DE69722271D1 - Herstellung von arylethern sowie damit verbundene reagentien und verfahren - Google Patents

Herstellung von arylethern sowie damit verbundene reagentien und verfahren

Info

Publication number
DE69722271D1
DE69722271D1 DE69722271T DE69722271T DE69722271D1 DE 69722271 D1 DE69722271 D1 DE 69722271D1 DE 69722271 T DE69722271 T DE 69722271T DE 69722271 T DE69722271 T DE 69722271T DE 69722271 D1 DE69722271 D1 DE 69722271D1
Authority
DE
Germany
Prior art keywords
arylethers
production
methods
related reagents
reagents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69722271T
Other languages
English (en)
Other versions
DE69722271T2 (de
Inventor
L Buchwald
P Wolfe
Michael Palucki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Massachusetts Institute of Technology
Original Assignee
Massachusetts Institute of Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massachusetts Institute of Technology filed Critical Massachusetts Institute of Technology
Publication of DE69722271D1 publication Critical patent/DE69722271D1/de
Application granted granted Critical
Publication of DE69722271T2 publication Critical patent/DE69722271T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/16—Preparation of ethers by reaction of esters of mineral or organic acids with hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
    • C07D311/82—Xanthenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/94—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • C07D313/02—Seven-membered rings
    • C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D313/08—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/22—Ortho- or ortho- and peri-condensed systems containing three rings containing only six-membered rings
    • C07C2603/24—Anthracenes; Hydrogenated anthracenes
DE69722271T 1996-10-10 1997-10-10 Herstellung von arylethern sowie damit verbundene reagentien und verfahren Expired - Lifetime DE69722271T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US728449 1996-10-10
US08/728,449 US5847166A (en) 1996-10-10 1996-10-10 Synthesis of aryl ethers
PCT/US1997/018719 WO1998015515A1 (en) 1996-10-10 1997-10-10 Synthesis of aryl ethers, methods and reagents related thereto

Publications (2)

Publication Number Publication Date
DE69722271D1 true DE69722271D1 (de) 2003-06-26
DE69722271T2 DE69722271T2 (de) 2004-04-01

Family

ID=24926897

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69722271T Expired - Lifetime DE69722271T2 (de) 1996-10-10 1997-10-10 Herstellung von arylethern sowie damit verbundene reagentien und verfahren

Country Status (11)

Country Link
US (2) US5847166A (de)
EP (3) EP1245553A3 (de)
JP (1) JP2001501954A (de)
AT (1) ATE240923T1 (de)
AU (1) AU4759297A (de)
CA (1) CA2267153C (de)
DE (1) DE69722271T2 (de)
DK (1) DK1027316T3 (de)
ES (1) ES2200162T3 (de)
PT (1) PT1027316E (de)
WO (1) WO1998015515A1 (de)

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US5847166A (en) * 1996-10-10 1998-12-08 Massachusetts Institute Of Technology Synthesis of aryl ethers
DE19725872A1 (de) * 1997-06-18 1998-12-24 Basf Ag Verfahren zur Herstellung von Butenylethern
US6323366B1 (en) 1997-07-29 2001-11-27 Massachusetts Institute Of Technology Arylamine synthesis
US5977361A (en) * 1997-10-16 1999-11-02 Yale University Transition metal-catalyzed process for preparing N-aryl compounds
US6057456A (en) * 1997-10-16 2000-05-02 Yale University Transition metal-catalyzed process for preparing alpha-arylated carbonyl-containing compounds
US6414173B1 (en) 1998-07-02 2002-07-02 University Of Maryland Hypervalent silane and siloxane derivatives and the use thereof
US7223879B2 (en) 1998-07-10 2007-05-29 Massachusetts Institute Of Technology Ligands for metals and improved metal-catalyzed processes based thereon
EP1354887B1 (de) * 1998-07-10 2007-04-25 Massachussetts Institute of Technology Ligande für Metalle und verbesserte Metall-katalysierte Verfahren, die darauf basieren
US6395916B1 (en) 1998-07-10 2002-05-28 Massachusetts Institute Of Technology Ligands for metals and improved metal-catalyzed processes based thereon
US6307087B1 (en) 1998-07-10 2001-10-23 Massachusetts Institute Of Technology Ligands for metals and improved metal-catalyzed processes based thereon
ES2257864T3 (es) * 1998-07-10 2006-08-01 Massachusetts Institute Of Technology Ligandos para metales y procesos mejorados catalizados por metales basados en los mismos.
US6100398A (en) * 1998-10-14 2000-08-08 Yale University Transition metal-catalyzed process for preparing N-aryl amine compounds
EP1233970A2 (de) * 1999-11-24 2002-08-28 Massachusetts Institute Of Technology Schutzgruppen nützlich bei der synthese von polysacchariden, natürliche produkte und kombinatorische bibliotheken
US6562989B2 (en) 2000-08-07 2003-05-13 Yale University Catalyst for aromatic C—O, C—N, and C—C bond formation
DE10222330A1 (de) * 2002-05-17 2003-11-27 Degussa Verfahren zur katalysatorfreien Herstellung von Alkoxybenzonitrilen
US6489512B1 (en) 2002-06-21 2002-12-03 Rhodia Chirex Inc. Method for making aryl hydrazines and substituted indoles
AP2006003700A0 (en) 2004-02-13 2006-08-31 Warner Lambert Co Androgen receptor modulators
BRPI0509759A (pt) * 2004-04-13 2007-10-16 Warner Lambert Co moduladores de androgênio
US7138555B2 (en) 2004-04-20 2006-11-21 Xerox Corporation Process for preparing iodoaromatic compounds and using the same
EP1740533A1 (de) * 2004-04-22 2007-01-10 Warner-Lambert Company LLC Androgenmodulatoren
CA2570047C (en) * 2004-07-08 2010-09-28 Warner-Lambert Company Llc 4-cycloalkoxy benzonitriles as androgen modulators
WO2006018732A1 (en) * 2004-08-18 2006-02-23 Warner-Lambert Company Llc Androgen modulators
TW200724139A (en) * 2005-05-05 2007-07-01 Warner Lambert Co Androgen modulators
US20090170886A1 (en) * 2005-08-08 2009-07-02 Pfizer Inc Androgen modulators
ES2776889T3 (es) 2007-03-12 2020-08-03 Intra Cellular Therapies Inc Síntesis de gamma-carbolinas condensadas a heterociclo sustituido
EP2231680B1 (de) 2007-12-12 2018-03-28 Massachusetts Institute of Technology Liganden für übergangsmetallkatalysierte kreuzkupplungen und verfahren zu deren anwendung
US20090326280A1 (en) * 2008-06-27 2009-12-31 Todd Coleman Systems and Methods for the Preparation of Alkyl Aryl Ethers
JP2010202589A (ja) * 2009-03-04 2010-09-16 Kuraray Co Ltd ２，３−ジヒドロ−チエノ［３，４−ｂ］フラン誘導体の製造方法、及びそれに用いられる新規化合物
US20120318317A1 (en) 2010-02-10 2012-12-20 Arizona Board Of Regents On Behalf Of The University Of Arizona Molecular thermoelectric device
CA2936749C (en) 2010-06-11 2019-07-09 Joshua R. Giguere Transition metal-catalyzed processes for the preparation of n-allyl compounds and use thereof
EP2593439B1 (de) 2010-07-16 2016-08-17 AbbVie Bahamas Ltd. Verfahren zur herstellung antiviraler verbindungen
CA2804827A1 (en) 2010-07-16 2012-01-19 Shashank Shekhar Phosphine ligands for catalytic reactions
US8975443B2 (en) 2010-07-16 2015-03-10 Abbvie Inc. Phosphine ligands for catalytic reactions
US9255074B2 (en) 2010-07-16 2016-02-09 Abbvie Inc. Process for preparing antiviral compounds
RU2014145682A (ru) 2012-04-14 2016-06-10 Интра-Селлулар Терапиз, Инк Органические соединения
CN105377859B (zh) 2013-03-08 2018-04-17 英属哥伦比亚大学 作为显像剂的取代的有机氟硼酸盐
CN114366741A (zh) 2013-12-03 2022-04-19 细胞内治疗公司 新方法
DK3125893T3 (da) 2014-04-04 2023-11-20 Intra Cellular Therapies Inc Deutererede heterocyklus-fusionerede gamma-carboliner som antagonister af 5-ht2a-receptorer
WO2015154030A1 (en) 2014-04-04 2015-10-08 Intra-Cellular Therapies, Inc. Organic compounds
JP6476396B2 (ja) * 2015-03-10 2019-03-06 国立大学法人名古屋大学 環化触媒、クロマン類の製法及びピロリジン類の製法
WO2017132408A1 (en) 2016-01-26 2017-08-03 Intra-Cellular Therapies, Inc. Organic compounds
PT3407889T (pt) 2016-03-25 2021-07-14 Intra Cellular Therapies Inc Compostos orgânicos e a sua utilização no tratamento ou prevenção de distúrbios do sistema nervoso central
WO2017172811A1 (en) 2016-03-28 2017-10-05 Intra-Cellular Therapies, Inc. Novel co-crystals
EP3436455A4 (de) 2016-03-28 2019-09-04 Intra-Cellular Therapies, Inc. Neuartige salze und kristalle
US10682354B2 (en) 2016-03-28 2020-06-16 Intra-Cellular Therapies, Inc. Compositions and methods
CN110072518B (zh) 2016-10-12 2021-10-26 细胞内治疗公司 无定形固体分散体
WO2018126140A1 (en) 2016-12-29 2018-07-05 Intra-Cellular Therapies, Inc. Organic compounds
WO2018126143A1 (en) 2016-12-29 2018-07-05 Intra-Cellular Therapies, Inc. Organic compounds
IL268970B2 (en) 2017-03-24 2023-12-01 Intra Cellular Therapies Inc Oral preparations of heterocyclic gamma carboline derivatives fused for absorption through mucous membranes
AU2018307480B2 (en) 2017-07-26 2023-11-23 Intra-Cellular Therapies, Inc. Organic compounds
MX2020000968A (es) 2017-07-26 2020-09-28 Intra Cellular Therapies Inc Compuestos organicos.
CN110831941A (zh) 2018-06-11 2020-02-21 细胞内治疗公司 取代的杂环稠合的γ-咔啉类化合物合成
CN112313200A (zh) 2018-06-26 2021-02-02 大金工业株式会社 氟乙烯基醚化合物的制造方法
CA3108558A1 (en) 2018-08-31 2020-03-05 Intra-Cellular Therapies, Inc. Novel methods
WO2020047407A1 (en) 2018-08-31 2020-03-05 Intra-Cellular Therapies, Inc. Novel methods

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE734904A (de) * 1969-04-10 1969-12-22
US5847166A (en) * 1996-10-10 1998-12-08 Massachusetts Institute Of Technology Synthesis of aryl ethers

Also Published As

Publication number Publication date
EP1245553A3 (de) 2003-12-10
US6166226A (en) 2000-12-26
AU4759297A (en) 1998-05-05
EP1254884A2 (de) 2002-11-06
US5847166A (en) 1998-12-08
EP1027316A1 (de) 2000-08-16
EP1254884A3 (de) 2003-12-10
DK1027316T3 (da) 2003-09-15
ATE240923T1 (de) 2003-06-15
CA2267153A1 (en) 1998-04-16
PT1027316E (pt) 2003-10-31
WO1998015515A1 (en) 1998-04-16
DE69722271T2 (de) 2004-04-01
EP1027316B1 (de) 2003-05-21
CA2267153C (en) 2004-07-20
ES2200162T3 (es) 2004-03-01
JP2001501954A (ja) 2001-02-13
EP1245553A2 (de) 2002-10-02

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