DE69801902T2 - Verfahren zur herstellung von synthetischen knochenersatzmaterialien mit kontrollierter porosität - Google Patents
Verfahren zur herstellung von synthetischen knochenersatzmaterialien mit kontrollierter porositätInfo
- Publication number
- DE69801902T2 DE69801902T2 DE69801902T DE69801902T DE69801902T2 DE 69801902 T2 DE69801902 T2 DE 69801902T2 DE 69801902 T DE69801902 T DE 69801902T DE 69801902 T DE69801902 T DE 69801902T DE 69801902 T2 DE69801902 T2 DE 69801902T2
- Authority
- DE
- Germany
- Prior art keywords
- particles
- organic compound
- temperature
- ceramic
- process according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000004519 manufacturing process Methods 0.000 title claims description 4
- 239000000316 bone substitute Substances 0.000 title description 10
- 239000000919 ceramic Substances 0.000 claims abstract description 41
- 238000000034 method Methods 0.000 claims abstract description 29
- 239000011148 porous material Substances 0.000 claims abstract description 15
- 210000000988 bone and bone Anatomy 0.000 claims abstract description 4
- 239000002245 particle Substances 0.000 claims description 51
- 229920003229 poly(methyl methacrylate) Polymers 0.000 claims description 27
- 239000004926 polymethyl methacrylate Substances 0.000 claims description 27
- 150000002894 organic compounds Chemical class 0.000 claims description 16
- 229920000642 polymer Polymers 0.000 claims description 15
- 230000008569 process Effects 0.000 claims description 15
- 230000009477 glass transition Effects 0.000 claims description 12
- 150000001875 compounds Chemical class 0.000 claims description 11
- 239000000725 suspension Substances 0.000 claims description 11
- 239000001506 calcium phosphate Substances 0.000 claims description 9
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims description 9
- 229910052588 hydroxylapatite Inorganic materials 0.000 claims description 8
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 claims description 8
- 229910000389 calcium phosphate Inorganic materials 0.000 claims description 6
- 235000011010 calcium phosphates Nutrition 0.000 claims description 6
- 235000019731 tricalcium phosphate Nutrition 0.000 claims description 6
- 238000011049 filling Methods 0.000 claims description 5
- 238000010438 heat treatment Methods 0.000 claims description 5
- 229920000193 polymethacrylate Polymers 0.000 claims description 5
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- 239000004925 Acrylic resin Substances 0.000 claims description 4
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- 229910052751 metal Inorganic materials 0.000 claims description 4
- 239000002184 metal Substances 0.000 claims description 4
- 238000007669 thermal treatment Methods 0.000 claims description 4
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- 239000004793 Polystyrene Substances 0.000 claims description 3
- 239000012736 aqueous medium Substances 0.000 claims description 3
- 239000000203 mixture Substances 0.000 claims description 3
- -1 polyethylene Polymers 0.000 claims description 3
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- 229920002223 polystyrene Polymers 0.000 claims description 3
- 229910000391 tricalcium phosphate Inorganic materials 0.000 claims description 3
- 229940078499 tricalcium phosphate Drugs 0.000 claims description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 3
- 238000001816 cooling Methods 0.000 claims description 2
- 239000011347 resin Substances 0.000 claims description 2
- 229920005989 resin Polymers 0.000 claims description 2
- 229920001169 thermoplastic Polymers 0.000 claims description 2
- 238000005979 thermal decomposition reaction Methods 0.000 claims 2
