DE69833215D1 - Mit metall überzogenen proteinkolloidalen teilchen und herstellungsverfahren dafür - Google Patents

Mit metall überzogenen proteinkolloidalen teilchen und herstellungsverfahren dafür

Info

Publication number
DE69833215D1
DE69833215D1 DE69833215T DE69833215T DE69833215D1 DE 69833215 D1 DE69833215 D1 DE 69833215D1 DE 69833215 T DE69833215 T DE 69833215T DE 69833215 T DE69833215 T DE 69833215T DE 69833215 D1 DE69833215 D1 DE 69833215D1
Authority
DE
Germany
Prior art keywords
production
metal
colloidal particles
coated protein
protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69833215T
Other languages
English (en)
Inventor
Olavi Siiman
Kristie Gordon
M Rodriguez
Alexander Burshteyn
A Maples
Keller Whitesell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beckman Coulter Inc
Original Assignee
Coulter International Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Coulter International Corp filed Critical Coulter International Corp
Application granted granted Critical
Publication of DE69833215D1 publication Critical patent/DE69833215D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5094—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for blood cell populations
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54353—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand attached to the carrier via a chemical coupling agent
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54393—Improving reaction conditions or stability, e.g. by coating or irradiation of surface, by reduction of non-specific binding, by promotion of specific binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/544—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being organic
    • G01N33/548—Carbohydrates, e.g. dextran
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/551—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being inorganic
    • G01N33/553—Metal or metal coated
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2991—Coated

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Inorganic Chemistry (AREA)
  • Ecology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
DE69833215T 1997-10-09 1998-10-01 Mit metall überzogenen proteinkolloidalen teilchen und herstellungsverfahren dafür Expired - Lifetime DE69833215D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/947,811 US5945293A (en) 1997-10-09 1997-10-09 Protein-colloidal metal-aminodextran coated particle and methods of preparation and use
PCT/US1998/020788 WO1999019731A1 (en) 1997-10-09 1998-10-01 Protein-colloidal metal-aminodextran coated particle and methods of preparation and use

Publications (1)

Publication Number Publication Date
DE69833215D1 true DE69833215D1 (de) 2006-04-06

Family

ID=25486824

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69833215T Expired - Lifetime DE69833215D1 (de) 1997-10-09 1998-10-01 Mit metall überzogenen proteinkolloidalen teilchen und herstellungsverfahren dafür

Country Status (6)

Country Link
US (1) US5945293A (de)
EP (1) EP1023602B1 (de)
JP (1) JP2001520383A (de)
CN (1) CN1276871A (de)
DE (1) DE69833215D1 (de)
WO (1) WO1999019731A1 (de)

Families Citing this family (39)

