DE69831741T2 - Modifizierte adenovirale fiber und sie enthaltende adenoviren - Google Patents
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- DE69831741T2 DE69831741T2 DE69831741T DE69831741T DE69831741T2 DE 69831741 T2 DE69831741 T2 DE 69831741T2 DE 69831741 T DE69831741 T DE 69831741T DE 69831741 T DE69831741 T DE 69831741T DE 69831741 T2 DE69831741 T2 DE 69831741T2
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Classifications
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- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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- A61K38/00—Medicinal preparations containing peptides
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- C12N2710/10011—Adenoviridae
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- C12N2810/00—Vectors comprising a targeting moiety
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- C12N2810/80—Vectors comprising as targeting moiety peptide derived from defined protein from vertebrates
- C12N2810/85—Vectors comprising as targeting moiety peptide derived from defined protein from vertebrates mammalian
- C12N2810/851—Vectors comprising as targeting moiety peptide derived from defined protein from vertebrates mammalian from growth factors; from growth regulators
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- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/42—Vector systems having a special element relevant for transcription being an intron or intervening sequence for splicing and/or stability of RNA
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- Plant Pathology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9703987A FR2761688A1 (fr) | 1997-04-02 | 1997-04-02 | Fibre adenovirale modifiee et adenovirus cibles |
| FR9703987 | 1997-04-02 | ||
| FR9704747A FR2761689B1 (fr) | 1997-04-02 | 1997-04-17 | Fibre adenovirale modifiee et adenovirus cibles |
| FR9704747 | 1997-04-17 | ||
| PCT/FR1998/000668 WO1998044121A1 (fr) | 1997-04-02 | 1998-04-02 | Fibre adenovirale modifiee et adenovirus cibles |
Publications (2)
| Publication Number | Publication Date |
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| DE69831741D1 DE69831741D1 (de) | 2006-02-09 |
| DE69831741T2 true DE69831741T2 (de) | 2006-07-06 |
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| Application Number | Title | Priority Date | Filing Date |
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| DE69831741T Expired - Fee Related DE69831741T2 (de) | 1997-04-02 | 1998-04-02 | Modifizierte adenovirale fiber und sie enthaltende adenoviren |
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| US (2) | US6569677B1 (OSRAM) |
| EP (1) | EP0991763B1 (OSRAM) |
| JP (1) | JP2001522236A (OSRAM) |
| AT (1) | ATE305513T1 (OSRAM) |
| AU (1) | AU741728B2 (OSRAM) |
| CA (1) | CA2285565A1 (OSRAM) |
| DE (1) | DE69831741T2 (OSRAM) |
| DK (1) | DK0991763T3 (OSRAM) |
| ES (1) | ES2246533T3 (OSRAM) |
| FR (1) | FR2761689B1 (OSRAM) |
| WO (1) | WO1998044121A1 (OSRAM) |
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| US7232899B2 (en) | 1996-09-25 | 2007-06-19 | The Scripps Research Institute | Adenovirus vectors, packaging cell lines, compositions, and methods for preparation and use |
