26 | 2005-02-16 | Dompe S.P.A. | Aparato y metodo para la formacion de particulas micronicas y submicronicas. |
-
2002
- 2002-07-16 TW TW091115856A patent/TW586963B/zh not_active IP Right Cessation
- 2002-07-17 AU AU2002314390A patent/AU2002314390B2/en not_active Expired
- 2002-07-17 CA CA2454331A patent/CA2454331C/en not_active Expired - Lifetime
- 2002-07-17 GB GB0216565A patent/GB2381214B/en not_active Expired - Lifetime
- 2002-07-17 MX MXPA04000201A patent/MXPA04000201A/es not_active Application Discontinuation
- 2002-07-17 EP EP02740962.2A patent/EP1409123B1/en not_active Expired - Lifetime
- 2002-07-17 KR KR10-2004-7000666A patent/KR20040018466A/ko not_active Application Discontinuation
- 2002-07-17 WO PCT/GB2002/003296 patent/WO2003008082A1/en active Application Filing
- 2002-07-17 JP JP2003513681A patent/JP4369227B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
GB2381214A (en) | 2003-04-30 |
EP1409123A1 (en) | 2004-04-21 |
JP2004534648A (ja) | 2004-11-18 |
KR20040018466A (ko) | 2004-03-03 |
TW586963B (en) | 2004-05-11 |
CA2454331C (en) | 2011-05-24 |
AU2002314390B2 (en) | 2007-11-22 |
JP4369227B2 (ja) | 2009-11-18 |
GB0216565D0 (en) | 2002-08-28 |
EP1409123B1 (en) | 2015-11-04 |
WO2003008082A1 (en) | 2003-01-30 |
GB2381214B (en) | 2004-01-21 |
CA2454331A1 (en) | 2003-01-30 |
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Legal Events
Date | Code | Title | Description |
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FA | Abandonment or withdrawal |