ATE495269T1 - Adarb2 proteine als diagnostische und therapeutische targets für neurodegenerative erkrankungen - Google Patents

Adarb2 proteine als diagnostische und therapeutische targets für neurodegenerative erkrankungen

Info

Publication number
ATE495269T1
ATE495269T1 AT06777334T AT06777334T ATE495269T1 AT E495269 T1 ATE495269 T1 AT E495269T1 AT 06777334 T AT06777334 T AT 06777334T AT 06777334 T AT06777334 T AT 06777334T AT E495269 T1 ATE495269 T1 AT E495269T1
Authority
AT
Austria
Prior art keywords
adarb2
disease
alzheimer
neurodegenerative diseases
diagnostic
Prior art date
Application number
AT06777334T
Other languages
English (en)
Inventor
Johannes Pohlner
Der Kammer Heinz Von
Original Assignee
Evotec Neurosciences Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Evotec Neurosciences Gmbh filed Critical Evotec Neurosciences Gmbh
Application granted granted Critical
Publication of ATE495269T1 publication Critical patent/ATE495269T1/de

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Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2535/00Reactions characterised by the assay type for determining the identity of a nucleotide base or a sequence of oligonucleotides
    • C12Q2535/101Sanger sequencing method, i.e. oligonucleotide sequencing using primer elongation and dideoxynucleotides as chain terminators
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/112Disease subtyping, staging or classification
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/156Polymorphic or mutational markers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/158Expression markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Neurology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Hospice & Palliative Care (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Psychiatry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT06777334T 2005-06-16 2006-06-14 Adarb2 proteine als diagnostische und therapeutische targets für neurodegenerative erkrankungen ATE495269T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US69086205P 2005-06-16 2005-06-16
EP05105316 2005-06-16
PCT/EP2006/063215 WO2006134128A2 (en) 2005-06-16 2006-06-14 Diagnostic and therapeutic target adarb2 proteins for neurodegenerative diseases

Publications (1)

Publication Number Publication Date
ATE495269T1 true ATE495269T1 (de) 2011-01-15

Family

ID=35355216

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06777334T ATE495269T1 (de) 2005-06-16 2006-06-14 Adarb2 proteine als diagnostische und therapeutische targets für neurodegenerative erkrankungen

Country Status (6)

Country Link
US (1) US20100008921A1 (de)
EP (1) EP1891241B1 (de)
JP (1) JP2008546379A (de)
AT (1) ATE495269T1 (de)
DE (1) DE602006019582D1 (de)
WO (1) WO2006134128A2 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2646592T3 (es) * 2007-06-13 2017-12-14 Alcediag Muestra de tejido periférico que contiene células que expresan 5HTR2C y/o ADARs, como marcadores de la alteración del mecanismo de edición del ARNm de 5HTR2C y sus aplicaciones
CN101821407B (zh) 2007-07-10 2013-09-18 纽瑞姆制药(1991)有限公司 神经退行性疾病中的cd44剪接变体
EP2202321A1 (de) * 2008-12-17 2010-06-30 Biocortech Beurteilung des potentiellen Risikos von durch Arzneimittel ausgelösten Stimmungsstörungen und Selbstmord, Verwendung einer dafür vorgesehenen Plattform
US10456493B2 (en) 2017-06-23 2019-10-29 Allied Bioscience, Inc. Infection control apparatus

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5763174A (en) * 1994-02-17 1998-06-09 The Wistar Institute Of Anatomy & Biology RNA editing enzyme and methods of use thereof
DE4438391C2 (de) 1994-10-27 1997-07-03 Evotec Biosystems Gmbh Vorrichtung zur Bestimmung stoffspezifischer Parameter eines oder weniger Moleküle mittels Korrelations-Spektroskopie
EP0836090A1 (de) 1996-10-12 1998-04-15 Evotec BioSystems GmbH Probenanalyseverfahren durch Bestimmung der spezifischen Helligkeitsverteilung von Teilchen
DE19649048C1 (de) 1996-11-27 1998-04-09 Evotec Biosystems Gmbh Verfahren zur Unterscheidung oder Erfassung von Partikeln in einer Probe durch Identifizierung von Signalabschnitten zeitaufgelöster, optischer Rohsignale aus der Probe auf Basis von Einzelphotonendetektion
EP0945718A1 (de) 1998-03-21 1999-09-29 Evotec BioSystems AG Ein Verfahren zur Probencharakterisierung durch Bestimmung einer Funktion mindestens einer spezifischen Eigenschaft von Einheiten der Probe
US6200818B1 (en) 1997-12-23 2001-03-13 Evotec Biosystems Ag Method for detecting reactions by means of coincidence analysis
WO2000052451A1 (en) 1999-03-03 2000-09-08 Evotec Analytical Systems Gmbh Homogeneous fluorescence assay
EP1175602B1 (de) 1999-04-29 2003-03-19 Evotec OAI AG Verfahren zur erfassung von fluoreszierenden molekülen oder anderen teilchen mittels erzeugenden funktionen
US6690463B2 (en) 2000-02-10 2004-02-10 Evotec Biosystems Ag Fluorescence intensity and lifetime distribution analysis
EP1254353B1 (de) 2000-02-10 2004-04-14 Evotec OAI AG Fluoreszenzintensitätsanalyse unter verwendung einer vielzahl von verteilungen: konkurrierende bestimmung von diffusionszeiten und molekularer helligkeit
DE10030798A1 (de) 2000-06-29 2002-01-10 Evotec Analytical Sys Gmbh Kompetitives Assay-Verfahren
ATE350485T1 (de) 2000-08-11 2007-01-15 Evotec Ag Verfahren zum nachweis von acetylase oder deacetylase aktivität in einem immunoassay

Also Published As

Publication number Publication date
US20100008921A1 (en) 2010-01-14
JP2008546379A (ja) 2008-12-25
EP1891241A2 (de) 2008-02-27
WO2006134128A2 (en) 2006-12-21
WO2006134128A3 (en) 2007-03-08
DE602006019582D1 (de) 2011-02-24
EP1891241B1 (de) 2011-01-12

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