DE69725739D1 - Meningokokkus b-epitop ausbildende monoklonale antikoerper und deren verwendung zur herstellung von impfstoffzusammenstellungen - Google Patents
Meningokokkus b-epitop ausbildende monoklonale antikoerper und deren verwendung zur herstellung von impfstoffzusammenstellungenInfo
- Publication number
- DE69725739D1 DE69725739D1 DE69725739T DE69725739T DE69725739D1 DE 69725739 D1 DE69725739 D1 DE 69725739D1 DE 69725739 T DE69725739 T DE 69725739T DE 69725739 T DE69725739 T DE 69725739T DE 69725739 D1 DE69725739 D1 DE 69725739D1
- Authority
- DE
- Germany
- Prior art keywords
- menb
- vaccine compositions
- mimetics
- antibodies
- epitop
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000000203 mixture Substances 0.000 title abstract 2
- 229960005486 vaccine Drugs 0.000 title abstract 2
- 241000617590 Escherichia coli K1 Species 0.000 abstract 2
- 241000588677 Neisseria meningitidis serogroup B Species 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 230000003213 activating effect Effects 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 230000001363 autoimmune Effects 0.000 abstract 1
- 230000000295 complement effect Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000000763 evoking effect Effects 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 210000002966 serum Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/22—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Neisseriaceae (F)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
- C07K16/1217—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Neisseriaceae (F)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56911—Bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
- G01N2333/22—Assays involving biological materials from specific organisms or of a specific nature from bacteria from Neisseriaceae (F), e.g. Acinetobacter
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/807—Hapten conjugated with peptide or protein
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/808—Materials and products related to genetic engineering or hybrid or fused cell technology, e.g. hybridoma, monoclonal products
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- Analytical Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Physics & Mathematics (AREA)
- Virology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Oncology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2579996P | 1996-08-27 | 1996-08-27 | |
US25799 | 1996-08-27 | ||
PCT/US1997/015167 WO1998008874A1 (en) | 1996-08-27 | 1997-08-27 | Monoclonal antibodies that define unique meningococcal b epitopes and their use in the preparation of vaccine compositions |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69725739D1 true DE69725739D1 (de) | 2003-12-11 |
DE69725739T2 DE69725739T2 (de) | 2004-08-05 |
Family
ID=21828119
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69725739T Expired - Lifetime DE69725739T2 (de) | 1996-08-27 | 1997-08-27 | Meningokokkus b-epitop ausbildende monoklonale antikoerper und deren verwendung zur herstellung von impfstoffzusammenstellungen |
Country Status (7)
Country | Link |
---|---|
US (4) | US6048527A (de) |
EP (1) | EP0922059B1 (de) |
JP (2) | JP4150082B2 (de) |
AT (1) | ATE252602T1 (de) |
CA (1) | CA2264585C (de) |
DE (1) | DE69725739T2 (de) |
WO (1) | WO1998008874A1 (de) |
Families Citing this family (58)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9422096D0 (en) * | 1994-11-02 | 1994-12-21 | Biocine Spa | Combined meningitis vaccine |
US5811102A (en) * | 1995-06-07 | 1998-09-22 | National Research Council Of Canada | Modified meningococcal polysaccharide conjugate vaccines |
ATE208629T1 (de) * | 1996-08-27 | 2001-11-15 | Chiron Corp | Neisseria meningitidis serogruppe b glykokonjugate und verfahren zu deren verwendung |
ATE252602T1 (de) * | 1996-08-27 | 2003-11-15 | Chiron Corp | Meningokokkus b-epitop ausbildende monoklonale antikoerper und deren verwendung zur herstellung von impfstoffzusammenstellungen |
PT1630168E (pt) | 1997-08-27 | 2011-07-20 | Novartis Vaccines & Diagnostic | Compostos miméticos moleculares de péptidos de meningococos do serogrupo b |
GB9823835D0 (en) * | 1998-10-30 | 1998-12-23 | Univ London | Component for vaccine |
JP2002536295A (ja) * | 1998-12-14 | 2002-10-29 | パラチン テクノロジーズ, インク. | 金属ペプチド組合せライブラリ及びその利用法 |
ES2184659T1 (es) | 1999-08-06 | 2003-04-16 | Ivigene Corp | Polinucleotidos microbianos expresados durante la infeccion de un organismo hospedante. |
US7033748B2 (en) * | 1999-08-06 | 2006-04-25 | Ivigene Corporation | Identification of microbial polynucleotides expressed during infection of a host |
US7049398B1 (en) * | 1999-08-12 | 2006-05-23 | Palatin Technologies, Inc. | Melanocortin metallopeptide constructs, combinatorial libraries and applications |
US6838553B1 (en) * | 1999-10-05 | 2005-01-04 | Academia Sinica | Peptide repeat immunogens |
US7189405B1 (en) * | 1999-10-29 | 2007-03-13 | Rice Peter A | Peptide mimics of conserved gonococcal epitopes and methods and compositions using them |
WO2001036006A1 (en) * | 1999-11-19 | 2001-05-25 | Palatin Technologies, Inc. | Opioid metallopeptide compositions and methods |
DK2289545T3 (en) * | 2000-01-17 | 2016-09-05 | Glaxosmithkline Biologicals Sa | Supplemented OMV vaccine against meningococcus |
GB0024200D0 (en) * | 2000-10-03 | 2000-11-15 | Smithkline Beecham Sa | Component vaccine |
US7385025B2 (en) * | 2000-12-19 | 2008-06-10 | Palatin Technologies, Inc. | Metallopeptide compounds |
AU2002238106A1 (en) * | 2001-02-13 | 2002-08-28 | Palatin Technologies, Inc. | Melanocortin metallopeptides for treatment of sexual dysfunction |
US20020131953A1 (en) * | 2001-03-14 | 2002-09-19 | Ut Southwestern Medical Center | In situ langerhans cell vaccine |
RU2322451C2 (ru) * | 2001-04-17 | 2008-04-20 | Новартис Вэксинс Энд Диагностикс, Инк. | Молекулярные миметики эпитопов менингококка в, которые вызывают выработку функционально активных антител |
MX339524B (es) | 2001-10-11 | 2016-05-30 | Wyeth Corp | Composiciones inmunogenicas novedosas para la prevencion y tratamiento de enfermedad meningococica. |
KR100506118B1 (ko) * | 2002-04-19 | 2005-08-04 | 학교법인연세대학교 | 수막염균증 백신 조성물 |
EP1411061A1 (de) * | 2002-10-16 | 2004-04-21 | Centre National De La Recherche Scientifique (Cnrs) | Poly-alpha2,8-sialylsäure mimetische Peptide und ihre Verwendungen |
US20070020293A1 (en) * | 2003-06-23 | 2007-01-25 | Michon Francis J | Vaccines against group neisseria meningitidis and meningococcal combinations thereof |
AU2005244081B2 (en) * | 2004-05-11 | 2011-10-06 | Abgenomics Cooperatief U.A. | T-cell death-inducing epitopes |
US8148335B2 (en) * | 2004-06-23 | 2012-04-03 | Children's Hospital & Research Center Oakland | De-N-acetyl sialic acid antigens, antibodies thereto, and methods of use in cancer therapy |
WO2006002402A2 (en) * | 2004-06-23 | 2006-01-05 | Children's Hospital & Research Center At Oakland | Polysaccharide derivatives and uses in induction of an immune response |
US8052971B2 (en) * | 2005-11-21 | 2011-11-08 | MG Biologics | Oral use of specific antibodies for intestinal health |
WO2007070372A2 (en) * | 2005-12-09 | 2007-06-21 | Entremed, Inc. | Compositions and methods for inhibiting cellular proliferation |
MX2008008185A (es) * | 2005-12-23 | 2008-11-14 | Childrens Hosp & Res Ct Oak | Antigenos de acido des-n-acetil-sialico, anticuerpos para los mismos, y metodos de uso en la terapia de cancer. |
AR058736A1 (es) * | 2005-12-29 | 2008-02-20 | Ct Ingenieria Genetica Biotech | Peptidos mimeticos de carbohidratos y su empleo en formulaciones farmaceuticas |
CA2636983A1 (en) * | 2006-01-13 | 2007-07-26 | Baxter International Inc. | Method for purifying polysaccharides |
GB0606155D0 (en) * | 2006-03-28 | 2006-05-10 | Liverpool School Of Tropical M | Bacterial vaccine |
EP2007427A4 (de) * | 2006-04-11 | 2012-04-04 | Yeda Res & Dev | Verbesserte impfstoffe mit multimeren hsp60-peptid-trägern |
GB0611914D0 (en) * | 2006-06-15 | 2006-07-26 | Teti Giuseppe | Peptides that mimic non-human cross-reactive protective epitopes of the group Bmeningococcal capsulsar polysaccharide |
AR064642A1 (es) | 2006-12-22 | 2009-04-15 | Wyeth Corp | Polinucleotido vector que lo comprende celula recombinante que comprende el vector polipeptido , anticuerpo , composicion que comprende el polinucleotido , vector , celula recombinante polipeptido o anticuerpo , uso de la composicion y metodo para preparar la composicion misma y preparar una composi |
US20100189740A1 (en) * | 2007-06-20 | 2010-07-29 | Francis Michon | Modified polysaccharides for conjugate vaccines |
EP2183261A4 (de) * | 2007-07-03 | 2010-09-15 | Childrens Hosp & Res Ct Oak | Polysialylsäurederivate, herstellungsverfahren und anwendungen bei der steigerung von produktion und targeting von krebsantigenen |
CA2692419C (en) * | 2007-07-03 | 2017-12-05 | Children's Hospital & Research Center At Oakland | Inhibitors of polysialic acid de-n-acetylase and methods for using the same |
JP5702600B2 (ja) * | 2007-07-03 | 2015-04-15 | チルドレンズ ホスピタル アンド リサーチ センター アット オークランド | オリゴシアル酸誘導体、製造方法および免疫学的使用 |
US8067730B2 (en) | 2007-07-20 | 2011-11-29 | The George Washington University | Laser ablation electrospray ionization (LAESI) for atmospheric pressure, In vivo, and imaging mass spectrometry |
US20100285446A1 (en) * | 2007-07-20 | 2010-11-11 | Akos Vertes | Methods for Detecting Metabolic States by Laser Ablation Electrospray Ionization Mass Spectrometry |
US7960336B2 (en) * | 2007-08-03 | 2011-06-14 | Pharmain Corporation | Composition for long-acting peptide analogs |
US8563527B2 (en) * | 2007-08-20 | 2013-10-22 | Pharmain Corporation | Oligonucleotide core carrier compositions for delivery of nucleic acid-containing therapeutic agents, methods of making and using the same |
US20090156459A1 (en) * | 2007-11-16 | 2009-06-18 | Pharmain Corporation | Cationic-Core Carrier Compositions for Delivery of Therapeutic Agents, Methods of Making and Using the Same |
WO2009117409A2 (en) * | 2008-03-18 | 2009-09-24 | Merck & Co., Inc. | A high throughput protein interaction assay |
TW201103980A (en) * | 2009-07-08 | 2011-02-01 | Abbott Biologicals Bv | Viral vaccine and use thereof |
KR101594228B1 (ko) | 2010-08-23 | 2016-02-15 | 와이어쓰 엘엘씨 | 네이세리아 메닌기티디스 rLP2086 항원의 안정한 제제 |
AU2011300409B2 (en) | 2010-09-10 | 2015-03-26 | Wyeth Llc | Non-lipidated variants of Neisseria meningitidis ORF2086 antigens |
WO2012054879A1 (en) * | 2010-10-22 | 2012-04-26 | Duke University | Compositions and methods for the treatment of septic arthritis, osteomyelitis, and bacteremia |
WO2013085572A2 (en) | 2011-07-14 | 2013-06-13 | The George Washington University | Plume collimation for laser ablation electrospray ionization mass spectrometry |
US10598666B2 (en) * | 2012-03-08 | 2020-03-24 | Glaxosmithkline Biologicals Sa | In vitro potency assay for protein-based meningococcal vaccines |
KR101763625B1 (ko) | 2012-03-09 | 2017-08-01 | 화이자 인코포레이티드 | 수막염균 조성물 및 이의 사용 방법 |
SA115360586B1 (ar) | 2012-03-09 | 2017-04-12 | فايزر انك | تركيبات لعلاج الالتهاب السحائي البكتيري وطرق لتحضيرها |
US9802987B2 (en) | 2013-03-08 | 2017-10-31 | Pfizer Inc. | Immunogenic fusion polypeptides |
US9770504B2 (en) * | 2013-05-03 | 2017-09-26 | The Board Of Regents Of The University Of Texas System | Generating peptoid vaccines |
US9822150B2 (en) | 2013-09-08 | 2017-11-21 | Pfizer Inc. | Neisseria meningitidis compositions and methods thereof |
KR20170103009A (ko) | 2015-02-19 | 2017-09-12 | 화이자 인코포레이티드 | 나이세리아 메닌지티디스 조성물 및 그의 방법 |
PE20191107A1 (es) | 2017-01-31 | 2019-08-26 | Pfizer | Composiciones de neisseria meningitidis y metodos respectivos |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4356170A (en) | 1981-05-27 | 1982-10-26 | Canadian Patents & Development Ltd. | Immunogenic polysaccharide-protein conjugates |
EP0145359B1 (de) * | 1983-11-21 | 1991-01-16 | The Wellcome Foundation Limited | Komplexe, Verfahren zu ihrer Herstellung und dieselben enthaltende Formulierungen |
US4727136A (en) * | 1985-10-01 | 1988-02-23 | Canadian Patents And Development Ltd. | Modified meningococcal group B polysaccharide for conjugate vaccine |
US4970070A (en) * | 1986-02-07 | 1990-11-13 | Genetic Systems Corporation | Protective monoclonal antibody compositions for infections due to group B streptococcus |
WO1990006696A2 (en) * | 1988-12-19 | 1990-06-28 | Praxis Biologics, Inc. | Meningococcal class 1 outer-membrane protein vaccine |
SU1708846A1 (ru) * | 1989-11-22 | 1992-01-30 | Научно-исследовательский институт вакцин и сывороток им.И.И.Мечникова | Штамм бактерий NeISSeRIa меNINGIтIDIS серогруппы В - продуцент капсульного полисахарида и полисахаридно-белкового комплекса |
AU641715B2 (en) * | 1989-12-14 | 1993-09-30 | National Research Council Of Canada | Improved meningococcal polysaccharide conjugate vaccine |
GB9422096D0 (en) * | 1994-11-02 | 1994-12-21 | Biocine Spa | Combined meningitis vaccine |
US5811102A (en) | 1995-06-07 | 1998-09-22 | National Research Council Of Canada | Modified meningococcal polysaccharide conjugate vaccines |
ATE252602T1 (de) | 1996-08-27 | 2003-11-15 | Chiron Corp | Meningokokkus b-epitop ausbildende monoklonale antikoerper und deren verwendung zur herstellung von impfstoffzusammenstellungen |
ATE208629T1 (de) * | 1996-08-27 | 2001-11-15 | Chiron Corp | Neisseria meningitidis serogruppe b glykokonjugate und verfahren zu deren verwendung |
PT1630168E (pt) | 1997-08-27 | 2011-07-20 | Novartis Vaccines & Diagnostic | Compostos miméticos moleculares de péptidos de meningococos do serogrupo b |
-
1997
- 1997-08-27 AT AT97941371T patent/ATE252602T1/de active
- 1997-08-27 EP EP97941371A patent/EP0922059B1/de not_active Expired - Lifetime
- 1997-08-27 JP JP51191598A patent/JP4150082B2/ja not_active Expired - Fee Related
- 1997-08-27 DE DE69725739T patent/DE69725739T2/de not_active Expired - Lifetime
- 1997-08-27 CA CA002264585A patent/CA2264585C/en not_active Expired - Fee Related
- 1997-08-27 WO PCT/US1997/015167 patent/WO1998008874A1/en active IP Right Grant
- 1997-08-27 US US08/925,002 patent/US6048527A/en not_active Expired - Lifetime
-
2001
- 2001-07-23 US US09/910,552 patent/US6642354B2/en not_active Expired - Fee Related
-
2003
- 2003-08-19 US US10/643,465 patent/US7063949B2/en not_active Expired - Fee Related
-
2005
- 2005-10-05 US US11/244,209 patent/US7504254B2/en not_active Expired - Fee Related
-
2007
- 2007-08-28 JP JP2007221879A patent/JP2008044947A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
JP2001500372A (ja) | 2001-01-16 |
US20040077840A1 (en) | 2004-04-22 |
JP2008044947A (ja) | 2008-02-28 |
DE69725739T2 (de) | 2004-08-05 |
US7063949B2 (en) | 2006-06-20 |
CA2264585A1 (en) | 1998-03-05 |
EP0922059B1 (de) | 2003-10-22 |
WO1998008874A1 (en) | 1998-03-05 |
CA2264585C (en) | 2005-06-14 |
US20060035284A1 (en) | 2006-02-16 |
ATE252602T1 (de) | 2003-11-15 |
US20020197260A1 (en) | 2002-12-26 |
JP4150082B2 (ja) | 2008-09-17 |
US7504254B2 (en) | 2009-03-17 |
US6048527A (en) | 2000-04-11 |
EP0922059A1 (de) | 1999-06-16 |
US6642354B2 (en) | 2003-11-04 |
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