- GNFTZDOKVXKIBK-UHFFFAOYSA-N 3-(2-methoxyethoxy)benzohydrazide Chemical compound COCCOC1=CC=CC(C(=O)NN)=C1 GNFTZDOKVXKIBK-UHFFFAOYSA-N 0.000 claims 1
- FGUUSXIOTUKUDN-IBGZPJMESA-N C1(=CC=CC=C1)N1C2=C(NC([C@H](C1)NC=1OC(=NN=1)C1=CC=CC=C1)=O)C=CC=C2 Chemical compound C1(=CC=CC=C1)N1C2=C(NC([C@H](C1)NC=1OC(=NN=1)C1=CC=CC=C1)=O)C=CC=C2 FGUUSXIOTUKUDN-IBGZPJMESA-N 0.000 claims 1
- 239000011505 plaster Substances 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 abstract description 2
- 239000000843 powder Substances 0.000 description 5
- 238000009826 distribution Methods 0.000 description 4
- 229940082569 selenite Drugs 0.000 description 4
- MCAHWIHFGHIESP-UHFFFAOYSA-L selenite(2-) Chemical compound [O-][Se]([O-])=O MCAHWIHFGHIESP-UHFFFAOYSA-L 0.000 description 4
- 238000004581 coalescence Methods 0.000 description 3
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- 239000012620 biological material Substances 0.000 description 1
- 239000012455 biphasic mixture Substances 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 210000002449 bone cell Anatomy 0.000 description 1
- 230000010478 bone regeneration Effects 0.000 description 1
- 150000007942 carboxylates Chemical class 0.000 description 1
- 238000005266 casting Methods 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
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- 238000004033 diameter control Methods 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000010218 electron microscopic analysis Methods 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 238000001033 granulometry Methods 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 238000005470 impregnation Methods 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
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- 210000003739 neck Anatomy 0.000 description 1
- 230000009972 noncorrosive effect Effects 0.000 description 1
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Classifications
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/12—Phosphorus-containing materials, e.g. apatite
-
- C—CHEMISTRY; METALLURGY
- C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
- C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
- C04B35/00—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
- C04B35/01—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxide ceramics
- C04B35/447—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxide ceramics based on phosphates, e.g. hydroxyapatite
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- A61F2002/30004—Material related properties of the prosthesis or of a coating on the prosthesis the prosthesis being made from materials having different values of a given property at different locations within the same prosthesis
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0014—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
- A61F2250/0023—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in porosity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00005—The prosthesis being constructed from a particular material
- A61F2310/00179—Ceramics or ceramic-like structures
- A61F2310/00293—Ceramics or ceramic-like structures containing a phosphorus-containing compound, e.g. apatite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00005—The prosthesis being constructed from a particular material
- A61F2310/00353—Bone cement, e.g. polymethylmethacrylate or PMMA
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S623/00—Prosthesis, i.e. artificial body members, parts thereof, or aids and accessories therefor
- Y10S623/92—Method or apparatus for preparing or treating prosthetic
- Y10S623/923—Bone
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S623/00—Prosthesis, i.e. artificial body members, parts thereof, or aids and accessories therefor
- Y10S623/924—Material characteristic
- Y10S623/926—Synthetic
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/249921—Web or sheet containing structurally defined element or component
- Y10T428/249953—Composite having voids in a component [e.g., porous, cellular, etc.]
- Y10T428/249961—With gradual property change within a component
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/249921—Web or sheet containing structurally defined element or component
- Y10T428/249953—Composite having voids in a component [e.g., porous, cellular, etc.]
- Y10T428/249967—Inorganic matrix in void-containing component
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Ceramic Engineering (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Inorganic Chemistry (AREA)
- Dermatology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Manufacturing & Machinery (AREA)
- Vascular Medicine (AREA)
- Materials Engineering (AREA)
- Structural Engineering (AREA)
- Organic Chemistry (AREA)
- Materials For Medical Uses (AREA)
- Porous Artificial Stone Or Porous Ceramic Products (AREA)
- Manufacture Of Porous Articles, And Recovery And Treatment Of Waste Products (AREA)
- Compositions Of Oxide Ceramics (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9701309A FR2758988B1 (fr) | 1997-02-05 | 1997-02-05 | Procede d'elaboration de substituts osseux synthetiques d'architecture poreuse parfaitement maitrisee |
| PCT/FR1998/000213 WO1998034654A1 (fr) | 1997-02-05 | 1998-02-05 | Procede d'elaboration de substituts osseux synthetiques de porosite controlee |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69801902D1 DE69801902D1 (de) | 2001-11-08 |
| DE69801902T2 true DE69801902T2 (de) | 2002-04-25 |
Family
ID=9503361
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69801902T Expired - Lifetime DE69801902T2 (de) | 1997-02-05 | 1998-02-05 | Verfahren zur herstellung von synthetischen knochenersatzmaterialien mit kontrollierter porosität |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6316091B1 (enExample) |
| EP (1) | EP0964707B1 (enExample) |
| JP (1) | JP4222633B2 (enExample) |
| AT (1) | ATE206313T1 (enExample) |
| AU (1) | AU6298398A (enExample) |
| DE (1) | DE69801902T2 (enExample) |
| DK (1) | DK0964707T3 (enExample) |
| ES (1) | ES2161517T3 (enExample) |
| FR (1) | FR2758988B1 (enExample) |
| WO (1) | WO1998034654A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE20205016U1 (de) * | 2002-03-30 | 2003-08-14 | Mathys Medizinaltechnik Ag, Bettlach | Chirurgisches Implantat |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6383519B1 (en) * | 1999-01-26 | 2002-05-07 | Vita Special Purpose Corporation | Inorganic shaped bodies and methods for their production and use |
| US6458162B1 (en) | 1999-08-13 | 2002-10-01 | Vita Special Purpose Corporation | Composite shaped bodies and methods for their production and use |
| CA2328818A1 (en) * | 1999-12-16 | 2001-06-16 | Isotis B.V. | Porous ceramic body |
| DE29922585U1 (de) * | 1999-12-22 | 2000-07-20 | Biovision GmbH, 98693 Ilmenau | Temporärer Knochendefektfüller |
| US8545786B2 (en) * | 2000-09-22 | 2013-10-01 | Colorado School Of Mines | Manufacture of porous net-shaped materials comprising alpha or beta tricalcium phosphate or mixtures thereof |
| US6949251B2 (en) | 2001-03-02 | 2005-09-27 | Stryker Corporation | Porous β-tricalcium phosphate granules for regeneration of bone tissue |
| JP5007476B2 (ja) * | 2001-03-23 | 2012-08-22 | オリンパス株式会社 | 人工骨材 |
| FR2823305B1 (fr) * | 2001-04-05 | 2003-06-20 | Francine Monchau | Procede de controle de la coalescence des particules formant un edifice, notamment destine a etre utilise dans la fabrication de produits a pores interconnectes, par exemple, implant osseux |
