ATE335819T1 - Hedgehog wechselwirkende proteine und ihre darauf bezogenen anwendungen - Google Patents

Hedgehog wechselwirkende proteine und ihre darauf bezogenen anwendungen

Info

Publication number
ATE335819T1
ATE335819T1 AT97943410T AT97943410T ATE335819T1 AT E335819 T1 ATE335819 T1 AT E335819T1 AT 97943410 T AT97943410 T AT 97943410T AT 97943410 T AT97943410 T AT 97943410T AT E335819 T1 ATE335819 T1 AT E335819T1
Authority
AT
Austria
Prior art keywords
hedgehog
interacting proteins
related applications
proteins
hedgehog interacting
Prior art date
Application number
AT97943410T
Other languages
English (en)
Inventor
Andrew P Mcmahon
Pao Tien Chuang
Original Assignee
Harvard College
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Harvard College filed Critical Harvard College
Application granted granted Critical
Publication of ATE335819T1 publication Critical patent/ATE335819T1/de

Links

Classifications

    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06FELECTRIC DIGITAL DATA PROCESSING
    • G06F13/00Interconnection of, or transfer of information or other signals between, memories, input/output devices or central processing units
    • G06F13/38Information transfer, e.g. on bus
    • G06F13/42Bus transfer protocol, e.g. handshake; Synchronisation
    • G06F13/4204Bus transfer protocol, e.g. handshake; Synchronisation on a parallel bus
    • G06F13/4234Bus transfer protocol, e.g. handshake; Synchronisation on a parallel bus being a memory bus
    • G06F13/4243Bus transfer protocol, e.g. handshake; Synchronisation on a parallel bus being a memory bus with synchronous protocol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00Genetically modified animals
    • A01K2217/05Animals comprising random inserted nucleic acids (transgenic)
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00Genetically modified animals
    • A01K2217/07Animals genetically altered by homologous recombination
    • A01K2217/075Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Theoretical Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT97943410T 1996-09-20 1997-09-19 Hedgehog wechselwirkende proteine und ihre darauf bezogenen anwendungen ATE335819T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US2615596P 1996-09-20 1996-09-20

Publications (1)

Publication Number Publication Date
ATE335819T1 true ATE335819T1 (de) 2006-09-15

Family

ID=21830211

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97943410T ATE335819T1 (de) 1996-09-20 1997-09-19 Hedgehog wechselwirkende proteine und ihre darauf bezogenen anwendungen

Country Status (11)

Country Link
US (3) US6514724B1 (de)
EP (1) EP0935656B1 (de)
JP (1) JP4083810B2 (de)
AT (1) ATE335819T1 (de)
AU (1) AU742972B2 (de)
CA (1) CA2266429C (de)
DE (1) DE69736484T2 (de)
DK (1) DK0935656T3 (de)
ES (1) ES2278396T3 (de)
IL (3) IL128999A0 (de)
WO (1) WO1998012326A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999000117A2 (en) * 1997-06-27 1999-01-07 Ontogeny, Inc. Neuroprotective methods and reagents
US7144997B2 (en) 1997-07-24 2006-12-05 Curis, Inc. Vertebrate embryonic patterning-inducing proteins, compositions and uses related therto
US6639051B2 (en) 1997-10-20 2003-10-28 Curis, Inc. Regulation of epithelial tissue by hedgehog-like polypeptides, and formulations and uses related thereto
US6309879B1 (en) 1997-12-08 2001-10-30 Curis, Inc. Human patched genes and proteins, and uses related thereto
US20030166132A1 (en) * 1998-08-26 2003-09-04 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
ATE404583T1 (de) 1998-11-02 2008-08-15 Curis Inc Funktionelle antagonisten von hedgehog-aktivität
US6884770B1 (en) 1998-11-06 2005-04-26 Curis, Inc. Methods and compositions for treating or preventing peripheral neuropathies
JP2003501395A (ja) * 1999-06-08 2003-01-14 ローランティス・リミテッド 治療的使用
US7517870B2 (en) * 2004-12-03 2009-04-14 Fondazione Telethon Use of compounds that interfere with the hedgehog signaling pathway for the manufacture of a medicament for preventing, inhibiting, and/or reversing ocular diseases related with ocular neovascularization
CA2650338C (en) * 2006-04-27 2013-04-16 Illinois Tool Works Inc. Pan chiller system with single state coolant
KR101771714B1 (ko) * 2008-05-30 2017-08-25 제넨테크, 인크. 변이체 hhip1 단백질 및 방법 및 그의 용도
US9616114B1 (en) 2014-09-18 2017-04-11 David Gordon Bermudes Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity
AU2016323806A1 (en) * 2015-09-16 2018-05-10 La Jolla Nanomedical A cellular activity targeted nanoparticle system and methods of producing the nanoparticle system
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
US11180535B1 (en) 2016-12-07 2021-11-23 David Gordon Bermudes Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
WO2023211805A1 (en) * 2022-04-26 2023-11-02 The Regents Of The University Of California Hhip-fc fusion proteins and uses thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5200313A (en) * 1983-08-05 1993-04-06 Miles Inc. Nucleic acid hybridization assay employing detectable anti-hybrid antibodies
US5789543A (en) * 1993-12-30 1998-08-04 President And Fellows Of Harvard College Vertebrate embryonic pattern-inducing proteins and uses related thereto
NZ278765A (en) * 1993-12-30 1998-05-27 Harvard College Vertebrate proteins involved in spatial arrangements of differentiated tissues called hedgehog proteins, their production and use
EP1616942A3 (de) * 1994-10-07 2006-11-22 The Board Of Trustees Of The Leland Stanford Junior University Patched Gene und ihre Verwendung
US6281332B1 (en) * 1994-12-02 2001-08-28 The Johns Hopkins University School Of Medicine Hedgehog-derived polypeptides

Also Published As

Publication number Publication date
IL181578A0 (en) 2007-07-04
US7115394B2 (en) 2006-10-03
US20030143595A1 (en) 2003-07-31
DK0935656T3 (da) 2006-12-11
CA2266429A1 (en) 1998-03-26
US6514724B1 (en) 2003-02-04
IL128999A (en) 2008-03-20
EP0935656B1 (de) 2006-08-09
CA2266429C (en) 2010-05-18
US7585671B2 (en) 2009-09-08
EP0935656A1 (de) 1999-08-18
IL181578A (en) 2010-12-30
WO1998012326A1 (en) 1998-03-26
JP4083810B2 (ja) 2008-04-30
AU4489297A (en) 1998-04-14
DE69736484T2 (de) 2007-03-29
US20070054290A1 (en) 2007-03-08
ES2278396T3 (es) 2007-08-01
JP2001501468A (ja) 2001-02-06
AU742972B2 (en) 2002-01-17
DE69736484D1 (de) 2006-09-21
IL128999A0 (en) 2000-02-17

Similar Documents

Publication Publication Date Title
IL181578A (en) Antibodies which are specifically immunoreactive with hedgehog interacting proteins and a hybridoma producing such antibodies
DE69739665D1 (de) Isoliertes, dimerisches fibroblasten-aktivierendes protein alpha und anwendungen desselben
HUP0102005A2 (hu) CD23 elleni antitestek, ezek származékai, és gyógyászati alkalmazásuk
DE69435307D1 (de) Bazillus Thuringiensis und dessen insektizide Proteine
ATE361364T1 (de) Antikörper gegen die ed-b domäne von fibronektin, ihre herstellung und verwendungen
DE69735599D1 (de) Ölkörper und damit assoziierte proteine als affinitätsmatrix
UA84432C2 (ru) Очищенные пептиды и соединения, которые их содержат
MX343200B (es) Composiciones y metodos para aumentar la mineralizacion ósea.
DE69333062D1 (de) 4-mercaptoacetylamino-[2]benzazepinon(3)- derivate, und verwendung als enkephalinase-inhibitoren
ATE421973T1 (de) Inzektizide proteinen von bacillus thuringiensis
DE69433406T2 (de) Antikörper gegen cd40
MY119820A (en) Guanidine mimics as factor xa inhibitors
ID23374A (id) Halogenopirimidin
DE60137307D1 (de) Substituierte sapogenine und ihre verwendung
ATE320488T1 (de) Mutanten des lag-3 proteins, ihre expression und verwendung
WO1998004582A8 (en) Isolated peptides derived from mage-2
DE69836129D1 (de) Oxidierte fragmente des apolipoprotein b und ihre verwendung
DE60221805D1 (de) Peptide mit affinität zu gp120, und ihre verwendungen
EA200000875A1 (ru) Белки, взаимодействующие с каспазой-8
DE60221501D1 (de) Bfit (brown fat inducible thioesterase) polypeptide und polynukleotide und ihre verwendung
WO2003044185A3 (en) Purified polypeptides involved in general metabolism
WO1999050385A3 (en) Regulation of glycosaminoglycan synthesis, methods and reagents related thereto
WO2003083099A3 (en) Purified polypeptides involved in protein synthesis and modification
WO2003027139A3 (en) Novel purified polypeptides involved in membrane biosynthesis
DE69726796T2 (de) Ausbalanzierter Schieber, Erschütterungs- und Stossresistent, für bewegliche Kontakten von thermischen Hilfschaltern und dergleichen

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 0935656

Country of ref document: EP