DE60022195D1 - Verfahren und vorrichtung zur herstellung von teilchen - Google Patents

Verfahren und vorrichtung zur herstellung von teilchen

Info

Publication number
DE60022195D1
DE60022195D1 DE60022195T DE60022195T DE60022195D1 DE 60022195 D1 DE60022195 D1 DE 60022195D1 DE 60022195 T DE60022195 T DE 60022195T DE 60022195 T DE60022195 T DE 60022195T DE 60022195 D1 DE60022195 D1 DE 60022195D1
Authority
DE
Germany
Prior art keywords
fluid gas
vehicle system
mixing chamber
disorder
controlled
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60022195T
Other languages
English (en)
Other versions
DE60022195T2 (de
Inventor
Catherine Boissier
Hakan Glad
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
AstraZeneca AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Application granted granted Critical
Publication of DE60022195D1 publication Critical patent/DE60022195D1/de
Publication of DE60022195T2 publication Critical patent/DE60022195T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/26—Nozzle-type reactors, i.e. the distribution of the initial reactants within the reactor is effected by their introduction or injection through nozzles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/04—Solvent extraction of solutions which are liquid
    • B01D11/0403—Solvent extraction of solutions which are liquid with a supercritical fluid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/04—Solvent extraction of solutions which are liquid
    • B01D11/0403—Solvent extraction of solutions which are liquid with a supercritical fluid
    • B01D11/0407—Solvent extraction of solutions which are liquid with a supercritical fluid the supercritical fluid acting as solvent for the solute
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/04—Solvent extraction of solutions which are liquid
    • B01D11/0403—Solvent extraction of solutions which are liquid with a supercritical fluid
    • B01D11/0411—Solvent extraction of solutions which are liquid with a supercritical fluid the supercritical fluid acting as solvent for the solvent and as anti-solvent for the solute, e.g. formation of particles from solutions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/04—Solvent extraction of solutions which are liquid
    • B01D11/0488—Flow sheets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/44—Mixers in which the components are pressed through slits
    • B01F25/441—Mixers in which the components are pressed through slits characterised by the configuration of the surfaces forming the slits
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/02—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
    • B01J2/04—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops in a gaseous medium
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J3/00—Processes of utilising sub-atmospheric or super-atmospheric pressure to effect chemical or physical change of matter; Apparatus therefor
    • B01J3/008—Processes carried out under supercritical conditions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
    • B01F2101/22—Mixing of ingredients for pharmaceutical or medical compositions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00049—Controlling or regulating processes
    • B01J2219/00051—Controlling the temperature
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00049—Controlling or regulating processes
    • B01J2219/00162—Controlling or regulating processes controlling the pressure

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Dispersion Chemistry (AREA)
  • Accessories For Mixers (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Mixers With Rotating Receptacles And Mixers With Vibration Mechanisms (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Glanulating (AREA)
DE60022195T 1999-05-07 2000-05-04 Verfahren und vorrichtung zur herstellung von teilchen Expired - Lifetime DE60022195T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE9901667A SE9901667D0 (sv) 1999-05-07 1999-05-07 Method and device for forming particles
SE9901667 1999-05-07
PCT/SE2000/000877 WO2000067892A1 (en) 1999-05-07 2000-05-04 Method and device for forming particles

Publications (2)

Publication Number Publication Date
DE60022195D1 true DE60022195D1 (de) 2005-09-29
DE60022195T2 DE60022195T2 (de) 2006-06-29

Family

ID=20415513

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60022195T Expired - Lifetime DE60022195T2 (de) 1999-05-07 2000-05-04 Verfahren und vorrichtung zur herstellung von teilchen

Country Status (13)

Country Link
US (1) US6551532B1 (de)
EP (1) EP1191998B1 (de)
JP (1) JP2002543961A (de)
KR (1) KR20020013871A (de)
CN (1) CN1350475A (de)
AT (1) ATE302647T1 (de)
AU (1) AU759786B2 (de)
CA (1) CA2368087A1 (de)
DE (1) DE60022195T2 (de)
MX (1) MXPA01011099A (de)
NZ (1) NZ515146A (de)
SE (1) SE9901667D0 (de)
WO (1) WO2000067892A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0027357D0 (en) 2000-11-09 2000-12-27 Bradford Particle Design Plc Particle formation methods and their products
IL157346A0 (en) 2001-02-26 2004-02-19 Dompe Spa Apparatus and method for micron and submicron particle formation
FR2824754B1 (fr) * 2001-05-15 2004-05-28 Separex Sa Procede d'obtention de particules solides a partir d'au moins un produit hydrosoluble
GB0208742D0 (en) 2002-04-17 2002-05-29 Bradford Particle Design Ltd Particulate materials
EP1494796B1 (de) * 2002-04-12 2014-06-04 Feyecon B.V. Verfahren zur herstellung von kleinen teilchen
US6998051B2 (en) * 2002-07-03 2006-02-14 Ferro Corporation Particles from supercritical fluid extraction of emulsion
KR20060015587A (ko) 2003-05-08 2006-02-17 넥타 쎄라퓨틱스 유케이 리미티드 미립물
PT1685126E (pt) * 2003-10-16 2007-04-30 Teva Pharma Preparação de candesartan cilexetil
US7692023B2 (en) * 2004-02-11 2010-04-06 Teva Pharmaceutical Industries Ltd. Candesartan cilexetil polymorphs
CN1953973A (zh) * 2004-05-05 2007-04-25 特瓦制药工业有限公司 高纯度坎地沙坦酯的制备
WO2005123720A1 (en) * 2004-06-18 2005-12-29 Ranbaxy Laboratories Limited Fine particles of the angiotensin ii antagonist candesartan cilexetil and process for production thereof
ES2429941T3 (es) * 2005-05-10 2013-11-18 Teva Pharmaceutical Industries, Ltd. Candesartán cilexetilo micronizado estable y métodos para preparar el mismo
US10669383B2 (en) * 2006-10-31 2020-06-02 Evonik Corporation Spheronized polymer particles
DK2425820T3 (en) 2007-02-11 2015-07-13 Map Pharmaceuticals Inc A method for the therapeutic administration of DHE in order to enable quick relief of migraine, while minimizing the adverse event profile
ES2326402B1 (es) * 2008-04-07 2010-08-10 Activery Biotech, S.L. Procedimiento para la preparacion de combinaciones amorfas de antagonistas del receptor de angiotensina ii y diureticos.
CA2767773C (en) 2011-02-11 2015-11-24 Grain Processing Corporation Composition comprising a salt and a crystallization interrupter

