DE69735669D1 - Deoxynojirimycin derivate und ihre verwendung als glukosesylceramidase-inhibitoren - Google Patents
Deoxynojirimycin derivate und ihre verwendung als glukosesylceramidase-inhibitorenInfo
- Publication number
- DE69735669D1 DE69735669D1 DE69735669T DE69735669T DE69735669D1 DE 69735669 D1 DE69735669 D1 DE 69735669D1 DE 69735669 T DE69735669 T DE 69735669T DE 69735669 T DE69735669 T DE 69735669T DE 69735669 D1 DE69735669 D1 DE 69735669D1
- Authority
- DE
- Germany
- Prior art keywords
- sylceramidase
- inhibitors
- glucose
- deoxynojirimycin
- deoxynojirimycin derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP96202010 | 1996-07-15 | ||
EP96202010 | 1996-07-15 | ||
PCT/NL1997/000411 WO1998002161A1 (en) | 1996-07-15 | 1997-07-14 | Deoxynojirimycin derivatives and their uses as glucosylceramidase inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69735669D1 true DE69735669D1 (de) | 2006-05-24 |
DE69735669T2 DE69735669T2 (de) | 2007-03-29 |
Family
ID=8224192
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69735669T Expired - Lifetime DE69735669T2 (de) | 1996-07-15 | 1997-07-14 | Deoxynojirimycin derivate und ihre verwendung als glukosesylceramidase-inhibitoren |
Country Status (9)
Country | Link |
---|---|
US (1) | US6177447B1 (de) |
EP (1) | EP0912179B1 (de) |
JP (5) | JP4564108B2 (de) |
AT (1) | ATE322900T1 (de) |
AU (1) | AU732552B2 (de) |
CA (1) | CA2260790C (de) |
DE (1) | DE69735669T2 (de) |
IL (1) | IL128036A (de) |
WO (1) | WO1998002161A1 (de) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6098631A (en) * | 1998-01-21 | 2000-08-08 | The Regents Of The University Of Michigan | Compositions and methods for treating autoimmune disease |
US6274597B1 (en) | 1998-06-01 | 2001-08-14 | Mount Sinai School Of Medicine Of New York University | Method of enhancing lysosomal α-Galactosidase A |
US6610703B1 (en) * | 1998-12-10 | 2003-08-26 | G.D. Searle & Co. | Method for treatment of glycolipid storage diseases |
GB0100889D0 (en) | 2001-01-12 | 2001-02-21 | Oxford Glycosciences Uk Ltd | Compounds |
GB9909066D0 (en) * | 1999-04-20 | 1999-06-16 | Oxford Glycosciences Uk Ltd | Therapies |
GB9909064D0 (en) | 1999-04-20 | 1999-06-16 | Oxford Glycosciences Uk Ltd | Therapies |
CA2378776A1 (en) | 1999-07-26 | 2001-02-01 | G.D. Searle & Co. | Use of long-chain n-alkyl derivatives of deoxynojirimycin and a glucocerebrosidase enzyme for the manufacture of medicament for the treatment of glycolipid storage diseases |
US7182953B2 (en) * | 1999-12-15 | 2007-02-27 | Celgene Corporation | Methods and compositions for the prevention and treatment of atherosclerosis restenosis and related disorders |
AU2001236713A1 (en) * | 2000-02-17 | 2001-08-27 | Genzyme Corporation | Methods for treatment of lysosomal storage diseases |
WO2001097829A2 (en) * | 2000-06-19 | 2001-12-27 | Genzyme Corporation | Combination enzyme replacement, gene therapy and small molecule therapy for lysosomal storage diseases |
US7138262B1 (en) * | 2000-08-18 | 2006-11-21 | Shire Human Genetic Therapies, Inc. | High mannose proteins and methods of making high mannose proteins |
AU2002348971A1 (en) * | 2001-10-12 | 2003-04-28 | Stefana M. Petrescu | Ph-sensitive liposomes for targeted drug delivery |
AU2003246942B2 (en) | 2002-07-17 | 2009-06-25 | Idorsia Pharmaceuticals Ltd | Piperidinetriol derivatives as inhibitors of glycosylceramide synthase |
AU2003248960B2 (en) | 2002-07-17 | 2009-06-25 | Idorsia Pharmaceuticals Ltd | Piperidinetriol derivatives as inhibitors of glycosylceramidsynthase |
GB0313677D0 (en) | 2003-06-13 | 2003-07-16 | Oxford Glycosciences Uk Ltd | Novel compound |
GB0313678D0 (en) | 2003-06-13 | 2003-07-16 | Oxford Glycosciences Uk Ltd | Novel compounds |
PL1680112T3 (pl) * | 2003-10-29 | 2011-05-31 | Genzyme Corp | N-(5-adamantan-1-ylometoksypentylo)deoksynojirimycyna lub dopuszczalna farmaceutycznie sól stosowane w leczeniu oporności na insulinę |
EP1528056A1 (de) * | 2003-10-29 | 2005-05-04 | Academisch Ziekenhuis bij de Universiteit van Amsterdam | Deoxynojirimycin Derivate und ihre Verwendung als Glukosesylceramidase-Inhibitoren |
AU2004289327A1 (en) * | 2003-11-12 | 2005-05-26 | Amicus Therapeutics Inc. | Glucoimidazole and polyhydroxycyclohexenyl amine derivatives to treat Gaucher disease |
WO2005063706A1 (en) * | 2003-12-23 | 2005-07-14 | Macrozyme Dnm B.V. | Synthesis of nojirimycins |
US20090111812A1 (en) * | 2004-06-14 | 2009-04-30 | Musc Foundation For Research Development | Methods for treating inflammatory disorders |
JP5364382B2 (ja) | 2006-02-07 | 2013-12-11 | シャイアー ヒューマン ジェネティック セラピーズ インコーポレイテッド | 遊離チオール部分を有するタンパク質の安定化された組成物 |
CN101479288B (zh) | 2006-04-24 | 2012-06-27 | 大学医疗中心 | 囊性纤维化的改进的治疗 |
US8546369B2 (en) * | 2008-05-30 | 2013-10-01 | Northern Innovations Holding Corp. | Salts of creatine imino sugar amides |
EP2411526A4 (de) * | 2009-03-27 | 2012-09-19 | Zacharon Pharmaceuticals Inc | Modulatoren der gangliosidenbiosynthese |
MX2012001268A (es) | 2009-07-28 | 2012-09-12 | Shire Human Genetic Therapies | Composiciones y metodos para tratar enfermedad de gaucher. |
US9453847B2 (en) | 2010-07-19 | 2016-09-27 | Shire Human Genetic Therapies, Inc. | Mannose receptor C type 1 (MRC1) codon optimized cell line and uses thereof |
CA2865614A1 (en) | 2012-03-02 | 2013-09-06 | Shire Human Genetic Therapies, Inc. | Compositions and methods for treating type iii gaucher disease |
WO2013184780A1 (en) * | 2012-06-06 | 2013-12-12 | Unither Virology, Llc | Novel iminosugars and their applications |
WO2014017915A2 (en) | 2012-07-27 | 2014-01-30 | Universiteit Utrecht Holding B.V. | Urea and guanidinium derivatives of iminosugars |
EP3122726B1 (de) | 2014-03-27 | 2018-08-29 | Academisch Medisch Centrum | N-(5-((aryl oder heteroaryl)methyloxy)pentyl)-substituierte iminozucker als glucosylceramid-synthase-hemmer |
CA2976449C (en) * | 2015-02-11 | 2022-08-09 | Icahn School Of Medicine At Mount Sinai | Benzenesulfonamide upregulators of npc1 for neimann-pick disease and other lysosomal storage disorders |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2925943A1 (de) | 1979-06-27 | 1981-01-29 | Bayer Ag | 1-alkadien-2,4-yl-2-hydroxymethyl3,4,5-trihydroxypiperidine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
DE3007078A1 (de) | 1980-02-26 | 1981-09-10 | Bayer Ag, 5090 Leverkusen | Neue derivate von 3,4,5-trihydroxypiperidin, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel sowie in der tierernaehrung |
DE3024901A1 (de) * | 1980-07-01 | 1982-01-28 | Bayer Ag, 5090 Leverkusen | Herbizide mittel auf basis von piperidin-derivaten |
DE3507019A1 (de) * | 1985-02-28 | 1986-08-28 | Bayer Ag, 5090 Leverkusen | Neue derivate von 3,4,5-trihydroxypiperidin, verfahren zu ihrer herstellung und ihre verwendung |
US4880902A (en) | 1987-08-27 | 1989-11-14 | Shell Oil Company | Copolymerization of carbon monoxide and olefin with diphosphine having heterocyclic substituents as catalyst |
EP0350012A3 (de) * | 1988-07-08 | 1990-09-05 | Meiji Seika Kaisha Ltd. | Antivirale Zusammensetzung |
JPH02306962A (ja) * | 1989-05-19 | 1990-12-20 | Meiji Seika Kaisha Ltd | 新規n―置換―1―デオキシノジリマイシン誘導体及びそれを含有する癌細胞転移抑制剤 |
DK0477160T3 (da) * | 1990-09-20 | 1996-05-20 | Monsanto Co | Fremgangsmåde til fremstilling af N-substitueret 1-deoxynojirimycin |
DK0675727T3 (da) * | 1992-12-10 | 2002-08-05 | Enzon Inc | Glycolipidenzympolymerkonjugater |
US5429177A (en) | 1993-07-09 | 1995-07-04 | Sierra Regenators, Inc. | Foil regenerator |
AU1876095A (en) * | 1994-02-25 | 1995-09-11 | G.D. Searle & Co. | Use of 1-deoxynojirimycin and its derivatives for treating mammals infected with respiratory syncytial virus |
-
1997
- 1997-07-14 AU AU34647/97A patent/AU732552B2/en not_active Expired
- 1997-07-14 WO PCT/NL1997/000411 patent/WO1998002161A1/en active IP Right Grant
- 1997-07-14 DE DE69735669T patent/DE69735669T2/de not_active Expired - Lifetime
- 1997-07-14 IL IL12803697A patent/IL128036A/xx not_active IP Right Cessation
- 1997-07-14 EP EP97930879A patent/EP0912179B1/de not_active Expired - Lifetime
- 1997-07-14 CA CA002260790A patent/CA2260790C/en not_active Expired - Lifetime
- 1997-07-14 JP JP50587698A patent/JP4564108B2/ja not_active Expired - Lifetime
- 1997-07-14 US US09/230,005 patent/US6177447B1/en not_active Expired - Lifetime
- 1997-07-14 AT AT97930879T patent/ATE322900T1/de not_active IP Right Cessation
-
2009
- 2009-11-18 JP JP2009262461A patent/JP2010031062A/ja not_active Withdrawn
-
2013
- 2013-10-04 JP JP2013208841A patent/JP2014024857A/ja not_active Withdrawn
-
2016
- 2016-01-14 JP JP2016004873A patent/JP2016056203A/ja not_active Withdrawn
-
2017
- 2017-04-18 JP JP2017081926A patent/JP2017122133A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
CA2260790A1 (en) | 1998-01-22 |
WO1998002161A1 (en) | 1998-01-22 |
JP2014024857A (ja) | 2014-02-06 |
ATE322900T1 (de) | 2006-04-15 |
EP0912179A1 (de) | 1999-05-06 |
IL128036A0 (en) | 1999-11-30 |
JP2000516577A (ja) | 2000-12-12 |
JP2017122133A (ja) | 2017-07-13 |
US6177447B1 (en) | 2001-01-23 |
JP2010031062A (ja) | 2010-02-12 |
JP4564108B2 (ja) | 2010-10-20 |
JP2016056203A (ja) | 2016-04-21 |
AU732552B2 (en) | 2001-04-26 |
EP0912179B1 (de) | 2006-04-12 |
CA2260790C (en) | 2007-01-09 |
AU3464797A (en) | 1998-02-09 |
IL128036A (en) | 2005-08-31 |
DE69735669T2 (de) | 2007-03-29 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8327 | Change in the person/name/address of the patent owner |
Owner name: GENZYME CORP., CAMBRIDGE, MASS., US |