ATE435281T1 - Im cadasil bezogenes gen, diagnostikums-verfahren und therapeutische verwendung - Google Patents
Im cadasil bezogenes gen, diagnostikums-verfahren und therapeutische verwendungInfo
- Publication number
- ATE435281T1 ATE435281T1 AT97936721T AT97936721T ATE435281T1 AT E435281 T1 ATE435281 T1 AT E435281T1 AT 97936721 T AT97936721 T AT 97936721T AT 97936721 T AT97936721 T AT 97936721T AT E435281 T1 ATE435281 T1 AT E435281T1
- Authority
- AT
- Austria
- Prior art keywords
- cadasil
- therapeutic use
- diagnostic methods
- gene related
- gene
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70567—Nuclear receptors, e.g. retinoic acid receptor [RAR], RXR, nuclear orphan receptors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A61P25/12—Antiepileptics; Anticonvulsants for grand-mal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- High Energy & Nuclear Physics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Pain & Pain Management (AREA)
- Cell Biology (AREA)
- Immunology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9609733A FR2751985B1 (fr) | 1996-08-01 | 1996-08-01 | Gene implique dans le cadasil, methode de diagnostic et application therapeutique |
FR9704680A FR2751986B1 (fr) | 1996-08-01 | 1997-04-16 | Gene implique dans le cadasil, methode de diagnostic et application therapeutique |
PCT/FR1997/001433 WO1998005775A1 (fr) | 1996-08-01 | 1997-07-31 | Gene implique dans le cadasil, methode de diagnostic et application therapeutique |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE435281T1 true ATE435281T1 (de) | 2009-07-15 |
Family
ID=26232895
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT97936721T ATE435281T1 (de) | 1996-08-01 | 1997-07-31 | Im cadasil bezogenes gen, diagnostikums-verfahren und therapeutische verwendung |
Country Status (9)
Country | Link |
---|---|
US (3) | US6537775B1 (de) |
EP (1) | EP0915973B1 (de) |
JP (2) | JP4463329B2 (de) |
AT (1) | ATE435281T1 (de) |
CA (1) | CA2262459C (de) |
DE (1) | DE69739478D1 (de) |
ES (1) | ES2328304T3 (de) |
FR (1) | FR2751986B1 (de) |
WO (1) | WO1998005775A1 (de) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2751986B1 (fr) * | 1996-08-01 | 1998-12-31 | Inst Nat Sante Rech Med | Gene implique dans le cadasil, methode de diagnostic et application therapeutique |
US6984522B2 (en) | 2000-08-03 | 2006-01-10 | Regents Of The University Of Michigan | Isolation and use of solid tumor stem cells |
US8044259B2 (en) | 2000-08-03 | 2011-10-25 | The Regents Of The University Of Michigan | Determining the capability of a test compound to affect solid tumor stem cells |
JP2005503792A (ja) * | 2001-08-22 | 2005-02-10 | ガラパゴス・ジェノミックス・ナムローゼ・フェンノートシャップ | ハイ・スループット・スクリーニングにおいて同定される骨の恒常性のモジュレーター |
WO2005111072A2 (en) * | 2004-04-29 | 2005-11-24 | The Trustees Of Columbia University In The City Of New York | Notch-based fusion proteins and uses thereof |
CN1763196B (zh) * | 2004-09-13 | 2010-09-08 | 首都医科大学宣武医院 | 基因突变类型及基因测序方法 |
US7585968B2 (en) * | 2005-03-28 | 2009-09-08 | Isis Pharmaceuticals, Inc. | Compositions and their uses directed to thymus and activation-regulated chemokine (TARC) |
EP2511298B1 (de) | 2005-10-31 | 2019-01-16 | Oncomed Pharmaceuticals, Inc. | Zusammensetzungen und Verfahren zur Behandlung von Krebs unter Verwendung von menschlichen FZD Rezeptoren |
US7723477B2 (en) | 2005-10-31 | 2010-05-25 | Oncomed Pharmaceuticals, Inc. | Compositions and methods for inhibiting Wnt-dependent solid tumor cell growth |
JP5129149B2 (ja) * | 2005-10-31 | 2013-01-23 | ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン | 癌を処置および診断するための組成物および方法 |
WO2007145840A2 (en) | 2006-06-13 | 2007-12-21 | Oncomed Pharmaceuticals, Inc. | Compositions and methods for diagnosing and treating cancer |
TW200824707A (en) * | 2006-10-19 | 2008-06-16 | Genentech Inc | Anti-Notch3 agonist antibodies and their use in the treatment of Notch3-related diseases |
CN101563366B (zh) | 2006-10-19 | 2012-10-03 | 健泰科生物技术公司 | 抗notch3激动性抗体及其在制备治疗notch3相关疾病的药物中的用途 |
AR064388A1 (es) * | 2006-12-18 | 2009-04-01 | Genentech Inc | Anticuerpos antagonistas anti- notch3 y su uso en la prevencion y el tratamiento de enfermedades relacionadas con el receptor notch3 |
CA2676008A1 (en) | 2007-01-24 | 2008-07-31 | Oncomed Pharmaceuticals, Inc. | Compositions and methods for diagnosing and treating cancer |
WO2008092002A2 (en) | 2007-01-24 | 2008-07-31 | The Regents Of The University Of Michigan | Compositions and methods for treating and diagnosing pancreatic cancer |
US20090208491A1 (en) * | 2007-02-14 | 2009-08-20 | Austin Gurney | Compositions and Methods for Diagnosing and Treating Cancer |
PE20090321A1 (es) | 2007-06-04 | 2009-04-20 | Genentech Inc | Anticuerpos anti-notch1 nrr, metodo de preparacion y composicion farmaceutica |
JP2010536855A (ja) | 2007-08-23 | 2010-12-02 | ザ・トラスティーズ・オブ・コランビア・ユニバーシティー・イン・ザ・シティー・オブ・ニューヨーク | ヒト化Notch融合タンパク質の組成物および治療方法 |
WO2009036167A1 (en) * | 2007-09-14 | 2009-03-19 | Vanderbilt University | Targeting of notch3 receptor function for cancer therapy |
MX2011000233A (es) | 2008-07-08 | 2011-05-19 | Oncomed Pharm Inc | Agentes de union del receptor notch1 y metodos para su uso. |
US9132189B2 (en) | 2008-07-08 | 2015-09-15 | Oncomed Pharmaceuticals, Inc. | Notch1 binding agents and methods of use thereof |
KR20110074846A (ko) * | 2008-08-22 | 2011-07-04 | 더 트러스티스 오브 컬럼비아 유니버시티 인 더 시티 오브 뉴욕 | 노치3 신호전달의 디코이 억제제로서의 인간 노치3 기반 융합 단백질 |
DK2331136T3 (en) | 2008-09-26 | 2018-03-05 | Oncomed Pharm Inc | FRIZZLED BINDING AGENTS AND APPLICATIONS THEREOF |
AU2010207073B8 (en) * | 2009-01-26 | 2017-05-18 | Academisch Ziekenhuis Leiden H.O.D.N. Lumc | Means and methods for modulating NOTCH3 protein expression and/or the coding region of NOTCH3; compositions and use thereof in the treatment of CADASIL |
TWI535445B (zh) | 2010-01-12 | 2016-06-01 | 安可美德藥物股份有限公司 | Wnt拮抗劑及治療和篩選方法 |
EP2523682B1 (de) | 2010-01-13 | 2015-12-16 | Oncomed Pharmaceuticals, Inc. | Notch1-bindende wirkstoffe und verfahren zu deren verwendung |
AU2011235904B2 (en) | 2010-04-01 | 2015-10-08 | Oncomed Pharmaceuticals, Inc. | Frizzled-binding agents and uses thereof |
WO2011140295A2 (en) * | 2010-05-06 | 2011-11-10 | President And Fellows Of Harvard College | Modulators of notch receptor signaling and methods of use thereof |
AR088048A1 (es) | 2011-10-04 | 2014-05-07 | Univ Columbia | Señuelos notch1 humanos |
