DE69911221T2 - Methode und gerät zur darreichung von therapeutischen mitteln in verbindung mit dem plazieren von radioaktiven körnern - Google Patents
Methode und gerät zur darreichung von therapeutischen mitteln in verbindung mit dem plazieren von radioaktiven körnern Download PDFInfo
- Publication number
- DE69911221T2 DE69911221T2 DE69911221T DE69911221T DE69911221T2 DE 69911221 T2 DE69911221 T2 DE 69911221T2 DE 69911221 T DE69911221 T DE 69911221T DE 69911221 T DE69911221 T DE 69911221T DE 69911221 T2 DE69911221 T2 DE 69911221T2
- Authority
- DE
- Germany
- Prior art keywords
- therapeutic
- adjunctive
- segments
- radioactive
- seeds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 230000002285 radioactive effect Effects 0.000 title claims description 19
- 239000003814 drug Substances 0.000 title claims description 11
- 229940124597 therapeutic agent Drugs 0.000 title description 8
- 238000000034 method Methods 0.000 title description 6
- 230000001225 therapeutic effect Effects 0.000 claims description 37
- 238000002725 brachytherapy Methods 0.000 claims description 25
- 206010028980 Neoplasm Diseases 0.000 claims description 18
- 238000002560 therapeutic procedure Methods 0.000 claims description 14
- 125000006850 spacer group Chemical group 0.000 claims description 9
- 238000011282 treatment Methods 0.000 claims description 8
- 201000011510 cancer Diseases 0.000 claims description 6
- 238000002513 implantation Methods 0.000 claims description 6
- 239000012830 cancer therapeutic Substances 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 238000011275 oncology therapy Methods 0.000 claims description 2
- 230000005855 radiation Effects 0.000 description 19
- 230000007170 pathology Effects 0.000 description 10
- 230000035945 sensitivity Effects 0.000 description 5
- 230000000694 effects Effects 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 239000011159 matrix material Substances 0.000 description 4
- KDLHZDBZIXYQEI-UHFFFAOYSA-N palladium Substances [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 description 4
- 210000001519 tissue Anatomy 0.000 description 4
- 238000011360 adjunctive therapy Methods 0.000 description 3
- 230000003211 malignant effect Effects 0.000 description 3
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- 206010060862 Prostate cancer Diseases 0.000 description 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 description 2
- 238000010276 construction Methods 0.000 description 2
- 230000005672 electromagnetic field Effects 0.000 description 2
- 239000010931 gold Substances 0.000 description 2
- 239000005556 hormone Substances 0.000 description 2
- 229940088597 hormone Drugs 0.000 description 2
- 230000036210 malignancy Effects 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 210000000056 organ Anatomy 0.000 description 2
- 238000001959 radiotherapy Methods 0.000 description 2
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 1
- FERIUCNNQQJTOY-UHFFFAOYSA-M Butyrate Chemical compound CCCC([O-])=O FERIUCNNQQJTOY-UHFFFAOYSA-M 0.000 description 1
- FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Natural products CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 description 1
- 102000016938 Catalase Human genes 0.000 description 1
- 108010053835 Catalase Proteins 0.000 description 1
- GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 description 1
- 206010020843 Hyperthermia Diseases 0.000 description 1
- 229930012538 Paclitaxel Natural products 0.000 description 1
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000000556 agonist Substances 0.000 description 1
- 239000002246 antineoplastic agent Substances 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 229940105657 catalase Drugs 0.000 description 1
- 230000022131 cell cycle Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 229940127089 cytotoxic agent Drugs 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 238000011347 external beam therapy Methods 0.000 description 1
- 229960002949 fluorouracil Drugs 0.000 description 1
- SDUQYLNIPVEERB-QPPQHZFASA-N gemcitabine Chemical compound O=C1N=C(N)C=CN1[C@H]1C(F)(F)[C@H](O)[C@@H](CO)O1 SDUQYLNIPVEERB-QPPQHZFASA-N 0.000 description 1
- 229960005277 gemcitabine Drugs 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 238000001794 hormone therapy Methods 0.000 description 1
- 230000036031 hyperthermia Effects 0.000 description 1
- 238000009169 immunotherapy Methods 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 229910052741 iridium Inorganic materials 0.000 description 1
- GKOZUEZYRPOHIO-UHFFFAOYSA-N iridium atom Chemical compound [Ir] GKOZUEZYRPOHIO-UHFFFAOYSA-N 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 229950010514 misonidazole Drugs 0.000 description 1
- OBBCSXFCDPPXOL-UHFFFAOYSA-N misonidazole Chemical compound COCC(O)CN1C=CN=C1[N+]([O-])=O OBBCSXFCDPPXOL-UHFFFAOYSA-N 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 229960001592 paclitaxel Drugs 0.000 description 1
- 229910052763 palladium Inorganic materials 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000000191 radiation effect Effects 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000011477 surgical intervention Methods 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 238000011521 systemic chemotherapy Methods 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 description 1
- 239000010936 titanium Substances 0.000 description 1
- 229910052719 titanium Inorganic materials 0.000 description 1
- 238000011277 treatment modality Methods 0.000 description 1
- 229960005486 vaccine Drugs 0.000 description 1
- 239000013598 vector Substances 0.000 description 1
- 238000009941 weaving Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
- A61N5/1027—Interstitial radiation therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
- A61K51/1282—Devices used in vivo and carrying the radioactive therapeutic or diagnostic agent, therapeutic or in vivo diagnostic kits, stents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
- A61N2005/1019—Sources therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
- A61N2005/1019—Sources therefor
- A61N2005/1023—Means for creating a row of seeds, e.g. spacers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
- A61N2005/1019—Sources therefor
- A61N2005/1024—Seeds
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- Engineering & Computer Science (AREA)
- Optics & Photonics (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Dispersion Chemistry (AREA)
- Radiology & Medical Imaging (AREA)
- Pathology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Radiation-Therapy Devices (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/098,617 US6159143A (en) | 1998-06-17 | 1998-06-17 | Method and device for delivery of therapeutic agents in conjunction with isotope seed placement |
| US98617 | 1998-06-17 | ||
| PCT/US1999/012408 WO1999065532A1 (en) | 1998-06-17 | 1999-06-03 | Method and device for delivery of therapeutic agents in conjuction with isotope seed placement |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69911221D1 DE69911221D1 (de) | 2003-10-16 |
| DE69911221T2 true DE69911221T2 (de) | 2004-03-18 |
Family
ID=22270143
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69911221T Expired - Lifetime DE69911221T2 (de) | 1998-06-17 | 1999-06-03 | Methode und gerät zur darreichung von therapeutischen mitteln in verbindung mit dem plazieren von radioaktiven körnern |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US6159143A (https=) |
| EP (1) | EP1109583B1 (https=) |
| JP (2) | JP4806488B2 (https=) |
| AU (1) | AU769312B2 (https=) |
| CA (1) | CA2334810C (https=) |
| DE (1) | DE69911221T2 (https=) |
| WO (1) | WO1999065532A1 (https=) |
Families Citing this family (96)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69413209T2 (de) | 1994-06-10 | 1999-03-04 | Schneider Europ Gmbh | Arzneigerät für die Behandlung eines Teiles von Körpergefäss mittels Ionisierungsbestrahlung |
