DE60022195D1 - Verfahren und vorrichtung zur herstellung von teilchen - Google Patents
Verfahren und vorrichtung zur herstellung von teilchenInfo
- Publication number
- DE60022195D1 DE60022195D1 DE60022195T DE60022195T DE60022195D1 DE 60022195 D1 DE60022195 D1 DE 60022195D1 DE 60022195 T DE60022195 T DE 60022195T DE 60022195 T DE60022195 T DE 60022195T DE 60022195 D1 DE60022195 D1 DE 60022195D1
- Authority
- DE
- Germany
- Prior art keywords
- fluid gas
- vehicle system
- mixing chamber
- disorder
- controlled
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/26—Nozzle-type reactors, i.e. the distribution of the initial reactants within the reactor is effected by their introduction or injection through nozzles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D11/00—Solvent extraction
- B01D11/04—Solvent extraction of solutions which are liquid
- B01D11/0403—Solvent extraction of solutions which are liquid with a supercritical fluid
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D11/00—Solvent extraction
- B01D11/04—Solvent extraction of solutions which are liquid
- B01D11/0403—Solvent extraction of solutions which are liquid with a supercritical fluid
- B01D11/0407—Solvent extraction of solutions which are liquid with a supercritical fluid the supercritical fluid acting as solvent for the solute
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D11/00—Solvent extraction
- B01D11/04—Solvent extraction of solutions which are liquid
- B01D11/0403—Solvent extraction of solutions which are liquid with a supercritical fluid
- B01D11/0411—Solvent extraction of solutions which are liquid with a supercritical fluid the supercritical fluid acting as solvent for the solvent and as anti-solvent for the solute, e.g. formation of particles from solutions
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D11/00—Solvent extraction
- B01D11/04—Solvent extraction of solutions which are liquid
- B01D11/0488—Flow sheets
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
- B01F25/40—Static mixers
- B01F25/44—Mixers in which the components are pressed through slits
- B01F25/441—Mixers in which the components are pressed through slits characterised by the configuration of the surfaces forming the slits
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
- B01J2/02—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
- B01J2/04—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops in a gaseous medium
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J3/00—Processes of utilising sub-atmospheric or super-atmospheric pressure to effect chemical or physical change of matter; Apparatus therefor
- B01J3/008—Processes carried out under supercritical conditions
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
- B01F2101/22—Mixing of ingredients for pharmaceutical or medical compositions
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00049—Controlling or regulating processes
- B01J2219/00051—Controlling the temperature
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00049—Controlling or regulating processes
- B01J2219/00162—Controlling or regulating processes controlling the pressure
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Dispersion Chemistry (AREA)
- Accessories For Mixers (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Mixers With Rotating Receptacles And Mixers With Vibration Mechanisms (AREA)
- Glanulating (AREA)
- Manufacturing Of Micro-Capsules (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9901667 | 1999-05-07 | ||
SE9901667A SE9901667D0 (sv) | 1999-05-07 | 1999-05-07 | Method and device for forming particles |
PCT/SE2000/000877 WO2000067892A1 (en) | 1999-05-07 | 2000-05-04 | Method and device for forming particles |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60022195D1 true DE60022195D1 (de) | 2005-09-29 |
