DE69810740T2 - Bioreaktor - Google Patents
BioreaktorInfo
- Publication number
- DE69810740T2 DE69810740T2 DE69810740T DE69810740T DE69810740T2 DE 69810740 T2 DE69810740 T2 DE 69810740T2 DE 69810740 T DE69810740 T DE 69810740T DE 69810740 T DE69810740 T DE 69810740T DE 69810740 T2 DE69810740 T2 DE 69810740T2
- Authority
- DE
- Germany
- Prior art keywords
- bioreactor
- cell loading
- making
- methods
- providing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
- C12M25/10—Hollow fibers or tubes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
- C12M29/16—Hollow fibers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Sustainable Development (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Materials For Medical Uses (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/861,503 US5955353A (en) | 1997-05-22 | 1997-05-22 | Hollow fiber bioreactor with an extrafilament flow plug |
PCT/US1998/010111 WO1998053046A1 (en) | 1997-05-22 | 1998-05-13 | Bioreactor |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69810740D1 DE69810740D1 (de) | 2003-02-20 |
DE69810740T2 true DE69810740T2 (de) | 2003-10-16 |
Family
ID=25335987
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69810740T Expired - Lifetime DE69810740T2 (de) | 1997-05-22 | 1998-05-13 | Bioreaktor |
Country Status (9)
Country | Link |
---|---|
US (1) | US5955353A (de) |
EP (1) | EP0915965B1 (de) |
JP (1) | JP2000515391A (de) |
AT (1) | ATE231181T1 (de) |
AU (1) | AU738641B2 (de) |
CA (1) | CA2262812C (de) |
DE (1) | DE69810740T2 (de) |
NZ (1) | NZ333786A (de) |
WO (1) | WO1998053046A1 (de) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102005021305A1 (de) * | 2005-05-09 | 2006-11-16 | Fresenius Medical Care Deutschland Gmbh | Reaktoreinheit und Reaktor mit einer derartigen Reaktoreinheit |
Families Citing this family (46)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6271023B1 (en) * | 1997-02-04 | 2001-08-07 | Akzo Nobel N.V. | Module made of at least two-type hollow fibres, and production of same |
JP3553858B2 (ja) * | 1999-08-25 | 2004-08-11 | 東洋紡績株式会社 | 血管網類似構造体を有する細胞培養用モジュール |
US6752926B2 (en) | 2000-10-20 | 2004-06-22 | Trustees Of Stevens Institute Of Technology | Method and apparatus for treatment of wastewater |
US6582955B2 (en) * | 2001-05-11 | 2003-06-24 | Spectrum Laboratories, Inc. | Bioreactor with application as blood therapy device |
US6607501B2 (en) | 2001-05-14 | 2003-08-19 | Reynolds G. Gorsuch | Process and apparatus for utilization of in vivo extracted plasma with tissue engineering devices, bioreactors, artificial organs, and cell therapy applications |
US6566126B2 (en) * | 2001-06-22 | 2003-05-20 | Fibercell Systems, Inc. | Apparatus and method for growing cells |
US6702561B2 (en) * | 2001-07-12 | 2004-03-09 | Nxstage Medical, Inc. | Devices for potting a filter for blood processing |
AU2002326689A1 (en) * | 2001-08-17 | 2003-03-03 | Ivars V. Ivansons | Hemodialysis assembly and method |
US6852231B2 (en) * | 2002-02-15 | 2005-02-08 | Denco, Inc. | Spin-hemodialysis assembly and method |
CA2476917A1 (en) * | 2002-02-19 | 2003-08-28 | Bioarttis, Inc. | Artificial vessel scaffold and artificial organs therefrom |
JP3933058B2 (ja) * | 2002-02-25 | 2007-06-20 | 日立化成工業株式会社 | マイクロ流体システム用支持ユニット及びその製造方法 |
US7531351B2 (en) * | 2004-06-14 | 2009-05-12 | Probiogen Ag | Liquid-gas-phase exposure reactor for cell culturing |
EP1832861B1 (de) | 2004-11-30 | 2020-04-29 | Hitachi Chemical Company, Ltd. | Analytische vorbehandlungsvorrichtung |
