DE69726182T2 - Methoden und pharmazeutische zusammenstellungen zur wachstumsverhinderung von tumorzellen enthaltend einen ppar-gamma agonisten und einen map kinase inhibitor - Google Patents

Methoden und pharmazeutische zusammenstellungen zur wachstumsverhinderung von tumorzellen enthaltend einen ppar-gamma agonisten und einen map kinase inhibitor Download PDF

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Publication number
DE69726182T2
DE69726182T2 DE69726182T DE69726182T DE69726182T2 DE 69726182 T2 DE69726182 T2 DE 69726182T2 DE 69726182 T DE69726182 T DE 69726182T DE 69726182 T DE69726182 T DE 69726182T DE 69726182 T2 DE69726182 T2 DE 69726182T2
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DE
Germany
Prior art keywords
pparγ
cell
cells
carcinoma
pparγ agonist
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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DE69726182T
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German (de)
English (en)
Other versions
DE69726182D1 (de
Inventor
M. Bruce SPIEGELMAN
Soner Altiok
Elisabetta Mueller
Pasha Serraf
Peter Tontonoz
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Dana Farber Cancer Institute Inc
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Dana Farber Cancer Institute Inc
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Priority claimed from US08/923,346 external-priority patent/US6552055B2/en
Application filed by Dana Farber Cancer Institute Inc filed Critical Dana Farber Cancer Institute Inc
Publication of DE69726182D1 publication Critical patent/DE69726182D1/de
Application granted granted Critical
Publication of DE69726182T2 publication Critical patent/DE69726182T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE69726182T 1996-12-11 1997-12-11 Methoden und pharmazeutische zusammenstellungen zur wachstumsverhinderung von tumorzellen enthaltend einen ppar-gamma agonisten und einen map kinase inhibitor Expired - Lifetime DE69726182T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US76655396A 1996-12-11 1996-12-11
US766553 1996-12-11
US923346 1997-09-04
US08/923,346 US6552055B2 (en) 1996-12-11 1997-09-04 Methods and pharmaceutical compositions for inhibiting tumor cell growth
PCT/US1997/022879 WO1998025598A2 (en) 1996-12-11 1997-12-11 Methods and pharmaceutical compositions for inhibiting tumour cell growth

Publications (2)

Publication Number Publication Date
DE69726182D1 DE69726182D1 (de) 2003-12-18
DE69726182T2 true DE69726182T2 (de) 2004-08-12

Family

ID=27117766

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69726182T Expired - Lifetime DE69726182T2 (de) 1996-12-11 1997-12-11 Methoden und pharmazeutische zusammenstellungen zur wachstumsverhinderung von tumorzellen enthaltend einen ppar-gamma agonisten und einen map kinase inhibitor
DE69739828T Expired - Lifetime DE69739828D1 (de) 1996-12-11 1997-12-11 Methoden und pharmazeutische Zusammensetzungen zur Inhibition des Tumorwachstums

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69739828T Expired - Lifetime DE69739828D1 (de) 1996-12-11 1997-12-11 Methoden und pharmazeutische Zusammensetzungen zur Inhibition des Tumorwachstums

Country Status (8)

Country Link
US (1) US7635708B2 (https=)
EP (2) EP1410799B1 (https=)
JP (2) JP4549443B2 (https=)
AT (2) ATE462433T1 (https=)
AU (1) AU5601898A (https=)
CA (1) CA2274756C (https=)
DE (2) DE69726182T2 (https=)
WO (1) WO1998025598A2 (https=)

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Also Published As

Publication number Publication date
WO1998025598A2 (en) 1998-06-18
EP1410799B1 (en) 2010-03-31
ATE462433T1 (de) 2010-04-15
JP2001510462A (ja) 2001-07-31
US20030144330A1 (en) 2003-07-31
DE69726182D1 (de) 2003-12-18
US7635708B2 (en) 2009-12-22
EP0948324B1 (en) 2003-11-12
CA2274756A1 (en) 1998-06-18
AU5601898A (en) 1998-07-03
JP4550133B2 (ja) 2010-09-22
JP2009063566A (ja) 2009-03-26
WO1998025598A3 (en) 1998-07-30
CA2274756C (en) 2007-03-13
JP4549443B2 (ja) 2010-09-22
ATE253903T1 (de) 2003-11-15
EP1410799A1 (en) 2004-04-21
EP0948324A2 (en) 1999-10-13
DE69739828D1 (de) 2010-05-12

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