DE602005019540D1 - Diagnostische und therapeutische verwendung des mal2-gens und proteins bei neurodegenerativen krankheiten - Google Patents
Diagnostische und therapeutische verwendung des mal2-gens und proteins bei neurodegenerativen krankheitenInfo
- Publication number
- DE602005019540D1 DE602005019540D1 DE602005019540T DE602005019540T DE602005019540D1 DE 602005019540 D1 DE602005019540 D1 DE 602005019540D1 DE 602005019540 T DE602005019540 T DE 602005019540T DE 602005019540 T DE602005019540 T DE 602005019540T DE 602005019540 D1 DE602005019540 D1 DE 602005019540D1
- Authority
- DE
- Germany
- Prior art keywords
- disease
- alzheimer
- protein
- mal2
- gene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 108090000623 proteins and genes Proteins 0.000 title abstract 3
- 101000962438 Homo sapiens Protein MAL2 Proteins 0.000 title abstract 2
- 230000001225 therapeutic effect Effects 0.000 title abstract 2
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 title 1
- 208000024827 Alzheimer disease Diseases 0.000 abstract 4
- 238000000034 method Methods 0.000 abstract 3
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 2
- 101150026452 Mal2 gene Proteins 0.000 abstract 1
- 102100039191 Protein MAL2 Human genes 0.000 abstract 1
- 210000004556 brain Anatomy 0.000 abstract 1
- 230000004770 neurodegeneration Effects 0.000 abstract 1
- 230000000069 prophylactic effect Effects 0.000 abstract 1
- 238000012216 screening Methods 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/112—Disease subtyping, staging or classification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2814—Dementia; Cognitive disorders
- G01N2800/2821—Alzheimer
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/50—Determining the risk of developing a disease
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Pathology (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Urology & Nephrology (AREA)
- Microbiology (AREA)
- Wood Science & Technology (AREA)
- Hematology (AREA)
- Neurology (AREA)
- Toxicology (AREA)
- General Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Cell Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US54914704P | 2004-03-03 | 2004-03-03 | |
| PCT/EP2005/050850 WO2005085472A2 (en) | 2004-03-03 | 2005-02-28 | Diagnostic and therapeutic use of mal2 gene and protein for neurodegenerative diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE602005019540D1 true DE602005019540D1 (de) | 2010-04-08 |
Family
ID=34919441
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE602005019540T Active DE602005019540D1 (de) | 2004-03-03 | 2005-02-28 | Diagnostische und therapeutische verwendung des mal2-gens und proteins bei neurodegenerativen krankheiten |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20070166718A1 (de) |
| EP (1) | EP1721008B1 (de) |
| AT (1) | ATE458834T1 (de) |
| DE (1) | DE602005019540D1 (de) |
| WO (1) | WO2005085472A2 (de) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012045324A1 (en) * | 2010-10-07 | 2012-04-12 | Mediagnost Gesellschaft Fur Forschung Und Herstellung Von Diagnostika Gmbh | Method for detecting a parkinson's disease and test system |
| US20140286910A1 (en) * | 2013-03-19 | 2014-09-25 | Nikolai Tankovich | Stem cells and methods incorporating environmental factors as a means for enhancing stem cell proliferation and plasticity |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2388922A1 (en) * | 1999-11-19 | 2001-05-25 | Human Genome Sciences, Inc. | 23 human secreted proteins |
| JP2003532383A (ja) * | 2000-01-18 | 2003-11-05 | ヒューマン ジノーム サイエンシーズ， インコーポレイテッド | ヒトポリヌクレオチド、ポリペプチド、および抗体 |
| US6926898B2 (en) * | 2000-04-12 | 2005-08-09 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| US6783969B1 (en) * | 2001-03-05 | 2004-08-31 | Nuvelo, Inc. | Cathepsin V-like polypeptides |
| WO2002071928A2 (en) * | 2001-03-14 | 2002-09-19 | Millennium Pharmaceuticals, Inc. | Nucleic acid molecules and proteins for the identification, assessment, prevention, and therapy of ovarian cancer |
-
2005
- 2005-02-28 EP EP05716834A patent/EP1721008B1/de not_active Not-in-force
- 2005-02-28 DE DE602005019540T patent/DE602005019540D1/de active Active
- 2005-02-28 WO PCT/EP2005/050850 patent/WO2005085472A2/en not_active Application Discontinuation
- 2005-02-28 US US10/591,678 patent/US20070166718A1/en not_active Abandoned
- 2005-02-28 AT AT05716834T patent/ATE458834T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ATE458834T1 (de) | 2010-03-15 |
| EP1721008B1 (de) | 2010-02-24 |
| WO2005085472A3 (en) | 2005-11-03 |
| EP1721008A2 (de) | 2006-11-15 |
| US20070166718A1 (en) | 2007-07-19 |
| WO2005085472A2 (en) | 2005-09-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| R082 | Change of representative |
Ref document number: 1721008 Country of ref document: EP Representative=s name: VON KREISLER SELTING WERNER, DE |