DE69736484D1 - Hedgehog wechselwirkende proteine und ihre darauf bezogenen anwendungen - Google Patents

Hedgehog wechselwirkende proteine und ihre darauf bezogenen anwendungen

Info

Publication number
DE69736484D1
DE69736484D1 DE69736484T DE69736484T DE69736484D1 DE 69736484 D1 DE69736484 D1 DE 69736484D1 DE 69736484 T DE69736484 T DE 69736484T DE 69736484 T DE69736484 T DE 69736484T DE 69736484 D1 DE69736484 D1 DE 69736484D1
Authority
DE
Germany
Prior art keywords
hedgehog
proteins
related applications
interactive proteins
interactive
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69736484T
Other languages
English (en)
Other versions
DE69736484T2 (de
Inventor
P Mcmahon
Tien Chuang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Harvard College
Harvard University
Original Assignee
Harvard College
Harvard University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Harvard College, Harvard University filed Critical Harvard College
Publication of DE69736484D1 publication Critical patent/DE69736484D1/de
Application granted granted Critical
Publication of DE69736484T2 publication Critical patent/DE69736484T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06F—ELECTRIC DIGITAL DATA PROCESSING
    • G06F13/00—Interconnection of, or transfer of information or other signals between, memories, input/output devices or central processing units
    • G06F13/38—Information transfer, e.g. on bus
    • G06F13/42—Bus transfer protocol, e.g. handshake; Synchronisation
    • G06F13/4204—Bus transfer protocol, e.g. handshake; Synchronisation on a parallel bus
    • G06F13/4234—Bus transfer protocol, e.g. handshake; Synchronisation on a parallel bus being a memory bus
    • G06F13/4243—Bus transfer protocol, e.g. handshake; Synchronisation on a parallel bus being a memory bus with synchronous protocol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Theoretical Computer Science (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE69736484T 1996-09-20 1997-09-19 Hedgehog wechselwirkende proteine und ihre darauf bezogenen anwendungen Expired - Lifetime DE69736484T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2615596P 1996-09-20 1996-09-20
US26155P 1996-09-20
PCT/US1997/016741 WO1998012326A1 (en) 1996-09-20 1997-09-19 Hedgehog interacting proteins and uses related thereto

Publications (2)

Publication Number Publication Date
DE69736484D1 true DE69736484D1 (de) 2006-09-21
DE69736484T2 DE69736484T2 (de) 2007-03-29

Family

ID=21830211

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69736484T Expired - Lifetime DE69736484T2 (de) 1996-09-20 1997-09-19 Hedgehog wechselwirkende proteine und ihre darauf bezogenen anwendungen

Country Status (11)

Country Link
US (3) US6514724B1 (de)
EP (1) EP0935656B1 (de)
JP (1) JP4083810B2 (de)
AT (1) ATE335819T1 (de)
AU (1) AU742972B2 (de)
CA (1) CA2266429C (de)
DE (1) DE69736484T2 (de)
DK (1) DK0935656T3 (de)
ES (1) ES2278396T3 (de)
IL (3) IL128999A0 (de)
WO (1) WO1998012326A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU8173098A (en) 1997-06-27 1999-01-19 Ontogeny, Inc. Neuroprotective methods and reagents
US7144997B2 (en) 1997-07-24 2006-12-05 Curis, Inc. Vertebrate embryonic patterning-inducing proteins, compositions and uses related therto
US6639051B2 (en) 1997-10-20 2003-10-28 Curis, Inc. Regulation of epithelial tissue by hedgehog-like polypeptides, and formulations and uses related thereto
AU1716599A (en) 1997-12-08 1999-06-28 Curis, Inc. Human patched genes and proteins, and uses related thereto
US7339033B2 (en) * 1998-06-26 2008-03-04 Genentech, Inc. Pro1481
WO2000025725A2 (en) 1998-11-02 2000-05-11 Biogen, Inc. Functional antagonists of hedgehog activity
US6884770B1 (en) 1998-11-06 2005-04-26 Curis, Inc. Methods and compositions for treating or preventing peripheral neuropathies
EP1183040B1 (de) * 1999-06-08 2004-12-01 Lorantis Limited Therapeutische verwendung eines inhibitors des hedgehog signalübertragungsweges
US7517870B2 (en) * 2004-12-03 2009-04-14 Fondazione Telethon Use of compounds that interfere with the hedgehog signaling pathway for the manufacture of a medicament for preventing, inhibiting, and/or reversing ocular diseases related with ocular neovascularization
WO2007127133A2 (en) * 2006-04-27 2007-11-08 Illinois Tool Works Inc. Pan chiller system with single state coolant
DK2294197T3 (en) 2008-05-30 2016-02-29 Genentech Inc VARIANT HHIP1 PROTEIN AND METHODS AND APPLICATIONS THEREOF
US9616114B1 (en) 2014-09-18 2017-04-11 David Gordon Bermudes Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity
WO2017049125A1 (en) * 2015-09-16 2017-03-23 La Jolla Nanomedical A cellular activity targeted nanoparticle system and methods of producing the nanoparticle system
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
US11180535B1 (en) 2016-12-07 2021-11-23 David Gordon Bermudes Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
WO2023211805A1 (en) * 2022-04-26 2023-11-02 The Regents Of The University Of California Hhip-fc fusion proteins and uses thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5200313A (en) * 1983-08-05 1993-04-06 Miles Inc. Nucleic acid hybridization assay employing detectable anti-hybrid antibodies
US5789543A (en) * 1993-12-30 1998-08-04 President And Fellows Of Harvard College Vertebrate embryonic pattern-inducing proteins and uses related thereto
EP0741783B1 (de) * 1993-12-30 2009-03-18 President And Fellows Of Harvard College "hedgehog-like" proteine von wirbeltieren, die embryonale strukturen induzieren
DK0804548T3 (da) * 1994-10-07 2005-11-07 Univ Leland Stanford Junior Patched-gener og deres anvendelse
US6281332B1 (en) * 1994-12-02 2001-08-28 The Johns Hopkins University School Of Medicine Hedgehog-derived polypeptides

Also Published As

Publication number Publication date
EP0935656A1 (de) 1999-08-18
US7585671B2 (en) 2009-09-08
JP2001501468A (ja) 2001-02-06
CA2266429C (en) 2010-05-18
IL128999A0 (en) 2000-02-17
EP0935656B1 (de) 2006-08-09
US20030143595A1 (en) 2003-07-31
IL128999A (en) 2008-03-20
ATE335819T1 (de) 2006-09-15
JP4083810B2 (ja) 2008-04-30
CA2266429A1 (en) 1998-03-26
IL181578A (en) 2010-12-30
WO1998012326A1 (en) 1998-03-26
US20070054290A1 (en) 2007-03-08
AU4489297A (en) 1998-04-14
US7115394B2 (en) 2006-10-03
DK0935656T3 (da) 2006-12-11
AU742972B2 (en) 2002-01-17
DE69736484T2 (de) 2007-03-29
ES2278396T3 (es) 2007-08-01
IL181578A0 (en) 2007-07-04
US6514724B1 (en) 2003-02-04

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