DE69733618T2 - Biokonjugate und verabreichung von bioaktiven substanzen - Google Patents
Biokonjugate und verabreichung von bioaktiven substanzen Download PDFInfo
- Publication number
- DE69733618T2 DE69733618T2 DE69733618T DE69733618T DE69733618T2 DE 69733618 T2 DE69733618 T2 DE 69733618T2 DE 69733618 T DE69733618 T DE 69733618T DE 69733618 T DE69733618 T DE 69733618T DE 69733618 T2 DE69733618 T2 DE 69733618T2
- Authority
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- Germany
- Prior art keywords
- bioconjugate
- cells
- atom
- cobalt
- bioactive
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- 230000000975 bioactive effect Effects 0.000 title claims description 39
- GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical group [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 claims abstract description 43
- 150000004700 cobalt complex Chemical class 0.000 claims description 46
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- 125000004429 atom Chemical group 0.000 claims description 22
- 239000003446 ligand Substances 0.000 claims description 22
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 22
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 20
- 239000002246 antineoplastic agent Substances 0.000 claims description 19
- 108091034117 Oligonucleotide Proteins 0.000 claims description 18
- 229910017052 cobalt Inorganic materials 0.000 claims description 16
- 239000010941 cobalt Substances 0.000 claims description 16
- 150000001875 compounds Chemical class 0.000 claims description 16
- 125000006850 spacer group Chemical group 0.000 claims description 16
- 229910052799 carbon Inorganic materials 0.000 claims description 15
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- ASARMUCNOOHMLO-WLORSUFZSA-L cobalt(2+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2s)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+2].[N-]([C@@H]1[C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@H](C)OP([O-])(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O ASARMUCNOOHMLO-WLORSUFZSA-L 0.000 description 44
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0028—Disruption, e.g. by heat or ultrasounds, sonophysical or sonochemical activation, e.g. thermosensitive or heat-sensitive liposomes, disruption of calculi with a medicinal preparation and ultrasounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0042—Photocleavage of drugs in vivo, e.g. cleavage of photolabile linkers in vivo by UV radiation for releasing the pharmacologically-active agent from the administered agent; photothrombosis or photoocclusion
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Dermatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Saccharide Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2443096P | 1996-08-27 | 1996-08-27 | |
| US2503696P | 1996-08-27 | 1996-08-27 | |
| US25036P | 1996-08-27 | ||
| US24430P | 1996-08-27 | ||
| PCT/US1997/014140 WO1998008859A1 (en) | 1996-08-27 | 1997-08-22 | Bioconjugates and delivery of bioactive agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69733618D1 DE69733618D1 (de) | 2005-07-28 |
| DE69733618T2 true DE69733618T2 (de) | 2006-05-11 |
Family
ID=26698439
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69733618T Expired - Lifetime DE69733618T2 (de) | 1996-08-27 | 1997-08-22 | Biokonjugate und verabreichung von bioaktiven substanzen |
Country Status (11)
| Country | Link |
|---|---|
| US (4) | US6315978B1 (enExample) |
| EP (1) | EP1007533B1 (enExample) |
| JP (1) | JP2001501596A (enExample) |
| AT (1) | ATE298344T1 (enExample) |
| AU (1) | AU738431B2 (enExample) |
| CA (1) | CA2264592C (enExample) |
| DE (1) | DE69733618T2 (enExample) |
| ES (1) | ES2244006T3 (enExample) |
| NZ (1) | NZ334870A (enExample) |
| PT (1) | PT1007533E (enExample) |
| WO (1) | WO1998008859A1 (enExample) |
Families Citing this family (71)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5739313A (en) | 1995-11-13 | 1998-04-14 | Regents Of The University Of Minnesota | Radionuclide labeling of vitamin B12 and coenzymes thereof |
| KR20020032421A (ko) * | 1999-04-16 | 2002-05-03 | 메이오 파운데이션 포 메디칼 에쥬케이션 앤드 리써치 | 항암제로서 유용한 코발라민 컨쥬게이트 |
| US6806363B1 (en) | 1999-04-16 | 2004-10-19 | Mayo Foundation For Medical Education & Research | Cobalamin conjugates useful as antitumor agents |
| WO2001028592A1 (en) * | 1999-10-15 | 2001-04-26 | Mayo Foundation For Medical Education And Research | Cobalamin conjugates useful as imaging agents and as antitumor agents |
| US7591995B2 (en) * | 1999-10-15 | 2009-09-22 | Mayo Foundation For Medical Education And Research | Cobalamin conjugates useful as imaging and therapeutic agents |
| AU785505B2 (en) | 1999-10-15 | 2009-02-26 | Mayo Foundation For Medical Education And Research | Cobalamin conjugates useful as imaging and therapeutic agents |
| US7067111B1 (en) | 1999-10-25 | 2006-06-27 | Board Of Regents, University Of Texas System | Ethylenedicysteine (EC)-drug conjugates, compositions and methods for tissue specific disease imaging |
| US6797521B2 (en) * | 1999-10-26 | 2004-09-28 | University Of Utah Research Foundation | Fluorescent cobalamins and uses thereof |
| DE10012120A1 (de) * | 2000-03-13 | 2001-09-27 | Ktb Tumorforschungs Gmbh | Therapeutische und diagnostische Ligandensysteme mit Transportmolekülbindenden Eigenschaften und diese enthaltende Arzneimittel |
| WO2001092288A2 (en) * | 2000-05-31 | 2001-12-06 | Mayo Foundation For Medical Education And Research | Cobalamin compounds useful as antibiotic agents and as imaging agents |
| US20020049155A1 (en) * | 2000-05-31 | 2002-04-25 | Hogenkamp Henricus P.C. | Cobalamin compounds useful as cardiovascular agents and as imaging agents |
| CN1292798C (zh) | 2000-06-02 | 2007-01-03 | 德克萨斯州立大学董事会 | 乙二半胱氨酸(ec)－药物缀合物 |
| EP1754712A3 (en) * | 2000-10-25 | 2009-01-14 | Mayo Foundation For Medical Education And Research | Transcobalamin binding conjugates useful for treating abnormal cellular proliferation |
| WO2002055530A2 (en) * | 2000-10-25 | 2002-07-18 | Mayo Foundation | Transcobalamin binding conjugates useful for treating abnormal cellular proliferation |
| AU2002239342A1 (en) * | 2000-11-22 | 2002-06-03 | Rxkinetix, Inc. | Treatment of mucositis |
| WO2002076394A2 (en) * | 2001-03-22 | 2002-10-03 | The Ohio State University Research Foundation | Enzyme-based anti-cancer compositions and methods |
| US6752986B2 (en) * | 2001-05-24 | 2004-06-22 | The Cleveland Clinic Foundation | Composition and methods for affecting metallocorrinoid uptake |
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| WO2003026674A1 (en) * | 2001-09-28 | 2003-04-03 | Mayo Foundation For Medical Education And Research | Coadministration of transport protein with conjugated cobalamin to deliver agents |
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| US9657294B2 (en) | 2002-02-20 | 2017-05-23 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA) |
| US20040047917A1 (en) * | 2002-09-06 | 2004-03-11 | Stephen Wilson | Drug delivery and targeting with vitamin B12 conjugates |
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| EP1596815A4 (en) * | 2003-02-20 | 2007-07-04 | Cleveland Clinic Foundation | COMPOSITION AND METHOD FOR INHIBITING THE SURVIVAL OF CELLS |
| US7232805B2 (en) * | 2003-09-10 | 2007-06-19 | Inflabloc Pharmaceuticals, Inc. | Cobalamin conjugates for anti-tumor therapy |
| US7119065B2 (en) * | 2003-10-29 | 2006-10-10 | Nagoya Industrial Science Research Institute | Metal complex-protein composite and oxidation catalyst |
| US9050378B2 (en) | 2003-12-10 | 2015-06-09 | Board Of Regents, The University Of Texas System | N2S2 chelate-targeting ligand conjugates |
| US7840263B2 (en) | 2004-02-27 | 2010-11-23 | Cardiac Pacemakers, Inc. | Method and apparatus for device controlled gene expression |
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| US7729761B2 (en) * | 2004-07-14 | 2010-06-01 | Cardiac Pacemakers, Inc. | Method and apparatus for controlled gene or protein delivery |
| US8288557B2 (en) | 2004-07-23 | 2012-10-16 | Endocyte, Inc. | Bivalent linkers and conjugates thereof |
| US8202507B2 (en) * | 2004-09-23 | 2012-06-19 | The Regents Of The University Of California | Assay for vitamin B12 absorption and method of making labeled vitamin B12 |
| US8060219B2 (en) | 2004-12-20 | 2011-11-15 | Cardiac Pacemakers, Inc. | Epicardial patch including isolated extracellular matrix with pacing electrodes |
| US7981065B2 (en) | 2004-12-20 | 2011-07-19 | Cardiac Pacemakers, Inc. | Lead electrode incorporating extracellular matrix |
| EP1893038A1 (en) * | 2005-05-17 | 2008-03-05 | Cargill, Incorporated | Granular lecithins, granular lysolecithins, process for their production and compositions containing them |
| BRPI0615354A2 (pt) * | 2005-08-19 | 2011-05-17 | Endocyte Inc | conjugado de liberação de fármaco de ligação de receptor, composição farmacêutica que o compreende, bem como seu uso |
| US7774057B2 (en) | 2005-09-06 | 2010-08-10 | Cardiac Pacemakers, Inc. | Method and apparatus for device controlled gene expression for cardiac protection |
| CA2635603C (en) * | 2005-11-30 | 2016-01-19 | Endo Pharmaceuticals Inc. | Treatment of xerostomia |
| US10925977B2 (en) | 2006-10-05 | 2021-02-23 | Ceil>Point, LLC | Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications |
| WO2008101231A2 (en) | 2007-02-16 | 2008-08-21 | Endocyte, Inc. | Methods and compositions for treating and diagnosing kidney disease |
| EP2131855A2 (en) | 2007-03-05 | 2009-12-16 | Syracuse University | A conjugate of insulin and vitamin b12 for oral delivery |
| CN104127878A (zh) | 2007-03-14 | 2014-11-05 | 恩多塞特公司 | 结合配体连接的微管溶素递药缀合物 |
| US20080233135A1 (en) * | 2007-03-19 | 2008-09-25 | Gebhard John R | Cobalamin taxane bioconjugates |
| BRPI0811248A2 (pt) | 2007-05-16 | 2014-11-04 | Ktb Tumorforschungs Gmbh | Formulação de antraciclina de baixa viscosidade. |
| US9877965B2 (en) | 2007-06-25 | 2018-01-30 | Endocyte, Inc. | Vitamin receptor drug delivery conjugates for treating inflammation |
| CN104383553A (zh) | 2007-06-25 | 2015-03-04 | 恩多塞特公司 | 含有亲水性间隔区接头的共轭物 |
| US8529426B2 (en) | 2007-10-18 | 2013-09-10 | The Invention Science Fund I Llc | Ionizing-radiation-responsive compositions, methods, and systems |
| US9557635B2 (en) * | 2007-10-18 | 2017-01-31 | Gearbox, Llc | Ionizing-radiation-responsive compositions, methods, and systems |
| US8684898B2 (en) * | 2007-10-18 | 2014-04-01 | The Invention Science Fund I Llc | Ionizing-radiation-responsive compositions, methods, and systems |
| US8168958B2 (en) * | 2007-10-18 | 2012-05-01 | The Invention Science Fund I, Llc | Ionizing-radiation-responsive compositions, methods, and systems |
| US8164074B2 (en) * | 2007-10-18 | 2012-04-24 | The Invention Science Fund I, Llc | Ionizing-radiation-responsive compositions, methods, and systems |
| GB2453860B (en) | 2007-10-18 | 2011-03-16 | Searete Llc | Ionizing-radiation-responsive compositions,methods and systems |
| US8227204B2 (en) * | 2007-10-18 | 2012-07-24 | The Invention Science Fund I, Llc | Ionizing-radiation-responsive compositions, methods, and systems |
| US20090104113A1 (en) * | 2007-10-18 | 2009-04-23 | Searete Llc | Ionizing-radiation-responsive compositions, methods, and systems |
| US20090169484A1 (en) | 2007-12-28 | 2009-07-02 | Ihi Corporation | Iron-salen complex |
| JP2009274962A (ja) * | 2008-05-12 | 2009-11-26 | Yoshihiro Ishikawa | 鉄サレン錯体、磁性を有する薬剤、薬剤の誘導システム、並びに磁気検出装置 |
| US20100016256A1 (en) * | 2008-07-21 | 2010-01-21 | Gebhard John R | Taxane Compounds for Treating Eye Disease |
| WO2010058280A1 (ja) * | 2008-11-20 | 2010-05-27 | 株式会社Ihi | 自己磁性金属サレン錯体化合物 |
| CN102834512A (zh) * | 2010-04-06 | 2012-12-19 | 株式会社Ihi | 金属salen配合物衍生物及其制造方法 |
| WO2011130716A2 (en) | 2010-04-16 | 2011-10-20 | Access Pharmaceuticals, Inc. | A nanostructures containing vitamin b12 for facilitated delivery of drugs across biological barriers |
| KR20140026396A (ko) | 2011-03-08 | 2014-03-05 | 어섹스 팔마큐티칼스 인코포레이티드 | 생물학적 막을 가로질러 활성물질의 전달을 위한 표적화된 나노담체 시스템 |
| WO2013126797A1 (en) | 2012-02-24 | 2013-08-29 | Purdue Research Foundation | Cholecystokinin b receptor targeting for imaging and therapy |
| US20140080175A1 (en) | 2012-03-29 | 2014-03-20 | Endocyte, Inc. | Processes for preparing tubulysin derivatives and conjugates thereof |
| HK1212618A1 (zh) | 2012-10-16 | 2016-06-17 | 恩多塞特公司 | 含有非天然氨基酸的藥物遞送綴合物以及其使用方法 |
| US9352049B2 (en) | 2013-03-14 | 2016-05-31 | Albany Molecular Research, Inc. | Ligand-therapeutic agent conjugates, silicon-based linkers, and methods for making and using them |
| JP2016516774A (ja) * | 2013-04-08 | 2016-06-09 | ユニバーシティー オブ ノースキャロライナ アット チャペル ヒルＵｎｉｖｅｒｓｉｔｙ Ｏｆ Ｎｏｒｔｈ Ｃａｒｏｌｉｎａ Ａｔ Ｃｈａｐｅｌ Ｈｉｌｌ | 光応答性化合物 |
| RS57418B1 (sr) * | 2013-05-22 | 2018-09-28 | Alnylam Pharmaceuticals Inc | Serpina1 irnk sastavi i postupci njihove primene |
| CA2922698C (en) * | 2013-08-29 | 2023-01-03 | City Of Hope | Cell penetrating conjugates comprising non-cell penetrating antibodies covalently attached to one or more phosphorothioate nucleic acids |
| GR20130100654A (el) * | 2013-11-22 | 2015-06-18 | Χρηστος Γκολφινου Ταπεινος | Επιφανειακως τροποποιημενα πολλαπλως αποκρινομενα σε ερεθισματα νανο/μικρο-δοχεια ως φορεις φαρμακων για στοχευμενη θεραπεια διαφορων μορφων καρκινου |
| WO2020113130A1 (en) * | 2018-11-29 | 2020-06-04 | The Trustees Of Dartmouth College | Tumor targeting vitamin b12 derivatives for x-ray activated chemotherapy |
| GB202018713D0 (en) | 2020-11-27 | 2021-01-13 | Quadram Inst Bioscience | Methods and compositions utilising vitamin b12 binding |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4758421A (en) * | 1985-03-15 | 1988-07-19 | The Board Of Trustees Of The Leland Stanford Junior University | Bleomycin conjugates and method |
| NZ217821A (en) * | 1985-10-10 | 1989-07-27 | Biotech Australia Pty Ltd | Oral delivery system; complex of active agent and vitamin b12 or analogue thereof |
| EP0394277B1 (en) * | 1987-07-15 | 1998-01-14 | THE UNITED STATES OF AMERICA as represented by the Secretary United States Department of Commerce | Second generation monoclonal antibodies having binding specificity to tag-72 and human carcinomas and methods for employing the same |
| US5047227A (en) * | 1988-02-08 | 1991-09-10 | Cytogen Corporation | Novel and improved antibodies for site specific attachment of compounds |
| WO1990012095A1 (en) * | 1989-04-03 | 1990-10-18 | Purdue Research Foundation | Method for enhancing transmembrane transport of exogenous molecules |
| US5608046A (en) * | 1990-07-27 | 1997-03-04 | Isis Pharmaceuticals, Inc. | Conjugated 4'-desmethyl nucleoside analog compounds |
| US5763569A (en) * | 1991-08-23 | 1998-06-09 | The Brigham And Women's Hospital, Inc | Calcium receptor-active molecules |
| WO1994028015A1 (en) * | 1993-05-20 | 1994-12-08 | Biotech Australia Pty. Limited | Lhrh antagonists |
| US5548064A (en) * | 1993-05-24 | 1996-08-20 | Biotech Australia Pty Limited | Vitamin B12 conjugates with EPO, analogues thereof and pharmaceutical compositions |
| EP0754189B1 (en) * | 1994-04-08 | 2002-10-09 | Receptagen Corporation | Receptor modulating agents and methods relating thereto |
| US5574018A (en) * | 1994-07-29 | 1996-11-12 | Amgen Inc. | Conjugates of vitamin B12 and proteins |
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1997
- 1997-08-22 JP JP10511674A patent/JP2001501596A/ja active Pending
- 1997-08-22 DE DE69733618T patent/DE69733618T2/de not_active Expired - Lifetime
- 1997-08-22 NZ NZ334870A patent/NZ334870A/xx not_active IP Right Cessation
- 1997-08-22 CA CA2264592A patent/CA2264592C/en not_active Expired - Fee Related
- 1997-08-22 PT PT97939382T patent/PT1007533E/pt unknown
- 1997-08-22 AT AT97939382T patent/ATE298344T1/de active
- 1997-08-22 US US09/202,328 patent/US6315978B1/en not_active Expired - Fee Related
- 1997-08-22 AU AU41482/97A patent/AU738431B2/en not_active Ceased
- 1997-08-22 ES ES97939382T patent/ES2244006T3/es not_active Expired - Lifetime
- 1997-08-22 EP EP97939382A patent/EP1007533B1/en not_active Expired - Lifetime
- 1997-08-22 WO PCT/US1997/014140 patent/WO1998008859A1/en not_active Ceased
-
2001
- 2001-10-22 US US09/982,940 patent/US6790827B2/en not_active Expired - Lifetime
- 2001-10-22 US US09/982,968 patent/US6777237B2/en not_active Expired - Lifetime
- 2001-10-22 US US09/982,892 patent/US6776976B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| NZ334870A (en) | 2000-12-22 |
| WO1998008859A1 (en) | 1998-03-05 |
| JP2001501596A (ja) | 2001-02-06 |
| DE69733618D1 (de) | 2005-07-28 |
| US20020111294A1 (en) | 2002-08-15 |
| US20020115595A1 (en) | 2002-08-22 |
| AU4148297A (en) | 1998-03-19 |
| US20020049154A1 (en) | 2002-04-25 |
| US6776976B2 (en) | 2004-08-17 |
| CA2264592A1 (en) | 1998-03-05 |
| ES2244006T3 (es) | 2005-12-01 |
| US6790827B2 (en) | 2004-09-14 |
| EP1007533A4 (en) | 2002-08-07 |
| US6777237B2 (en) | 2004-08-17 |
| AU738431B2 (en) | 2001-09-20 |
| PT1007533E (pt) | 2005-09-30 |
| EP1007533A1 (en) | 2000-06-14 |
| EP1007533B1 (en) | 2005-06-22 |
| US6315978B1 (en) | 2001-11-13 |
| CA2264592C (en) | 2012-02-21 |
| ATE298344T1 (de) | 2005-07-15 |
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