DE69825292T2 - Verwendung von inosine zur herstellung eines medikamentes zur stimulierung des axonwachstums von zns-neuronen - Google Patents

Verwendung von inosine zur herstellung eines medikamentes zur stimulierung des axonwachstums von zns-neuronen Download PDF

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Publication number
DE69825292T2
DE69825292T2 DE69825292T DE69825292T DE69825292T2 DE 69825292 T2 DE69825292 T2 DE 69825292T2 DE 69825292 T DE69825292 T DE 69825292T DE 69825292 T DE69825292 T DE 69825292T DE 69825292 T2 DE69825292 T2 DE 69825292T2
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Prior art keywords
inosine
neurons
purine nucleoside
adenosine
administered
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Expired - Lifetime
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DE69825292T
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German (de)
English (en)
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DE69825292D1 (de
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I. Larry BENOWITZ
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Boston Childrens Hospital
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Boston Childrens Hospital
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A61K31/708—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid having oxo groups directly attached to the purine ring system, e.g. guanosine, guanylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
DE69825292T 1997-09-02 1998-02-20 Verwendung von inosine zur herstellung eines medikamentes zur stimulierung des axonwachstums von zns-neuronen Expired - Lifetime DE69825292T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US921902 1997-09-02
US08/921,902 US6440455B1 (en) 1997-09-02 1997-09-02 Methods for modulating the axonal outgrowth of central nervous system neurons
PCT/US1998/003001 WO1999011274A1 (en) 1997-09-02 1998-02-20 Use of purine nucleosides for modulating the axonal outgrowth of central nervous system neurons

Publications (2)

Publication Number Publication Date
DE69825292D1 DE69825292D1 (de) 2004-09-02
DE69825292T2 true DE69825292T2 (de) 2005-05-25

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DE69825292T Expired - Lifetime DE69825292T2 (de) 1997-09-02 1998-02-20 Verwendung von inosine zur herstellung eines medikamentes zur stimulierung des axonwachstums von zns-neuronen

Country Status (12)

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US (8) US6440455B1 (enExample)
EP (2) EP1009412B1 (enExample)
JP (1) JP4601816B2 (enExample)
KR (1) KR100564789B1 (enExample)
CN (1) CN1286632A (enExample)
AT (1) ATE271874T1 (enExample)
AU (1) AU748961B2 (enExample)
CA (1) CA2302156C (enExample)
DE (1) DE69825292T2 (enExample)
NZ (1) NZ503073A (enExample)
RU (1) RU2212241C2 (enExample)
WO (1) WO1999011274A1 (enExample)

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JP6153281B1 (ja) * 2015-08-26 2017-06-28 株式会社スタージェン 細胞内ａｔｐ増強剤
WO2020140730A1 (zh) * 2018-12-30 2020-07-09 广州君赫生物科技有限公司 硫鸟嘌呤在制备治疗adsl缺陷症药物中应用
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Also Published As

Publication number Publication date
US7338666B2 (en) 2008-03-04
US20070213294A1 (en) 2007-09-13
RU2000108443A (ru) 2002-02-10
US20040014710A1 (en) 2004-01-22
EP1009412A1 (en) 2000-06-21
JP4601816B2 (ja) 2010-12-22
US20020137721A1 (en) 2002-09-26
US20020055484A1 (en) 2002-05-09
US7935680B2 (en) 2011-05-03
AU6656898A (en) 1999-03-22
KR100564789B1 (ko) 2006-03-28
RU2212241C2 (ru) 2003-09-20
EP1466606A2 (en) 2004-10-13
US20050277614A1 (en) 2005-12-15
AU748961B2 (en) 2002-06-13
CN1286632A (zh) 2001-03-07
US6440455B1 (en) 2002-08-27
ATE271874T1 (de) 2004-08-15
JP2001516695A (ja) 2001-10-02
WO1999011274A1 (en) 1999-03-11
US20020128223A1 (en) 2002-09-12
DE69825292D1 (de) 2004-09-02
EP1466606A3 (en) 2004-11-24
EP1009412B1 (en) 2004-07-28
US6551612B2 (en) 2003-04-22
US20020042390A1 (en) 2002-04-11
CA2302156A1 (en) 1999-03-11
CA2302156C (en) 2006-11-21
NZ503073A (en) 2002-11-26
HK1029916A1 (en) 2001-04-20
KR20010023578A (ko) 2001-03-26

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