| AU4070499A (en) | 1998-04-30 | 1999-11-16 | Cornell Research Foundation Inc. | Adenoviral vectors with tandem fiber proteins |
| US6455314B1 (en) | 1998-09-11 | 2002-09-24 | Genvec, Inc. | Alternatively targeted adenovirus |
| EP1020529B1 (en) * | 1998-11-20 | 2005-06-01 | Crucell Holland B.V. | Gene delivery vectors provided with a tissue tropism for smooth muscle cells, and/or endothelial cells |
| IL133032A (en) * | 1998-11-20 | 2007-06-03 | Introgene Bv | Adenoviral gene delivery vectors provided with a tissue tropism for smooth muscle cells and /or endothelial cells |
| JP2000279178A (ja) * | 1999-02-24 | 2000-10-10 | Japan Found Cancer Res | ウイルスベクター |
| DE19932688B4 (de) * | 1999-07-13 | 2009-10-08 | Scil Proteins Gmbh | Design von Beta-Faltblatt-Proteinen des gamma-II-kristallins antikörperähnlichen |
| AU783879B2 (en) * | 1999-11-25 | 2005-12-15 | Transgene S.A. | Modified adenovirus fibre and uses |
| CA2410665C (en) * | 2000-05-31 | 2017-11-07 | University Of Saskatchewan | Modified bovine adenovirus having altered tropism |
| IL153143A0 (en) * | 2000-06-02 | 2003-06-24 | Novartis Ag | Adenovirus particles with mutagenized fiber proteins |
| CA2491805A1 (en) * | 2002-07-10 | 2004-01-22 | Transgene S.A. | Modified adenoviral fiber with ablated binding to cellular receptors |
| US20060281090A1 (en) * | 2003-05-01 | 2006-12-14 | University Of Washington Uw Tech Transfer- Invention Licensing | Capsid-modified adenovirus vectors and methods of using the same |
| AU2004238979B2 (en) * | 2003-05-14 | 2008-12-18 | Istituto Di Ricerche Di Biologia Molecolare P Angeletti Spa | Broadening adenovirus tropism |
| DE10324447A1 (de) | 2003-05-28 | 2004-12-30 | Scil Proteins Gmbh | Generierung künstlicher Bindungsproteine auf der Grundlage von Ubiquitin |
| GB0313132D0 (en) | 2003-06-06 | 2003-07-09 | Ich Productions Ltd | Peptide ligands |
| WO2005030927A2 (en) * | 2003-09-23 | 2005-04-07 | Uab Research Foundation | Methods and compositions for in vivo inflammation monitoring |
| SI2163260T1 (sl) * | 2004-01-23 | 2017-07-31 | Msd Italia S.R.L. | Nosilci šimpanzjih adenovirusnih cepiv |
| DE102004049479A1 (de) | 2004-10-11 | 2006-04-13 | Scil Proteins Gmbh | Proteinkonjugate zur Verwendung in Therapie, Diagnose und Chromatographie |
| US20070010016A1 (en) * | 2005-03-11 | 2007-01-11 | Mccelland Alan | Gene transfer with adenoviruses having modified fiber proteins |
| JP5475279B2 (ja) * | 2005-06-17 | 2014-04-16 | イステイチユート・デイ・リチエルケ・デイ・ビオロジア・モレコラーレ・ピ・アンジエレツテイ・エツセ・エルレ・エルレ | Ｃ型肝炎ウイルス核酸ワクチン |
| WO2007094653A1 (en) * | 2006-02-13 | 2007-08-23 | Vereniging Voor Christelijk Hoger Onderwijs, Wetenschappelijk Onderzoek En Patientenzorg | Adenovirus particles having a chimeric adenovirus spike protein, use thereof and methods for producing such particles. |
| EP1925664A1 (en) * | 2006-11-15 | 2008-05-28 | Scil proteins GmbH | Artificial binding proteins based on a modified alpha helical region of ubiquitin |
| US10131921B2 (en) * | 2008-03-06 | 2018-11-20 | Mayo Foundation For Medical Education And Research | Single cycle replicating adenovirus vectors |
| KR101436222B1 (ko) | 2009-12-14 | 2014-09-01 | 쉴 프로테인즈 게엠베하 | 리간드 결합능력을 가진 헤테로-다량체 변형 유비퀴틴 단백질을 확인하는 방법 |
| EP2721152B1 (en) | 2011-06-15 | 2019-03-27 | Navigo Proteins GmbH | Dimeric binding proteins based on modified ubiquitins |
