DE69726182T2 - Methoden und pharmazeutische zusammenstellungen zur wachstumsverhinderung von tumorzellen enthaltend einen ppar-gamma agonisten und einen map kinase inhibitor - Google Patents

Methoden und pharmazeutische zusammenstellungen zur wachstumsverhinderung von tumorzellen enthaltend einen ppar-gamma agonisten und einen map kinase inhibitor Download PDF

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Publication number
DE69726182T2
DE69726182T2 DE69726182T DE69726182T DE69726182T2 DE 69726182 T2 DE69726182 T2 DE 69726182T2 DE 69726182 T DE69726182 T DE 69726182T DE 69726182 T DE69726182 T DE 69726182T DE 69726182 T2 DE69726182 T2 DE 69726182T2
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DE
Germany
Prior art keywords
pparγ
cell
cells
carcinoma
pparγ agonist
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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DE69726182T
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German (de)
English (en)
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DE69726182D1 (de
Inventor
M. Bruce SPIEGELMAN
Soner Altiok
Elisabetta Mueller
Pasha Serraf
Peter Tontonoz
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Dana Farber Cancer Institute Inc
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Dana Farber Cancer Institute Inc
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Filing date
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Priority claimed from US08/923,346 external-priority patent/US6552055B2/en
Application filed by Dana Farber Cancer Institute Inc filed Critical Dana Farber Cancer Institute Inc
Publication of DE69726182D1 publication Critical patent/DE69726182D1/de
Application granted granted Critical
Publication of DE69726182T2 publication Critical patent/DE69726182T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DE69726182T 1996-12-11 1997-12-11 Methoden und pharmazeutische zusammenstellungen zur wachstumsverhinderung von tumorzellen enthaltend einen ppar-gamma agonisten und einen map kinase inhibitor Expired - Lifetime DE69726182T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US76655396A 1996-12-11 1996-12-11
US766553 1996-12-11
US923346 1997-09-04
US08/923,346 US6552055B2 (en) 1996-12-11 1997-09-04 Methods and pharmaceutical compositions for inhibiting tumor cell growth
PCT/US1997/022879 WO1998025598A2 (en) 1996-12-11 1997-12-11 Methods and pharmaceutical compositions for inhibiting tumour cell growth

Publications (2)

Publication Number Publication Date
DE69726182D1 DE69726182D1 (de) 2003-12-18
DE69726182T2 true DE69726182T2 (de) 2004-08-12

Family

ID=27117766

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69726182T Expired - Lifetime DE69726182T2 (de) 1996-12-11 1997-12-11 Methoden und pharmazeutische zusammenstellungen zur wachstumsverhinderung von tumorzellen enthaltend einen ppar-gamma agonisten und einen map kinase inhibitor
DE69739828T Expired - Lifetime DE69739828D1 (de) 1996-12-11 1997-12-11 Methoden und pharmazeutische Zusammensetzungen zur Inhibition des Tumorwachstums

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69739828T Expired - Lifetime DE69739828D1 (de) 1996-12-11 1997-12-11 Methoden und pharmazeutische Zusammensetzungen zur Inhibition des Tumorwachstums

Country Status (8)

Country Link
US (1) US7635708B2 (enExample)
EP (2) EP1410799B1 (enExample)
JP (2) JP4549443B2 (enExample)
AT (2) ATE462433T1 (enExample)
AU (1) AU5601898A (enExample)
CA (1) CA2274756C (enExample)
DE (2) DE69726182T2 (enExample)
WO (1) WO1998025598A2 (enExample)

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Also Published As

Publication number Publication date
EP0948324A2 (en) 1999-10-13
CA2274756A1 (en) 1998-06-18
US7635708B2 (en) 2009-12-22
JP2009063566A (ja) 2009-03-26
ATE253903T1 (de) 2003-11-15
EP0948324B1 (en) 2003-11-12
JP4550133B2 (ja) 2010-09-22
CA2274756C (en) 2007-03-13
EP1410799A1 (en) 2004-04-21
DE69726182D1 (de) 2003-12-18
US20030144330A1 (en) 2003-07-31
EP1410799B1 (en) 2010-03-31
DE69739828D1 (de) 2010-05-12
JP4549443B2 (ja) 2010-09-22
AU5601898A (en) 1998-07-03
JP2001510462A (ja) 2001-07-31
WO1998025598A2 (en) 1998-06-18
ATE462433T1 (de) 2010-04-15
WO1998025598A3 (en) 1998-07-30

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