| FR2823674B1 (fr) * | 2001-04-19 | 2004-11-12 | Limousine De Brevet Soc | Procede de fabrication de substituts osseux et d'elements implantables en ceramique poreuse a tres haute resistance |
| US7695521B2 (en) * | 2001-05-01 | 2010-04-13 | Amedica Corporation | Hip prosthesis with monoblock ceramic acetabular cup |
| KR100426446B1 (ko) * | 2001-07-28 | 2004-04-13 | 홍국선 | 직선형 다공성 골 충진재 및 그 제조 방법 |
| DE60218336T2 (de) * | 2001-10-30 | 2007-10-31 | Eyeborn (Proprietary) Ltd., Brummeria | Orbitalimplantat |
| JP3739715B2 (ja) * | 2002-03-19 | 2006-01-25 | オリンパス株式会社 | 人工骨および組織工学用担体 |
| DE10258773A1 (de) * | 2002-12-16 | 2004-07-08 | SDGI Holding, Inc., Wilmington | Knochenersatzmaterial |
| EP1601632B1 (en) * | 2003-01-23 | 2010-08-25 | University Of Bath | Bone substitute material |
| GB0318901D0 (en) * | 2003-08-12 | 2003-09-17 | Univ Bath | Improvements in or relating to bone substitute material |
| DE60321571D1 (de) * | 2003-09-16 | 2008-07-24 | Olympus Corp | Künstlicher Knochen und Trägermaterial zum Gewebeaufbau |
| US7189263B2 (en) | 2004-02-03 | 2007-03-13 | Vita Special Purpose Corporation | Biocompatible bone graft material |
| US8083746B2 (en) * | 2004-05-07 | 2011-12-27 | Arthrex, Inc. | Open wedge osteotomy system and surgical method |
| WO2005114323A2 (en) | 2004-05-12 | 2005-12-01 | Therics, Inc. | Manufacturing process of three dimensional printing |
| DE102004027657A1 (de) * | 2004-06-07 | 2006-02-02 | Zow Ag | Gekammerter Werkstoff als Implantat, Knochenersatz und allgemein als Werkstoff |
| US9220595B2 (en) | 2004-06-23 | 2015-12-29 | Orthovita, Inc. | Shapeable bone graft substitute and instruments for delivery thereof |
| US7473678B2 (en) | 2004-10-14 | 2009-01-06 | Biomimetic Therapeutics, Inc. | Platelet-derived growth factor compositions and methods of use thereof |
| WO2007061889A2 (en) | 2005-11-17 | 2007-05-31 | Biomimetic Therapeutics, Inc. | Maxillofacial bone augmentation using rhpdgf-bb and a biocompatible matrix |
| ES2427993T3 (es) | 2006-02-09 | 2013-11-05 | Biomimetic Therapeutics, Llc | Composiciones y métodos para el tratamiento de hueso |
| CA2656050C (en) | 2006-06-29 | 2015-02-03 | Orthovita, Inc. | Kit for bone graft comprising collagen,calcium phosphate,and bioactive glass |
| WO2008005427A2 (en) | 2006-06-30 | 2008-01-10 | Biomimetic Therapeutics, Inc. | Pdgf-biomatrix compositions and methods for treating rotator cuff injuries |
| US9161967B2 (en) | 2006-06-30 | 2015-10-20 | Biomimetic Therapeutics, Llc | Compositions and methods for treating the vertebral column |
| US8449622B2 (en) * | 2006-09-11 | 2013-05-28 | Warsaw Orthopedic, Inc. | Multi-phase osteochondral implantable device |
| EP2462895B1 (en) | 2006-11-03 | 2016-11-02 | BioMimetic Therapeutics, LLC | Compositions and methods for arthrodetic procedures |
| US20080195476A1 (en) * | 2007-02-09 | 2008-08-14 | Marchese Michael A | Abandonment remarketing system |
| EP2014256A1 (en) * | 2007-07-12 | 2009-01-14 | Straumann Holding AG | Composite bone repair material |
| CA2715254A1 (en) | 2008-02-07 | 2009-08-13 | Biomimetic Therapeutics, Inc. | Compositions and methods for distraction osteogenesis |
| CN102231992B (zh) | 2008-09-09 | 2015-05-20 | 生物模拟治疗公司 | 用于治疗肌腱和韧带损伤的血小板衍生生长因子的组合物和方法 |
| US20110151027A1 (en) * | 2009-12-21 | 2011-06-23 | Theodore D Clineff | Strontium-doped calcium phosphate bone graft materials |
| US8758791B2 (en) * | 2010-01-26 | 2014-06-24 | Warsaw Orthopedic, Inc. | Highly compression resistant matrix with porous skeleton |
| BR112012020566B1 (pt) | 2010-02-22 | 2021-09-21 | Biomimetic Therapeutics, Llc | Composição de fator de crescimento derivado de plaqueta |
| TWI411595B (zh) * | 2010-04-07 | 2013-10-11 | Univ Kaohsiung Medical | 以溫感水膠製備含多孔性陶瓷組合物的方法 |
| EP2569342B1 (en) | 2010-05-11 | 2022-01-26 | Howmedica Osteonics Corp. | Organophosphorous, multivalent metal compounds,&polymer adhesive interpenetrating network compositions&methods |
