DE69736396D1 - Sphärische Teilchen, Verfahren zu deren Herstellung und pharmazeutische ZUsammensetzungen mit diesen - Google Patents

Sphärische Teilchen, Verfahren zu deren Herstellung und pharmazeutische ZUsammensetzungen mit diesen

Info

Publication number
DE69736396D1
DE69736396D1 DE69736396T DE69736396T DE69736396D1 DE 69736396 D1 DE69736396 D1 DE 69736396D1 DE 69736396 T DE69736396 T DE 69736396T DE 69736396 T DE69736396 T DE 69736396T DE 69736396 D1 DE69736396 D1 DE 69736396D1
Authority
DE
Germany
Prior art keywords
preparation
pharmaceutical compositions
spherical particles
spherical
particles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69736396T
Other languages
English (en)
Other versions
DE69736396T2 (de
Inventor
Yasutoyo Fusejima
Yasuhiro Takemura
Nagayoshi Myo
Hisayoshi Kato
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Freund Corp
Original Assignee
Freund Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Freund Corp filed Critical Freund Corp
Publication of DE69736396D1 publication Critical patent/DE69736396D1/de
Application granted granted Critical
Publication of DE69736396T2 publication Critical patent/DE69736396T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/14—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic in rotating dishes or pans
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/16—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by suspending the powder material in a gas, e.g. in fluidised beds or as a falling curtain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/10—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of compressed tablets

Landscapes

  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)
  • Glanulating (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
DE69736396T 1996-09-10 1997-09-05 Sphärische Teilchen, Verfahren zu deren Herstellung und pharmazeutische Zusammensetzungen mit diesen Expired - Fee Related DE69736396T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP26016796 1996-09-10
JP26016796 1996-09-10
JP9218989A JPH10139659A (ja) 1996-09-10 1997-07-31 球形粒子群、その製造方法及びそれを用いた球形粒子製剤
JP21898997 1997-07-31
PCT/JP1997/003134 WO1998010751A1 (fr) 1996-09-10 1997-09-05 Groupe de particules spheriques, son procede de production et produits pharmaceutiques particulaires spheriques constitues desdits groupes de particules

Publications (2)

Publication Number Publication Date
DE69736396D1 true DE69736396D1 (de) 2006-09-07
DE69736396T2 DE69736396T2 (de) 2007-08-09

Family

ID=26522860

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69736396T Expired - Fee Related DE69736396T2 (de) 1996-09-10 1997-09-05 Sphärische Teilchen, Verfahren zu deren Herstellung und pharmazeutische Zusammensetzungen mit diesen

Country Status (5)

Country Link
US (1) US6171619B1 (de)
EP (1) EP0958812B1 (de)
JP (1) JPH10139659A (de)
DE (1) DE69736396T2 (de)
WO (1) WO1998010751A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19808634A1 (de) * 1998-02-24 1999-08-26 Schering Ag Mantel für eine pharmazeutische Zusammensetzung
US6613360B1 (en) * 1998-10-01 2003-09-02 Powderject Research Limited Particle formation
TWI256309B (en) * 1999-10-13 2006-06-11 Akzo Nobel Nv New formulation of mirtazapine
EP1238662B1 (de) 2001-03-07 2006-05-31 Dainippon Sumitomo Pharma Co., Ltd. Verfahren zur Herstellung von Arzneistoffgranulatkörnern, die Arzneistoffgranulatkörner sowie diese enthaltende pharmazeutische Zubereitungen
JP4848101B2 (ja) * 2001-08-17 2011-12-28 株式会社フジモト・コーポレーション 徐放性マイクロペレット
ATE329582T1 (de) * 2002-04-29 2006-07-15 Egyt Gyogyszervegyeszeti Gyar Herstellung von tabletten von pharmazeutisch aktiven substanzen mit ungünstigen tablettierungseigenschaften mit einer mikrokristalline zellulose enthaltenden granulierflüssigkeit
US9107804B2 (en) 2002-12-10 2015-08-18 Nortec Development Associates, Inc. Method of preparing biologically active formulations
EP1708684A2 (de) * 2003-09-26 2006-10-11 Alza Corporation Arzneimittelbeschichtung mit hoher arzneimittelbeladung und verfahren dafür
WO2005123042A1 (en) * 2004-06-10 2005-12-29 Glatt Air Techniques, Inc. Controlled release pharmaceutical formulation
JP4944467B2 (ja) * 2005-03-24 2012-05-30 第一三共株式会社 医薬用組成物
CN101203246B (zh) * 2005-03-24 2011-02-02 第一三共株式会社 药物组合物
EP2050438B1 (de) 2006-07-26 2016-10-19 Asahi Kasei Kabushiki Kaisha Kugelförmiges grobes granulat und herstellungsverfahren dafür
DE102012007671A1 (de) 2012-04-16 2013-10-17 Acino Pharma Ag Pellets mit hohem Wirkstoffgehalt
JP6251667B2 (ja) * 2014-06-03 2017-12-20 アサヒカルピスウェルネス株式会社 錠剤型即放性製剤及びその製造方法
CN109529716A (zh) * 2017-09-22 2019-03-29 霍尼韦尔国际公司 将粉末造粒的方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH072761B2 (ja) * 1985-03-20 1995-01-18 不二パウダル株式会社 微結晶セルロ−ス球形顆粒及びその製造法
JPH0232932B2 (ja) * 1986-05-16 1990-07-24 Fuji Sangyo Kk Ryushikakohohooyobisochi
DE3623321A1 (de) * 1986-07-11 1988-01-21 Bayer Ag Verfahren zur kontinuierlichen herstellung von sphaerischen granulaten
US5026560A (en) * 1987-01-29 1991-06-25 Takeda Chemical Industries, Ltd. Spherical granules having core and their production
JP2542122B2 (ja) * 1990-04-18 1996-10-09 旭化成工業株式会社 球状核、球形顆粒およびその製造方法
JP2820829B2 (ja) * 1991-03-07 1998-11-05 武田薬品工業株式会社 有核散剤およびその製造方法
JPH04283520A (ja) * 1991-03-12 1992-10-08 Asahi Chem Ind Co Ltd 球状核および球形顆粒
JP3219787B2 (ja) * 1991-05-28 2001-10-15 フロイント産業株式会社 球形粒子の製造方法
JPH06205955A (ja) * 1993-01-07 1994-07-26 Sanden Corp オゾン溶解装置
JP3349535B2 (ja) * 1993-01-12 2002-11-25 フロイント産業株式会社 球形顆粒の製造方法
ZA94614B (en) * 1993-02-11 1994-08-12 Sasol Chem Ind Pty Solvent extraction

Also Published As

Publication number Publication date
JPH10139659A (ja) 1998-05-26
EP0958812B1 (de) 2006-07-26
DE69736396T2 (de) 2007-08-09
EP0958812A4 (de) 2003-07-02
WO1998010751A1 (fr) 1998-03-19
EP0958812A1 (de) 1999-11-24
US6171619B1 (en) 2001-01-09

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee