DE69737290T2 - Substrat fangende protein tyrosin phosphatase - Google Patents

Substrat fangende protein tyrosin phosphatase Download PDF

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Publication number
DE69737290T2
DE69737290T2 DE69737290T DE69737290T DE69737290T2 DE 69737290 T2 DE69737290 T2 DE 69737290T2 DE 69737290 T DE69737290 T DE 69737290T DE 69737290 T DE69737290 T DE 69737290T DE 69737290 T2 DE69737290 T2 DE 69737290T2
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DE
Germany
Prior art keywords
protein
ptp
tyrosine
tyrosine phosphatase
cas
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69737290T
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German (de)
English (en)
Other versions
DE69737290D1 (en
Inventor
Nicholas Huntington TONKS
J. Andrew Bothell FLINT
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Cold Spring Harbor Laboratory
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Cold Spring Harbor Laboratory
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Application filed by Cold Spring Harbor Laboratory filed Critical Cold Spring Harbor Laboratory
Publication of DE69737290D1 publication Critical patent/DE69737290D1/de
Application granted granted Critical
Publication of DE69737290T2 publication Critical patent/DE69737290T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/16Hydrolases (3) acting on ester bonds (3.1)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00Uses of viruses
    • C12N2799/02Uses of viruses as vector
    • C12N2799/021Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/026Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a baculovirus

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Alcoholic Beverages (AREA)
  • Peptides Or Proteins (AREA)
DE69737290T 1996-07-25 1997-07-24 Substrat fangende protein tyrosin phosphatase Expired - Fee Related DE69737290T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US685992 1996-07-25
US08/685,992 US5912138A (en) 1996-07-25 1996-07-25 Substrate trapping protein tyrosine phosphatases
PCT/US1997/013016 WO1998004712A2 (en) 1996-07-25 1997-07-24 Substrate trapping protein tyrosine phosphatases

Publications (2)

Publication Number Publication Date
DE69737290D1 DE69737290D1 (en) 2007-03-15
DE69737290T2 true DE69737290T2 (de) 2007-11-08

Family

ID=24754471

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69737290T Expired - Fee Related DE69737290T2 (de) 1996-07-25 1997-07-24 Substrat fangende protein tyrosin phosphatase

Country Status (9)

Country Link
US (2) US5912138A (OSRAM)
EP (1) EP0918867B1 (OSRAM)
JP (1) JP2000515760A (OSRAM)
AT (1) ATE352625T1 (OSRAM)
AU (1) AU728405B2 (OSRAM)
CA (1) CA2262440A1 (OSRAM)
DE (1) DE69737290T2 (OSRAM)
ES (1) ES2281915T3 (OSRAM)
WO (1) WO1998004712A2 (OSRAM)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7541151B2 (en) 1997-06-05 2009-06-02 Duke University Single-cell biosensor for the measurement of GPCR ligands in a test sample
US5891646A (en) * 1997-06-05 1999-04-06 Duke University Methods of assaying receptor activity and constructs useful in such methods
US6528271B1 (en) 1997-06-05 2003-03-04 Duke University Inhibition of βarrestin mediated effects prolongs and potentiates opioid receptor-mediated analgesia
AU3922999A (en) * 1998-05-21 1999-12-13 Mcgill University Agents interfering with the binding of protein tyrosine phosphatase pest to domains of signalling proteins as inhibitors of cell migration and/or of focal adhesion
US6156551A (en) * 1998-06-05 2000-12-05 Beth Israel Deaconess Medical Center Activated mutants of SH2-domain-containing protein tyrosine phosphatases and methods of use thereof
US6248327B1 (en) 1998-09-11 2001-06-19 Vanderbilt University Modulation of endothelial cell surface receptor activity in the regulation of angiogenesis
US7176289B1 (en) 1998-09-11 2007-02-13 Vanderbilt University Modulation of endothelial cell surface receptor activity in the regulation of angiogenesis
US6355786B1 (en) 1998-10-30 2002-03-12 Vanderbilt University Purified and isolated protein zero related (PZR) and therapeutic and screening methods using same
CA2366101A1 (en) 1999-03-08 2000-09-14 Merck Frosst Canada & Co. Intact cell assay for protein tyrosine phosphatases
US6852520B1 (en) 1999-03-24 2005-02-08 Ceptyr, Inc. DSP-2 dual-specificity phosphatase
US6492157B1 (en) 1999-04-07 2002-12-10 Ceptyr, Inc. DSP-9 dual-specificity phosphatase
US6841369B1 (en) 1999-04-07 2005-01-11 Ceptyr, Inc. DSP-4 dual specificity phosphatase
JP2002542785A (ja) 1999-04-23 2002-12-17 セプティア, インコーポレイテッド Dsp−10二重特異性mapキナーゼホスファターゼ
US6645753B1 (en) 1999-04-27 2003-11-11 Ceptyr, Inc. DSP-5 dual-specificity phosphatase
WO2000075339A1 (en) * 1999-06-03 2000-12-14 Cold Spring Harbor Laboratory Substrate trapping protein tyrosine phosphatases
US7078210B2 (en) 1999-07-02 2006-07-18 Ceptyr, Inc. DSP-3 dual-specificity phosphatase
WO2001005983A1 (en) 1999-07-20 2001-01-25 Ceptyr, Inc. Dsp-11 dual-specificity map kinase phosphatase
US6902919B2 (en) 2000-02-02 2005-06-07 Ceptyr, Inc. DSP-12 and DSP-13 dual-specificity phosphatases
CA2435507A1 (en) * 2000-02-14 2001-08-23 Ceptyr, Inc. Improved assay for protein tyrosine phosphatases
US6825021B2 (en) 2000-09-19 2004-11-30 Ceptyr, Inc. DSP-15 dual-specificity phosphatase
US8071348B2 (en) * 2002-01-14 2011-12-06 Albert Einstein College Of Medicine Of Yeshiva University Protein tyrosine phosphatase substrate-trapping double mutant and uses thereof
US20030215899A1 (en) * 2002-02-13 2003-11-20 Ceptyr, Inc. Reversible oxidation of protein tyrosine phosphatases
US20030182669A1 (en) * 2002-03-19 2003-09-25 Rockman Howard A. Phosphoinositide 3-kinase mediated inhibition of GPCRs
CA2525976A1 (en) * 2002-05-23 2003-12-04 Ceptyr, Inc. Modulation of ptp1b signal transduction by rna interference
US7290215B2 (en) * 2002-06-03 2007-10-30 Microsoft Corporation Dynamic wizard interface system and method
PL377714A1 (pl) * 2002-11-26 2006-02-06 Cold Spring Harbor Laboratory Białka oddziałujące z receptorową tyrozynową fosfatazą białkową DEP-1 oraz sposoby ich wykorzystania
US20070238129A1 (en) * 2006-03-29 2007-10-11 Moyer Susanne C Catalytically inactive enzymes for affinity binding
US20120269814A1 (en) * 2009-11-10 2012-10-25 Amgen Inc. Anti-c mpl antibodies
CN113899902B (zh) * 2020-06-22 2024-10-29 上海科技大学 一种酪氨酸磷酸酶底物鉴定方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2054602C (en) * 1991-10-31 2003-04-22 Anthony Pawson Method for assaying for a substance that affects an sh2-phosphorylated ligand regulatory system
US5589375A (en) * 1992-10-06 1996-12-31 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E. V. PTP 1D: a novel protein tyrosine phosphatase
US5585233A (en) * 1993-03-23 1996-12-17 Max-Planck Gesellschaft Zur Forderung Der Wissenschaften E.V. PTP-S31: A novel protein tyrosine phosphatase
CA2170515C (en) * 1993-09-01 2002-11-12 Leonel Jorge Gonez Nucleotide sequences for novel protein tyrosine phosphatases
US5744313A (en) * 1994-12-09 1998-04-28 The Regents Of The University Of California Assay employing novel protein domain which binds tyrosine phosphorylated proteins

Also Published As

Publication number Publication date
US5912138A (en) 1999-06-15
EP0918867B1 (en) 2007-01-24
WO1998004712A2 (en) 1998-02-05
EP0918867A2 (en) 1999-06-02
ATE352625T1 (de) 2007-02-15
ES2281915T3 (es) 2007-10-01
JP2000515760A (ja) 2000-11-28
AU5939598A (en) 1999-02-16
AU728405B2 (en) 2001-01-11
DE69737290D1 (en) 2007-03-15
WO1998004712A3 (en) 1998-03-12
US5951979A (en) 1999-09-14
CA2262440A1 (en) 1998-02-05

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8339 Ceased/non-payment of the annual fee