| US8765189B2 (en) | 2011-05-13 | 2014-07-01 | Howmedica Osteonic Corp. | Organophosphorous and multivalent metal compound compositions and methods |
| KR101408083B1 (ko) * | 2012-05-18 | 2014-06-17 | 서울대학교산학협력단 | 경사기공 구조를 갖는 다공성 세라믹 소결체의 제조방법 |
| CN102697584B (zh) * | 2012-06-05 | 2014-07-02 | 西北工业大学 | 一种孔隙连通性可控的人工骨支架的制备 |
| US10118827B2 (en) | 2013-05-10 | 2018-11-06 | Reed A. Ayers | Combustion synthesis of calcium phosphate constructs and powders doped with atoms, molecules, ions, or compounds |
| US11433159B2 (en) | 2019-07-26 | 2022-09-06 | Warsaw Orthopedic, Inc. | Hydratable and flowable implantable compositions and methods of making and using them |
| US11311647B2 (en) | 2019-07-26 | 2022-04-26 | Warsaw Orthopedic, Inc. | Implantable calcium phosphate compositions and methods |
| US11498880B2 (en) | 2019-07-26 | 2022-11-15 | Warsaw Orthopedic, Inc. | Calcium phosphate granules and methods of making them |
| MX2022001514A (es) * | 2019-08-08 | 2022-03-11 | Evonik Operations Gmbh | Proceso para producir espumas rigidas de metacrilato de polimetilo como materiales de nucleo en paletas de rotor de plantas de energia eolica y en la construccion de barcos. |
| EP4027949A4 (en) | 2019-09-11 | 2023-06-14 | Warsaw Orthopedic, Inc. | HYDRATABLE COMPOSITIONS COMPRISING MACROPARTICLES AND METHODS OF MAKING THEM |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS577856A (en) * | 1980-06-13 | 1982-01-16 | Mitsubishi Mining & Cement Co | Manufacture of calcium phosphate porous body |
| JPS577859A (en) * | 1980-06-13 | 1982-01-16 | Mitsubishi Mining & Cement Co | Manufacture of calcium phosphate porous body |
| DE4033291A1 (de) * | 1990-10-19 | 1992-04-23 | Draenert Klaus | Werkstoff und verfahren zu seiner herstellung |
| US5298205A (en) * | 1992-05-11 | 1994-03-29 | Polyceramics, Inc. | Ceramic filter process |
| DE4403509A1 (de) * | 1994-02-04 | 1995-08-10 | Draenert Klaus | Werkstoff und Verfahren zu seiner Herstellung |
| JP3457675B2 (ja) * | 1994-05-24 | 2003-10-20 | テクノロジィ ファイナンス コーポレイション (プロプライエタリー)リミテッド | 骨修復と置換のための生体適合材料と骨インプラント |
-
1997
- 1997-02-05 FR FR9701309A patent/FR2758988B1/fr not_active Expired - Fee Related
-
1998
- 1998-02-05 DE DE69801902T patent/DE69801902T2/de not_active Expired - Lifetime
- 1998-02-05 AU AU62983/98A patent/AU6298398A/en not_active Abandoned
- 1998-02-05 DK DK98906978T patent/DK0964707T3/da active
- 1998-02-05 EP EP98906978A patent/EP0964707B1/fr not_active Expired - Lifetime
- 1998-02-05 WO PCT/FR1998/000213 patent/WO1998034654A1/fr not_active Ceased
- 1998-02-05 JP JP53387598A patent/JP4222633B2/ja not_active Expired - Fee Related
- 1998-02-05 ES ES98906978T patent/ES2161517T3/es not_active Expired - Lifetime
- 1998-02-05 US US09/367,017 patent/US6316091B1/en not_active Expired - Lifetime
- 1998-02-05 AT AT98906978T patent/ATE206313T1/de not_active IP Right Cessation
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE20205016U1 (de) * | 2002-03-30 | 2003-08-14 | Mathys Medizinaltechnik Ag, Bettlach | Chirurgisches Implantat |
Also Published As
| Publication number | Publication date |
|---|---|
| DE69801902D1 (de) | 2001-11-08 |
| JP4222633B2 (ja) | 2009-02-12 |
| DK0964707T3 (da) | 2002-01-28 |
| EP0964707B1 (fr) | 2001-10-04 |
| ATE206313T1 (de) | 2001-10-15 |
| WO1998034654A1 (fr) | 1998-08-13 |
| FR2758988A1 (fr) | 1998-08-07 |
| FR2758988B1 (fr) | 2000-01-21 |
| US6316091B1 (en) | 2001-11-13 |
| EP0964707A1 (fr) | 1999-12-22 |
| AU6298398A (en) | 1998-08-26 |
| ES2161517T3 (es) | 2001-12-01 |
| JP2001510375A (ja) | 2001-07-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8327 | Change in the person/name/address of the patent owner |
Owner name: WARSAW ORTHOPEDIC, INC., WARSAW, IND., US |