JP5038149B2 (ja) * | 2004-12-27 | 2012-10-03 | フレゼニウス メディカル ケアー ドイチュラント ゲゼルシャフト ミット ベシュレンクテル ハフツング | リアクタユニット及びそのリアクタユニットを備えたリアクタ |
DE102004062828B4 (de) * | 2004-12-27 | 2007-01-11 | Fresenius Medical Care Deutschland Gmbh | Reaktor mit einer rotierbar angeordneten Reaktoreinheit |
US7989157B2 (en) * | 2005-01-11 | 2011-08-02 | Medtronic, Inc. | Solution for storing bioprosthetic tissue used in a biological prosthesis |
DE102006011828A1 (de) | 2006-03-13 | 2007-09-20 | Gesellschaft für Schwerionenforschung mbH | Bestrahlungsverifikationsvorrichtung für Strahlentherapieanlagen und Verfahren zur Handhabung derselben |
WO2007116267A1 (en) * | 2006-04-12 | 2007-10-18 | Synexa Life Sciences (Pty) Ltd | Bioreactor |
US9057044B2 (en) | 2006-08-30 | 2015-06-16 | Meir Israelowitz | Laminar flow reactor |
CA2680130C (en) * | 2007-03-05 | 2016-01-12 | Caridianbct, Inc. | Cell expansion system and methods of use |
JP2010519936A (ja) * | 2007-03-05 | 2010-06-10 | カリディアンビーシーティー、インコーポレーテッド | 中空繊維バイオリアクター内における細胞の動きを制御する方法 |
DE102007011975A1 (de) | 2007-03-09 | 2008-09-11 | Hohner Maschinenbau Gmbh | Vorrichtung zum Zusammentragen flacher Druckprodukte, insbesondere von gefalzten bzw. ungefalzten Bogen, Karten oder dergleichen |
DE102009003972B4 (de) * | 2009-01-07 | 2011-04-28 | Sartorius Stedim Biotech Gmbh | Abgassystem für Bioreaktoren |
US20100247693A1 (en) * | 2009-03-24 | 2010-09-30 | Marini Jan L | Cosmetic formulation to treat rosacea telangiectasia |
US8778669B2 (en) | 2009-07-22 | 2014-07-15 | Corning Incorporated | Multilayer tissue culture vessel |
JP5864429B2 (ja) | 2009-11-09 | 2016-02-17 | スポットライト テクノロジー パートナーズ エルエルシーSpotlight Technology Partners Llc | 架橋ヒドロゲル組成物、ヒドロゲル組成物の形成方法、及びキット |
EP2498764B1 (de) | 2009-11-09 | 2017-09-06 | Spotlight Technology Partners LLC | Fragmentierte hydrogele |
US9057045B2 (en) | 2009-12-29 | 2015-06-16 | Terumo Bct, Inc. | Method of loading and distributing cells in a bioreactor of a cell expansion system |
CN101787348B (zh) * | 2010-02-24 | 2013-01-23 | 中国科学院过程工程研究所 | 一种强化传质传热的仿生生物反应器 |
CN101886032B (zh) * | 2010-02-24 | 2013-01-23 | 中国科学院过程工程研究所 | 一种利用微管系统强化传质传热的生物反应器 |
EP2625263B1 (de) | 2010-10-08 | 2020-03-11 | Terumo BCT, Inc. | Konfigurierbare verfahren und systeme für züchtung und ernte von zellen in einem hohlfaser-bioreaktorsystem |
CN102258817A (zh) * | 2011-05-13 | 2011-11-30 | 浙江大学 | 螺旋形中空纤维管人工肝生物反应器 |
CN102225222A (zh) * | 2011-05-13 | 2011-10-26 | 浙江大学 | U形中空纤维管人工肝生物反应器 |
EP2885393A1 (de) | 2012-08-20 | 2015-06-24 | Terumo BCT, Inc. | Verfahren zum laden und verteilen von zellen in einem bioreaktor eines zellexpansionssystems |
US9005550B2 (en) | 2012-10-29 | 2015-04-14 | Corning Incorporated | Multi-layered cell culture vessel with manifold grips |
JP6633522B2 (ja) | 2013-11-16 | 2020-01-22 | テルモ ビーシーティー、インコーポレーテッド | バイオリアクターにおける細胞増殖 |
US11008547B2 (en) | 2014-03-25 | 2021-05-18 | Terumo Bct, Inc. | Passive replacement of media |
US10077421B2 (en) | 2014-04-24 | 2018-09-18 | Terumo Bct, Inc. | Measuring flow rate |
JP6830059B2 (ja) | 2014-09-26 | 2021-02-17 | テルモ ビーシーティー、インコーポレーテッド | スケジュール化された細胞フィーディング |
WO2016183231A1 (en) | 2015-05-12 | 2016-11-17 | Baker Group, LLP | Method and system for a bioartificial organ |
WO2017004592A1 (en) | 2015-07-02 | 2017-01-05 | Terumo Bct, Inc. | Cell growth with mechanical stimuli |
EP3464565A4 (de) | 2016-05-25 | 2020-01-01 | Terumo BCT, Inc. | Zellexpansion |
US11104874B2 (en) | 2016-06-07 | 2021-08-31 | Terumo Bct, Inc. | Coating a bioreactor |
US11685883B2 (en) | 2016-06-07 | 2023-06-27 | Terumo Bct, Inc. | Methods and systems for coating a cell growth surface |
US11624046B2 (en) | 2017-03-31 | 2023-04-11 | Terumo Bct, Inc. | Cell expansion |
CN117247899A (zh) | 2017-03-31 | 2023-12-19 | 泰尔茂比司特公司 | 细胞扩增 |
Family Cites Families (60)
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US3734851A (en) * | 1969-12-29 | 1973-05-22 | K Matsumura | Method and device for purifying blood |
US3883393A (en) * | 1972-05-18 | 1975-05-13 | Us Health Education & Welfare | Cell culture on semi-permeable tubular membranes |
US4488911A (en) * | 1975-10-22 | 1984-12-18 | Luck Edward E | Non-antigenic collagen and articles of manufacture |
US4220725A (en) * | 1978-04-03 | 1980-09-02 | United States Of America | Capillary cell culture device |
US4241187A (en) * | 1979-03-27 | 1980-12-23 | United States Of America | Method and apparatus for cell and tissue culture |
US4293413A (en) * | 1979-12-28 | 1981-10-06 | Baxter Travenol Laboratories, Inc. | Dialyzer blood circuit and bubble traps |
US5106743A (en) * | 1981-01-26 | 1992-04-21 | Trustees Of Boston University | Hydrogels capable of supporting cell growth |
DE3107527A1 (de) * | 1981-02-27 | 1982-09-16 | Klaus Prof. Dr. 8400 Regensburg Heckmann | Hyperfiltrationsmembranen mit trennschichten aus monomolekularen filmen von tensiden |
JPS5928472A (ja) * | 1982-08-09 | 1984-02-15 | Koken:Kk | 細胞培養用基質およびこの基質を用いた細胞培養・分離法 |
US4537860A (en) * | 1982-12-08 | 1985-08-27 | Monsanto Company | Static cell culture maintenance system |
US4514499A (en) * | 1983-02-04 | 1985-04-30 | Corning Glass Works | Cell culture using a monolithic support |
US4692411A (en) * | 1983-09-06 | 1987-09-08 | Ghose Rabindra N | Separation of specific biological cells by a biochemical filter |
DE3409501A1 (de) * | 1984-03-15 | 1985-10-24 | Sandoz-Patent-GmbH, 7850 Lörrach | Verfahren zur kultivierung von zellen |
US4804628A (en) * | 1984-10-09 | 1989-02-14 | Endotronics, Inc. | Hollow fiber cell culture device and method of operation |
US4647539A (en) * | 1985-05-24 | 1987-03-03 | Endotronics, Inc. | Method and apparatus for growing cells in vitro |
IL75554A (en) * | 1985-06-18 | 1993-01-14 | Yeda Res & Dev | Matrix for cell cultivation in vitro |
US4720462A (en) * | 1985-11-05 | 1988-01-19 | Robert Rosenson | Culture system for the culture of solid tissue masses and method of using the same |
US4675002A (en) * | 1985-12-02 | 1987-06-23 | Viles Joseph M | Liver assist device employing transformed cell lines |
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US5108923A (en) * | 1986-04-25 | 1992-04-28 | Collaborative Research, Inc. | Bioadhesives for cell and tissue adhesion |
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DE3720665A1 (de) * | 1987-06-23 | 1989-01-05 | Schael Wilfried | Vorrichtung zur haemodialyse und haemofiltration |
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US5108926A (en) * | 1987-09-08 | 1992-04-28 | Board Of Regents, The University Of Texas System | Apparatus for the precise positioning of cells |
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FR2640638B1 (fr) * | 1988-12-20 | 1991-02-15 | Commissariat Energie Atomique | Bioreacteur et dispositif pour la culture de cellules animales |
US4959148A (en) * | 1989-01-23 | 1990-09-25 | Clark Iii William T | Method and apparatus for specific affinity enhanced transport bioreactor |
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US5013437A (en) * | 1989-10-30 | 1991-05-07 | The Dow Chemical Company | Hollow fiber membrane fluid separation device adapted for boreside feed which contains multiple concentric stages |
EP0532522B1 (de) * | 1990-05-16 | 1996-04-10 | Baylor College Of Medicine | Eine permanente menschliche hepatogene zellinie und seine verwendung in der unterstützung der leberfunktion |
JPH0728722B2 (ja) * | 1990-06-29 | 1995-04-05 | 富士写真フイルム株式会社 | バイオリアクター装置 |
US5198110A (en) * | 1990-07-02 | 1993-03-30 | Asahi Medical Co., Ltd. | Bundle of permselective hollow fibers and a fluid separator containing the same |
AU9031591A (en) * | 1990-10-29 | 1992-05-26 | Regents Of The University Of Minnesota | A bioartificial liver |
US5270192A (en) * | 1991-02-07 | 1993-12-14 | Monsanto Company | Biological artificial liver |
JP3026516B2 (ja) * | 1991-05-15 | 2000-03-27 | 株式会社クラレ | 細胞培養器 |
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DE4206585C2 (de) * | 1992-03-03 | 1994-11-24 | Augustinus Dr Med Bader | Vorrichtung zur Massenkultur von Zellen |
US5512474A (en) * | 1992-05-29 | 1996-04-30 | Bsi Corporation | Cell culture support containing a cell adhesion factor and a positively-charged molecule |
DE4230194C2 (de) * | 1992-09-09 | 1995-07-27 | Joerg Dr Med Gerlach | Reaktor zur Züchtung und zur Nutzung von Stoffwechselleistungen und/oder zum Erhalt von Mikroorganismen |
US5368555A (en) * | 1992-12-29 | 1994-11-29 | Hepatix, Inc. | Organ support system |
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US5411662A (en) * | 1994-02-25 | 1995-05-02 | Praxair Technology, Inc. | Fluid separation assembly having an purge control valve |
ES2142981T3 (es) * | 1994-09-02 | 2000-05-01 | Terumo Corp | Dializador. |
US5643794A (en) * | 1995-06-07 | 1997-07-01 | W.R. Grace & Co.-Conn. | Apparatus for bioprocessing a circulating fluid |
WO1997016527A1 (en) * | 1995-10-30 | 1997-05-09 | Cellex Biosciences, Inc. | Cultureware for bioartificial liver |
-
1997
- 1997-05-22 US US08/861,503 patent/US5955353A/en not_active Expired - Fee Related
-
1998
- 1998-05-13 NZ NZ333786A patent/NZ333786A/xx unknown
- 1998-05-13 EP EP98922389A patent/EP0915965B1/de not_active Expired - Lifetime
- 1998-05-13 AU AU74947/98A patent/AU738641B2/en not_active Ceased
- 1998-05-13 AT AT98922389T patent/ATE231181T1/de not_active IP Right Cessation
- 1998-05-13 JP JP10550484A patent/JP2000515391A/ja not_active Ceased
- 1998-05-13 CA CA2262812A patent/CA2262812C/en not_active Expired - Fee Related
- 1998-05-13 WO PCT/US1998/010111 patent/WO1998053046A1/en active IP Right Grant
- 1998-05-13 DE DE69810740T patent/DE69810740T2/de not_active Expired - Lifetime
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102005021305A1 (de) * | 2005-05-09 | 2006-11-16 | Fresenius Medical Care Deutschland Gmbh | Reaktoreinheit und Reaktor mit einer derartigen Reaktoreinheit |
Also Published As
Publication number | Publication date |
---|---|
AU7494798A (en) | 1998-12-11 |
CA2262812A1 (en) | 1998-11-26 |
EP0915965A1 (de) | 1999-05-19 |
NZ333786A (en) | 2000-07-28 |
CA2262812C (en) | 2011-02-08 |
AU738641B2 (en) | 2001-09-20 |
US5955353A (en) | 1999-09-21 |
ATE231181T1 (de) | 2003-02-15 |
JP2000515391A (ja) | 2000-11-21 |
DE69810740D1 (de) | 2003-02-20 |
WO1998053046A1 (en) | 1998-11-26 |
EP0915965B1 (de) | 2003-01-15 |
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