| SG11201507393TA (en) | 2013-03-14 | 2015-10-29 | Salk Inst For Biological Studi | Oncolytic adenovirus compositions |
| PL3198009T3 (pl) | 2014-09-24 | 2022-01-24 | Salk Institute For Biological Studies | Onkolityczne wirusy nowotworowe i sposoby zastosowania |
| EP3253785B1 (en) | 2015-02-06 | 2019-04-10 | Navigo Proteins Gmbh | Novel egfr binding proteins |
| CN107922483B (zh) | 2015-07-16 | 2021-07-30 | 纳维格蛋白质有限公司 | 新型免疫球蛋白结合蛋白及其在亲和纯化中的用途 |
| WO2017013136A1 (en) | 2015-07-20 | 2017-01-26 | Scil Proteins Gmbh | Novel binding proteins based on di-ubiquitin muteins and methods for generation |
| JP7054527B2 (ja) | 2016-02-23 | 2022-04-14 | ソーク インスティテュート フォー バイオロジカル スタディーズ | アデノウイルスの複製動態を測定するための高スループットアッセイ |
| JP7015551B2 (ja) | 2016-02-23 | 2022-02-15 | ソーク インスティテュート フォー バイオロジカル スタディーズ | ウイルス動態への影響を最小限にするための治療用アデノウイルスにおける外因性遺伝子発現 |
| AU2017260274A1 (en) | 2016-05-04 | 2018-11-01 | Navigo Proteins Gmbh | Targeted compounds for the site-specific coupling of chemical moieties comprising a peptide linker |
| CA3030208A1 (en) | 2016-08-11 | 2018-02-15 | Navigo Proteins Gmbh | Novel alkaline stable immunoglobulin binding proteins |
| WO2018035387A1 (en) | 2016-08-17 | 2018-02-22 | The Broad Institute, Inc. | Novel crispr enzymes and systems |
| WO2018035388A1 (en) | 2016-08-17 | 2018-02-22 | The Broad Institute, Inc. | Novel crispr enzymes and systems |
| WO2018111767A1 (en) | 2016-12-12 | 2018-06-21 | Salk Institute For Biological Studies | Tumor-targeting synthetic adenoviruses and uses thereof |
| US12350368B2 (en) | 2017-04-14 | 2025-07-08 | The Broad Institute, Inc. | Delivery of large payloads |
| WO2019135816A2 (en) | 2017-10-23 | 2019-07-11 | The Broad Institute, Inc. | Novel nucleic acid modifiers |
| US11414466B2 (en) | 2017-11-07 | 2022-08-16 | Navigo Proteins Gmbh | Fusion proteins with specificity for ED-B and long serum half-life for diagnosis or treatment of cancer |
| EP3710039A4 (en) | 2017-11-13 | 2021-08-04 | The Broad Institute, Inc. | METHODS AND COMPOSITIONS FOR TREATMENT OF CANCER BY TARGETING THE CLEC2D-KLRB1 PATH |
| JP7430395B2 (ja) | 2018-04-09 | 2024-02-13 | ソーク インスティテュート フォー バイオロジカル スタディーズ | 複製特質が増強された腫瘍溶解性アデノウイルス組成物 |
| AU2019406778A1 (en) | 2018-12-17 | 2021-07-22 | Massachusetts Institute Of Technology | Crispr-associated transposase systems and methods of use thereof |
| CA3123986A1 (en) | 2018-12-18 | 2020-06-25 | Navigo Proteins Gmbh | Novel folr1 specific binding proteins for cancer diagnosis and treatment |
| WO2020236972A2 (en) | 2019-05-20 | 2020-11-26 | The Broad Institute, Inc. | Non-class i multi-component nucleic acid targeting systems |
| US12297426B2 (en) | 2019-10-01 | 2025-05-13 | The Broad Institute, Inc. | DNA damage response signature guided rational design of CRISPR-based systems and therapies |
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| CA3255225A1 (en) | 2022-04-04 | 2023-10-12 | The Regents Of The University Of California | COMPOSITIONS AND METHODS OF GENETIC COMPLEMENTATION |
| WO2025072383A1 (en) | 2023-09-25 | 2025-04-03 | The Broad Institute, Inc. | Viral open reading frames, uses thereof, and methods of detecting the same |
| WO2025097055A2 (en) | 2023-11-02 | 2025-05-08 | The Broad Institute, Inc. | Compositions and methods of use of t cells in immunotherapy |