DE60022195T2 DE60022195T2 (de) | 2006-06-29 |
Family
ID=20415513
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60022195T Expired - Lifetime DE60022195T2 (de) | 1999-05-07 | 2000-05-04 | Verfahren und vorrichtung zur herstellung von teilchen |
Country Status (13)
Country | Link |
---|---|
US (1) | US6551532B1 (de) |
EP (1) | EP1191998B1 (de) |
JP (1) | JP2002543961A (de) |
KR (1) | KR20020013871A (de) |
CN (1) | CN1350475A (de) |
AT (1) | ATE302647T1 (de) |
AU (1) | AU759786B2 (de) |
CA (1) | CA2368087A1 (de) |
DE (1) | DE60022195T2 (de) |
MX (1) | MXPA01011099A (de) |
NZ (1) | NZ515146A (de) |
SE (1) | SE9901667D0 (de) |
WO (1) | WO2000067892A1 (de) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0027357D0 (en) | 2000-11-09 | 2000-12-27 | Bradford Particle Design Plc | Particle formation methods and their products |
CN100531886C (zh) | 2001-02-26 | 2009-08-26 | 多姆普Pha.R.Ma公司 | 形成微米和亚微米颗粒的装置及其方法 |
FR2824754B1 (fr) * | 2001-05-15 | 2004-05-28 | Separex Sa | Procede d'obtention de particules solides a partir d'au moins un produit hydrosoluble |
GB0208742D0 (en) | 2002-04-17 | 2002-05-29 | Bradford Particle Design Ltd | Particulate materials |
CA2482272C (en) * | 2002-04-12 | 2011-08-16 | Feyecon Development & Implementation B.V. | Process for small particle formation |
US6998051B2 (en) * | 2002-07-03 | 2006-02-14 | Ferro Corporation | Particles from supercritical fluid extraction of emulsion |
CA2524773C (en) | 2003-05-08 | 2014-04-08 | Nektar Therapeutics Uk Ltd | Particulate coformulations of active substances with excipients |
WO2005037821A2 (en) * | 2003-10-16 | 2005-04-28 | Teva Pharmaceutical Industries Ltd. | Preparation of candesartan cilexetil |
EP1713795A2 (de) * | 2004-02-11 | 2006-10-25 | Teva Pharmaceutical Industries Ltd. | Candesartan-cilexetil-polymorphe |
US20050250827A1 (en) * | 2004-05-05 | 2005-11-10 | Etinger Marina Y | Preparation of candesartan cilexetil in high purity |
WO2005123720A1 (en) * | 2004-06-18 | 2005-12-29 | Ranbaxy Laboratories Limited | Fine particles of the angiotensin ii antagonist candesartan cilexetil and process for production thereof |
ES2429941T3 (es) * | 2005-05-10 | 2013-11-18 | Teva Pharmaceutical Industries, Ltd. | Candesartán cilexetilo micronizado estable y métodos para preparar el mismo |
ATE539102T1 (de) * | 2006-10-31 | 2012-01-15 | Surmodics Pharmaceuticals Inc | Kugelförmige polymer-partikel |
ES2691033T3 (es) | 2007-02-11 | 2018-11-23 | Map Pharmaceuticals Inc. | Método de administración terapéutica de DHE para activar el alivio rápido de la migraña a la vez que se reduce al mínimo el perfil de los efectos secundarios |
ES2326402B1 (es) * | 2008-04-07 | 2010-08-10 | Activery Biotech, S.L. | Procedimiento para la preparacion de combinaciones amorfas de antagonistas del receptor de angiotensina ii y diureticos. |
US9808030B2 (en) | 2011-02-11 | 2017-11-07 | Grain Processing Corporation | Salt composition |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1066029A (en) * | 1973-03-16 | 1979-11-13 | Alberto Rabassa | Process for the preparation of non-dusty, easily wetted and readily soluble granulates |
JPS5243163A (en) * | 1975-10-02 | 1977-04-04 | Matsushita Electric Ind Co Ltd | Mixer for fluid |
US4179222A (en) | 1978-01-11 | 1979-12-18 | Systematix Controls, Inc. | Flow turbulence generating and mixing device |
ES481924A1 (es) * | 1978-06-28 | 1980-09-01 | Gen Foods Ltd | Un procedimiento mejorado para obtener un producto alimenti-cio secado por pulverizacion, tal como cafe, destrina y si- milares. |
NL8001874A (nl) * | 1980-03-29 | 1981-11-02 | Stamicarbon | Inrichting voor het versproeien van een vloeistof met behulp van een gas. |
US4606939A (en) * | 1983-06-22 | 1986-08-19 | The Ohio State University Research Foundation | Small particle formation |
JPS61138529A (ja) * | 1984-12-10 | 1986-06-26 | Idemitsu Petrochem Co Ltd | サイズ用乳化液の製造方法 |
US4606940A (en) * | 1984-12-21 | 1986-08-19 | The Ohio State University Research Foundation | Small particle formation and encapsulation |
CH669336A5 (de) * | 1985-12-11 | 1989-03-15 | Sulzer Ag | |
DE3851106T2 (de) * | 1987-07-13 | 1994-12-01 | Kinematica Gmbh | Vorrichtung zum Mischen fliessfähiger Medien. |
SE462704B (sv) * | 1987-12-09 | 1990-08-20 | Hg Tech Ab | Foerfarande vid atomisering av vaetskor och anordning foer genomfoerande av foerfarandet |
DE3744329A1 (de) | 1987-12-28 | 1989-07-06 | Schwarz Pharma Gmbh | Verfahren zur herstellung einer mindestens einen wirkstoff und einen traeger umfassenden zubereitung |
HU209603B (en) | 1988-10-05 | 1994-09-28 | Upjohn Co | Process for production of solid powders in finalydivided microcristallin form |
US5178325A (en) | 1991-06-25 | 1993-01-12 | Union Carbide Chemicals & Plastics Technology Corporation | Apparatus and methods for application of coatings with compressible fluids as diluent by spraying from an orifice |
US5891471A (en) * | 1993-11-23 | 1999-04-06 | Euro-Celtique, S.A. | Pharmaceutical multiparticulates |
GB9413202D0 (en) * | 1994-06-30 | 1994-08-24 | Univ Bradford | Method and apparatus for the formation of particles |
JP3986086B2 (ja) * | 1996-03-01 | 2007-10-03 | ザ ユニバーシティ オブ カンザス | 近臨界および超臨界反溶媒を用いる粒子析出方法および被覆方法 |
ATE202272T1 (de) * | 1996-10-18 | 2001-07-15 | Alza Corp | Vorrichtung mit mehreren strömungspfaden zur oralen verabreichung von boluseinheiten |
GB9703673D0 (en) * | 1997-02-21 | 1997-04-09 | Bradford Particle Design Ltd | Method and apparatus for the formation of particles |
TW580397B (en) * | 1997-05-27 | 2004-03-21 | Takeda Chemical Industries Ltd | Solid preparation |
US6342250B1 (en) * | 1997-09-25 | 2002-01-29 | Gel-Del Technologies, Inc. | Drug delivery devices comprising biodegradable protein for the controlled release of pharmacologically active agents and method of making the drug delivery devices |
DE69811233T2 (de) * | 1997-10-27 | 2003-11-20 | Merck Patent Gmbh | Feste lösungen und dispersionen von eines schlecht wasserlöslichen wirkstoffes |
-
1999
- 1999-05-07 SE SE9901667A patent/SE9901667D0/xx unknown
-
2000
- 2000-05-04 KR KR1020017014121A patent/KR20020013871A/ko not_active Application Discontinuation
- 2000-05-04 US US09/600,068 patent/US6551532B1/en not_active Expired - Fee Related
- 2000-05-04 EP EP00930027A patent/EP1191998B1/de not_active Expired - Lifetime
- 2000-05-04 NZ NZ515146A patent/NZ515146A/en unknown
- 2000-05-04 AT AT00930027T patent/ATE302647T1/de not_active IP Right Cessation
- 2000-05-04 CN CN00807307A patent/CN1350475A/zh active Pending
- 2000-05-04 WO PCT/SE2000/000877 patent/WO2000067892A1/en active IP Right Grant
- 2000-05-04 CA CA002368087A patent/CA2368087A1/en not_active Abandoned
- 2000-05-04 JP JP2000616911A patent/JP2002543961A/ja active Pending
- 2000-05-04 AU AU47923/00A patent/AU759786B2/en not_active Ceased
- 2000-05-04 MX MXPA01011099A patent/MXPA01011099A/es unknown
- 2000-05-04 DE DE60022195T patent/DE60022195T2/de not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
NZ515146A (en) | 2003-07-25 |
EP1191998B1 (de) | 2005-08-24 |
AU4792300A (en) | 2000-11-21 |
JP2002543961A (ja) | 2002-12-24 |
EP1191998A1 (de) | 2002-04-03 |
ATE302647T1 (de) | 2005-09-15 |
AU759786B2 (en) | 2003-05-01 |
CA2368087A1 (en) | 2000-11-16 |
CN1350475A (zh) | 2002-05-22 |
SE9901667D0 (sv) | 1999-05-07 |
MXPA01011099A (es) | 2002-06-04 |
WO2000067892A1 (en) | 2000-11-16 |
US6551532B1 (en) | 2003-04-22 |
KR20020013871A (ko) | 2002-02-21 |
DE60022195T2 (de) | 2006-06-29 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |