DE69830737D1 - Transgene tiermodelle für herz-hypertrophie und deren verwendungen - Google Patents
Transgene tiermodelle für herz-hypertrophie und deren verwendungenInfo
- Publication number
- DE69830737D1 DE69830737D1 DE69830737T DE69830737T DE69830737D1 DE 69830737 D1 DE69830737 D1 DE 69830737D1 DE 69830737 T DE69830737 T DE 69830737T DE 69830737 T DE69830737 T DE 69830737T DE 69830737 D1 DE69830737 D1 DE 69830737D1
- Authority
- DE
- Germany
- Prior art keywords
- cardiac hypertrophy
- animal models
- transgenic animal
- activity
- gene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 206010007572 Cardiac hypertrophy Diseases 0.000 title abstract 5
- 208000006029 Cardiomegaly Diseases 0.000 title abstract 5
- 238000011820 transgenic animal model Methods 0.000 title 1
- 230000000694 effects Effects 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 102100022789 Calcium/calmodulin-dependent protein kinase type IV Human genes 0.000 abstract 1
- 206010019280 Heart failures Diseases 0.000 abstract 1
- 101000974816 Homo sapiens Calcium/calmodulin-dependent protein kinase type IV Proteins 0.000 abstract 1
- 210000004413 cardiac myocyte Anatomy 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000001969 hypertrophic effect Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/20—Animal model comprising regulated expression system
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/035—Animal model for multifactorial diseases
- A01K2267/0375—Animal model for cardiovascular diseases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
- G01N2333/4701—Details
- G01N2333/4712—Muscle proteins, e.g. myosin, actin, protein
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Environmental Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Biodiversity & Conservation Biology (AREA)
- Heart & Thoracic Surgery (AREA)
- Plant Pathology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Animal Husbandry (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6286497P | 1997-10-16 | 1997-10-16 | |
US62864P | 1997-10-16 | ||
US6517897P | 1997-11-10 | 1997-11-10 | |
US65178P | 1997-11-10 | ||
US8185398P | 1998-04-15 | 1998-04-15 | |
US81853P | 1998-04-15 | ||
US6141798A | 1998-04-16 | 1998-04-16 | |
US61417 | 1998-04-16 | ||
PCT/US1998/021988 WO1999019473A1 (en) | 1997-10-16 | 1998-10-16 | Transgenic animal models for cardiac hypertrophy and uses thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69830737D1 true DE69830737D1 (de) | 2005-08-04 |
DE69830737T2 DE69830737T2 (de) | 2006-06-01 |
Family
ID=27490205
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69830737T Expired - Fee Related DE69830737T2 (de) | 1997-10-16 | 1998-10-16 | Transgene tiermodelle für herz-hypertrophie und deren verwendungen |
Country Status (9)
Country | Link |
---|---|
US (3) | US6201165B1 (de) |
EP (3) | EP1023441A1 (de) |
JP (3) | JP2001520170A (de) |
AT (1) | ATE298793T1 (de) |
AU (2) | AU748334B2 (de) |
CA (2) | CA2306448A1 (de) |
DE (1) | DE69830737T2 (de) |
ES (1) | ES2241173T3 (de) |
WO (2) | WO1999019471A1 (de) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999019471A1 (en) * | 1997-10-16 | 1999-04-22 | Board Of Regents, The University Of Texas System | Models and treatments for cardiac hypertrophy in relation with nf-at3 function |
CA2352599A1 (en) * | 1998-11-24 | 2000-06-02 | Gerald R. Crabtree | Nf-at mediates cardiac hypertrophy, methods and reagents related thereto |
ATE422556T1 (de) * | 1999-08-20 | 2009-02-15 | Univ Texas | Hdac4- und hdac5-abhängige regulation der genexpression im herzen |
US20070032853A1 (en) | 2002-03-27 | 2007-02-08 | Hossainy Syed F | 40-O-(2-hydroxy)ethyl-rapamycin coated stent |