| WO2025129158A1 (en) | 2023-12-15 | 2025-06-19 | The Broad Institute, Inc. | Engineered arc delivery vesicles and uses thereof |
| WO2025250808A1 (en) | 2024-05-29 | 2025-12-04 | The Brigham And Women’S Hospital, Inc. | Anti-crispr delivery compositions and methods |
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| WO1994017832A1 (en) * | 1993-02-09 | 1994-08-18 | The Scripps Research Institute | Targeting and delivery of genes and antiviral agents into cells by the adenovirus penton |
| FR2705686B1 (fr) | 1993-05-28 | 1995-08-18 | Transgene Sa | Nouveaux adénovirus défectifs et lignées de complémentation correspondantes. |
| US5543328A (en) | 1993-08-13 | 1996-08-06 | Genetic Therapy, Inc. | Adenoviruses having modified fiber proteins |
| US5820868A (en) | 1993-12-09 | 1998-10-13 | Veterinary Infectious Disease Organization | Recombinant protein production in bovine adenovirus expression vector system |
| US6312699B1 (en) * | 1994-03-28 | 2001-11-06 | Uab Research Foundation | Ligands added to adenovirus fiber |
| US5846782A (en) * | 1995-11-28 | 1998-12-08 | Genvec, Inc. | Targeting adenovirus with use of constrained peptide motifs |
| DK0787200T3 (da) * | 1994-10-28 | 2005-08-15 | Univ Pennsylvania | Forbedret adenovirus og fremgangsmåder til anvendelse heraf |
| FR2727689A1 (fr) | 1994-12-01 | 1996-06-07 | Transgene Sa | Nouveau procede de preparation d'un vecteur viral |
| US5770442A (en) * | 1995-02-21 | 1998-06-23 | Cornell Research Foundation, Inc. | Chimeric adenoviral fiber protein and methods of using same |
| JP3420586B2 (ja) * | 1995-11-28 | 2003-06-23 | ジェンベク、インコーポレイティッド | 細胞への遣伝子導入のためのベクターおよび方法 |
| WO2001016344A1 (fr) * | 1999-08-27 | 2001-03-08 | Transgene S.A. | Fibre adenovirale modifiee et utilisations |
-
1997
- 1997-04-17 FR FR9704747A patent/FR2761689B1/fr not_active Expired - Fee Related
-
1998
- 1998-04-02 WO PCT/FR1998/000668 patent/WO1998044121A1/fr not_active Ceased
- 1998-04-02 US US09/402,401 patent/US6569677B1/en not_active Expired - Fee Related
- 1998-04-02 AU AU70547/98A patent/AU741728B2/en not_active Ceased
- 1998-04-02 CA CA002285565A patent/CA2285565A1/fr not_active Abandoned
- 1998-04-02 AT AT98917294T patent/ATE305513T1/de not_active IP Right Cessation
- 1998-04-02 ES ES98917294T patent/ES2246533T3/es not_active Expired - Lifetime
- 1998-04-02 DE DE69831741T patent/DE69831741T2/de not_active Expired - Fee Related
- 1998-04-02 DK DK98917294T patent/DK0991763T3/da active
- 1998-04-02 EP EP98917294A patent/EP0991763B1/fr not_active Expired - Lifetime
- 1998-04-02 JP JP54126098A patent/JP2001522236A/ja not_active Ceased
-
2003
- 2003-04-01 US US10/402,954 patent/US7256036B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ATE305513T1 (de) | 2005-10-15 |
| US20030175243A1 (en) | 2003-09-18 |
| JP2001522236A (ja) | 2001-11-13 |
| US6569677B1 (en) | 2003-05-27 |
| FR2761689B1 (fr) | 1999-06-25 |
| DE69831741D1 (de) | 2006-02-09 |
| EP0991763A1 (fr) | 2000-04-12 |
| WO1998044121A1 (fr) | 1998-10-08 |
| AU741728B2 (en) | 2001-12-06 |
| CA2285565A1 (fr) | 1998-10-08 |
| FR2761689A1 (fr) | 1998-10-09 |
| US7256036B2 (en) | 2007-08-14 |
| DK0991763T3 (da) | 2006-02-20 |
| ES2246533T3 (es) | 2006-02-16 |
| EP0991763B1 (fr) | 2005-09-28 |
| AU7054798A (en) | 1998-10-22 |
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