DE69739478D1 - Im cadasil bezogenes gen, diagnostikums-verfahren und therapeutische verwendung - Google Patents
Im cadasil bezogenes gen, diagnostikums-verfahren und therapeutische verwendungInfo
- Publication number
- DE69739478D1 DE69739478D1 DE69739478T DE69739478T DE69739478D1 DE 69739478 D1 DE69739478 D1 DE 69739478D1 DE 69739478 T DE69739478 T DE 69739478T DE 69739478 T DE69739478 T DE 69739478T DE 69739478 D1 DE69739478 D1 DE 69739478D1
- Authority
- DE
- Germany
- Prior art keywords
- cadasil
- therapeutic use
- diagnostic methods
- related gene
- gene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70567—Nuclear receptors, e.g. retinoic acid receptor [RAR], RXR, nuclear orphan receptors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A61P25/12—Antiepileptics; Anticonvulsants for grand-mal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9609733A FR2751985B1 (fr) | 1996-08-01 | 1996-08-01 | Gene implique dans le cadasil, methode de diagnostic et application therapeutique |
FR9704680A FR2751986B1 (fr) | 1996-08-01 | 1997-04-16 | Gene implique dans le cadasil, methode de diagnostic et application therapeutique |
PCT/FR1997/001433 WO1998005775A1 (fr) | 1996-08-01 | 1997-07-31 | Gene implique dans le cadasil, methode de diagnostic et application therapeutique |
Publications (1)
Publication Number | Publication Date |
---|---|
DE69739478D1 true DE69739478D1 (de) | 2009-08-13 |
Family
ID=26232895
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69739478T Expired - Lifetime DE69739478D1 (de) | 1996-08-01 | 1997-07-31 | Im cadasil bezogenes gen, diagnostikums-verfahren und therapeutische verwendung |
Country Status (9)
Country | Link |
---|---|
US (3) | US6537775B1 (de) |
EP (1) | EP0915973B1 (de) |
JP (2) | JP4463329B2 (de) |
AT (1) | ATE435281T1 (de) |
CA (1) | CA2262459C (de) |
DE (1) | DE69739478D1 (de) |
ES (1) | ES2328304T3 (de) |
FR (1) | FR2751986B1 (de) |
WO (1) | WO1998005775A1 (de) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2751986B1 (fr) * | 1996-08-01 | 1998-12-31 | Inst Nat Sante Rech Med | Gene implique dans le cadasil, methode de diagnostic et application therapeutique |
US8044259B2 (en) * | 2000-08-03 | 2011-10-25 | The Regents Of The University Of Michigan | Determining the capability of a test compound to affect solid tumor stem cells |
US6984522B2 (en) | 2000-08-03 | 2006-01-10 | Regents Of The University Of Michigan | Isolation and use of solid tumor stem cells |
CA2457879A1 (en) * | 2001-08-22 | 2003-03-06 | Galapagos Genomics N.V. | Modulators of bone homeostasis identified in a high-throughput screen |
WO2005111072A2 (en) * | 2004-04-29 | 2005-11-24 | The Trustees Of Columbia University In The City Of New York | Notch-based fusion proteins and uses thereof |
CN1763196B (zh) * | 2004-09-13 | 2010-09-08 | 首都医科大学宣武医院 | 基因突变类型及基因测序方法 |
US7585968B2 (en) * | 2005-03-28 | 2009-09-08 | Isis Pharmaceuticals, Inc. | Compositions and their uses directed to thymus and activation-regulated chemokine (TARC) |
US7723477B2 (en) | 2005-10-31 | 2010-05-25 | Oncomed Pharmaceuticals, Inc. | Compositions and methods for inhibiting Wnt-dependent solid tumor cell growth |
WO2007053577A2 (en) | 2005-10-31 | 2007-05-10 | Oncomed Pharmaceuticals, Inc. | Compositions and methods for diagnosing and treating cancer |
AU2006308847C1 (en) | 2005-10-31 | 2012-05-10 | Oncomed Pharmaceuticals, Inc. | Compositions and methods for treating and diagnosing cancer |
JP2009539403A (ja) | 2006-06-13 | 2009-11-19 | オンコメッド ファーマシューティカルズ インコーポレイテッド | 癌を診断および処置するための組成物および方法 |
AU2007309229B8 (en) | 2006-10-19 | 2013-05-09 | Genentech, Inc. | Anti-Notch3 agonist antibodies and their use in the treatment of Notch3-related diseases |
TW200823293A (en) | 2006-10-19 | 2008-06-01 | Genentech Inc | Novel anti-Notch3 antibodies and their use in the detection and diagnosis of disease |
TWI419904B (zh) * | 2006-12-18 | 2013-12-21 | Genentech Inc | 拮抗劑抗-notch3抗體及其用於預防及治療notch3相關疾病之用途 |
US8148147B2 (en) | 2007-01-24 | 2012-04-03 | The Regents Of The University Of Michigan | Compositions and methods for treating and diagnosing pancreatic cancer |
CA2676008A1 (en) | 2007-01-24 | 2008-07-31 | Oncomed Pharmaceuticals, Inc. | Compositions and methods for diagnosing and treating cancer |
US20090208491A1 (en) * | 2007-02-14 | 2009-08-20 | Austin Gurney | Compositions and Methods for Diagnosing and Treating Cancer |
PE20090321A1 (es) | 2007-06-04 | 2009-04-20 | Genentech Inc | Anticuerpos anti-notch1 nrr, metodo de preparacion y composicion farmaceutica |
WO2009025867A2 (en) | 2007-08-23 | 2009-02-26 | The Trustees Of Columbia University In The City Of New York | Compositions of humanized notch fusion proteins and methods of treatment |
US7807630B2 (en) | 2007-09-14 | 2010-10-05 | Vanderbilt University | Targeting of Notch3 receptor function for cancer therapy |
US9132189B2 (en) | 2008-07-08 | 2015-09-15 | Oncomed Pharmaceuticals, Inc. | Notch1 binding agents and methods of use thereof |
CN102112490B (zh) | 2008-07-08 | 2014-10-22 | 昂考梅德药品有限公司 | Notch1受体结合剂和其使用方法 |
AU2009283134B2 (en) | 2008-08-22 | 2015-05-14 | The Trustees Of Columbia University In The City Of New York | Human Notch3 based fusion proteins as decoy inhibitors of Notch3 signaling |
TWI506037B (zh) | 2008-09-26 | 2015-11-01 | Oncomed Pharm Inc | 捲曲結合劑類及彼等之用途 |
JP2012515547A (ja) * | 2009-01-26 | 2012-07-12 | アカデミス ズィーケンハイス レイデン ハー.オー.デー.エン. エルユーエムセー | Notch3タンパク質発現および/またはnotch3のコード領域を調節するための手段および方法;cadasilの処置におけるその組成物および使用 |
TWI535445B (zh) | 2010-01-12 | 2016-06-01 | 安可美德藥物股份有限公司 | Wnt拮抗劑及治療和篩選方法 |
AU2011205316B2 (en) | 2010-01-13 | 2015-05-28 | Oncomed Pharmaceuticals, Inc. | Notch1 binding agents and methods of use thereof |
CN102971337B (zh) | 2010-04-01 | 2016-09-21 | 昂考梅德药品有限公司 | 卷曲蛋白结合药剂及其应用 |
WO2011140295A2 (en) * | 2010-05-06 | 2011-11-10 | President And Fellows Of Harvard College | Modulators of notch receptor signaling and methods of use thereof |
AR088048A1 (es) | 2011-10-04 | 2014-05-07 | Univ Columbia | Señuelos notch1 humanos |