| DE69426071T2 (de) | 1994-06-24 | 2001-05-10 | Schneider (Europe) Gmbh, Buelach | Arzneigerät für die Behandlung eines Teiles eines Körpergefässes mittels Ionisierungsbestrahlung |
| US6234951B1 (en) | 1996-02-29 | 2001-05-22 | Scimed Life Systems, Inc. | Intravascular radiation delivery system |
| US8668737B2 (en) | 1997-10-10 | 2014-03-11 | Senorx, Inc. | Tissue marking implant |
| US7637948B2 (en) | 1997-10-10 | 2009-12-29 | Senorx, Inc. | Tissue marking implant |
| US6161034A (en) * | 1999-02-02 | 2000-12-12 | Senorx, Inc. | Methods and chemical preparations for time-limited marking of biopsy sites |
| US6347241B2 (en) * | 1999-02-02 | 2002-02-12 | Senorx, Inc. | Ultrasonic and x-ray detectable biopsy site marker and apparatus for applying it |
| US6159143A (en) * | 1998-06-17 | 2000-12-12 | Scimed Life Systems, Inc. | Method and device for delivery of therapeutic agents in conjunction with isotope seed placement |
| DE19850203C1 (de) * | 1998-10-23 | 2000-05-31 | Eurotope Entwicklungsgesellsch | Radioaktive Jod-125-Seeds basierend auf Keramikträgern und Verfahren zur Herstellung dieser Seeds |
| US7983734B2 (en) * | 2003-05-23 | 2011-07-19 | Senorx, Inc. | Fibrous marker and intracorporeal delivery thereof |
| US20090030309A1 (en) | 2007-07-26 | 2009-01-29 | Senorx, Inc. | Deployment of polysaccharide markers |
| US7651505B2 (en) | 2002-06-17 | 2010-01-26 | Senorx, Inc. | Plugged tip delivery for marker placement |
| US8361082B2 (en) | 1999-02-02 | 2013-01-29 | Senorx, Inc. | Marker delivery device with releasable plug |
| US6862470B2 (en) | 1999-02-02 | 2005-03-01 | Senorx, Inc. | Cavity-filling biopsy site markers |
| US20080039819A1 (en) * | 2006-08-04 | 2008-02-14 | Senorx, Inc. | Marker formed of starch or other suitable polysaccharide |
| US6725083B1 (en) | 1999-02-02 | 2004-04-20 | Senorx, Inc. | Tissue site markers for in VIVO imaging |
| US9820824B2 (en) | 1999-02-02 | 2017-11-21 | Senorx, Inc. | Deployment of polysaccharide markers for treating a site within a patent |
| US8498693B2 (en) | 1999-02-02 | 2013-07-30 | Senorx, Inc. | Intracorporeal marker and marker delivery device |
| US6685913B1 (en) * | 1999-03-09 | 2004-02-03 | Thomas Jefferson University | Lipid soluble radioactive metal chelates for tumor therapy |
| US6679824B1 (en) * | 1999-04-28 | 2004-01-20 | Medi-Physics, Inc. | Products and methods for brachytherapy |
| US6575991B1 (en) | 1999-06-17 | 2003-06-10 | Inrad, Inc. | Apparatus for the percutaneous marking of a lesion |
| US6264600B1 (en) * | 1999-10-21 | 2001-07-24 | Peter D. Grimm | Hollow suture member with radioactive seeds positioned therein for treatment of prostate cancer |
| CA2388844A1 (en) * | 1999-11-12 | 2001-05-25 | Angiotech Pharmaceuticals, Inc. | Compositions and methods for treating disease utilizing a combination of radioactive therapy and cell-cycle inhibitors |
| US6575888B2 (en) | 2000-01-25 | 2003-06-10 | Biosurface Engineering Technologies, Inc. | Bioabsorbable brachytherapy device |
| US6749553B2 (en) * | 2000-05-18 | 2004-06-15 | Theragenics Corporation | Radiation delivery devices and methods for their manufacture |
| US6450939B1 (en) * | 2000-11-06 | 2002-09-17 | Peter D. Grimm | Hinged spacer element for joining radioactive seeds used in treatment of cancer |
| WO2004026111A2 (en) | 2000-11-16 | 2004-04-01 | Microspherix Llc | Flexible and/or elastic brachytherapy seed or strand |
| US6514193B2 (en) | 2000-11-16 | 2003-02-04 | Microspherix Llc | Method of administering a therapeutically active substance |
| AU2002239290A1 (en) | 2000-11-20 | 2002-06-03 | Senorx, Inc. | Tissue site markers for in vivo imaging |
| US6800055B2 (en) | 2001-02-21 | 2004-10-05 | Cordis Corporation | Low attenuating radioactive seeds |
| US6669621B2 (en) | 2001-03-14 | 2003-12-30 | Cordis Corporation | Method and assembly for containing radioactive materials |
| US6497646B1 (en) | 2001-03-14 | 2002-12-24 | Cordis Corporation | Intravascular radiotherapy source ribbon having variable radiopacity |
| US7094198B2 (en) * | 2001-11-02 | 2006-08-22 | Worldwide Medical Technologies, Llc | Delivery system and method for interstitial radiation therapy using seed elements with ends having one of projections and indentations |
| US6761680B2 (en) * | 2001-11-02 | 2004-07-13 | Richard A. Terwilliger | Delivery system and method for interstitial radiation therapy using seed strands constructed with preformed strand housing |
| US6786858B2 (en) * | 2001-11-02 | 2004-09-07 | Ideamatrix, Inc. | Delivery system and method for interstitial radiotherapy using hollow seeds |
| US7060020B2 (en) * | 2001-11-02 | 2006-06-13 | Ideamatrix, Inc. | Delivery system and method for interstitial radiation therapy |
| US6820318B2 (en) | 2001-11-02 | 2004-11-23 | Ideamatrix, Inc. | System for manufacturing interstitial radiation therapy seed strands |
| US7074291B2 (en) * | 2001-11-02 | 2006-07-11 | Worldwide Medical Technologies, L.L.C. | Delivery system and method for interstitial radiation therapy using strands constructed with extruded strand housings |
| EP2008690B1 (en) | 2002-09-10 | 2013-11-06 | Cianna Medical, Inc. | Brachytherapy apparatus |
| US20060036158A1 (en) | 2003-11-17 | 2006-02-16 | Inrad, Inc. | Self-contained, self-piercing, side-expelling marking apparatus |
| US6918869B2 (en) | 2002-12-02 | 2005-07-19 | Scimed Life Systems | System for administering a combination of therapies to a body lumen |
| WO2004064727A2 (en) * | 2003-01-16 | 2004-08-05 | Georgetown University | Method of cancer treatment using hdac inhibitors |
| US6932758B1 (en) * | 2003-02-12 | 2005-08-23 | Bruno Schmidt | Coupled seed train |
| US7037252B2 (en) * | 2003-05-05 | 2006-05-02 | Draxis Specialty Pharmaceuticals, Inc. | Brachytherapy seed transport devices and methods for using same |
| US6997862B2 (en) * | 2003-05-13 | 2006-02-14 | Ideamatrix, Inc. | Delivery system and method for interstitial radiation therapy using seed strands with custom end spacing |
| US7877133B2 (en) | 2003-05-23 | 2011-01-25 | Senorx, Inc. | Marker or filler forming fluid |
| US20050119562A1 (en) * | 2003-05-23 | 2005-06-02 | Senorx, Inc. | Fibrous marker formed of synthetic polymer strands |
| US7922646B2 (en) * | 2003-08-20 | 2011-04-12 | International Brachytherapy, S.A. | Plastic brachytherapy sources |
| US20050080314A1 (en) * | 2003-10-09 | 2005-04-14 | Terwilliger Richard A. | Shielded transport for multiple brachytheapy implants with integrated measuring and cutting board |
| US20050273002A1 (en) | 2004-06-04 | 2005-12-08 | Goosen Ryan L | Multi-mode imaging marker |
| US7540998B2 (en) * | 2003-11-19 | 2009-06-02 | Biocompatibles Uk Limited | Delivery system and prescription method for interstitial radiation therapy using enhanced parametric release sterilization techniques |
| US7351192B2 (en) * | 2004-05-25 | 2008-04-01 | Core Oncology, Inc. | Selectively loadable/sealable bioresorbable carrier assembly for radioisotope seeds |
| US10357328B2 (en) | 2005-04-20 | 2019-07-23 | Bard Peripheral Vascular, Inc. and Bard Shannon Limited | Marking device with retractable cannula |
| US8187159B2 (en) | 2005-07-22 | 2012-05-29 | Biocompatibles, UK | Therapeutic member including a rail used in brachytherapy and other radiation therapy |
| US7736293B2 (en) | 2005-07-22 | 2010-06-15 | Biocompatibles Uk Limited | Implants for use in brachytherapy and other radiation therapy that resist migration and rotation |
| CA2562580C (en) | 2005-10-07 | 2014-04-29 | Inrad, Inc. | Drug-eluting tissue marker |
| US20080230001A1 (en) * | 2006-02-23 | 2008-09-25 | Meadwestvaco Corporation | Method for treating a substrate |
| US20070265487A1 (en) * | 2006-05-09 | 2007-11-15 | Worldwide Medical Technologies Llc | Applicators for use in positioning implants for use in brachytherapy and other radiation therapy |
| US7988611B2 (en) | 2006-05-09 | 2011-08-02 | Biocompatibles Uk Limited | After-loader for positioning implants for needle delivery in brachytherapy and other radiation therapy |
| US20090216063A1 (en) * | 2008-01-29 | 2009-08-27 | Biocompatibles Uk Limited | Bio-absorbable brachytherapy strands |
| US20100228074A1 (en) * | 2006-08-25 | 2010-09-09 | C.R. Bard, Inc. | Therapeutic and Directionally Dosed Implants |
| US7874976B1 (en) | 2006-09-07 | 2011-01-25 | Biocompatibles Uk Limited | Echogenic strands and spacers therein |
| US7878964B1 (en) | 2006-09-07 | 2011-02-01 | Biocompatibles Uk Limited | Echogenic spacers and strands |
| ES2443526T3 (es) | 2006-10-23 | 2014-02-19 | C.R. Bard, Inc. | Marcador mamario |
| US9579077B2 (en) | 2006-12-12 | 2017-02-28 | C.R. Bard, Inc. | Multiple imaging mode tissue marker |
| US8401622B2 (en) | 2006-12-18 | 2013-03-19 | C. R. Bard, Inc. | Biopsy marker with in situ-generated imaging properties |
| US20080269540A1 (en) * | 2007-04-27 | 2008-10-30 | Worldwide Medical Technologies Llc | Seed cartridge adaptor and methods for use therewith |
| WO2009065058A1 (en) * | 2007-11-16 | 2009-05-22 | Boston Scientific Scimed, Inc. | Apparatus for drug release in tissue ablation procedures |
| US9586035B2 (en) | 2007-12-11 | 2017-03-07 | Massachusetts Institute Of Technology | Implantable drug delivery device and methods for treatment of the bladder and other body vesicles or lumens |
| WO2009099767A2 (en) | 2008-01-31 | 2009-08-13 | C.R. Bard, Inc. | Biopsy tissue marker |
| US9327061B2 (en) | 2008-09-23 | 2016-05-03 | Senorx, Inc. | Porous bioabsorbable implant |
| WO2010077244A1 (en) | 2008-12-30 | 2010-07-08 | C.R. Bard Inc. | Marker delivery device for tissue marker placement |
| TW201034641A (en) * | 2009-02-28 | 2010-10-01 | Charles Knezevich | Apparatus, system, and method for creating immunologically enhanced spaces in-vivo |
| CN102470237A (zh) | 2009-06-26 | 2012-05-23 | 塔里斯生物医药公司 | 用于可植入药物递送装置的固体药物片剂 |
| US9017312B2 (en) | 2009-09-10 | 2015-04-28 | Taris Biomedical Llc | Implantable device for controlled drug delivery |
| WO2011050049A2 (en) * | 2009-10-21 | 2011-04-28 | The University Of North Carolina At Chapel Hill | Delivery systems for brachytherapy, and associated methods |
| PL3884988T3 (pl) * | 2009-12-17 | 2025-09-08 | Taris Biomedical Llc | Urządzenie implantowalne z tolerancją wewnątrzpęcherzową |
| EP3711750B1 (en) | 2010-08-05 | 2023-09-06 | TARIS Biomedical LLC | Implantable drug delivery devices for genitourinary sites |
| EP2887994B1 (en) | 2012-08-24 | 2019-02-20 | Boston Scientific Corporation | Device for improving brachytherapy |
| PT2968880T (pt) | 2013-03-15 | 2025-07-07 | Taris Biomedical Llc | Dispositivos de aplicação de fármaco com componente permeável a fármaco |
| CN113413393B (zh) | 2013-08-19 | 2025-03-04 | 塔里斯生物医药公司 | 多单元药物递送装置和方法 |
| USD716451S1 (en) | 2013-09-24 | 2014-10-28 | C. R. Bard, Inc. | Tissue marker for intracorporeal site identification |
| USD716450S1 (en) | 2013-09-24 | 2014-10-28 | C. R. Bard, Inc. | Tissue marker for intracorporeal site identification |
| USD715942S1 (en) | 2013-09-24 | 2014-10-21 | C. R. Bard, Inc. | Tissue marker for intracorporeal site identification |
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| KR102658706B1 (ko) | 2015-04-23 | 2024-04-17 | 타리스 바이오메디컬 엘엘씨 | 약물-투과성 성분을 구비한 약물 전달 장치 및 방법 |
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- 1999-06-03 EP EP99935304A patent/EP1109583B1/en not_active Expired - Lifetime
- 1999-06-03 JP JP2000554409A patent/JP4806488B2/ja not_active Expired - Fee Related
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2000
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2011
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| CA2334810C (en) | 2009-06-16 |
| AU769312B2 (en) | 2004-01-22 |
| EP1109583B1 (en) | 2003-09-10 |
| EP1109583A1 (en) | 2001-06-27 |
| JP2002518350A (ja) | 2002-06-25 |
| JP4806488B2 (ja) | 2011-11-02 |
| DE69911221D1 (de) | 2003-10-16 |
| US6159143A (en) | 2000-12-12 |
| JP5106649B2 (ja) | 2012-12-26 |
| AU5081199A (en) | 2000-01-05 |
| WO1999065532A1 (en) | 1999-12-23 |
| CA2334810A1 (en) | 1999-12-23 |
| JP2011156373A (ja) | 2011-08-18 |
| US6537193B1 (en) | 2003-03-25 |
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