DE69826281D1 - Benzo[5,6]cyclohepta[1,2b]pyridine derivate anwendbar als farnesyl protein transferase inhibitoren - Google Patents

Benzo[5,6]cyclohepta[1,2b]pyridine derivate anwendbar als farnesyl protein transferase inhibitoren

Info

Publication number
DE69826281D1
DE69826281D1 DE69826281T DE69826281T DE69826281D1 DE 69826281 D1 DE69826281 D1 DE 69826281D1 DE 69826281 T DE69826281 T DE 69826281T DE 69826281 T DE69826281 T DE 69826281T DE 69826281 D1 DE69826281 D1 DE 69826281D1
Authority
DE
Germany
Prior art keywords
aryl
alkyl
aralkyl
heteroaryl
protein transferase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69826281T
Other languages
English (en)
Other versions
DE69826281T2 (de
Inventor
G Taveras
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme Corp
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of DE69826281D1 publication Critical patent/DE69826281D1/de
Application granted granted Critical
Publication of DE69826281T2 publication Critical patent/DE69826281T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE69826281T 1997-06-17 1998-06-15 Benzo[5,6]cyclohepta[1,2b]pyridine derivate anwendbar als farnesyl protein transferase inhibitoren Expired - Lifetime DE69826281T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US87767397A 1997-06-17 1997-06-17
US877673 1997-06-17
PCT/US1998/011498 WO1998057962A1 (en) 1997-06-17 1998-06-15 Benzo(5,6)cyclohepta(1,2b)pyridine derivatives useful for inhibition of farnesyl protein transferase

Publications (2)

Publication Number Publication Date
DE69826281D1 true DE69826281D1 (de) 2004-10-21
DE69826281T2 DE69826281T2 (de) 2005-11-17

Family

ID=25370476

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69826281T Expired - Lifetime DE69826281T2 (de) 1997-06-17 1998-06-15 Benzo[5,6]cyclohepta[1,2b]pyridine derivate anwendbar als farnesyl protein transferase inhibitoren

Country Status (14)

Country Link
EP (1) EP0993460B1 (de)
JP (1) JP2002504147A (de)
KR (1) KR20010013828A (de)
CN (1) CN1172932C (de)
AT (1) ATE276247T1 (de)
AU (1) AU753533B2 (de)
CA (1) CA2293372C (de)
DE (1) DE69826281T2 (de)
ES (1) ES2226142T3 (de)
HK (1) HK1028238A1 (de)
HU (1) HUP0004806A3 (de)
IL (1) IL133390A0 (de)
NZ (1) NZ501615A (de)
WO (1) WO1998057962A1 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA05006354A (es) * 2002-12-13 2005-08-26 Smithkline Beecham Corp Antagonistas ccr5 como agentes terapeuticos.
DE10334493B4 (de) * 2003-07-29 2006-01-05 Klingelnberg Gmbh Verfahren zum Fräsen von Spiralkegelrädern
EP3741745B1 (de) 2018-01-19 2023-04-26 Yuki Gosei Kogyo Co., Ltd. Verfahren zur herstellung eines n-alkoxycarbonylpiperidinderivats und zwischenprodukt dafür

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5089496A (en) * 1986-10-31 1992-02-18 Schering Corporation Benzo[5,6]cycloheptapyridine compounds, compositions and method of treating allergies
ES2056214T3 (es) * 1988-04-28 1994-10-01 Schering Corp Compuestos de benzopirido-piperidina, -piperidilideno y -piperazina, composiciones, metodos de preparacion y metodos de uso.
IL111235A (en) * 1993-10-15 2001-03-19 Schering Plough Corp Medicinal preparations for inhibiting protein G activity and for the treatment of malignant diseases, containing tricyclic compounds, some such new compounds and a process for the preparation of some of them
US5719148A (en) * 1993-10-15 1998-02-17 Schering Corporation Tricyclic amide and urea compounds useful for inhibition of g-protein function and for treatment of proliferative diseases

Also Published As

Publication number Publication date
HK1028238A1 (en) 2001-02-09
CN1267298A (zh) 2000-09-20
ES2226142T3 (es) 2005-03-16
NZ501615A (en) 2002-02-01
JP2002504147A (ja) 2002-02-05
HUP0004806A2 (hu) 2001-10-28
KR20010013828A (ko) 2001-02-26
CN1172932C (zh) 2004-10-27
DE69826281T2 (de) 2005-11-17
WO1998057962A1 (en) 1998-12-23
CA2293372C (en) 2009-01-13
HUP0004806A3 (en) 2002-11-28
EP0993460B1 (de) 2004-09-15
EP0993460A1 (de) 2000-04-19
AU7815398A (en) 1999-01-04
ATE276247T1 (de) 2004-10-15
IL133390A0 (en) 2001-04-30
CA2293372A1 (en) 1998-12-23
AU753533B2 (en) 2002-10-17

Similar Documents

Publication Publication Date Title
CA2161542A1 (en) Novel 5-Pyrrolyl-2-Pyridylmethylsulfinyl Benzimidazole Derivatives
ES2044836T3 (es) Derivado de la piperidina, su utilizacion y compuesto farmaceutico que lo contiene.
NO912821D0 (no) Fremgangsmaate for fremstilling av tioalkyltiocefalosporinderivater.
PL309874A1 (en) Novel derivatives of pyrrolocarbasol, method of obtaining them and pharmaceutical composition containing such derivatives
EA200100090A2 (ru) Новые пиперидин-4-сульфонамидные производные, способ их получения и содержащие их фармацевтические композиции
ATE356816T1 (de) Trizyklische keto amid derivative als farnesyl protein transferase inhibitoren
DE69826281D1 (de) Benzo[5,6]cyclohepta[1,2b]pyridine derivate anwendbar als farnesyl protein transferase inhibitoren
HUP0001129A2 (hu) Eljárás 2-alkil-3-aminotiofén-származékok előállítására és új 3-aminotiofén-származékok
ATE219486T1 (de) Trizyklische indol-2-carbonsäure derivate als selektive nmda rezeptor antagonisten
ATE504572T1 (de) Derivate von aromatische heterocyclen enthaltende integraseinhibitoren
ATE237611T1 (de) Cyclische harnstoff- und lactamderivate von benzo(5,6)cycloheptapyridinen zur verwendung als farnesyl-protein-transferase-hemmer
ATE218137T1 (de) Benzo(5,6)cyclohepta(1,2-b)pyridin derivate als farnesyl protein transferase inhibitoren
DE69826301D1 (de) Benzo[5,6]cyclohepta[1,2-b]pyridin derivate anwendbar als farnesyl protein tranferase inhibitoren
DE69817826D1 (de) Benzo[5,6]cyclohepta[1,2b]pyridine derivate anwendbar als farnesyl protein transferase inhibitoren
AU2002214320A1 (en) Imidazole derivatives, process for their preparation and their use
AU4666289A (en) Imidazolyl and pyridyl derivatives of phenyl substituted 1,4-dihydro-pyridines and process for their preparation
BG102429A (en) Derivatives of 5-naphthalen-1-yl-1,3-dioxan, their preparation and usage as therapeutical means
DE69231244D1 (de) Pyrazolothiazolopyrimidin-derivate
ATE247106T1 (de) Substituierte benzocycloheptapyridine derivate verwendbar als farnesyl protein transferase inhibitoren

Legal Events

Date Code Title Description
8364 No opposition during term of opposition