JP2003534809A (ja) * | 2000-05-30 | 2003-11-25 | メディジェーン アクチェンゲゼルシャフト | 心臓病のための新規ターゲット遺伝子 |
JP2002078483A (ja) * | 2000-06-28 | 2002-03-19 | Takeda Chem Ind Ltd | 心筋細胞の調製法および心疾患治療薬の探索法 |
EP2090663A3 (de) * | 2000-06-28 | 2009-11-11 | Takeda Pharmaceutical Company Limited | Verfahren zur Herstellung von Herzmuskelzellen und Verfahren zum Suchen von Abhilfen für Herzkrankheiten |
US7629308B2 (en) | 2000-07-07 | 2009-12-08 | Board Of Regents, The University Of Texas System | Methods relating to muscle selective calcineurin interacting protein (MCIP) |
US8568766B2 (en) | 2000-08-24 | 2013-10-29 | Gattadahalli M. Anantharamaiah | Peptides and peptide mimetics to treat pathologies associated with eye disease |
WO2002046419A2 (en) * | 2000-11-07 | 2002-06-13 | Board Of Regents, The University Of Texas System | Methods and compositions relating to muscle specific sarcomeric calcineurin-binding proteins (calsarcins) |
US7327862B2 (en) * | 2001-04-30 | 2008-02-05 | Chase Medical, L.P. | System and method for facilitating cardiac intervention |
US7526112B2 (en) * | 2001-04-30 | 2009-04-28 | Chase Medical, L.P. | System and method for facilitating cardiac intervention |
DE10126371A1 (de) * | 2001-05-30 | 2003-02-27 | Medigene Ag | Verfahren zur Identifizierung von Substanzen gegen Herzmuskelzellen-Hypertrophie |
EP1605262A1 (de) * | 2001-09-27 | 2005-12-14 | Board Of Regents The University Of Texas System | Methode zur Idenfitikation von Inhibitoren der Herzhypertrophie |
US20030186289A1 (en) * | 2002-01-22 | 2003-10-02 | Myogen, Inc. | Model cell systems for screening of anti-hypertrophic therapeutics |
US20030221207A1 (en) * | 2002-02-13 | 2003-11-27 | Pharmacia Corporation, Global Patent Department | Cardiac-specific 11beta hydroxysteroid dehydrogenase type 2 transgenic mice |
US20040106647A1 (en) * | 2002-06-28 | 2004-06-03 | Schneider Michael D. | Modulators of Cdk9 as a therapeutic target in cardiac hypertrophy |
US20040082613A1 (en) * | 2002-06-28 | 2004-04-29 | Schneider Michael D. | Modulators of Cdk9 as a therapeutic target in cardiac hypertrophy |
EP3254673A1 (de) | 2002-11-13 | 2017-12-13 | The UAB Research Foundation | Apolipoprotein e-imitierende synthetische einzeldomäne-polypeptide und anwendungsverfahren |
EP1593087A4 (de) * | 2003-01-30 | 2006-10-04 | Chase Medical Lp | Verfahren und system zur bildverarbeitung und konturbewertung |
US20040229360A1 (en) * | 2003-03-13 | 2004-11-18 | Jeffrey Robbins | Cardiac-preferred genetic alteration of transgenic rabbits |
US20050118344A1 (en) | 2003-12-01 | 2005-06-02 | Pacetti Stephen D. | Temperature controlled crimping |
US7951532B2 (en) * | 2003-11-12 | 2011-05-31 | Children's Hospital Medical Center | Method of screening a midkine modulating agent |
US7333643B2 (en) * | 2004-01-30 | 2008-02-19 | Chase Medical, L.P. | System and method for facilitating cardiac intervention |
EP1740945B1 (de) | 2004-04-07 | 2018-09-19 | Ncardia AG | Nichtinvasive, in-vitro-funktionelle gewebetestsysteme |
US8318488B1 (en) | 2004-05-11 | 2012-11-27 | Axiogenesis Ag | Assay for drug discovery based on in vitro differentiated cells |
JP4682310B2 (ja) * | 2004-12-28 | 2011-05-11 | 独立行政法人産業技術総合研究所 | 天然型l−システインまたはその誘導体を用いたホタル発光基質の生合成システム及び本システムを含んだ発光基質溶液 |
ES2387682T3 (es) * | 2005-01-10 | 2012-09-28 | Debiopharm S.A. | Utilización de un undecapéptido cíclico para la preparación de un medicamento administrable durante situaciones isquémicas miocárdicas |
EP1945242A2 (de) * | 2005-07-22 | 2008-07-23 | The Regents of the University of Colorado, A Body Corporate | Hemmung von extrazellulärer signalregulierter kinase 1/2 als behandlung von herzhypertrophie und herzinsuffizienz |
CA2623106C (en) | 2005-09-19 | 2013-12-24 | Histogenics Corporation | Cell-support matrix having narrowly defined uniformly vertically and non-randomly organized porosity and pore density and a method for preparation thereof |
JP2010514790A (ja) * | 2006-12-28 | 2010-05-06 | リメリック バイオファーマ, インコーポレイテッド | 治療処置のための方法および組成物 |
CA2693338A1 (en) * | 2007-07-31 | 2009-02-05 | Limerick Biopharma, Inc. | Phosphorylated pyrone analogs and methods |
US8557767B2 (en) | 2007-08-28 | 2013-10-15 | Uab Research Foundation | Synthetic apolipoprotein E mimicking polypeptides and methods of use |
WO2009032693A2 (en) | 2007-08-28 | 2009-03-12 | Uab Research Foundation | Synthetic apolipoprotein e mimicking polypeptides and methods of use |
US20110218253A1 (en) * | 2010-01-26 | 2011-09-08 | Lange Nicholas T | Imaging-based identification of a neurological disease or a neurological disorder |
EP3189069B1 (de) | 2014-07-31 | 2024-10-23 | UAB Research Foundation | Apoe-mimetische peptide und erhöhte wirksamkeit für klares plasmacholesterol |
WO2016085876A1 (en) | 2014-11-25 | 2016-06-02 | The Broad Institute Inc. | Clonal haematopoiesis |
EP3224381B1 (de) | 2014-11-25 | 2019-09-04 | The Brigham and Women's Hospital, Inc. | Verfahren zur identifizierung von personen mit einer prädisposition für eine kardiometabolische krankheit oder davon betroffenen personen |
US10077420B2 (en) | 2014-12-02 | 2018-09-18 | Histogenics Corporation | Cell and tissue culture container |
KR102634017B1 (ko) * | 2018-10-26 | 2024-02-05 | 고려대학교 산학협력단 | 심비대증 동물 모델 제작용 재조합 벡터, 상기 재조합 벡터로 형질전환된 심비대증 동물 모델 및 이의 제작 방법 |
US20230134859A1 (en) * | 2020-03-31 | 2023-05-04 | Sky Pharma Co., Ltd. | Method for screening for, method for producing, and method for designing drug active ingredients |
AU2022408189A1 (en) * | 2021-12-10 | 2024-06-20 | Aavantibio, Inc. | Methods and compositions for treating mybpc3 related hypertrophic cardiomyopathy with a viral vector |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
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US4987071A (en) | 1986-12-03 | 1991-01-22 | University Patents, Inc. | RNA ribozyme polymerases, dephosphorylases, restriction endoribonucleases and methods |
ES2059558T3 (es) | 1987-06-17 | 1994-11-16 | Sandoz Ag | Ciclosporins y su uso como productos farmaceuticos. |
US5284826A (en) | 1989-07-24 | 1994-02-08 | Sandoz Ltd. | 0-hydroxyethyl and acyloxyethyl derivatives of [ser]8 cyclosporins |
GB9113872D0 (en) | 1991-06-27 | 1991-08-14 | Sandoz Ag | Improvements in or relating to organic compounds |
TW215434B (de) | 1992-03-07 | 1993-11-01 | Hoechst Ag | |
GB9206874D0 (en) | 1992-03-30 | 1992-05-13 | Connaught Lab | Generation of improved inducible mammalian expression vectors |
CA2135646A1 (en) | 1992-05-11 | 1993-11-25 | Kenneth G. Draper | Method and reagent for inhibiting viral replication |
WO1994021634A1 (en) | 1993-03-17 | 1994-09-29 | Abbott Laboratories | Substituted alicyclic-aliphatic amine-containing macrocyclic immunomodulators |
MY110603A (en) | 1993-05-27 | 1998-08-29 | Novartis Ag | Tetrahydropyran derivatives |
US5589362A (en) | 1993-06-14 | 1996-12-31 | Basf Aktiengesellschaft | Tetracycline regulated transcriptional modulators with altered DNA binding specificities |
US5866755A (en) | 1993-06-14 | 1999-02-02 | Basf Aktiengellschaft | Animals transgenic for a tetracycline-regulated transcriptional inhibitor |
EP0705334A1 (de) | 1993-06-14 | 1996-04-10 | Basf Aktiengesellschaft | Strenge kontrolle der genexpression in eukaryotischen zellen durch auf tetrazyklin ansprechende promotoren |
WO1995032726A1 (en) | 1994-06-01 | 1995-12-07 | Yuhan Corporation | Cyclosporin containing composition and process for the preparation thereof |
AU682703B2 (en) | 1994-06-13 | 1997-10-16 | Alza Corporation | Dosage form for administering drug in liquid formulation |
US5612455A (en) * | 1994-07-05 | 1997-03-18 | Tularik, Inc. | Nuclear factors and binding assay |
IE75744B1 (en) | 1995-04-03 | 1997-09-24 | Elan Corp Plc | Controlled release biodegradable micro- and nanospheres containing cyclosporin |
SG68529A1 (en) * | 1995-05-25 | 1999-11-16 | Univ Singapore | The use of des-aspartate-angiotensin i (agr-val-tyr-ile-his-pro-phe-his-leu) as an anti-cardiac hypertrophic agent |
BR9606603A (pt) | 1995-08-25 | 1997-09-30 | Sangstat Medical Corp | Formulação de ciclosporina dispersão aquosa de nanopartículas de ciclosporina kit e processo de preparação de dispersão aquosa de partículas de ciclosporina |
WO1997040163A1 (en) | 1996-04-19 | 1997-10-30 | Metin Colpan | Nucleic acid vaccination for parvoviral infections |
US6147080A (en) | 1996-12-18 | 2000-11-14 | Vertex Pharmaceuticals Incorporated | Inhibitors of p38 |
AU733883B2 (en) | 1997-02-04 | 2001-05-31 | Bristol-Myers Squibb Company | Dihydropyrimidone derivatives as NPY antagonists |
WO1999019471A1 (en) * | 1997-10-16 | 1999-04-22 | Board Of Regents, The University Of Texas System | Models and treatments for cardiac hypertrophy in relation with nf-at3 function |
-
1998
- 1998-10-15 WO PCT/US1998/021845 patent/WO1999019471A1/en not_active Application Discontinuation
- 1998-10-15 EP EP98952333A patent/EP1023441A1/de not_active Ceased
- 1998-10-15 CA CA002306448A patent/CA2306448A1/en not_active Abandoned
- 1998-10-15 JP JP2000516024A patent/JP2001520170A/ja active Pending
- 1998-10-15 AU AU98058/98A patent/AU748334B2/en not_active Ceased
- 1998-10-15 US US09/173,798 patent/US6201165B1/en not_active Expired - Lifetime
- 1998-10-15 US US09/173,799 patent/US6657104B1/en not_active Expired - Fee Related
- 1998-10-15 US US09/173,795 patent/US6673768B1/en not_active Expired - Fee Related
- 1998-10-16 EP EP98953672A patent/EP1025216B1/de not_active Expired - Lifetime
- 1998-10-16 ES ES98953672T patent/ES2241173T3/es not_active Expired - Lifetime
- 1998-10-16 AT AT98953672T patent/ATE298793T1/de not_active IP Right Cessation
- 1998-10-16 WO PCT/US1998/021988 patent/WO1999019473A1/en active IP Right Grant
- 1998-10-16 JP JP2000516026A patent/JP2001520010A/ja active Pending
- 1998-10-16 AU AU10992/99A patent/AU755428B2/en not_active Ceased
- 1998-10-16 CA CA002315244A patent/CA2315244A1/en not_active Abandoned
- 1998-10-16 EP EP05011835A patent/EP1645634A3/de not_active Withdrawn
- 1998-10-16 DE DE69830737T patent/DE69830737T2/de not_active Expired - Fee Related
-
2008
- 2008-06-02 JP JP2008145190A patent/JP2008253274A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
AU9805898A (en) | 1999-05-03 |
WO1999019473A1 (en) | 1999-04-22 |
AU755428B2 (en) | 2002-12-12 |
CA2306448A1 (en) | 1999-04-22 |
EP1025216A1 (de) | 2000-08-09 |
EP1025216B1 (de) | 2005-06-29 |
JP2001520010A (ja) | 2001-10-30 |
US6201165B1 (en) | 2001-03-13 |
JP2008253274A (ja) | 2008-10-23 |
US6673768B1 (en) | 2004-01-06 |
AU748334B2 (en) | 2002-05-30 |
AU1099299A (en) | 1999-05-03 |
EP1645634A2 (de) | 2006-04-12 |
US6657104B1 (en) | 2003-12-02 |
WO1999019471A1 (en) | 1999-04-22 |
ES2241173T3 (es) | 2005-10-16 |
JP2001520170A (ja) | 2001-10-30 |
EP1645634A3 (de) | 2009-06-17 |
ATE298793T1 (de) | 2005-07-15 |
DE69830737T2 (de) | 2006-06-01 |
EP1023441A1 (de) | 2000-08-02 |
CA2315244A1 (en) | 1999-04-22 |
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