DE69826263D1 - Sonodynamische therapie mit ultraschalsensibilisator - Google Patents

Sonodynamische therapie mit ultraschalsensibilisator

Info

Publication number
DE69826263D1
DE69826263D1 DE69826263T DE69826263T DE69826263D1 DE 69826263 D1 DE69826263 D1 DE 69826263D1 DE 69826263 T DE69826263 T DE 69826263T DE 69826263 T DE69826263 T DE 69826263T DE 69826263 D1 DE69826263 D1 DE 69826263D1
Authority
DE
Germany
Prior art keywords
sonodynamic therapy
sensitizer
sensitizer agent
ultrasonic
ultrasonic sensitizer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69826263T
Other languages
English (en)
Other versions
DE69826263T2 (de
Inventor
Alan Alfheim
Mark Henrichs
Paul Hohenschuh
Wilhelm Johannesen
Anthony Sanderson
Allen Snow
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GE Healthcare AS
Original Assignee
Amersham Health AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amersham Health AS filed Critical Amersham Health AS
Application granted granted Critical
Publication of DE69826263D1 publication Critical patent/DE69826263D1/de
Publication of DE69826263T2 publication Critical patent/DE69826263T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0028—Disruption, e.g. by heat or ultrasounds, sonophysical or sonochemical activation, e.g. thermosensitive or heat-sensitive liposomes, disruption of calculi with a medicinal preparation and ultrasounds
    • A61K41/0033—Sonodynamic cancer therapy with sonochemically active agents or sonosensitizers, having their cytotoxic effects enhanced through application of ultrasounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Semiconductor Lasers (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DE69826263T 1997-05-19 1998-05-19 Sonodynamische therapie mit ultraschalsensibilisator Expired - Lifetime DE69826263T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9710049 1997-05-19
GBGB9710049.9A GB9710049D0 (en) 1997-05-19 1997-05-19 Method
PCT/GB1998/001444 WO1998052609A1 (en) 1997-05-19 1998-05-19 Sonodynamic therapy using an ultrasound sensitizer compound

Publications (2)

Publication Number Publication Date
DE69826263D1 true DE69826263D1 (de) 2004-10-21
DE69826263T2 DE69826263T2 (de) 2005-10-27

Family

ID=10812481

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69826263T Expired - Lifetime DE69826263T2 (de) 1997-05-19 1998-05-19 Sonodynamische therapie mit ultraschalsensibilisator

Country Status (8)

Country Link
US (1) US6498945B1 (de)
EP (1) EP0979104B1 (de)
JP (1) JP4503103B2 (de)
AT (1) ATE275971T1 (de)
AU (1) AU7443898A (de)
DE (1) DE69826263T2 (de)
GB (1) GB9710049D0 (de)
WO (1) WO1998052609A1 (de)

Families Citing this family (126)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6593148B1 (en) * 1994-03-01 2003-07-15 Li-Cor, Inc. Cyanine dye compounds and labeling methods
JPH10279502A (ja) * 1997-03-31 1998-10-20 Katsuro Tachibana 光感受性物質の励起方法
WO1999062551A1 (en) * 1998-06-05 1999-12-09 Board Of Regents, The University Of Texas System Texaphyrin conjugates and uses thereof
CA2335808A1 (en) * 1998-07-06 2000-01-13 David Kessel Intracellular sensitizers for sonodynamic therapy
JP2000095758A (ja) 1998-09-18 2000-04-04 Schering Ag 近赤外蛍光造影剤および蛍光造影方法
US20030180221A1 (en) * 1998-09-18 2003-09-25 Schering Ag Near infrared fluorescent contrast agent and fluorescence imaging
US7547721B1 (en) 1998-09-18 2009-06-16 Bayer Schering Pharma Ag Near infrared fluorescent contrast agent and fluorescence imaging
DE60026313D1 (de) 1999-07-23 2006-04-27 Uutech Ltd Sensibilisierung von roten blutkörperchen gegenüber ultraschall durch einwirkung eines elektrischen feldes
US6915154B1 (en) * 1999-09-24 2005-07-05 National Research Council Of Canada Method and apparatus for performing intra-operative angiography
US20050182434A1 (en) 2000-08-11 2005-08-18 National Research Council Of Canada Method and apparatus for performing intra-operative angiography
US7897140B2 (en) 1999-12-23 2011-03-01 Health Research, Inc. Multi DTPA conjugated tetrapyrollic compounds for phototherapeutic contrast agents
DE10016559A1 (de) * 2000-04-03 2001-10-18 Eucro Europe Contract Res Gmbh System für den Transport von Aktivstoffen in einem biologischen System
US7597878B2 (en) * 2000-09-19 2009-10-06 Li-Cor, Inc. Optical fluorescent imaging
EP1319047B1 (de) 2000-09-19 2006-01-04 Li-Cor, Inc. Cyaninfarbstoffe
US7003345B1 (en) * 2000-10-17 2006-02-21 Lucid, Inc. System and method for enhancing microscope images of tissue using citric acid and agents of the like
US7139122B1 (en) * 2000-10-17 2006-11-21 Lucid, Inc. System and method for enhancing confocal reflectance images of tissue specimens
US6627664B2 (en) * 2001-01-30 2003-09-30 Altachem Pharma Ltd. Perylenequinones for use as sonosensitizers
CN1665535A (zh) * 2001-01-30 2005-09-07 阿尔塔切姆法尔马有限公司 和免疫治疗剂联合使用的苝醌
US6884797B2 (en) * 2001-03-30 2005-04-26 Robert F. Hofmann Targeted oxidative therapeutic formulation
US20030109824A1 (en) * 2001-11-07 2003-06-12 Microvena Corporation Distal protection device with local drug delivery to maintain patency
DE60210254D1 (de) * 2002-01-29 2006-05-18 Altachem Pharma Ltd Aminosubstituierter hypocrelline zur verwendung als sonosensitizer
US20040133112A1 (en) * 2002-03-08 2004-07-08 Milind Rajadhyaksha System and method for macroscopic and confocal imaging of tissue
AU2003248747A1 (en) 2002-06-27 2004-01-19 Health Research, Inc. Fluorinated chlorin and bacteriochlorin photosensitizers for photodynamic therapy
KR20050103907A (ko) * 2003-01-24 2005-11-01 쉐링 악티엔게젤샤프트 형광 진단을 위한 친수성의 티올-반응성 시아닌 염료 및그의 생체분자와의 접합체
EP1668575A4 (de) * 2003-04-07 2006-11-08 Silverbrook Res Pty Ltd Werbung auf standortbasis
US20050048109A1 (en) * 2003-08-26 2005-03-03 Ceramoptec Industries, Inc. Non-polar photosensitizer formulations for photodynamic therapy
US8986731B2 (en) * 2003-08-26 2015-03-24 Biolitec Pharma Marketing Ltd Pegylated liposomal formulations of hydrophobic photosensitizers for photodynamic therapy
US20080119421A1 (en) * 2003-10-31 2008-05-22 Jack Tuszynski Process for treating a biological organism
US20050095197A1 (en) * 2003-10-31 2005-05-05 Tuszynski Jack A. Anti-mitotic compound
US20070149496A1 (en) * 2003-10-31 2007-06-28 Jack Tuszynski Water-soluble compound
US7662114B2 (en) * 2004-03-02 2010-02-16 Focus Surgery, Inc. Ultrasound phased arrays
WO2006104510A2 (en) * 2004-08-20 2006-10-05 Technology Innovations, Llc Water-soluble compound
CA2584299A1 (en) * 2004-10-19 2006-04-27 Joe Z. Sostaric Methods and compositions for protecting cells from ultrasound-mediated cytolysis
US20060239921A1 (en) 2005-04-26 2006-10-26 Novadaq Technologies Inc. Real time vascular imaging during solid organ transplant
US20070134340A1 (en) * 2005-06-20 2007-06-14 Prasad Paras N Method for delivering hydrophobic drugs via nanocrystal formulations
US7720267B2 (en) * 2005-07-15 2010-05-18 Siemens Medical Solutions Usa, Inc. Method and apparatus for classifying tissue using image data
AU2006279189B2 (en) 2005-08-10 2011-08-04 Quest Pharmatech Inc. Perylenequinone derivatives and uses thereof
EP1933941A2 (de) 2005-08-25 2008-06-25 Philip R. Houle Behandlungssysteme zur abgabe von sensibilisatorlösungen
US20070122344A1 (en) 2005-09-02 2007-05-31 University Of Rochester Medical Center Office Of Technology Transfer Intraoperative determination of nerve location
US20070154538A1 (en) * 2005-12-29 2007-07-05 Ceramoptec Gmbh Removal of fat cells by PDT
US20070208331A1 (en) * 2006-03-02 2007-09-06 Chu Michael S Systems and methods of treatment within a gastrointestinal lumen
US8454991B2 (en) 2006-07-24 2013-06-04 Quest Pharmatech Inc. Method and device for photodynamic therapy
EP2051776A2 (de) * 2006-08-09 2009-04-29 Koninklijke Philips Electronics N.V. Vorrichtung und verfahren zur aktivierung einer physiologisch effektiven substanz durch ultraschallwellen, sowie kapsel
US20080161744A1 (en) 2006-09-07 2008-07-03 University Of Rochester Medical Center Pre-And Intra-Operative Localization of Penile Sentinel Nodes
WO2008042855A2 (en) * 2006-09-29 2008-04-10 The Trustees Of The University Of Pennsylvania Use of ultrasound as an antivascular agent
DE102006054523B4 (de) * 2006-11-20 2009-07-23 Novaled Ag Dithiolenübergangsmetallkomplexe und Selen-analoge Verbindungen, deren Verwendung als Dotand, organisches halbleitendes Material enthaltend die Komplexe, sowie elektronische oder optoelektronisches Bauelement enthaltend einen Komplex
EP2993197A1 (de) * 2006-11-29 2016-03-09 Sun Chemical Corporation Phthalocyaninfarbstoffe und deren verwendung als fluoreszierende sicherheitsmarkierungsmittel
US20090062724A1 (en) * 2007-08-31 2009-03-05 Rixen Chen System and apparatus for sonodynamic therapy
EP2036577A1 (de) 2007-09-14 2009-03-18 mivenion GmbH Diagnostische Stoffe für die optische bildgebende Untersuchung auf der Basis von nanopartikulären Formulierungen
JP5643101B2 (ja) 2007-10-25 2014-12-17 ワシントン・ユニバーシティＷａｓｈｉｎｇｔｏｎ Ｕｎｉｖｅｒｓｉｔｙ 散乱媒体の画像化方法、画像化装置及び画像化システム
WO2009065065A1 (en) * 2007-11-15 2009-05-22 Ceramoptec Industries, Inc. Pegylated liposomal formulations for photodynamic treatment of inflammatory diseases
EP2224963A1 (de) * 2007-11-19 2010-09-08 CeramOptec GmbH Pegylierte verbindungen für altersbedingte makuladegeneration
US8406860B2 (en) 2008-01-25 2013-03-26 Novadaq Technologies Inc. Method for evaluating blush in myocardial tissue
US10219742B2 (en) 2008-04-14 2019-03-05 Novadaq Technologies ULC Locating and analyzing perforator flaps for plastic and reconstructive surgery
EP2285421B1 (de) 2008-05-02 2018-04-11 Novadaq Technologies ULC Verfahren zur herstellung und verwendung substanzbeladener erythrozyten zur beobachtung und behandlung von mikrovaskulärer hämodynamik
GB0820309D0 (en) * 2008-11-06 2008-12-17 Middlesex University Higher Ed Detection of cancer
WO2010080991A2 (en) 2009-01-09 2010-07-15 Washington University In St. Louis Miniaturized photoacoustic imaging apparatus including a rotatable reflector
US20100178245A1 (en) * 2009-01-13 2010-07-15 Arnsdorf Morton F Biocompatible Microbubbles to Deliver Radioactive Compounds to Tumors, Atherosclerotic Plaques, Joints and Other Targeted Sites
US10492671B2 (en) 2009-05-08 2019-12-03 Novadaq Technologies ULC Near infra red fluorescence imaging for visualization of blood vessels during endoscopic harvest
US9086365B2 (en) 2010-04-09 2015-07-21 Lihong Wang Quantification of optical absorption coefficients using acoustic spectra in photoacoustic tomography
US8997572B2 (en) 2011-02-11 2015-04-07 Washington University Multi-focus optical-resolution photoacoustic microscopy with ultrasonic array detection
US8974830B2 (en) 2012-02-23 2015-03-10 Canon Kabushiki Kaisha Particles and contrast agent including the same for optical imaging
US9138492B2 (en) 2012-02-23 2015-09-22 Canon Kabushiki Kaisha Particle containing hydrophobic dye having cyanine structure, and contrast agent containing the particle
CA2914778A1 (en) 2012-06-21 2013-12-27 Novadaq Technologies Inc. Quantification and analysis of angiography and perfusion
EP3494997B1 (de) 2012-07-25 2019-09-18 The Broad Institute, Inc. Induzierbare dns-bindende proteine und genomperturbationstools sowie anwendungen davon
WO2014063005A1 (en) 2012-10-18 2014-04-24 Washington University Transcranialphotoacoustic/thermoacoustic tomography brain imaging informed by adjunct image data
WO2014139012A1 (en) 2013-03-15 2014-09-18 Suncor Energy Inc. Herbicidal compositions
WO2015077355A1 (en) 2013-11-19 2015-05-28 Washington University Systems and methods of grueneisen-relaxation photoacoustic microscopy and photoacoustic wavefront shaping
WO2016049756A1 (en) 2014-09-29 2016-04-07 Novadaq Technologies Inc. Imaging a target fluorophore in a biological material in the presence of autofluorescence
WO2016055837A1 (en) 2014-10-09 2016-04-14 Novadaq Technologies Inc. Quantification of absolute blood flow in tissue using fluorescence-mediated photoplethysmography
WO2016094874A1 (en) 2014-12-12 2016-06-16 The Broad Institute Inc. Escorted and functionalized guides for crispr-cas systems
TWI813532B (zh) 2015-06-18 2023-09-01 美商博得學院股份有限公司 降低脱靶效應的ｃｒｉｓｐｒ酶突變
WO2017106657A1 (en) 2015-12-18 2017-06-22 The Broad Institute Inc. Novel crispr enzymes and systems
WO2017189308A1 (en) 2016-04-19 2017-11-02 The Broad Institute Inc. Novel crispr enzymes and systems
EP3445853A1 (de) 2016-04-19 2019-02-27 The Broad Institute, Inc. Cpf1-komplexe mit reduzierter indelaktivität
SG11201810179RA (en) 2016-04-19 2018-12-28 Broad Inst Inc Novel crispr enzymes and systems
WO2018005873A1 (en) 2016-06-29 2018-01-04 The Broad Institute Inc. Crispr-cas systems having destabilization domain
EP3580609B1 (de) 2017-02-10 2023-05-24 Stryker European Operations Limited Handhaltbare offenfeld-fluoreszenzbildgebungssysteme und verfahren
US11963966B2 (en) 2017-03-31 2024-04-23 Dana-Farber Cancer Institute, Inc. Compositions and methods for treating ovarian tumors
US20200071773A1 (en) 2017-04-12 2020-03-05 Massachusetts Eye And Ear Infirmary Tumor signature for metastasis, compositions of matter methods of use thereof
WO2018209046A1 (en) 2017-05-10 2018-11-15 Washington University Snapshot photoacoustic photography using an ergodic relay
GB201708663D0 (en) * 2017-05-31 2017-07-12 Univ Ulster Therapy
WO2018232195A1 (en) 2017-06-14 2018-12-20 The Broad Institute, Inc. Compositions and methods targeting complement component 3 for inhibiting tumor growth
CN111328290A (zh) 2017-06-26 2020-06-23 博德研究所 用于靶向核酸编辑的基于crispr/cas-腺嘌呤脱氨酶的组合物、系统和方法
WO2019050963A1 (en) * 2017-09-05 2019-03-14 University Of Pittsburgh -Of The Commonwealth System Of Higher Education SONODYNAMIC THERAPY USING MICROBULLES AND METHODS AND SYSTEMS ULTRASOUNDED WITH PULSED WAVES
US11618896B2 (en) 2017-09-21 2023-04-04 The Broad Institute, Inc. Systems, methods, and compositions for targeted nucleic acid editing
EP3692152A4 (de) 2017-10-04 2021-12-01 The Broad Institute, Inc. Verfahren und zusammensetzungen zur veränderung der funktion und struktur von chromatinschleifen und/oder -domänen
WO2019094983A1 (en) 2017-11-13 2019-05-16 The Broad Institute, Inc. Methods and compositions for treating cancer by targeting the clec2d-klrb1 pathway
US11332736B2 (en) 2017-12-07 2022-05-17 The Broad Institute, Inc. Methods and compositions for multiplexing single cell and single nuclei sequencing
US11994512B2 (en) 2018-01-04 2024-05-28 Massachusetts Institute Of Technology Single-cell genomic methods to generate ex vivo cell systems that recapitulate in vivo biology with improved fidelity
US11957695B2 (en) 2018-04-26 2024-04-16 The Broad Institute, Inc. Methods and compositions targeting glucocorticoid signaling for modulating immune responses
US20210147831A1 (en) 2018-04-27 2021-05-20 The Broad Institute, Inc. Sequencing-based proteomics
WO2019232542A2 (en) 2018-06-01 2019-12-05 Massachusetts Institute Of Technology Methods and compositions for detecting and modulating microenvironment gene signatures from the csf of metastasis patients
CN113286884A (zh) 2018-08-07 2021-08-20 博德研究所 新型cas12b酶和系统
WO2020037082A1 (en) 2018-08-14 2020-02-20 California Institute Of Technology Multifocal photoacoustic microscopy through an ergodic relay
US20210355522A1 (en) 2018-08-20 2021-11-18 The Broad Institute, Inc. Inhibitors of rna-guided nuclease activity and uses thereof
WO2020041380A1 (en) 2018-08-20 2020-02-27 The Broad Institute, Inc. Methods and compositions for optochemical control of crispr-cas9
WO2020041387A1 (en) 2018-08-20 2020-02-27 The Brigham And Women's Hospital, Inc. Degradation domain modifications for spatio-temporal control of rna-guided nucleases
US11592652B2 (en) 2018-09-04 2023-02-28 California Institute Of Technology Enhanced-resolution infrared photoacoustic microscopy and spectroscopy
US20220088224A1 (en) 2018-09-18 2022-03-24 Vnv Newco Inc. Arc-based capsids and uses thereof
WO2020077135A1 (en) 2018-10-10 2020-04-16 Dana-Farber Cancer Institute, Inc. Modulating resistance to bcl-2 inhibitors
US20220411783A1 (en) 2018-10-12 2022-12-29 The Broad Institute, Inc. Method for extracting nuclei or whole cells from formalin-fixed paraffin-embedded tissues
US20210379057A1 (en) 2018-10-16 2021-12-09 Massachusetts Institute Of Technology Nutlin-3a for use in treating a mycobacterium tuberculosis infection
WO2020102610A1 (en) 2018-11-14 2020-05-22 The Broad Institute, Inc. Crispr system based droplet diagnostic systems and methods
WO2020124050A1 (en) 2018-12-13 2020-06-18 The Broad Institute, Inc. Tiled assays using crispr-cas based detection
AU2019406778A1 (en) 2018-12-17 2021-07-22 Massachusetts Institute Of Technology Crispr-associated transposase systems and methods of use thereof
US11739156B2 (en) 2019-01-06 2023-08-29 The Broad Institute, Inc. Massachusetts Institute of Technology Methods and compositions for overcoming immunosuppression
CN109851770A (zh) * 2019-01-29 2019-06-07 天津大学 一种双端氨基的聚乙二醇的制备方法
JP7474773B2 (ja) 2019-02-13 2024-04-25 アルフェウス メディカル，インク． 非侵襲的音響化学療法
US11369280B2 (en) 2019-03-01 2022-06-28 California Institute Of Technology Velocity-matched ultrasonic tagging in photoacoustic flowgraphy
US20220177863A1 (en) 2019-03-18 2022-06-09 The Broad Institute, Inc. Type vii crispr proteins and systems
EP3947687A1 (de) 2019-03-29 2022-02-09 Massachusetts Institute of Technology Konstrukte zur kontinuierlichen überwachung von lebenden zellen
US20220175926A1 (en) * 2019-03-29 2022-06-09 The Brigham And Women's Hospital, Inc. Targeted synergistic cancer immunotherapy
WO2020206036A1 (en) 2019-04-01 2020-10-08 The Broad Institute, Inc. Novel nucleic acid modifier
WO2020206046A1 (en) 2019-04-01 2020-10-08 The Broad Institute, Inc. Methods and compositions for cell therapy
WO2020236967A1 (en) 2019-05-20 2020-11-26 The Broad Institute, Inc. Random crispr-cas deletion mutant
WO2020236972A2 (en) 2019-05-20 2020-11-26 The Broad Institute, Inc. Non-class i multi-component nucleic acid targeting systems
US20220243178A1 (en) 2019-05-31 2022-08-04 The Broad Institute, Inc. Methods for treating metabolic disorders by targeting adcy5
US20220298501A1 (en) 2019-08-30 2022-09-22 The Broad Institute, Inc. Crispr-associated mu transposase systems
US11981922B2 (en) 2019-10-03 2024-05-14 Dana-Farber Cancer Institute, Inc. Methods and compositions for the modulation of cell interactions and signaling in the tumor microenvironment
US11986269B2 (en) 2019-11-05 2024-05-21 California Institute Of Technology Spatiotemporal antialiasing in photoacoustic computed tomography
KR102578025B1 (ko) * 2020-12-07 2023-09-15 (주)아이엠지티 초음파 감작제가 결합된 면역관문억제제 및 이의 용도
US11813330B2 (en) 2021-03-04 2023-11-14 Theralase Technologies, Inc. Sonodynamic therapy using sonodynamically activated coordination complexes of transition metals as sensitizing agents
CN113181060B (zh) * 2021-04-21 2022-05-13 武汉大学 一种具有除菌效果的复合纳米材料及其制备方法和应用
KR20230012254A (ko) * 2021-07-15 2023-01-26 인천대학교 산학협력단 초음파 감작제가 탑재된 종양 표적화 엑소좀 및 이의 제조방법
CN116161704A (zh) * 2023-02-14 2023-05-26 苏州大学 一种掺杂型镁铁水滑石及其制备方法与应用

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4207405A (en) * 1977-09-22 1980-06-10 The B. F. Goodrich Company Water-soluble phosphorus containing carboxylic polymers
US5283255A (en) * 1987-01-20 1994-02-01 The University Of British Columbia Wavelength-specific cytotoxic agents
US5040537A (en) * 1987-11-24 1991-08-20 Hitachi, Ltd. Method and apparatus for the measurement and medical treatment using an ultrasonic wave
JPH0629196B2 (ja) * 1987-12-01 1994-04-20 甲子郎 梅村 超音波による腫瘍治療用生理作用増強剤
US5733572A (en) * 1989-12-22 1998-03-31 Imarx Pharmaceutical Corp. Gas and gaseous precursor filled microspheres as topical and subcutaneous delivery vehicles
US5542935A (en) * 1989-12-22 1996-08-06 Imarx Pharmaceutical Corp. Therapeutic delivery systems related applications
US5016615A (en) * 1990-02-20 1991-05-21 Riverside Research Institute Local application of medication with ultrasound
JPH0454132A (ja) * 1990-06-20 1992-02-21 Hitachi Ltd 波動による腫瘍治療用生理作用増強剤及びその製法
CA2121129A1 (en) * 1991-10-29 1993-05-13 Patrick Soon-Shiong Crosslinkable polysaccharides, polycations and lipids useful for encapsulation and drug release
US5321357A (en) * 1992-08-07 1994-06-14 Yale University Three-dimensional detection, dosimetry and imaging of an energy field by formation of a polymer in a gel
US5362478A (en) * 1993-03-26 1994-11-08 Vivorx Pharmaceuticals, Inc. Magnetic resonance imaging with fluorocarbons encapsulated in a cross-linked polymeric shell
US6159445A (en) * 1994-07-20 2000-12-12 Nycomed Imaging As Light imaging contrast agents
US6176842B1 (en) * 1995-03-08 2001-01-23 Ekos Corporation Ultrasound assembly for use with light activated drugs
US5576013A (en) * 1995-03-21 1996-11-19 Eastern Virginia Medical School Treating vascular and neoplastic tissues
WO1997018851A1 (en) * 1995-11-24 1997-05-29 Ekos Corporation Hemostasis material and apparatus
US5840276A (en) * 1996-01-11 1998-11-24 Apfel Enterprises, Inc. Activatable infusable dispersions containing drops of a superheated liquid for methods of therapy and diagnosis
NZ331977A (en) * 1996-03-26 2000-07-28 Pharmacyclics Inc Texaphyrin in photodynamic therapy of pigment-related lesions
WO1998001131A1 (fr) * 1996-07-05 1998-01-15 Hitachi, Ltd. Medicaments induisant une action ultrasonore et appareil d'utilisation de ces medicaments
ES2206689T3 (es) * 1996-10-28 2004-05-16 Amersham Health As Agentes de contraste.
US5919135A (en) * 1997-02-28 1999-07-06 Lemelson; Jerome System and method for treating cellular disorders in a living being
US5817048A (en) * 1997-03-20 1998-10-06 Brown University Research Foundation Ultrasonic alternative to laser-based photodynamic therapy
IL120891A0 (en) * 1997-05-22 1997-09-30 Technion Res & Dev Foundation Photodynamic and sonodynamic therapy and agents for use therefor
GB9712525D0 (en) * 1997-06-16 1997-08-20 Nycomed Imaging As Method
US6233481B1 (en) * 1997-10-09 2001-05-15 Spectra Science Corporation Diagnostic application of sono-chemical excitation of fluorescent photosensitizers
US6071944A (en) * 1997-11-12 2000-06-06 Bowling Green State University Method of treatment of pigmented cancer cells utilizing photodynamic therapy

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JP2001525845A (ja) 2001-12-11
DE69826263T2 (de) 2005-10-27
ATE275971T1 (de) 2004-10-15
JP4503103B2 (ja) 2010-07-14
AU7443898A (en) 1998-12-11
GB9710049D0 (en) 1997-07-09
WO1998052609A1 (en) 1998-11-26
EP0979104A1 (de) 2000-02-16
EP0979104B1 (de) 2004-09-15
US6498945B1 (en) 2002-12-24

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