DE69902906T2 - Bilddarstellung und untersuchung der bewegung von einzelnen erythrozyten in blutgefässen - Google Patents
Bilddarstellung und untersuchung der bewegung von einzelnen erythrozyten in blutgefässenInfo
- Publication number
- DE69902906T2 DE69902906T2 DE69902906T DE69902906T DE69902906T2 DE 69902906 T2 DE69902906 T2 DE 69902906T2 DE 69902906 T DE69902906 T DE 69902906T DE 69902906 T DE69902906 T DE 69902906T DE 69902906 T2 DE69902906 T2 DE 69902906T2
- Authority
- DE
- Germany
- Prior art keywords
- images
- image
- movement
- imaging
- individual
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 230000033001 locomotion Effects 0.000 title claims abstract description 46
- 210000003743 erythrocyte Anatomy 0.000 title claims abstract description 43
- 210000004204 blood vessel Anatomy 0.000 title claims abstract description 22
- 238000000034 method Methods 0.000 claims abstract description 50
- 238000003384 imaging method Methods 0.000 claims abstract description 37
- 238000012545 processing Methods 0.000 claims abstract description 6
- 238000004458 analytical method Methods 0.000 claims description 26
- 210000001525 retina Anatomy 0.000 claims description 20
- 238000005286 illumination Methods 0.000 claims description 19
- 230000002207 retinal effect Effects 0.000 claims description 16
- 230000002452 interceptive effect Effects 0.000 claims description 6
- 210000001328 optic nerve Anatomy 0.000 claims description 6
- 210000003128 head Anatomy 0.000 claims description 5
- 238000005259 measurement Methods 0.000 claims description 5
- 238000012935 Averaging Methods 0.000 claims description 3
- 230000003287 optical effect Effects 0.000 claims 1
- 230000017531 blood circulation Effects 0.000 description 21
- 210000000601 blood cell Anatomy 0.000 description 9
- 239000013598 vector Substances 0.000 description 5
- 210000001736 capillary Anatomy 0.000 description 4
- 238000006073 displacement reaction Methods 0.000 description 4
- 238000000605 extraction Methods 0.000 description 4
- 210000002565 arteriole Anatomy 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- 238000012937 correction Methods 0.000 description 3
- 238000001514 detection method Methods 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 230000002792 vascular Effects 0.000 description 3
- 230000000007 visual effect Effects 0.000 description 3
- 238000002583 angiography Methods 0.000 description 2
- 210000004556 brain Anatomy 0.000 description 2
- 230000007850 degeneration Effects 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 description 2
- 239000005338 frosted glass Substances 0.000 description 2
- 238000010191 image analysis Methods 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 238000007689 inspection Methods 0.000 description 2
- 210000004126 nerve fiber Anatomy 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 230000000750 progressive effect Effects 0.000 description 2
- 238000002310 reflectometry Methods 0.000 description 2
- 230000004233 retinal vasculature Effects 0.000 description 2
- 230000003068 static effect Effects 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 230000009466 transformation Effects 0.000 description 2
- 210000000264 venule Anatomy 0.000 description 2
- 201000004569 Blindness Diseases 0.000 description 1
- 241001269524 Dura Species 0.000 description 1
- 206010029113 Neovascularisation Diseases 0.000 description 1
- 206010038862 Retinal exudates Diseases 0.000 description 1
- 208000014139 Retinal vascular disease Diseases 0.000 description 1
- 208000002847 Surgical Wound Diseases 0.000 description 1
- 230000002238 attenuated effect Effects 0.000 description 1
- 210000005056 cell body Anatomy 0.000 description 1
- 230000001427 coherent effect Effects 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 238000002405 diagnostic procedure Methods 0.000 description 1
- 230000004424 eye movement Effects 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 238000013534 fluorescein angiography Methods 0.000 description 1
- 239000007850 fluorescent dye Substances 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- MOFVSTNWEDAEEK-UHFFFAOYSA-M indocyanine green Chemical compound [Na+].[O-]S(=O)(=O)CCCCN1C2=CC=C3C=CC=CC3=C2C(C)(C)C1=CC=CC=CC=CC1=[N+](CCCCS([O-])(=O)=O)C2=CC=C(C=CC=C3)C3=C2C1(C)C MOFVSTNWEDAEEK-UHFFFAOYSA-M 0.000 description 1
- 229960004657 indocyanine green Drugs 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 230000002427 irreversible effect Effects 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 230000008338 local blood flow Effects 0.000 description 1
- 238000013507 mapping Methods 0.000 description 1
- 238000010606 normalization Methods 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000036961 partial effect Effects 0.000 description 1
- 238000004451 qualitative analysis Methods 0.000 description 1
- 238000011002 quantification Methods 0.000 description 1
- 210000001210 retinal vessel Anatomy 0.000 description 1
- 230000003595 spectral effect Effects 0.000 description 1
- 238000000844 transformation Methods 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
- 210000005166 vasculature Anatomy 0.000 description 1
- 238000012800 visualization Methods 0.000 description 1
- 229910052724 xenon Inorganic materials 0.000 description 1
- FHNFHKCVQCLJFQ-UHFFFAOYSA-N xenon atom Chemical compound [Xe] FHNFHKCVQCLJFQ-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01P—MEASURING LINEAR OR ANGULAR SPEED, ACCELERATION, DECELERATION, OR SHOCK; INDICATING PRESENCE, ABSENCE, OR DIRECTION, OF MOVEMENT
- G01P5/00—Measuring speed of fluids, e.g. of air stream; Measuring speed of bodies relative to fluids, e.g. of ship, of aircraft
- G01P5/001—Full-field flow measurement, e.g. determining flow velocity and direction in a whole region at the same time, flow visualisation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
- A61B3/12—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes
- A61B3/1241—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes specially adapted for observation of ocular blood flow, e.g. by fluorescein angiography
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Vascular Medicine (AREA)
- General Physics & Mathematics (AREA)
- Biophysics (AREA)
- Ophthalmology & Optometry (AREA)
- Aviation & Aerospace Engineering (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Hematology (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Eye Examination Apparatus (AREA)
- Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Apparatus For Radiation Diagnosis (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL12481498A IL124814A (en) | 1998-06-08 | 1998-06-08 | System and method for imaging and analysis of the movement of individual red blood corpuscles |
| PCT/IL1999/000303 WO1999063882A1 (en) | 1998-06-08 | 1999-06-07 | Imaging and analyzing movement of individual erythrocytes in blood vessels |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69902906D1 DE69902906D1 (de) | 2002-10-17 |
| DE69902906T2 true DE69902906T2 (de) | 2003-07-31 |
Family
ID=11071594
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69902906T Expired - Lifetime DE69902906T2 (de) | 1998-06-08 | 1999-06-07 | Bilddarstellung und untersuchung der bewegung von einzelnen erythrozyten in blutgefässen |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6588901B1 (enExample) |
| EP (1) | EP1085834B1 (enExample) |
| JP (1) | JP4139563B2 (enExample) |
| CN (1) | CN1163190C (enExample) |
| AT (1) | ATE223677T1 (enExample) |
| AU (1) | AU4162299A (enExample) |
| DE (1) | DE69902906T2 (enExample) |
| IL (1) | IL124814A (enExample) |
| WO (1) | WO1999063882A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102008028342A1 (de) * | 2008-06-13 | 2009-12-17 | Carl Zeiss Surgical Gmbh | Laser-Doppler-Bildgebungsverfahren und Vorrichtung zum Untersuchen eines Objekts |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2413483A1 (en) * | 2001-12-26 | 2003-06-26 | Kevin R. Forrester | Motion measuring device |
| DK1494579T3 (da) | 2002-04-02 | 2011-11-14 | Yeda Res & Dev | Karakterisering af bevægelige objekter i en stationær baggrund |
| WO2004005941A1 (en) * | 2002-07-05 | 2004-01-15 | Stichting Voor De Technische Wetenschappen | Two-point ensemble correlation method for piv applications |
| CN1744853B (zh) * | 2002-12-02 | 2010-05-12 | 耶德研究和发展有限公司 | 对象的脉管分析系统 |
| US8172763B2 (en) * | 2005-05-06 | 2012-05-08 | Yeda Research And Development Co., Ltd. | Imaging and analysis of movement of erythrocytes in blood vessels in relation to the cardiac cycle |
| JP2009517138A (ja) * | 2005-11-23 | 2009-04-30 | カプソ・ビジョン・インコーポレイテッド | 動き検出と「実体像」イメージの構築 |
| US7998115B2 (en) * | 2007-02-15 | 2011-08-16 | Baxter International Inc. | Dialysis system having optical flowrate detection |
| US8385997B2 (en) * | 2007-12-11 | 2013-02-26 | Tokitae Llc | Spectroscopic detection of malaria via the eye |
| US8403862B2 (en) * | 2007-12-20 | 2013-03-26 | Yeda Research And Development Co. Ltd. | Time-based imaging |
| JP5582520B2 (ja) * | 2009-02-18 | 2014-09-03 | 国立大学法人名古屋大学 | 血流観測装置 |
| JP5578735B2 (ja) * | 2009-05-13 | 2014-08-27 | 国立大学法人九州工業大学 | 血流画像診断装置 |
| WO2011110987A1 (en) * | 2010-03-12 | 2011-09-15 | Koninklijke Philips Electronics N.V. | Motion visualisation in angiographic images |
| US9161690B2 (en) | 2011-03-10 | 2015-10-20 | Canon Kabushiki Kaisha | Ophthalmologic apparatus and control method of the same |
| JP2012196245A (ja) * | 2011-03-18 | 2012-10-18 | Canon Inc | 眼科情報処理装置及びその制御方法 |
| EP2841941B1 (en) * | 2012-04-26 | 2018-02-14 | TissUse GmbH | Methods for determining and/or monitoring conditions of a three dimensional cell culture system and optical sensor device for conducting said methods |
| JP6200168B2 (ja) * | 2013-02-28 | 2017-09-20 | キヤノン株式会社 | 画像処理装置及び画像処理方法 |
| JP6198410B2 (ja) | 2013-02-28 | 2017-09-20 | キヤノン株式会社 | 画像処理装置及び画像処理方法 |
| JP6092659B2 (ja) | 2013-02-28 | 2017-03-08 | キヤノン株式会社 | 画像処理装置及び画像処理方法 |
| JP2017029651A (ja) * | 2015-08-06 | 2017-02-09 | ソニー株式会社 | 情報処理装置、情報処理方法、並びにプログラム |
| US10799129B2 (en) * | 2016-01-07 | 2020-10-13 | Panasonic Intellectual Property Management Co., Ltd. | Biological information measuring device including light source, light detector, and control circuit |
| JP6852730B2 (ja) * | 2016-04-05 | 2021-03-31 | ソニー株式会社 | スペックル測定装置およびスペックル測定方法 |
| JP6535701B2 (ja) * | 2017-05-31 | 2019-06-26 | 三菱電機エンジニアリング株式会社 | 撮像装置 |
| JP6850225B2 (ja) | 2017-09-01 | 2021-03-31 | 富士フイルム株式会社 | 医療画像処理装置、内視鏡装置、診断支援装置、及び、医療業務支援装置 |
| JP7512577B2 (ja) * | 2019-09-24 | 2024-07-09 | 株式会社ニコン | 撮影方法、眼科装置、およびプログラム |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6150550A (ja) * | 1985-07-08 | 1986-03-12 | オリンパス光学工業株式会社 | 血管顕微鏡 |
| US4856891A (en) * | 1987-02-17 | 1989-08-15 | Eye Research Institute Of Retina Foundation | Eye fundus tracker/stabilizer |
| JPH02257931A (ja) * | 1988-12-24 | 1990-10-18 | Hamamatsu Photonics Kk | 血管内血流計測装置及び計測方法 |
| JP2749115B2 (ja) * | 1989-04-17 | 1998-05-13 | 興和株式会社 | 眼科診断装置 |
| US5845639A (en) * | 1990-08-10 | 1998-12-08 | Board Of Regents Of The University Of Washington | Optical imaging methods |
| JP3171611B2 (ja) * | 1991-06-29 | 2001-05-28 | 株式会社ニデック | 眼科撮影装置 |
| JPH0537859A (ja) * | 1991-07-31 | 1993-02-12 | Shimadzu Corp | Ｘ線画像処理装置 |
| US5394199A (en) * | 1993-05-17 | 1995-02-28 | The Johns Hopkins University | Methods and apparatus for improved visualization of choroidal blood flow and aberrant vascular structures in the eye using fluorescent dye angiography |
| CA2207318A1 (en) * | 1994-12-09 | 1996-06-13 | Lloyd M. Aiello | Electronic imaging system for retinal examination and treatment |
| DE19650117A1 (de) * | 1996-12-03 | 1998-06-04 | Mira Gmbh | Ophthalmikroskopische Vorrichtung zur Beobachtung und Untersuchung des Augenhintergrundes |
| US5976502A (en) * | 1997-10-21 | 1999-11-02 | Gholam A. Peyman | Method of visualizing particles and blood cells containing a fluorescent lipophilic dye in the retina and choroid of the eye |
-
1998
- 1998-06-08 IL IL12481498A patent/IL124814A/xx not_active IP Right Cessation
-
1999
- 1999-06-07 DE DE69902906T patent/DE69902906T2/de not_active Expired - Lifetime
- 1999-06-07 AU AU41622/99A patent/AU4162299A/en not_active Abandoned
- 1999-06-07 WO PCT/IL1999/000303 patent/WO1999063882A1/en not_active Ceased
- 1999-06-07 US US09/719,046 patent/US6588901B1/en not_active Expired - Lifetime
- 1999-06-07 AT AT99925256T patent/ATE223677T1/de not_active IP Right Cessation
- 1999-06-07 JP JP2000552962A patent/JP4139563B2/ja not_active Expired - Lifetime
- 1999-06-07 CN CNB99807179XA patent/CN1163190C/zh not_active Expired - Lifetime
- 1999-06-07 EP EP99925256A patent/EP1085834B1/en not_active Expired - Lifetime
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102008028342A1 (de) * | 2008-06-13 | 2009-12-17 | Carl Zeiss Surgical Gmbh | Laser-Doppler-Bildgebungsverfahren und Vorrichtung zum Untersuchen eines Objekts |
Also Published As
| Publication number | Publication date |
|---|---|
| JP4139563B2 (ja) | 2008-08-27 |
| HK1036002A1 (en) | 2001-12-21 |
| ATE223677T1 (de) | 2002-09-15 |
| IL124814A0 (en) | 1999-01-26 |
| EP1085834B1 (en) | 2002-09-11 |
| JP2002517269A (ja) | 2002-06-18 |
| CN1305354A (zh) | 2001-07-25 |
| IL124814A (en) | 2003-04-10 |
| AU4162299A (en) | 1999-12-30 |
| US6588901B1 (en) | 2003-07-08 |
| CN1163190C (zh) | 2004-08-25 |
| DE69902906D1 (de) | 2002-10-17 |
| EP1085834A1 (en) | 2001-03-28 |
| WO1999063882A1 (en) | 1999-12-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8327 | Change in the person/name/address of the patent owner |
Owner name: YEDA RESEARCH AND DEVELOPMENT CO. LTD., REHOVOT, I |
|
| 8364 | No opposition during term of opposition |