CN104768579A (zh) | 2012-10-23 | 2015-07-08 | 昂科梅德制药有限公司 | 使用Wnt途径结合剂来治疗神经内分泌肿瘤的方法 |
TWI589590B (zh) | 2012-11-07 | 2017-07-01 | 輝瑞股份有限公司 | 抗切口3(anti-notch3)抗體及抗體-藥物共軛體 |
EP2950885B1 (de) | 2013-02-04 | 2018-11-21 | Oncomed Pharmaceuticals, Inc. | Verfahren und überwachung einer behandlung mit einem wnt-pfad-hemmer |
US9168300B2 (en) | 2013-03-14 | 2015-10-27 | Oncomed Pharmaceuticals, Inc. | MET-binding agents and uses thereof |
WO2018183219A2 (en) * | 2017-03-27 | 2018-10-04 | The Schepens Eye Research Institute, Inc. | Nucleic acid-based compositions and methods for treating small vessel diseases |
US11453718B2 (en) | 2017-03-27 | 2022-09-27 | The Schepens Eye Research Institute, Inc. | NOTCH3 agonist compositions and methods for treating small vessel diseases |
US20200103419A1 (en) * | 2017-03-27 | 2020-04-02 | The Schepens Eye Research Institute, Inc. | Blood biomarkers and diagnostic methods for small vessel diseases |
EP4347634A1 (de) * | 2021-06-02 | 2024-04-10 | Regeneron Pharmaceuticals, Inc. | Behandlung von zerebrovaskulären erkrankungen mit neurogenen locus notch homolog protein 3 (notch3) mitteln |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2116628A1 (en) * | 1994-02-28 | 1995-08-29 | Anne Marie Gisele Joutel | Method for the diagnosis of cadasil |
FR2751986B1 (fr) * | 1996-08-01 | 1998-12-31 | Inst Nat Sante Rech Med | Gene implique dans le cadasil, methode de diagnostic et application therapeutique |
-
1997
- 1997-04-16 FR FR9704680A patent/FR2751986B1/fr not_active Expired - Fee Related
- 1997-07-31 AT AT97936721T patent/ATE435281T1/de not_active IP Right Cessation
- 1997-07-31 EP EP97936721A patent/EP0915973B1/de not_active Expired - Lifetime
- 1997-07-31 CA CA2262459A patent/CA2262459C/fr not_active Expired - Lifetime
- 1997-07-31 ES ES97936721T patent/ES2328304T3/es not_active Expired - Lifetime
- 1997-07-31 US US09/230,652 patent/US6537775B1/en not_active Expired - Lifetime
- 1997-07-31 JP JP50767598A patent/JP4463329B2/ja not_active Expired - Lifetime
- 1997-07-31 WO PCT/FR1997/001433 patent/WO1998005775A1/fr active Application Filing
- 1997-07-31 DE DE69739478T patent/DE69739478D1/de not_active Expired - Lifetime
-
2000
- 2000-07-07 US US09/612,226 patent/US6995257B1/en not_active Expired - Fee Related
-
2003
- 2003-02-03 US US10/356,625 patent/US7138234B2/en not_active Expired - Fee Related
-
2009
- 2009-10-02 JP JP2009230857A patent/JP2010042012A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
CA2262459C (fr) | 2013-03-26 |
WO1998005775A1 (fr) | 1998-02-12 |
JP2010042012A (ja) | 2010-02-25 |
US6995257B1 (en) | 2006-02-07 |
EP0915973B1 (de) | 2009-07-01 |
US20030186290A1 (en) | 2003-10-02 |
ATE435281T1 (de) | 2009-07-15 |
JP2001500366A (ja) | 2001-01-16 |
US6537775B1 (en) | 2003-03-25 |
US7138234B2 (en) | 2006-11-21 |
JP4463329B2 (ja) | 2010-05-19 |
EP0915973A1 (de) | 1999-05-19 |
ES2328304T3 (es) | 2009-11-11 |
FR2751986A1 (fr) | 1998-02-06 |
FR2751986B1 (fr) | 1998-12-31 |
CA2262459A1 (fr) | 1998-02-12 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |