ATE283110T1 - Verfahren zur herstellung von teilchen - Google Patents

Verfahren zur herstellung von teilchen

Info

Publication number
ATE283110T1
ATE283110T1 AT99937888T AT99937888T ATE283110T1 AT E283110 T1 ATE283110 T1 AT E283110T1 AT 99937888 T AT99937888 T AT 99937888T AT 99937888 T AT99937888 T AT 99937888T AT E283110 T1 ATE283110 T1 AT E283110T1
Authority
AT
Austria
Prior art keywords
fluid
suspension
solution
substance
inlet means
Prior art date
Application number
AT99937888T
Other languages
English (en)
Inventor
Mazen Hermiz Hanna
Gwynfor Owen Humphreys
Richard Storey
Boris Shekunov
Original Assignee
Nektar Therapeutics Uk Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nektar Therapeutics Uk Ltd filed Critical Nektar Therapeutics Uk Ltd
Application granted granted Critical
Publication of ATE283110T1 publication Critical patent/ATE283110T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/24—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C07C233/25—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/04—Solvent extraction of solutions which are liquid
    • B01D11/0403—Solvent extraction of solutions which are liquid with a supercritical fluid
    • B01D11/0411—Solvent extraction of solutions which are liquid with a supercritical fluid the supercritical fluid acting as solvent for the solvent and as anti-solvent for the solute, e.g. formation of particles from solutions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/02—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
    • B01J2/04—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops in a gaseous medium
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/54—Improvements relating to the production of bulk chemicals using solvents, e.g. supercritical solvents or ionic liquids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Extraction Or Liquid Replacement (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicinal Preparation (AREA)
  • Glanulating (AREA)
  • Devices And Processes Conducted In The Presence Of Fluids And Solid Particles (AREA)
AT99937888T 1998-03-02 1999-02-26 Verfahren zur herstellung von teilchen ATE283110T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9804379.7A GB9804379D0 (en) 1998-03-02 1998-03-02 Method of particle formation
PCT/GB1999/000587 WO1999044733A1 (en) 1998-03-02 1999-02-26 Method of particle formation

Publications (1)

Publication Number Publication Date
ATE283110T1 true ATE283110T1 (de) 2004-12-15

Family

ID=10827831

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99937888T ATE283110T1 (de) 1998-03-02 1999-02-26 Verfahren zur herstellung von teilchen

Country Status (11)

Country Link
EP (1) EP1060008B1 (de)
JP (1) JP4593777B2 (de)
AT (1) ATE283110T1 (de)
AU (1) AU753115B2 (de)
CA (1) CA2321741C (de)
DE (1) DE69922173T2 (de)
ES (1) ES2232158T3 (de)
GB (2) GB9804379D0 (de)
MX (1) MXPA00008428A (de)
WO (1) WO1999044733A1 (de)
ZA (1) ZA991667B (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1185248B1 (de) 1999-06-09 2012-05-02 Robert E. Sievers Überkritische fluidgestützte verneblung und blasen trochnen
GB9915975D0 (en) * 1999-07-07 1999-09-08 Bradford Particle Design Ltd Method for the formation of particles
GB0027357D0 (en) 2000-11-09 2000-12-27 Bradford Particle Design Plc Particle formation methods and their products
AUPR197000A0 (en) 2000-12-08 2001-01-11 Unisearch Limited Synthesis of small particles
AU2002221320B2 (en) * 2000-12-08 2006-06-15 The University Of Sydney Synthesis of small particles
GB0102075D0 (en) 2001-01-26 2001-03-14 Astrazeneca Ab Process
WO2003006223A1 (en) * 2001-07-10 2003-01-23 University Technology Corporation Devices and methods for the production of particles
GB0208742D0 (en) 2002-04-17 2002-05-29 Bradford Particle Design Ltd Particulate materials
GB0126716D0 (en) * 2001-11-07 2002-01-02 Advanced Phytonics Ltd Method for the production of particles
MXPA05011343A (es) 2003-05-08 2005-12-12 Nektar Therapeutics Uk Ltd Materiales particulados.
EP1904219A4 (de) 2005-07-15 2011-07-27 Map Pharmaceuticals Inc Teilchenbildungsverfahren
EP2476412B1 (de) 2006-10-11 2014-03-19 Crititech, Inc. Apparat zur Abscheidung kleiner Medikamententeilchen in einen Behälter
AU2008214205B2 (en) 2007-02-11 2014-04-24 Map Pharmaceuticals, Inc. Method of therapeutic administration of DHE to enable rapid relief of migraine while minimizing side effect profile
AU2008331967B2 (en) 2007-12-07 2012-10-25 Xspray Microparticles Ab Method and arrangement for the production of particles
US8323685B2 (en) 2008-08-20 2012-12-04 Baxter International Inc. Methods of processing compositions containing microparticles
US8367427B2 (en) 2008-08-20 2013-02-05 Baxter International Inc. Methods of processing compositions containing microparticles
US8323615B2 (en) 2008-08-20 2012-12-04 Baxter International Inc. Methods of processing multi-phasic dispersions
MX350838B (es) 2011-02-11 2017-09-18 Grain Proc Corporation * Composicion de sal.
GB201402556D0 (en) 2014-02-13 2014-04-02 Crystec Ltd Improvements relating to inhalable particles
EP3325456A4 (de) 2015-07-22 2019-01-23 Anavex Life Sciences Corp. Kristallformen von tetra-hydro-n, n-dimethyl-2,2-diphenyl-3-furanmethanaminhydrochlorid, verfahren zur herstellung solcher formen und ihrer pharmazeutischen zusammensetzungen
CN111530103B (zh) * 2020-05-08 2021-08-31 福建蓝烟新材料有限公司 一种超临界喷雾干燥方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9313642D0 (en) * 1993-07-01 1993-08-18 Glaxo Group Ltd Method and apparatus for the formation of particles
SI9400079B (sl) * 1994-02-15 2003-02-28 Dr. Weidner Eckhard, Dipl. Ing. Postopek in naprava za pridobivanje in frakcioniranje majhnih delcev iz raztopin nasičenih s plinom
GB9413202D0 (en) * 1994-06-30 1994-08-24 Univ Bradford Method and apparatus for the formation of particles
EP0885038B1 (de) * 1996-03-01 2011-06-15 The University Of Kansas Methoden und vorrichtungen zur teilchenausfallung und -beschichtung mit fast kritischen oder uberkritischen anti-losungsmitteln
GB9703673D0 (en) * 1997-02-21 1997-04-09 Bradford Particle Design Ltd Method and apparatus for the formation of particles
US6228394B1 (en) * 1997-10-14 2001-05-08 Boehringer Ingelheim Pharmaceuticals, Inc. Supercritical fluid extraction of mould lubricant from hard shell capsules

Also Published As

Publication number Publication date
ES2232158T3 (es) 2005-05-16
JP4593777B2 (ja) 2010-12-08
MXPA00008428A (es) 2003-04-25
GB2334900B (en) 2000-04-19
ZA991667B (en) 1999-11-16
GB9904658D0 (en) 1999-04-21
DE69922173D1 (de) 2004-12-30
CA2321741C (en) 2007-10-30
GB9804379D0 (en) 1998-04-22
AU3260199A (en) 1999-09-20
EP1060008A1 (de) 2000-12-20
DE69922173T2 (de) 2005-12-01
CA2321741A1 (en) 1999-09-10
AU753115B2 (en) 2002-10-10
GB2334900A (en) 1999-09-08
JP2002505182A (ja) 2002-02-19
EP1060008B1 (de) 2004-11-24
WO1999044733A1 (en) 1999-09-10

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Legal Events

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