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7402981A (de) 1973-03-16 1974-09-18
JPS5243163A (en) * 1975-10-02 1977-04-04 Matsushita Electric Ind Co Ltd Mixer for fluid
US4179222A (en) * 1978-01-11 1979-12-18 Systematix Controls, Inc. Flow turbulence generating and mixing device
ES481924A1 (es) 1978-06-28 1980-09-01 Gen Foods Ltd Un procedimiento mejorado para obtener un producto alimenti-cio secado por pulverizacion, tal como cafe, destrina y si- milares.
NL8001874A (nl) * 1980-03-29 1981-11-02 Stamicarbon Inrichting voor het versproeien van een vloeistof met behulp van een gas.
US4606939A (en) * 1983-06-22 1986-08-19 The Ohio State University Research Foundation Small particle formation
JPS61138529A (ja) * 1984-12-10 1986-06-26 Idemitsu Petrochem Co Ltd サイズ用乳化液の製造方法
US4606940A (en) 1984-12-21 1986-08-19 The Ohio State University Research Foundation Small particle formation and encapsulation
CH669336A5 (de) * 1985-12-11 1989-03-15 Sulzer Ag
EP0300964B1 (de) * 1987-07-13 1994-08-17 Kinematica Ag Vorrichtung zum Mischen fliessfähiger Medien
SE462704B (sv) 1987-12-09 1990-08-20 Hg Tech Ab Foerfarande vid atomisering av vaetskor och anordning foer genomfoerande av foerfarandet
DE3744329A1 (de) 1987-12-28 1989-07-06 Schwarz Pharma Gmbh Verfahren zur herstellung einer mindestens einen wirkstoff und einen traeger umfassenden zubereitung
EP0437451B1 (de) 1988-10-05 1993-06-09 The Upjohn Company Feinverteiltes feste kristalline pulver durch niederschlag in einem anti-lösungsmittel
US5178325A (en) 1991-06-25 1993-01-12 Union Carbide Chemicals & Plastics Technology Corporation Apparatus and methods for application of coatings with compressible fluids as diluent by spraying from an orifice
US5891471A (en) * 1993-11-23 1999-04-06 Euro-Celtique, S.A. Pharmaceutical multiparticulates
GB9413202D0 (en) * 1994-06-30 1994-08-24 Univ Bradford Method and apparatus for the formation of particles
JP3986086B2 (ja) * 1996-03-01 2007-10-03 ザ ユニバーシティ オブ カンザス 近臨界および超臨界反溶媒を用いる粒子析出方法および被覆方法
US5910321A (en) * 1996-10-18 1999-06-08 Alza Corporation Multiple flow path device for oral delivery of discrete units
GB9703673D0 (en) * 1997-02-21 1997-04-09 Bradford Particle Design Ltd Method and apparatus for the formation of particles
TW580397B (en) * 1997-05-27 2004-03-21 Takeda Chemical Industries Ltd Solid preparation
US6342250B1 (en) * 1997-09-25 2002-01-29 Gel-Del Technologies, Inc. Drug delivery devices comprising biodegradable protein for the controlled release of pharmacologically active agents and method of making the drug delivery devices
CN1190187C (zh) * 1997-10-27 2005-02-23 默克专利股份有限公司 差水溶性药物的固态溶液和分散液

Also Published As

Publication number Publication date
CN1350475A (zh) 2002-05-22
DE60022195T2 (de) 2006-06-29
CA2368087A1 (en) 2000-11-16
WO2000067892A1 (en) 2000-11-16
EP1191998A1 (de) 2002-04-03
JP2002543961A (ja) 2002-12-24
AU4792300A (en) 2000-11-21
MXPA01011099A (es) 2002-06-04
NZ515146A (en) 2003-07-25
US6551532B1 (en) 2003-04-22
ATE302647T1 (de) 2005-09-15
EP1191998B1 (de) 2005-08-24
AU759786B2 (en) 2003-05-01
SE9901667D0 (sv) 1999-05-07
KR20020013871A (ko) 2002-02-21

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Legal Events

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