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US6344272B1 (en) * 1997-03-12 2002-02-05 Wm. Marsh Rice University Metal nanoshells
JP3620946B2 (ja) * 1997-03-17 2005-02-16 シスメックス株式会社 スキャッタグラムの表示方法および粒子計測装置
US6699724B1 (en) * 1998-03-11 2004-03-02 Wm. Marsh Rice University Metal nanoshells for biosensing applications
US6428811B1 (en) 1998-03-11 2002-08-06 Wm. Marsh Rice University Temperature-sensitive polymer/nanoshell composites for photothermally modulated drug delivery
DE10027776A1 (de) 2000-06-07 2002-02-14 Roche Diagnostics Gmbh Neuartige core-shell Partikel
US20020081617A1 (en) * 2000-11-08 2002-06-27 Tione Buranda Fluorescence and FRET based assays for biomolecules on beads
JP3605039B2 (ja) * 2001-01-09 2004-12-22 株式会社日立製作所 核酸マイクロアレイ、その製造方法及びそれを用いた核酸検出方法
US6696243B2 (en) 2001-01-23 2004-02-24 Coulter International Corp. Method for the analysis of soluble analytes
AU2002317418A1 (en) * 2001-07-11 2003-01-29 National Health Laboratory Service Cell enumeration
US7319002B2 (en) 2001-08-08 2008-01-15 The Trustees Of The University Of Pennsylvania Method for purification of viral vectors having proteins which bind sialic acid
US9201067B2 (en) * 2003-03-05 2015-12-01 Posco Size-controlled macromolecule
DE10154016B4 (de) * 2001-10-26 2004-02-12 Berlin Heart Ag Magnetflüssigkeit und Verfahren zur ihrer Herstellung
EP1534269B1 (de) * 2002-07-19 2013-10-30 The General Hospital Corporation Oxim-konjugate und verfahren zu ihrer bildung und verwendung
GB0227738D0 (en) * 2002-11-28 2003-01-08 Univ Liverpool Nanoparticle conjugates and method of production thereof
US20040191778A1 (en) * 2003-03-28 2004-09-30 Seiji Inaoka Colloidal silver-biomolecule complexes
US7083936B2 (en) * 2003-08-01 2006-08-01 Beckman Coulter, Inc. Aminodextran compositions and conjugates and method of making and using them
US20050069958A1 (en) * 2003-09-26 2005-03-31 Mills Rhonda A. Method for simultaneous evaluation of a sample containing a cellular target and a soluble analyte
JP4849432B2 (ja) * 2004-03-30 2012-01-11 ブラザー工業株式会社 圧電膜の製造方法、基板と圧電膜との積層構造、圧電アクチュエータおよびその製造方法
US7351591B2 (en) * 2004-03-30 2008-04-01 Intel Corporation Surface modification of metals for biomolecule detection using surface enhanced Raman scattering (SERS)
US7771660B2 (en) * 2004-05-04 2010-08-10 University Of North Carolina At Chapel Hill Electrophoretic interactive spectral methods and devices for the detection and/or characterization of biological particles
KR100668041B1 (ko) * 2004-06-23 2007-01-15 서강대학교산학협력단 초음파를 이용하는 기질-분자체막 복합체의 제조방법 및이에 사용되는 제조장치
US20060024744A1 (en) * 2004-07-28 2006-02-02 Mills Rhonda A Methods for substantially simultaneous evaluation of a sample containing a cellular target and a soluble analyte
JP5784868B2 (ja) * 2004-11-19 2015-09-24 コーニンクレッカ フィリップス エヌ ヴェ 分子撮像用の超音波造影剤及び粒子の使用
JP4706074B2 (ja) * 2005-03-29 2011-06-22 独立行政法人物質・材料研究機構 生体分子固定化用の三脚型機能性界面分子とこれを用いた遺伝子検出デバイス
JP4791867B2 (ja) * 2005-03-31 2011-10-12 日立マクセル株式会社 貴金属コート磁性粒子を用いた被検物質の検出方法
WO2007024825A2 (en) * 2005-08-26 2007-03-01 Genway Biotech, Inc. Immunoaffinity separation and analysis compositions and methods
US8338170B2 (en) 2008-04-21 2012-12-25 Viacyte, Inc. Methods for purifying endoderm and pancreatic endoderm cells derived from human embryonic stem cells
DK2283117T3 (da) 2008-04-21 2014-01-20 Viacyte Inc Fremgangsmåde til oprensning af pancreatiske endodermceller afledt fra humane embryoniske stamceller
US20090298178A1 (en) * 2008-06-03 2009-12-03 D Amour Kevin Allen Growth factors for production of definitive endoderm
JP5364310B2 (ja) * 2008-07-14 2013-12-11 アルフレッサファーマ株式会社 反応性物質が結合した微小粒子の安定化方法および該微小粒子含有試薬
CN105349517B (zh) 2008-11-14 2021-05-04 维赛特公司 源于人多能干细胞的胰腺细胞的包封
JP2011242387A (ja) * 2010-04-21 2011-12-01 Osaka Prefecture Univ 生物学的物質の捕獲又は分離用複合微粒子
KR20140049959A (ko) * 2010-10-13 2014-04-28 파마다이아그노스틱스 엔브이 나노 입자의 코팅 방법
EP2675902B1 (de) 2011-02-17 2019-03-27 The Trustees Of The University Of Pennsylvania Zusammensetzungen und method zur veränderung der gewebespezifität und verbesserung des aav9-vermittleten gentransfers
ES2862533T3 (es) * 2016-03-30 2021-10-07 Macroarray Diagnostics Gmbh Matriz de antígenos
CN105758835B (zh) * 2016-05-04 2018-03-27 成都爱兴生物科技有限公司 一种均相免疫分析poct检测方法及使用该检测方法的系统
CN106501505A (zh) * 2016-10-03 2017-03-15 王贤俊 一种胶乳定向偶联技术检测脂蛋白（a）的方法
CN106501536A (zh) * 2016-10-03 2017-03-15 王贤俊 一种胶乳定向偶联技术检测脂蛋白（a）的试剂盒
CN108132351B (zh) * 2017-12-22 2020-05-15 扬州大学 一种拉曼增强蛋白质检测的纳米探针器件及其制备方法

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DE2632478A1 (de) * 1975-07-23 1977-02-24 Coulter Electronics Verfahren zur erfassung und trennung von antigenen und antikoerperchen im blut und in anderen proben
US5231005A (en) * 1987-03-13 1993-07-27 Coulter Corporation Method and apparatus for screening cells or formed bodies with populations expressing selected characteristics
KR970007077B1 (ko) * 1987-03-13 1997-05-02 코울터 일렉트로닉스 인커퍼레이티드 광산란 기술을 이용한 다중-부분식별 분석 방법
US5223398A (en) * 1987-03-13 1993-06-29 Coulter Corporation Method for screening cells or formed bodies for enumeration of populations expressing selected characteristics
US5466609A (en) * 1990-10-31 1995-11-14 Coulter Corporation Biodegradable gelatin-aminodextran particle coatings of and processes for making same
US5639620A (en) * 1990-10-31 1997-06-17 Coulter Corporation Polymeric particles having a biodegradable gelatin or aminodextran coating and process for making same
BR9107024A (pt) * 1990-11-23 1993-08-31 Coulter Corp Processo e aparelho para analisar calculos de pelo menos um grupo de celulas de interesse e processo e aparelho para analisar pelo menos uma populacao de celulas sanguineas brancas ou um subconjunto desta pupolacao a partir de uma amostra sanguinea completa
US5248772A (en) * 1992-01-29 1993-09-28 Coulter Corporation Formation of colloidal metal dispersions using aminodextrans as reductants and protective agents
AU6830894A (en) * 1993-05-14 1994-12-12 Coulter Corporation Reticulocyte analyzing method and apparatus utilizing light scatter techniques
CA2164646A1 (en) * 1993-06-11 1994-12-22 Wade E. Bolton Anti-cd3 antibody-aminodextran conjugates for induction of t-cell activation and proliferation

Also Published As

Publication number Publication date
WO1999019731A9 (en) 1999-07-01
EP1023602B1 (de) 2006-01-11
CN1276871A (zh) 2000-12-13
JP2001520383A (ja) 2001-10-30
EP1023602A1 (de) 2000-08-02
WO1999019731A1 (en) 1999-04-22
US5945293A (en) 1999-08-31

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Legal Events

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8332 No legal effect for de