DE69906574T2 - Vorrichtung zum züchten von organischen zellen und erforschung ihrer elektrophysiologischen aktivität und dabei verwendete membran - Google Patents

Vorrichtung zum züchten von organischen zellen und erforschung ihrer elektrophysiologischen aktivität und dabei verwendete membran Download PDF

Info

Publication number
DE69906574T2
DE69906574T2 DE69906574T DE69906574T DE69906574T2 DE 69906574 T2 DE69906574 T2 DE 69906574T2 DE 69906574 T DE69906574 T DE 69906574T DE 69906574 T DE69906574 T DE 69906574T DE 69906574 T2 DE69906574 T2 DE 69906574T2
Authority
DE
Germany
Prior art keywords
cells
support
electrophysiological activity
researching
membrane used
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69906574T
Other languages
English (en)
Other versions
DE69906574D1 (de
Inventor
Claude Haenni
Luc Stoppini
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bio Cell Interface S A
Original Assignee
Bio Cell Interface S A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bio Cell Interface S A filed Critical Bio Cell Interface S A
Application granted granted Critical
Publication of DE69906574D1 publication Critical patent/DE69906574D1/de
Publication of DE69906574T2 publication Critical patent/DE69906574T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483Physical analysis of biological material
    • G01N33/4833Physical analysis of biological material of solid biological material, e.g. tissue samples, cell cultures
    • G01N33/4836Physical analysis of biological material of solid biological material, e.g. tissue samples, cell cultures using multielectrode arrays
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00Constructional details, e.g. recesses, hinges
    • C12M23/02Form or structure of the vessel
    • C12M23/04Flat or tray type, drawers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/02Membranes; Filters
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/04Filters; Permeable or porous membranes or plates, e.g. dialysis
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/46Means for regulation, monitoring, measurement or control, e.g. flow regulation of cellular or enzymatic activity or functionality, e.g. cell viability

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Sustainable Development (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Pathology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Optics & Photonics (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Clinical Laboratory Science (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
DE69906574T 1998-06-08 1999-06-04 Vorrichtung zum züchten von organischen zellen und erforschung ihrer elektrophysiologischen aktivität und dabei verwendete membran Expired - Fee Related DE69906574T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9807596A FR2779443B1 (fr) 1998-06-08 1998-06-08 Dispositif de culture de cellules organiques et d'etude de leur activite electrophysiologique et membrane utilisee dans un tel dispositif
PCT/CH1999/000243 WO1999064559A2 (fr) 1998-06-08 1999-06-04 Dispositif de culture de cellules organiques et d'etude de leur activite electrophysiologique et membrane utilisee dans un tel dispositif

Publications (2)

Publication Number Publication Date
DE69906574D1 DE69906574D1 (de) 2003-05-08
DE69906574T2 true DE69906574T2 (de) 2004-01-29

Family

ID=9527465

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69906574T Expired - Fee Related DE69906574T2 (de) 1998-06-08 1999-06-04 Vorrichtung zum züchten von organischen zellen und erforschung ihrer elektrophysiologischen aktivität und dabei verwendete membran

Country Status (10)

Country Link
US (1) US6689594B1 (de)
EP (1) EP1133691B1 (de)
JP (1) JP2002517225A (de)
AT (1) ATE236399T1 (de)
AU (1) AU4027999A (de)
DE (1) DE69906574T2 (de)
ES (1) ES2195572T3 (de)
FR (1) FR2779443B1 (de)
IL (1) IL140174A (de)
WO (1) WO1999064559A2 (de)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7485454B1 (en) * 2000-03-10 2009-02-03 Bioprocessors Corp. Microreactor
IL136232A0 (en) * 2000-05-18 2001-05-20 Bar Ilan University Res Author Measurements of enzymatic activity in a single, individual cell in population
JP3570715B2 (ja) 2001-06-05 2004-09-29 松下電器産業株式会社 マルチ電極を備えた信号検出用センサ
JP4192097B2 (ja) * 2001-10-25 2008-12-03 バル−イラン ユニバーシティ 相互作用型透明個別細胞バイオチッププロセッサー
JP4370082B2 (ja) * 2002-08-26 2009-11-25 独立行政法人科学技術振興機構 神経細胞培養マイクロチャンバー
IL154677A0 (en) 2003-02-27 2003-09-17 Univ Bar Ilan A method and apparatus for manipulating an individual cell
US9200245B2 (en) 2003-06-26 2015-12-01 Seng Enterprises Ltd. Multiwell plate
US8597597B2 (en) * 2003-06-26 2013-12-03 Seng Enterprises Ltd. Picoliter well holding device and method of making the same
WO2004113492A1 (en) * 2003-06-26 2004-12-29 Molecular Cytomics Ltd. Improved materials for constructing cell-chips, cell-chip covers, cell-chip coats, processed cell-chips and uses thereof
US7888110B2 (en) 2003-06-26 2011-02-15 Seng Enterprises Ltd. Pico liter well holding device and method of making the same
WO2005008626A1 (en) * 2003-07-11 2005-01-27 University Of North Carolina At Chapel Hill Methods and systems for controlling a computer using a video image and for combining the video image with a computer desktop
US20050064524A1 (en) * 2003-08-11 2005-03-24 Mordechai Deutsch Population of cells utilizable for substance detection and methods and devices using same
PL1656449T3 (pl) 2003-08-21 2009-08-31 Monsanto Technology Llc Desaturazy kwasów tłuszczowych z Primula
BRPI0506610A (pt) * 2004-02-03 2007-05-02 Chemagis Ltd montelucaste sódico amorfo, processo de preparação de montelucaste sódico amorfo, composição farmacêutica, método de tratamento utilizando a administração de montelucaste sódico amorfo, co-precipitado amorfo de montelucaste sódico e processo de preparação de co-precipitado amorfo de montelucaste sódico
US7403647B2 (en) * 2004-09-13 2008-07-22 Seng Enterprises Ltd. Method for identifying an image of a well in an image of a well-bearing component
US20080063251A1 (en) * 2004-07-07 2008-03-13 Mordechai Deutsch Method and Device for Identifying an Image of a Well in an Image of a Well-Bearing
WO2006021959A2 (en) * 2004-08-25 2006-03-02 Seng Enterprises Ltd. Method and device for isolating cells
WO2006037527A1 (en) * 2004-09-30 2006-04-13 Pamgene Bv Masked solid porous supports allowing fast and easy reagent exchange to accelerate electrode-based microarrays
ES2352344T3 (es) 2005-01-25 2011-02-17 Seng Enterprises Limited Dispositivo de microfluido para estudio de células.
GB0512214D0 (en) * 2005-06-15 2005-07-27 Capsant Neurotechnologies Ltd Method
GB0512216D0 (en) * 2005-06-15 2005-07-27 Capsant Neurotechnologies Ltd Device
US20070141555A1 (en) * 2005-10-11 2007-06-21 Mordechai Deutsch Current damper for the study of cells
US8288120B2 (en) * 2005-11-03 2012-10-16 Seng Enterprises Ltd. Method for studying floating, living cells
US20060223999A1 (en) * 2006-05-10 2006-10-05 Chemagis Ltd. Process for preparing montelukast and precursors thereof
JP2009544947A (ja) * 2006-07-24 2009-12-17 バイオツァー エントヴィックルングス−ゲーエムベーハー 細胞に関するオンライン測定のための装置
DE102007016629A1 (de) * 2007-04-05 2008-10-09 Micronas Gmbh Sensor zur Erfassung eines toxischen oder gefährlichen Gasgemisches und Betriebsverfahren
WO2009081409A2 (en) 2007-12-26 2009-07-02 Seng Enterprises Ltd. Device for the study of living cells
US9145540B1 (en) 2007-11-15 2015-09-29 Seng Enterprises Ltd. Device for the study of living cells
JP5200888B2 (ja) * 2008-11-21 2013-06-05 大日本印刷株式会社 パターン細胞培養用器具
JP5758989B2 (ja) * 2011-04-28 2015-08-05 株式会社日立製作所 細胞培養容器および細胞培養装置
CN102680526B (zh) * 2012-05-16 2014-07-02 清华大学 单细胞阵列微芯片及其制造、电测量和电穿孔方法
CN103630579A (zh) * 2013-02-27 2014-03-12 中国科学院电子学研究所 细胞阻抗分析的芯片及仪器
EP4170014A1 (de) 2021-10-21 2023-04-26 Alpvision SA Mikrofluidisches system zur robusten elektrischen langzeitmessung und/oder stimulation von zellkulturen
WO2024145528A1 (en) * 2022-12-29 2024-07-04 The Board Of Trustees Of The Leland Stanford Junior University Devices, systems and methods for electrophysical recordings of suspension cultures

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU1124022A1 (ru) * 1983-04-15 1984-11-15 Специальное конструкторское бюро биологического приборостроения АН СССР Камера дл регистрации электрофизиологических характеристик и фиксации потенциала мембраны биологического объекта
US5563067A (en) * 1994-06-13 1996-10-08 Matsushita Electric Industrial Co., Ltd. Cell potential measurement apparatus having a plurality of microelectrodes
FR2733055B1 (fr) * 1995-04-12 1997-12-19 Chemodyne Sa Nouveau dispositif d'etude de cultures organotypiques et ses applications en electrophysiologie
US6303082B1 (en) * 1999-12-15 2001-10-16 Nanogen, Inc. Permeation layer attachment chemistry and method

Also Published As

Publication number Publication date
US6689594B1 (en) 2004-02-10
AU4027999A (en) 1999-12-30
IL140174A0 (en) 2002-02-10
WO1999064559A2 (fr) 1999-12-16
EP1133691A2 (de) 2001-09-19
IL140174A (en) 2003-12-10
EP1133691B1 (de) 2003-04-02
WO1999064559A3 (fr) 2001-07-12
DE69906574D1 (de) 2003-05-08
ES2195572T3 (es) 2003-12-01
ATE236399T1 (de) 2003-04-15
FR2779443B1 (fr) 2000-08-04
JP2002517225A (ja) 2002-06-18
FR2779443A1 (fr) 1999-12-10

Similar Documents

Publication Publication Date Title
DE69906574D1 (de) Vorrichtung zum züchten von organischen zellen und erforschung ihrer elektrophysiologischen aktivität und dabei verwendete membran
DE69738996D1 (de) Miniaturisierte zellenanordnung und verfahren und vorrichtung zum screening mittels zellen
DE59807973D1 (de) Vorrichtung zum züchten und/oder behandeln von zellen
ATE346156T1 (de) Umkehrtransfektionsverfahren
WO2006028347B1 (en) Battery with porous material and fabrication method thereof
EA200870046A1 (ru) Ядерный фактор перепрограммирования
CA2259984A1 (en) Precise efficacy assay methods for active agents including chemotherapeutic agents
AR022734A1 (es) Reovirus para el tratamiento de trastornos de proliferacion celular
HUP0302796A2 (hu) Eljárás humán szövetből nyert rákos sejtek szaporítására és berendezés a szövetminták feldolgozására
DK0474790T3 (da) Medier til cellevækst og fremgangsmåde til fremstilling deraf
WO2007035604A3 (en) Scaffold carrier cartridge
DE60332595D1 (de) Membran-Elektroden-Einheit und Polymerelektrolytbrennstoffzelle die diese Einheit enthält
FI880383A0 (fi) Transformation och expression av en fraemmande gen i brassicaarter.
ATE513209T1 (de) Grenzflächen-patch-clamp-verfahren und -gerät
ES2038984T3 (es) Aparato de cultivo celular.
DE59805934D1 (de) Elektrochemische Halbzelle
ATE516342T1 (de) Aussetzen von zellen auf porösen substraten
ATE348876T1 (de) Verfahren zur vermehrung von natürlichen killerzellen
DE50012581D1 (de) Vorrichtung zum züchten und/oder behandeln von zellen
Huang et al. High-glucose-cultivated peripheral blood mononuclear cells impaired keratinocyte function via reduced IL-22 expression: implications on impaired diabetic wound healing.
ATE376052T1 (de) Zellkulturkammer für ein zellkultursystem
ZA913505B (en) Electrolyzer
WO2003006947A3 (en) Cell-screening assay and composition
WO2005063966A3 (de) Verfahren zur in vitro differenzierung neuronaler stammzellen oder von neuronalen stammzellen abgeleiteter zellen
CN101654698A (zh) 一种活性氮致内皮细胞损伤的药物筛选方法及应用

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee