DE69835145D1 - Transgene Mäuse die ein menschliche Antikörper exprimieren - Google Patents
Transgene Mäuse die ein menschliche Antikörper exprimierenInfo
- Publication number
- DE69835145D1 DE69835145D1 DE69835145T DE69835145T DE69835145D1 DE 69835145 D1 DE69835145 D1 DE 69835145D1 DE 69835145 T DE69835145 T DE 69835145T DE 69835145 T DE69835145 T DE 69835145T DE 69835145 D1 DE69835145 D1 DE 69835145D1
- Authority
- DE
- Germany
- Prior art keywords
- same
- human antibody
- fragment
- transgenic mice
- producing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 241000699660 Mus musculus Species 0.000 title 1
- 238000011830 transgenic mouse model Methods 0.000 title 1
- 210000004027 cell Anatomy 0.000 abstract 4
- 210000000349 chromosome Anatomy 0.000 abstract 3
- 239000012634 fragment Substances 0.000 abstract 3
- 238000004519 manufacturing process Methods 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 3
- 230000004927 fusion Effects 0.000 abstract 1
- 230000006801 homologous recombination Effects 0.000 abstract 1
- 238000002744 homologous recombination Methods 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 210000001519 tissue Anatomy 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0276—Knock-out vertebrates
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/15—Humanized animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/01—Animal expressing industrially exogenous proteins
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2517/00—Cells related to new breeds of animals
- C12N2517/02—Cells from transgenic animals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/30—Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Environmental Sciences (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Genetics & Genomics (AREA)
- Animal Behavior & Ethology (AREA)
- Animal Husbandry (AREA)
- Biodiversity & Conservation Biology (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
- Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP6230997 | 1997-02-28 | ||
JP6230997 | 1997-02-28 | ||
PCT/JP1998/000860 WO1998037757A1 (fr) | 1997-02-28 | 1998-03-02 | Cellules multipotentes comprenant des genes intrinseques dissocies |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69835145D1 true DE69835145D1 (de) | 2006-08-17 |
DE69835145T2 DE69835145T2 (de) | 2007-06-14 |
Family
ID=13196415
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69835145T Expired - Lifetime DE69835145T2 (de) | 1997-02-28 | 1998-03-02 | Transgene Mäuse die ein menschliches Antikörper exprimieren |
DE69841452T Expired - Lifetime DE69841452D1 (de) | 1997-02-28 | 1998-03-02 | Humanes Chromosomfragment und ein Vektor, der dies enthält |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69841452T Expired - Lifetime DE69841452D1 (de) | 1997-02-28 | 1998-03-02 | Humanes Chromosomfragment und ein Vektor, der dies enthält |
Country Status (7)
Country | Link |
---|---|
EP (2) | EP1707051B1 (de) |
JP (1) | JP4082740B2 (de) |
AT (2) | ATE332077T1 (de) |
AU (1) | AU6118998A (de) |
DE (2) | DE69835145T2 (de) |
DK (1) | DK0972445T3 (de) |
WO (1) | WO1998037757A1 (de) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN100400547C (zh) * | 1999-07-29 | 2008-07-09 | 米德列斯公司 | 前列腺特异膜抗原的人类单克隆抗体 |
EP1206906A4 (de) * | 1999-08-13 | 2004-12-29 | Kirin Brewery | Maus, die träger des menschlichen cytochrom p450 ist |
NZ517202A (en) | 1999-08-24 | 2004-05-28 | Medarex Inc | Human CTLA-4 antibodies and their uses |
US7063845B2 (en) | 2000-04-28 | 2006-06-20 | Gemini Science, Inc. | Human anti-CD40 antibodies |
US20030059427A1 (en) * | 2000-04-28 | 2003-03-27 | Force Walker R. | Isolation and characterization of highly active anti-CD40 antibody |
DE60131456T2 (de) | 2000-11-30 | 2008-07-10 | Medarex, Inc., Milpitas | Transchromosomale transgen-nagetiere zur herstellung von humanen antikörpern |
ATE374214T1 (de) | 2001-04-27 | 2007-10-15 | Kirin Brewery | Monoklonaler anti-cd-40-antikörper |
EP1391511B1 (de) | 2001-05-11 | 2008-06-11 | Kirin Pharma Kabushiki Kaisha | Künstliches menschliches chromosom mit dem gen für die lambda-leichte kette menschlicher antikörper |
US7153507B2 (en) * | 2001-08-23 | 2006-12-26 | Genmab A/S | Human antibodies specific for interleukin 15 (IL-15) |
US7247304B2 (en) | 2001-08-23 | 2007-07-24 | Genmab A/S | Methods of treating using anti-IL-15 antibodies |
EP1454524A4 (de) * | 2001-10-30 | 2004-12-08 | Tokyo Metropolitan Org Med Res | Hcv-gen-transgenes tier |
EP1503794B9 (de) | 2002-04-12 | 2012-09-19 | Medarex, Inc. | Behandlungsverfahren unter verwendung von ctla-4 antikörpern |
NZ568016A (en) | 2005-12-07 | 2011-12-22 | Medarex Inc | CTLA-4 antibody dosage escalation regimens |
GB0720552D0 (en) * | 2007-10-19 | 2007-11-28 | Iti Scotland Ltd | Multiple cluster knockout |
CA2780945C (en) | 2009-11-17 | 2018-09-04 | Kyowa Hakko Kirin Co., Ltd. | Human artificial chromosome vector |
EP2454939A1 (de) | 2010-11-18 | 2012-05-23 | Bayer CropScience AG | Verarbeitung nach der Ernte |
AU2012310880B2 (en) | 2011-09-21 | 2015-12-03 | Fujirebio Inc. | Antibody against affinity complex |
JP6683598B2 (ja) * | 2013-03-15 | 2020-04-22 | マックスサイト インコーポレーティッド | 安定なトランスフェクトされた細胞を生成するための方法および組成物 |
KR20170135966A (ko) | 2015-04-13 | 2017-12-08 | 맥스시티 인코포레이티드 | 게놈 dna를 변형시키기 위한 방법 및 조성물 |
JP2019506897A (ja) * | 2016-01-19 | 2019-03-14 | セルジーン コーポレイション | ヒトのセレブロンを発現するトランスジェニックマウス |
EP3533867A4 (de) * | 2016-10-31 | 2020-07-22 | National University Corporation Tottori University | Nichtmenschliches tier mit produktion von menschlichem antikörper und verfahren zur herstellung humaner antikörper unter verwendung davon |
FR3064484A1 (fr) | 2017-03-31 | 2018-10-05 | Laboratoire Francais Du Fractionnement Et Des Biotechnologies | Composition d'immunoglobulines utiles pour traiter des infections virales |
JP6775224B2 (ja) | 2018-03-16 | 2020-10-28 | 国立大学法人鳥取大学 | マウス人工染色体ベクター及びその使用 |
JPWO2023090361A1 (de) | 2021-11-16 | 2023-05-25 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3827145A1 (de) * | 1987-12-03 | 1989-06-15 | Biotechnolog Forschung Gmbh | Monoklonale antikoerper, hybridoma-zellinien zur gewinnung der antikoerper, verfahren zur gewinnung der antikoerper und der zellinien, sowie verwendung der antikoerper |
CA2006011A1 (en) * | 1988-12-21 | 1990-06-21 | Cecilia Lo | Transgenic organisms and cells and methods of producing transgenic organisms and cells |
JP3061480B2 (ja) * | 1992-05-26 | 2000-07-10 | 理化学研究所 | 胚性未分化細胞 |
JPH0767629A (ja) * | 1992-09-29 | 1995-03-14 | Deinaade:Kk | 標的遺伝子置換法 |
US5449604A (en) * | 1992-10-21 | 1995-09-12 | University Of Washington | Chromosome 14 and familial Alzheimers disease genetic markers and assays |
WO1994023049A2 (en) * | 1993-04-02 | 1994-10-13 | The Johns Hopkins University | The introduction and expression of large genomic sequences in transgenic animals |
EP0773288A3 (de) * | 1995-08-29 | 1997-07-09 | Kirin Brewery | Chimäre-Tier und dessen Verfahren zur Herstellung |
AU7057398A (en) * | 1997-04-11 | 1998-11-11 | Imperial College Of Science, Technology And Medicine | Chromosome transfer (xmmct) to es cells, induced during the exposure of microcells to radiation |
-
1998
- 1998-03-02 DE DE69835145T patent/DE69835145T2/de not_active Expired - Lifetime
- 1998-03-02 DE DE69841452T patent/DE69841452D1/de not_active Expired - Lifetime
- 1998-03-02 AU AU61189/98A patent/AU6118998A/en not_active Abandoned
- 1998-03-02 AT AT98905731T patent/ATE332077T1/de not_active IP Right Cessation
- 1998-03-02 EP EP06013837A patent/EP1707051B1/de not_active Expired - Lifetime
- 1998-03-02 AT AT06013837T patent/ATE455179T1/de not_active IP Right Cessation
- 1998-03-02 EP EP98905731A patent/EP0972445B1/de not_active Expired - Lifetime
- 1998-03-02 JP JP53752598A patent/JP4082740B2/ja not_active Expired - Lifetime
- 1998-03-02 WO PCT/JP1998/000860 patent/WO1998037757A1/ja active IP Right Grant
- 1998-03-02 DK DK98905731T patent/DK0972445T3/da active
Also Published As
Publication number | Publication date |
---|---|
EP1707051A2 (de) | 2006-10-04 |
EP0972445B1 (de) | 2006-07-05 |
DE69841452D1 (de) | 2010-03-04 |
AU6118998A (en) | 1998-09-18 |
DE69835145T2 (de) | 2007-06-14 |
WO1998037757A1 (fr) | 1998-09-03 |
JP4082740B2 (ja) | 2008-04-30 |
DK0972445T3 (da) | 2006-10-23 |
ATE332077T1 (de) | 2006-07-15 |
EP1707051A3 (de) | 2006-12-27 |
EP1707051B1 (de) | 2010-01-13 |
EP0972445A1 (de) | 2000-01-19 |
EP0972445A4 (de) | 2000-12-27 |
ATE455179T1 (de) | 2010-01-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8327 | Change in the person/name/address of the patent owner |
Owner name: KIRIN PHARMA KABUSHIKI KAISHA, SHIBUYA, TOKYO, JP |
|
8327 | Change in the person/name/address of the patent owner |
Owner name: KYOWA HAKKO KIRIN CO., LTD., TOKYO, JP |