DE69819759D1 - Zusammensetzungen, verfahren unfd geräte zur organerhaltung - Google Patents

Zusammensetzungen, verfahren unfd geräte zur organerhaltung

Info

Publication number
DE69819759D1
DE69819759D1 DE69819759T DE69819759T DE69819759D1 DE 69819759 D1 DE69819759 D1 DE 69819759D1 DE 69819759 T DE69819759 T DE 69819759T DE 69819759 T DE69819759 T DE 69819759T DE 69819759 D1 DE69819759 D1 DE 69819759D1
Authority
DE
Germany
Prior art keywords
organ
compositions
methods
devices
perfusion
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69819759T
Other languages
English (en)
Other versions
DE69819759T2 (de
Inventor
Waleed H Hassanein
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
US Department of Veterans Affairs VA
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/936,062 external-priority patent/US6100082A/en
Application filed by Individual filed Critical Individual
Application granted granted Critical
Publication of DE69819759D1 publication Critical patent/DE69819759D1/de
Publication of DE69819759T2 publication Critical patent/DE69819759T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A01N1/0236—Mechanical aspects
    • A01N1/0242—Apparatuses, i.e. devices used in the process of preservation of living parts, such as pumps, refrigeration devices or any other devices featuring moving parts and/or temperature controlling components
    • A01N1/0247—Apparatuses, i.e. devices used in the process of preservation of living parts, such as pumps, refrigeration devices or any other devices featuring moving parts and/or temperature controlling components for perfusion, i.e. for circulating fluid through organs, blood vessels or other living parts

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Dentistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Environmental Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Thermal Sciences (AREA)
  • Mechanical Engineering (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
DE69819759T 1997-09-23 1998-09-23 Zusammensetzungen, verfahren und vorrichtungen zur aufrechterhaltung eines organs Expired - Lifetime DE69819759T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US936062 1997-09-23
US08/936,062 US6100082A (en) 1997-09-23 1997-09-23 Perfusion apparatus and method including chemical compositions for maintaining an organ
US54698 1998-04-03
US09/054,698 US6046046A (en) 1997-09-23 1998-04-03 Compositions, methods and devices for maintaining an organ
PCT/US1998/019912 WO1999015011A1 (en) 1997-09-23 1998-09-23 Compositions, methods and devices for maintaining an organ

Publications (2)

Publication Number Publication Date
DE69819759D1 true DE69819759D1 (de) 2003-12-18
DE69819759T2 DE69819759T2 (de) 2004-09-23

Family

ID=26733365

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69819759T Expired - Lifetime DE69819759T2 (de) 1997-09-23 1998-09-23 Zusammensetzungen, verfahren und vorrichtungen zur aufrechterhaltung eines organs

Country Status (10)

Country Link
EP (1) EP1017274B1 (de)
JP (1) JP2001516768A (de)
AT (1) ATE253819T1 (de)
AU (1) AU728233B2 (de)
CA (1) CA2304598C (de)
DE (1) DE69819759T2 (de)
DK (1) DK1017274T3 (de)
ES (1) ES2210825T3 (de)
PT (1) PT1017274E (de)
WO (1) WO1999015011A1 (de)

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US8409846B2 (en) 1997-09-23 2013-04-02 The United States Of America As Represented By The Department Of Veteran Affairs Compositions, methods and devices for maintaining an organ
US6673594B1 (en) * 1998-09-29 2004-01-06 Organ Recovery Systems Apparatus and method for maintaining and/or restoring viability of organs
US6977140B1 (en) 1998-09-29 2005-12-20 Organ Recovery Systems, Inc. Method for maintaining and/or restoring viability of organs
DE69941362D1 (de) * 1998-09-29 2009-10-15 Organ Recovery Systems Inc Vorrichtung und verfahren zur erhaltung und/oder wiederherstellung der lebensfähigkeit von organen
DE69922985T2 (de) * 1998-10-22 2005-12-15 Medtronic, Inc., Minneapolis Verfahren zur untersuchung an einem isolierten perfundierten herz-präparat
GB9908335D0 (en) 1999-04-12 1999-06-09 Univ Cambridge Tech Methods and means for extracorporeal organ perfusion
US6582953B2 (en) * 1999-04-14 2003-06-24 Breonics, Inc. Organ chamber for exsanguinous metabolic support system
GB0028414D0 (en) 2000-11-22 2001-01-03 Univ Leeds Flush preservation solution
CA2446228A1 (en) * 2001-05-04 2002-11-14 Breonics, Inc. Organ chamber for exsanguinous metabolic support system
US7572622B2 (en) 2002-08-14 2009-08-11 Transmedic, Inc. Heart preservation chamber
ATE363233T1 (de) 2002-08-23 2007-06-15 Organ Recovery Systems Verbindungsanordnungen, insbesondere für transplantationsorgane
NL1024022C2 (nl) * 2003-07-30 2005-02-01 Technologiestichting Stw Draagbare preservatie-inrichting voor een donororgaan.
DE10340487B4 (de) * 2003-09-03 2007-07-12 Technische Universität Dresden Perfusionskreislauf
AU2016222388B2 (en) * 2004-10-07 2017-12-07 Transmedics, Inc. Systems and methods for ex-vivo organ care
NZ614472A (en) * 2004-10-07 2015-03-27 Transmedics Inc Systems and methods for ex-vivo organ care
US12010987B2 (en) 2004-10-07 2024-06-18 Transmedics, Inc. Systems and methods for ex-vivo organ care and for using lactate as an indication of donor organ status
US9301519B2 (en) 2004-10-07 2016-04-05 Transmedics, Inc. Systems and methods for ex-vivo organ care
US8304181B2 (en) 2004-10-07 2012-11-06 Transmedics, Inc. Method for ex-vivo organ care and for using lactate as an indication of donor organ status
AU2012216796B2 (en) * 2004-10-07 2014-11-27 Transmedics, Inc. Systems and methods for ex-vivo organ care
EP1897549B1 (de) 2005-06-07 2011-08-24 InBiotex Inc. Radikalfänger und aktiven-sauerstoff-eliminierendes mittel
US9078428B2 (en) 2005-06-28 2015-07-14 Transmedics, Inc. Systems, methods, compositions and solutions for perfusing an organ
IL301141A (en) * 2006-04-19 2023-05-01 Transmedics Inc Systems and methods for extracorporeal organ treatment
US20080145919A1 (en) * 2006-12-18 2008-06-19 Franklin Thomas D Portable organ and tissue preservation apparatus, kit and methods
ES2659970T3 (es) * 2007-03-01 2018-03-20 Lifeline Scientific, Inc. Regulación de la perfusión
US9457179B2 (en) 2007-03-20 2016-10-04 Transmedics, Inc. Systems for monitoring and applying electrical currents in an organ perfusion system
DE102007034132B4 (de) * 2007-07-21 2010-04-29 Technische Universität Dresden Perfusionsbeutel für explantierte Organe und Organteile
US9814230B2 (en) 2008-01-31 2017-11-14 Transmedics, Inc. Systems and methods for ex vivo lung care
ES2328660B1 (es) * 2008-05-14 2010-10-14 Fundacio Privada Clinic Per A La Recerca Biomedica Dispositivo para la preservacion de un injerto hepatico en condiciones de normotermia.
EP2482646A4 (de) 2009-09-25 2017-07-26 Vivoline Medical AB Behälter und trägerstruktur zur unterbringung eines organs
WO2011062621A2 (en) * 2009-11-17 2011-05-26 Harvard Bioscience, Inc. Bioreactors, systems, and methods for producing and/or analyzing organs
RU2012136795A (ru) * 2010-01-29 2014-03-10 Орган Текнолоджиз, Инк. Способ и устройство перфузионного культивирования органа или ткани
EP2611291B1 (de) * 2010-09-01 2020-03-25 Perfusion Fluid Technologies, Inc. Perfusionszusammensetzung
US20120148542A1 (en) * 2010-12-10 2012-06-14 Lifeline Scientific, Inc. Machine perfusion with complement inhibitors
US11178866B2 (en) 2011-03-15 2021-11-23 Paragonix Technologies, Inc. System for hypothermic transport of samples
US8828710B2 (en) 2011-03-15 2014-09-09 Paragonix Technologies, Inc. System for hypothermic transport of samples
CA2830307A1 (en) * 2011-03-23 2012-09-27 Vivoline Medical Ab Apparatus for maintaining a harvested organ viable and transportable
US20130011823A1 (en) 2011-04-14 2013-01-10 Hassanein Waleed H Organ care solution for ex-vivo machine perfusion of donor lungs
US8828034B2 (en) 2011-04-29 2014-09-09 Lifeline Scientific, Inc. Cannula
US9642625B2 (en) 2011-04-29 2017-05-09 Lifeline Scientific, Inc. Cannula for a donor organ with or without an aortic cuff or patch
US9022978B2 (en) 2011-04-29 2015-05-05 Lifeline Scientific, Inc. Universal sealring cannula
JP2013075888A (ja) * 2011-09-15 2013-04-25 Tokyo Metropolitan Univ 臓器保存装置
ES2685328T3 (es) 2011-11-10 2018-10-08 Organox Limited Sistemas de perfusión de órganos
EP2819720B1 (de) * 2012-03-01 2016-05-25 Medical Device Works NV Kit zur organperfusion
ES2388223B1 (es) 2012-06-29 2013-09-02 Grifols Sa Dispositivo para la perfusión de un injerto hepático
US10602740B2 (en) 2012-07-10 2020-03-31 Lifeline Scientific, Inc. Organ perfusion apparatus with downstream flow control
US20140017666A1 (en) * 2012-07-10 2014-01-16 Lifeline Scientific, Inc. Filtration in organ perfusion apparatus
US20140017665A1 (en) * 2012-07-10 2014-01-16 Lifeline Scientific, Inc. Organ transporter with oxygen generation
WO2015021513A1 (en) * 2013-08-16 2015-02-19 University Of Western Sydney Device for storing a tissue sample
SE538477C2 (sv) * 2013-10-24 2016-07-19 Vivoline Medical Ab Anordning för undersökning av ett isolerat slående hjärta
WO2015138999A1 (en) 2014-03-14 2015-09-17 The General Hospital Corporation Lung bioreactor
CA3185937A1 (en) 2014-06-02 2015-12-10 Transmedics, Inc. Ex vivo organ care system
BR112017010520B1 (pt) 2014-12-12 2022-08-30 Tevosol, Inc Aparelho e método para perfusão de órgãos
CN107949419B (zh) 2015-09-09 2021-03-05 特兰斯迈迪茨公司 离体器官护理系统用的主动脉插管
US10091986B2 (en) 2016-05-09 2018-10-09 Xor-Labs Toronto Inc. Organ perfusion device and method
GB2551795A (en) * 2016-06-30 2018-01-03 Spectrum Medical Ltd Heat exchanger
WO2018037836A1 (ja) * 2016-08-25 2018-03-01 株式会社Ｓｃｒｅｅｎホールディングス 持続灌流中の血管吻合方法
WO2018226993A1 (en) 2017-06-07 2018-12-13 Paragonix Technologies, Inc. Apparatus for tissue transport and preservation
JP6988286B2 (ja) * 2017-09-08 2022-01-05 株式会社ジェイ・エム・エス 臓器及び生体組織の輸送装置
JP2019048776A (ja) * 2017-09-08 2019-03-28 株式会社ジェイ・エム・エス 臓器及び生体組織の輸送装置
JP2020007297A (ja) * 2018-06-27 2020-01-16 株式会社Ｓｃｒｅｅｎホールディングス 灌流装置および灌流方法
WO2020004295A1 (ja) * 2018-06-27 2020-01-02 株式会社Ｓｃｒｅｅｎホールディングス 灌流装置および灌流方法
US11632951B2 (en) 2020-01-31 2023-04-25 Paragonix Technologies, Inc. Apparatus for tissue transport and preservation
GB2591784A (en) * 2020-02-06 2021-08-11 Univ Strathclyde Organ transport apparatus
GB2622998B (en) * 2020-02-20 2024-06-19 Deka Products Lp System and method for organ maintenance and transport
WO2021173535A1 (en) 2020-02-26 2021-09-02 Finless Foods Inc. Systems and methods for live fish tissue preservation
JP7406211B2 (ja) 2020-10-14 2023-12-27 株式会社島津製作所 臓器灌流装置および制御方法
WO2023023309A1 (en) 2021-08-20 2023-02-23 Finless Foods Inc. Systems and methods for fish tissue preservation
USD1031028S1 (en) 2022-09-08 2024-06-11 Paragonix Technologies, Inc. Tissue suspension adaptor

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BE755423A (fr) * 1969-10-06 1971-02-01 Baxter Laboratories Inc Procede et appareil pour la conservation d'organes
JPS59212701A (ja) * 1983-05-18 1984-12-01 Matsushita Electric Ind Co Ltd パタ−ンマツチングによる位置認識方法
WO1988005261A1 (en) * 1987-01-16 1988-07-28 Tops Systems, Inc. Total organ perfusion system
EP0376763A3 (de) * 1988-10-26 1992-04-01 McKelvey, Karen Vorrichtung zum Transport von menschlichen Organen, bestimmt zur Transplantation
JPH0499701A (ja) * 1988-10-26 1992-03-31 Mckelvey Karen 移植に使用するヒトの臓器の輸送用装置
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ATE423464T1 (de) * 1994-05-20 2009-03-15 Breonics Inc Verfahren zur überwachung der lebensfähigkeit transplantabler organe
WO1996029865A1 (en) * 1995-03-27 1996-10-03 Organ, Inc. Organ evaluation and resuscitation device and method
US5716378A (en) * 1996-06-06 1998-02-10 Medtronic, Inc. Heart preservation and transportation apparatus and method employing low rate cardiac pacing for improved removal of catabolites from the myocardium

Also Published As

Publication number Publication date
AU9504298A (en) 1999-04-12
WO1999015011A1 (en) 1999-04-01
CA2304598C (en) 2009-03-10
ES2210825T3 (es) 2004-07-01
PT1017274E (pt) 2004-04-30
AU728233B2 (en) 2001-01-04
EP1017274B1 (de) 2003-11-12
DE69819759T2 (de) 2004-09-23
DK1017274T3 (da) 2004-03-22
CA2304598A1 (en) 1999-04-01
EP1017274A1 (de) 2000-07-12
JP2001516768A (ja) 2001-10-02
ATE253819T1 (de) 2003-11-15

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: THE DEPARTMENT OF VETERANS AFFAIRS, WASHINGTON, D.

8381 Inventor (new situation)

Inventor name: HASSANEIN, WALEED H., NORTH ANDOVER, MASS., US

Inventor name: KHURI, SHUKRI, WESTWOOD, MASS., US

Inventor name: BIRJINIUK, VLADIMIR, WESTON, MASS., US

Inventor name: CRITTENDEN, MICHAEL D., HYDE PARK, MASS., US