WO2014066328A1 (en) | 2012-10-23 | 2014-05-01 | Oncomed Pharmaceuticals, Inc. | Methods of treating neuroendocrine tumors using wnt pathway-binding agents |
EP2917240A1 (de) | 2012-11-07 | 2015-09-16 | Pfizer Inc. | Antikörper gegen notch-3 und antikörper-wirkstoff-konjugate |
CA2899353A1 (en) | 2013-02-04 | 2014-08-07 | Oncomed Pharmaceuticals, Inc. | Methods and monitoring of treatment with a wnt pathway inhibitor |
US9168300B2 (en) | 2013-03-14 | 2015-10-27 | Oncomed Pharmaceuticals, Inc. | MET-binding agents and uses thereof |
US20200103419A1 (en) * | 2017-03-27 | 2020-04-02 | The Schepens Eye Research Institute, Inc. | Blood biomarkers and diagnostic methods for small vessel diseases |
WO2018183219A2 (en) * | 2017-03-27 | 2018-10-04 | The Schepens Eye Research Institute, Inc. | Nucleic acid-based compositions and methods for treating small vessel diseases |
WO2018183216A1 (en) | 2017-03-27 | 2018-10-04 | The Schepens Eye Research Institute, Inc. | Notch3 agonist compositions and methods for treating small vessel diseases |
WO2022256396A1 (en) * | 2021-06-02 | 2022-12-08 | Regeneron Pharmaceuticals, Inc. | Treatment of cerebrovascular disease with neurogenic locus notch homolog protein 3 (notch3) agents |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2116628A1 (en) * | 1994-02-28 | 1995-08-29 | Anne Marie Gisele Joutel | Method for the diagnosis of cadasil |
FR2751986B1 (fr) * | 1996-08-01 | 1998-12-31 | Inst Nat Sante Rech Med | Gene implique dans le cadasil, methode de diagnostic et application therapeutique |
-
1997
- 1997-04-16 FR FR9704680A patent/FR2751986B1/fr not_active Expired - Fee Related
- 1997-07-31 AT AT97936721T patent/ATE435281T1/de not_active IP Right Cessation
- 1997-07-31 DE DE69739478T patent/DE69739478D1/de not_active Expired - Lifetime
- 1997-07-31 US US09/230,652 patent/US6537775B1/en not_active Expired - Lifetime
- 1997-07-31 JP JP50767598A patent/JP4463329B2/ja not_active Expired - Lifetime
- 1997-07-31 CA CA2262459A patent/CA2262459C/fr not_active Expired - Lifetime
- 1997-07-31 EP EP97936721A patent/EP0915973B1/de not_active Expired - Lifetime
- 1997-07-31 ES ES97936721T patent/ES2328304T3/es not_active Expired - Lifetime
- 1997-07-31 WO PCT/FR1997/001433 patent/WO1998005775A1/fr active Application Filing
-
2000
- 2000-07-07 US US09/612,226 patent/US6995257B1/en not_active Expired - Fee Related
-
2003
- 2003-02-03 US US10/356,625 patent/US7138234B2/en not_active Expired - Fee Related
-
2009
- 2009-10-02 JP JP2009230857A patent/JP2010042012A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
WO1998005775A1 (fr) | 1998-02-12 |
EP0915973A1 (de) | 1999-05-19 |
JP2001500366A (ja) | 2001-01-16 |
JP4463329B2 (ja) | 2010-05-19 |
JP2010042012A (ja) | 2010-02-25 |
US6537775B1 (en) | 2003-03-25 |
CA2262459C (fr) | 2013-03-26 |
ES2328304T3 (es) | 2009-11-11 |
CA2262459A1 (fr) | 1998-02-12 |
US20030186290A1 (en) | 2003-10-02 |
US7138234B2 (en) | 2006-11-21 |
EP0915973B1 (de) | 2009-07-01 |
DE69739478D1 (de) | 2009-08-13 |
FR2751986A1 (fr) | 1998-02-06 |
FR2751986B1 (fr) | 1998-12-31 |
US6995257B1 (en) | 2006-02-07 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |