JP4601816B2 - 中枢神経系ニューロンの軸索の伸出を調節するためのプリンヌクレオシドの利用 - Google Patents
中枢神経系ニューロンの軸索の伸出を調節するためのプリンヌクレオシドの利用 Download PDFInfo
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- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
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- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
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- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
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- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
- A61K31/708—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid having oxo groups directly attached to the purine ring system, e.g. guanosine, guanylic acid
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| PCT/US1998/003001 WO1999011274A1 (en) | 1997-09-02 | 1998-02-20 | Use of purine nucleosides for modulating the axonal outgrowth of central nervous system neurons |
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Families Citing this family (42)
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| US6440455B1 (en) | 1997-09-02 | 2002-08-27 | Children's Medical Center Corporation | Methods for modulating the axonal outgrowth of central nervous system neurons |
| KR20070051953A (ko) * | 1998-11-02 | 2007-05-18 | 엘란 코포레이션, 피엘씨 | 다입자 변형 방출 조성물 |
| US20090297602A1 (en) * | 1998-11-02 | 2009-12-03 | Devane John G | Modified Release Loxoprofen Compositions |
| US7582680B1 (en) | 1998-11-12 | 2009-09-01 | Purdue Research Foundation | Methods and compositions for treating mammalian spinal cord injuries |
| US7172871B1 (en) * | 2000-09-07 | 2007-02-06 | Children's Medical Center Corporation | Methods and compositions for modulating axonal outgrowth of central nervous system neurons |
| FR2814077A1 (fr) * | 2000-09-20 | 2002-03-22 | Inst Nat Sante Rech Med | Utilisation de modulateurs de recepteurs a l'adenosine pour reguler la fonction des netrines et/ou de leurs recepteurs |
| EP1355666B1 (en) | 2000-12-22 | 2012-06-13 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Use of repulsive guidance molecule (RGM) and its modulators |
| NZ543953A (en) | 2001-04-24 | 2007-04-27 | Univ Chicago | Method and compositions for treating mammalian nerve tissue injuries |
| US7147647B2 (en) * | 2002-04-26 | 2006-12-12 | Medtronic, Inc. | Sintered titanium tube for the management of spinal cord injury |
| US20040106896A1 (en) * | 2002-11-29 | 2004-06-03 | The Regents Of The University Of California | System and method for forming a non-ablative cardiac conduction block |
| US7813473B2 (en) * | 2002-07-23 | 2010-10-12 | General Electric Company | Method and apparatus for generating temporally interpolated projections |
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| JP2006501936A (ja) * | 2002-10-04 | 2006-01-19 | エラン ファーマ インターナショナル，リミティド | 固体ナノ粒子活性薬剤のガンマ線照射 |
| GB0228723D0 (en) | 2002-12-09 | 2003-01-15 | Cambridge Biotechnology Ltd | Treatment of pain |
| US7199110B2 (en) * | 2002-12-30 | 2007-04-03 | Purdue Research Foundation | Method of treatment for spinal cord injury |
| CA2523035C (en) * | 2003-05-22 | 2011-04-26 | Elan Pharma International Ltd. | Sterilization of dispersions of nanoparticulate active agents with gamma radiation |
| GB0312844D0 (en) * | 2003-06-04 | 2003-07-09 | Paradigm Therapeutics Ltd | Use of compounds in medicine |
| WO2005016359A1 (en) * | 2003-08-19 | 2005-02-24 | Neurological Technologies Inc. | Method of promoting remyelination |
| US8912144B2 (en) * | 2003-12-16 | 2014-12-16 | Children's Medical Center Corporation | Method for treating stroke via administration of NEP1-40 and inosine |
| WO2006020365A2 (en) * | 2004-07-26 | 2006-02-23 | The Regents Of The University Of California | Method for prevention or treatment of inflamatory disease |
| US20060104969A1 (en) * | 2004-08-16 | 2006-05-18 | Massachusetts Institute Of Technology | Compositions and methods for enhancing structural and functional nervous system reorganization and recovery |
| CA2598288A1 (en) * | 2005-03-03 | 2006-09-14 | Elan Pharma International Limited | Nanoparticulate compositions of heterocyclic amide derivatives |
| WO2006111348A1 (de) * | 2005-04-18 | 2006-10-26 | Abbott Gmbh & Co. Kg | Verwendung von heparin und heparinderivaten zur modulation des neuritenwachstum-kontrollierenden nogo-rezeptors |
| WO2007039256A2 (de) | 2005-09-30 | 2007-04-12 | Abbott Gmbh & Co. Kg | Bindungsdomänen von proteinen der repulsive guidance molecule (rgm) proteinfamilie und funktionale fragmente davon sowie deren verwendung |
| AU2007234006A1 (en) * | 2006-03-31 | 2007-10-11 | Adenobio N.V. | Compositions, methods, and kits using adenosine and inosine in combination for diagnosis and treatment |
| US20080317843A1 (en) * | 2006-07-12 | 2008-12-25 | Elan Corporation Plc | Nanoparticulate formulations of modafinil |
| US8419710B2 (en) * | 2006-12-06 | 2013-04-16 | Medtronic, Inc. | Methods for infusing fluids via an implantable infusion system |
| US20080270686A1 (en) * | 2007-04-26 | 2008-10-30 | Grannan Michael F | Methods and system to cache content on a vehicle |
| US8133861B2 (en) * | 2008-02-29 | 2012-03-13 | Alseres Pharmaceuticals, Inc. | Systemic purine administration: modulating axonal outgrowth of central nervous system neurons |
| US8962803B2 (en) | 2008-02-29 | 2015-02-24 | AbbVie Deutschland GmbH & Co. KG | Antibodies against the RGM A protein and uses thereof |
| DK2502623T3 (en) | 2008-06-06 | 2016-07-04 | Children's Medical Center Corp | Promoting axonregeneration the adult cns by management of protein translation |
| CA2780069C (en) | 2009-12-08 | 2018-07-17 | Abbott Gmbh & Co. Kg | Monoclonal antibodies against the rgm a protein for use in the treatment of retinal nerve fiber layer degeneration |
| MX391536B (es) | 2012-01-27 | 2025-03-21 | Abbvie Deutschland | Composicion y metodo para el diagnostico y tratamiento de enfermedades asociadas con la degeneracion de neuritas. |
| US20140179741A1 (en) * | 2012-10-10 | 2014-06-26 | Massachusetts Institute Of Technology | Use of chelators of divalent cations to promote nerve regeneration |
| WO2014096958A1 (en) * | 2012-11-02 | 2014-06-26 | Academisch Medisch Centrum | Inosine monophosphate and salts thereof for use in the treatment of complement-related disorders |
| RU2517117C2 (ru) * | 2012-11-26 | 2014-05-27 | Государственное бюджетное образовательное учреждение высшего профессионального образования "Казанский государственный медицинский университет" Министерства здравоохранения и социального развития Российской Федерации (ГБОУ ВПО Казанский ГМУ Минздравсоцразвития России) | Способ стимулирования регенерации нерва с помощью наноструктурированного матрикса и генетических конструкций |
| JP6153281B1 (ja) * | 2015-08-26 | 2017-06-28 | 株式会社スタージェン | 細胞内ａｔｐ増強剤 |
| WO2020140730A1 (zh) * | 2018-12-30 | 2020-07-09 | 广州君赫生物科技有限公司 | 硫鸟嘌呤在制备治疗adsl缺陷症药物中应用 |
| EP3797764A1 (en) | 2019-09-27 | 2021-03-31 | Janusz Chupty Contissi | Pharmacological composition for treatment of nervous tissue dysfunction, in particular viral latency, and the use of j05 atc group substances in treatment of nervous tissue dysfunction, in particular viral latency |
| WO2021260740A1 (en) * | 2020-06-25 | 2021-12-30 | Celagenex Research (India) Pvt. Ltd. | Novel synergistic nutritional compositions for promoting axonal regeneration |
| WO2023055531A1 (en) * | 2021-09-28 | 2023-04-06 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Methods for treating peripheral neuropathy |
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| US3808027A (en) | 1972-03-29 | 1974-04-30 | Du Pont | Silica surfaced films |
| US4341868A (en) * | 1978-08-18 | 1982-07-27 | Kyowa Hakko Kogyo Co., Ltd. | Method and test composition for the determination of the substrate for xanthine oxidase |
| US4883666A (en) * | 1987-04-29 | 1989-11-28 | Massachusetts Institute Of Technology | Controlled drug delivery system for treatment of neural disorders |
| WO1988009335A1 (en) | 1987-05-26 | 1988-12-01 | Paul Gordon | Polymorphs of inosine and methods of making and using them |
| US5250414A (en) * | 1988-11-04 | 1993-10-05 | Erziehungsdirektion Of The Canton Zurich | Diagnostic methods using neurite growth regulatory factors |
| WO1991004032A1 (en) * | 1989-09-15 | 1991-04-04 | Gensia Pharmaceuticals, Inc. | Methods of treating neurodegenerative conditions |
| US5187162A (en) | 1989-09-15 | 1993-02-16 | Gensia Pharmaceuticals | Methods of treating neurodegenerative conditions |
| RU1755583C (ru) * | 1990-10-31 | 1994-08-30 | ВНИИ генетики и селекции промышленных микроорганизмов | Способ получения инозина |
| FR2692784B1 (fr) * | 1992-06-24 | 1995-06-30 | Pf Medicament | Utilisation de la guanosine, de ses precurseurs et ses derives pour la fabrication de medicaments destines a traiter les deficits fonctionnels cerebraux. |
| US5483130A (en) * | 1992-09-09 | 1996-01-09 | Axelerator, Inc. | Structure for accelerating heavy ions with uniformly spaced quadrupole focusing (USQF) |
| US5422343A (en) * | 1992-12-21 | 1995-06-06 | Otsuka Pharmaceutical Factory, Inc. | Prophylactic and therapeutic composition for MRSA infection |
| US5438130A (en) * | 1993-01-15 | 1995-08-01 | Cambridge Neuroscience, Inc. | Fucosylated guanosine disulfates as excitatory amino acid antagonists |
| RU2063753C1 (ru) | 1993-04-22 | 1996-07-20 | Василий Владимирович Афанасьев | Способ лечения экстрапирамидного синдрома при остром отравлении галоперидолом |
| ATE197672T1 (de) * | 1993-08-13 | 2000-12-15 | Seikagaku Kogyo Co Ltd | Arzneimittel gegen nervöse erkrankungen |
| US5587384A (en) | 1994-02-04 | 1996-12-24 | The Johns Hopkins University | Inhibitors of poly(ADP-ribose) synthetase and use thereof to treat NMDA neurotoxicity |
| RU2098085C1 (ru) * | 1994-04-07 | 1997-12-10 | Николай Васильевич Карсанов | Антигипоксическое средство |
| US5447939A (en) * | 1994-07-25 | 1995-09-05 | Glasky; Alvin J. | Carbon monoxide dependent guanylyl cyclase modifiers and methods of use |
| US5931809A (en) | 1995-07-14 | 1999-08-03 | Depotech Corporation | Epidural administration of therapeutic compounds with sustained rate of release |
| AU4808997A (en) * | 1996-09-30 | 1998-04-24 | Brigham And Women's Hospital | Methods and compounds for treatment of abnormal uterine bleeding |
| US6440455B1 (en) * | 1997-09-02 | 2002-08-27 | Children's Medical Center Corporation | Methods for modulating the axonal outgrowth of central nervous system neurons |
| US6855690B2 (en) * | 2000-06-01 | 2005-02-15 | Children's Medical Center Corporation | Methods and compositions for treating ocular disorders |
| GB2379797A (en) * | 2001-09-15 | 2003-03-19 | Zarlink Semiconductor Ab | Surface Emitting Laser |
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- 1998-02-20 AT AT98908565T patent/ATE271874T1/de not_active IP Right Cessation
- 1998-02-20 CA CA002302156A patent/CA2302156C/en not_active Expired - Fee Related
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| Publication number | Publication date |
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| US7338666B2 (en) | 2008-03-04 |
| US20070213294A1 (en) | 2007-09-13 |
| RU2000108443A (ru) | 2002-02-10 |
| US20040014710A1 (en) | 2004-01-22 |
| EP1009412A1 (en) | 2000-06-21 |
| US20020137721A1 (en) | 2002-09-26 |
| US20020055484A1 (en) | 2002-05-09 |
| US7935680B2 (en) | 2011-05-03 |
| AU6656898A (en) | 1999-03-22 |
| KR100564789B1 (ko) | 2006-03-28 |
| RU2212241C2 (ru) | 2003-09-20 |
| EP1466606A2 (en) | 2004-10-13 |
| US20050277614A1 (en) | 2005-12-15 |
| AU748961B2 (en) | 2002-06-13 |
| CN1286632A (zh) | 2001-03-07 |
| US6440455B1 (en) | 2002-08-27 |
| ATE271874T1 (de) | 2004-08-15 |
| JP2001516695A (ja) | 2001-10-02 |
| WO1999011274A1 (en) | 1999-03-11 |
| US20020128223A1 (en) | 2002-09-12 |
| DE69825292D1 (de) | 2004-09-02 |
| EP1466606A3 (en) | 2004-11-24 |
| EP1009412B1 (en) | 2004-07-28 |
| US6551612B2 (en) | 2003-04-22 |
| US20020042390A1 (en) | 2002-04-11 |
| CA2302156A1 (en) | 1999-03-11 |
| CA2302156C (en) | 2006-11-21 |
| DE69825292T2 (de) | 2005-05-25 |
| NZ503073A (en) | 2002-11-26 |
| HK1029916A1 (en) | 2001-04-20 |
| KR20010023578A (ko) | 2001-03-26 |
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