DE69733427D1 - Tetrahydrobezindol derivate - Google Patents

Tetrahydrobezindol derivate

Info

Publication number
DE69733427D1
DE69733427D1 DE69733427T DE69733427T DE69733427D1 DE 69733427 D1 DE69733427 D1 DE 69733427D1 DE 69733427 T DE69733427 T DE 69733427T DE 69733427 T DE69733427 T DE 69733427T DE 69733427 D1 DE69733427 D1 DE 69733427D1
Authority
DE
Germany
Prior art keywords
group
lower alkyl
hydrogen atom
carbamoyl
alkoxycarbonyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69733427T
Other languages
English (en)
Other versions
DE69733427T2 (de
Inventor
Masao Koyama
Chika Kikuchi
Osamu Ushiroda
Takashi Ando
Hiroshi Nagaso
Kazuyuki Fuji
Masayo Okuno
Toyokazu Hiranuma
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Meiji Seika Kaisha Ltd
Original Assignee
Meiji Seika Kaisha Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Meiji Seika Kaisha Ltd filed Critical Meiji Seika Kaisha Ltd
Application granted granted Critical
Publication of DE69733427D1 publication Critical patent/DE69733427D1/de
Publication of DE69733427T2 publication Critical patent/DE69733427T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/90—Benzo [c, d] indoles; Hydrogenated benzo [c, d] indoles
    • C07D209/92—Naphthostyrils
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
DE69733427T 1996-06-28 1997-06-27 Tetrahydrobezindol derivate Expired - Lifetime DE69733427T2 (de)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
JP16970296 1996-06-28
JP16970296 1996-06-28
JP9627197 1997-04-15
JP9627197 1997-04-15
JP13020197 1997-05-21
JP13020197 1997-05-21
JP14437697 1997-06-03
JP14437697 1997-06-03
PCT/JP1997/002226 WO1998000400A1 (fr) 1996-06-28 1997-06-27 Composes de tetrahydrobenzindole

Publications (2)

Publication Number Publication Date
DE69733427D1 true DE69733427D1 (de) 2005-07-07
DE69733427T2 DE69733427T2 (de) 2006-04-27

Family

ID=27468418

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69733427T Expired - Lifetime DE69733427T2 (de) 1996-06-28 1997-06-27 Tetrahydrobezindol derivate

Country Status (8)

Country Link
US (1) US6355642B1 (de)
EP (1) EP0937715B1 (de)
JP (1) JP4076234B2 (de)
AT (1) ATE296801T1 (de)
DE (1) DE69733427T2 (de)
ES (1) ES2243999T3 (de)
NO (1) NO311515B1 (de)
WO (1) WO1998000400A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1129578C (zh) 1997-12-25 2003-12-03 明治制果株式会社 四氢苯并吲哚衍生物
KR20010042904A (ko) 1998-04-22 2001-05-25 기따자또 이찌로 광학 활성 테트라하이드로벤즈인돌 유도체
US6960579B1 (en) 1998-05-19 2005-11-01 Alcon Manufacturing, Ltd. Serotonergic 5HT7 receptor compounds for treating ocular and CNS disorders
GB9828004D0 (en) * 1998-12-18 1999-02-10 Smithkline Beecham Plc Use
AU1025601A (en) * 1999-10-18 2001-04-30 Smithkline Beecham Plc Tetrahydrobenzindolone derivatives, their preparation and their use as 5-ht7 receptor antagonists
JP2004231514A (ja) * 2000-08-31 2004-08-19 Meiji Seika Kaisha Ltd ５−ｈｔ７受容体結合能を有し、かつ代謝的に安定なテトラヒドロベンズインドール誘導体
ITRM20010356A1 (it) * 2001-06-21 2002-12-23 Sigma Tau Ind Farmaceuti "5-alogeno derivati della triptamina utili come ligandi del recettore5-ht6 e/o 5-ht7 della serotonina.
US7786094B2 (en) * 2001-10-09 2010-08-31 Biopolymer Engineering, Inc. Use of beta-glucans against biological warfare weapons and pathogens including anthrax
US7553965B2 (en) 2002-11-07 2009-06-30 Laboratories Del Dr. Esteve, S.A. 5-HT7 receptor antagonists
EP1676840A1 (de) 2004-12-28 2006-07-05 Laboratorios Del Dr. Esteve, S.A. 5-HT7-Rezeptorantagonisten
US20070179155A1 (en) * 2003-06-20 2007-08-02 Brian Smith N-phenyl-piperazine derivatives and methods of prophylaxis or treatment of 5ht2c receptor associated diseases
NZ545836A (en) * 2003-09-17 2009-09-25 Janssen Pharmaceutica Nv Fused heterocyclic compounds as serotonin receptor modulators
US20070265300A1 (en) * 2004-05-11 2007-11-15 Egis Gyogyszergyar Rt. Pyridine Derivatives of Alkyl Oxindoles as 5-Ht7 Receptor Active Agents
TW200633721A (en) * 2004-12-14 2006-10-01 Shionogi & Co A pharmaceutical composition for treating constipation
US20090029979A1 (en) * 2005-07-07 2009-01-29 Bio-Medisinsk Innovasjon As 5-htx modulators
EP1917255A2 (de) 2005-07-29 2008-05-07 F. Hoffmann-Roche AG Indol-3-yl-carbonyl-piperidin- und piperazin-derivate
US7598255B2 (en) * 2005-08-04 2009-10-06 Janssen Pharmaceutica Nv Pyrimidine compounds as serotonin receptor modulators

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0429341A3 (en) * 1989-11-20 1991-11-13 Rhone-Poulenc Sante Heterocyclic derivatives, their preparation and pharmaceuticals containing them
FR2662696A2 (fr) 1989-12-13 1991-12-06 Rhone Poulenc Sante Antagonistes de la serotonine, leur preparation et medicaments les contenant.
US5077293A (en) * 1990-06-29 1991-12-31 Bristol-Myers Squibb Co. 1-indolyalkyl-4-(alkoxypyrimidinyl)piperazines
JP3190858B2 (ja) 1997-07-23 2001-07-23 山形日本電気株式会社 半導体装置およびその製造方法

Also Published As

Publication number Publication date
DE69733427T2 (de) 2006-04-27
NO986141L (no) 1999-02-17
JP4076234B2 (ja) 2008-04-16
ES2243999T3 (es) 2005-12-01
EP0937715B1 (de) 2005-06-01
NO311515B1 (no) 2001-12-03
US6355642B1 (en) 2002-03-12
EP0937715A1 (de) 1999-08-25
WO1998000400A1 (fr) 1998-01-08
EP0937715A4 (de) 2001-01-17
NO986141D0 (no) 1998-12-28
ATE296801T1 (de) 2005-06-15

Similar Documents

Publication Publication Date Title
DE69733427D1 (de) Tetrahydrobezindol derivate
NO20055655D0 (no) Anvendelse av azetidinkarboksamidderivater i terapi
GEP20053600B (en) 3-(4-Amidopyrrol-2-Ylmethlidene)-2- Indolinone Derivatives as Protein Kinase Inhibitors
MY138352A (en) Benzothiazole derivatives
PH12021551256A1 (en) Pantetheine derivatives and uses thereof
WO2006067165A3 (en) Indolidone derivatives for the treatment or prevention of fibrotic diseases
CY1107850T1 (el) Παραγωγα θειαδιαζολυλοπιπεραζiνης mε χρησιμοτητα στην αποτροπη ή στην αγωγη εναντι tου αλγους
KR950700258A (ko) 레티노이드 수용체(rar)에 결합하는 헤테로고리 탄산유도체(heterocyclic carbonic acid derivatives which bind to retinoid receptors(rar))
AUPR213700A0 (en) Antiviral agents
NO20020968L (no) Glukopyranosyloksypyrazolderivater, medisinske sammensetninger inneholdende det samme og intermediater forfremstillingen derav
MY142551A (en) Substituted diaryl heterocycles, process for their preparation and their use as medicaments
EA200501585A1 (ru) Производные азетидинкарбоксамида и их применение при лечении нарушений, опосредованных св1 рецепторами
ATE384058T1 (de) Thiazolderivate
IL169184A0 (en) Aromatic compounds as anti-inflammatory, immunomdulatory and anti-proliferatory agents
IL195016A0 (en) 1h-indol-5-yl-piperazin-1-yl-methanone derivatives
DE69429328T2 (de) N-(3-piperidinylcarbonyl)-b-alanin derivate als paf-antagonisten
MXPA01007940A (es) Derivados de azabicicloalcano y usos terapeuticos de los mismos.
EA200800071A1 (ru) Производные бензофуранила как ингибиторы 5-нт6-рецептора
TW200626571A (en) Arylsulfonylmethyl or arylsulfonamide substituted aromatic compounds suitable for treating disorders that respond to modulation of the dopamine D3 receptor
DE69512816T2 (de) Oxopyridylchinoxalin Derivate
NO964497L (no) Middel for behandling av cor pulmonale
EA200600891A1 (ru) Нитроксипроизводные гипотензивных лекарственных средств
AU2003264940A1 (en) Pyrazole derivatives and their use as therapeutic agents for hiv mediated diseases
CA2259218A1 (en) Tetrahydrobenzindole compound
GB2316944A (en) New catechol derivatives

Legal Events

Date Code Title Description
8364 No opposition during term of opposition