DE69720481T2 - Verfahren zur verwendung von oligonukleotiden mit modifizierten cpg dinukleosiden - Google Patents
Verfahren zur verwendung von oligonukleotiden mit modifizierten cpg dinukleosiden Download PDFInfo
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- DE69720481T2 DE69720481T2 DE69720481T DE69720481T DE69720481T2 DE 69720481 T2 DE69720481 T2 DE 69720481T2 DE 69720481 T DE69720481 T DE 69720481T DE 69720481 T DE69720481 T DE 69720481T DE 69720481 T2 DE69720481 T2 DE 69720481T2
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- cpg
- oligonucleotide
- oligonucleotides
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- modified
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Classifications
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- C12N2310/311—Phosphotriesters
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- C12N2310/312—Phosphonates
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C—CHEMISTRY; METALLURGY
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- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/321—2'-O-R Modification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/33—Chemical structure of the base
- C12N2310/334—Modified C
- C12N2310/3341—5-Methylcytosine
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/711,568 US5856462A (en) | 1996-09-10 | 1996-09-10 | Oligonucleotides having modified CpG dinucleosides |
| US711568 | 1996-09-10 | ||
| PCT/US1997/016017 WO1998011211A2 (en) | 1996-09-10 | 1997-09-10 | METHOD FOR USING OLIGONUCLEOTIDES HAVING MODIFIED CpG DINUCLEOSIDES |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69720481D1 DE69720481D1 (de) | 2003-05-08 |
| DE69720481T2 true DE69720481T2 (de) | 2004-02-12 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69720481T Expired - Lifetime DE69720481T2 (de) | 1996-09-10 | 1997-09-10 | Verfahren zur verwendung von oligonukleotiden mit modifizierten cpg dinukleosiden |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US5856462A (enExample) |
| EP (1) | EP0928335B1 (enExample) |
| JP (1) | JP5265067B2 (enExample) |
| AT (1) | ATE236248T1 (enExample) |
| AU (1) | AU4339997A (enExample) |
| CA (1) | CA2265917C (enExample) |
| DE (1) | DE69720481T2 (enExample) |
| DK (1) | DK0928335T3 (enExample) |
| ES (1) | ES2190541T3 (enExample) |
| PT (1) | PT928335E (enExample) |
| WO (1) | WO1998011211A2 (enExample) |
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| CA3266697A1 (en) | 2022-09-09 | 2024-03-14 | Access To Advanced Health Institute | COMPOSITION OF AN IMMUNOGENEOUS VACCINE CONTAINING A SAPONIN |
| WO2024186635A2 (en) | 2023-03-03 | 2024-09-12 | Celldex Therapeutics, Inc. | Anti-stem cell factor (scf) and anti-thymic stromal lymphopoietin (tslp) antibodies and bispecific constructs |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5194428A (en) * | 1986-05-23 | 1993-03-16 | Worcester Foundation For Experimental Biology | Inhibition of influenza virus replication by oligonucleotide phosphorothioates |
| US4806463A (en) * | 1986-05-23 | 1989-02-21 | Worcester Foundation For Experimental Biology | Inhibition of HTLV-III by exogenous oligonucleotides |
| US5149797A (en) * | 1990-02-15 | 1992-09-22 | The Worcester Foundation For Experimental Biology | Method of site-specific alteration of rna and production of encoded polypeptides |
| DE4200433A1 (de) * | 1992-01-10 | 1993-07-15 | Otto Hofstetter | Verfahren zur herstellung von stabilen fluessigen parfuemrohstoffmischungen mit hohem feststoffgehalt |
| US5652355A (en) * | 1992-07-23 | 1997-07-29 | Worcester Foundation For Experimental Biology | Hybrid oligonucleotide phosphorothioates |
| EP0702716A4 (en) * | 1993-05-17 | 1999-05-26 | Univ California | RIBOZYMIC GENE THERAPY FOR HIV INFECTION AND AIDS |
| EP0721503A1 (en) * | 1993-09-28 | 1996-07-17 | The General Hospital Corporation | USING ANTISENSE OLIGONUCLEOTIDES TO MODULATE NERVE GROWTH AND TO REVERSE $g(b)/A4 AMYLOID-INDUCED MORPHOLOGY |
| EP1167378B1 (en) * | 1994-07-15 | 2011-05-11 | University of Iowa Research Foundation | Immunomodulatory oligonucleotides |
| CA2208528A1 (en) * | 1994-12-22 | 1996-06-27 | Hybridon, Inc. | Synthesis of stereospecific oligonucleotide phosphorothioates |
-
1996
- 1996-09-10 US US08/711,568 patent/US5856462A/en not_active Expired - Lifetime
-
1997
- 1997-09-10 WO PCT/US1997/016017 patent/WO1998011211A2/en not_active Ceased
- 1997-09-10 PT PT97941505T patent/PT928335E/pt unknown
- 1997-09-10 AT AT97941505T patent/ATE236248T1/de not_active IP Right Cessation
- 1997-09-10 ES ES97941505T patent/ES2190541T3/es not_active Expired - Lifetime
- 1997-09-10 JP JP51382298A patent/JP5265067B2/ja not_active Expired - Fee Related
- 1997-09-10 AU AU43399/97A patent/AU4339997A/en not_active Abandoned
- 1997-09-10 DK DK97941505T patent/DK0928335T3/da active
- 1997-09-10 CA CA002265917A patent/CA2265917C/en not_active Expired - Lifetime
- 1997-09-10 EP EP97941505A patent/EP0928335B1/en not_active Expired - Lifetime
- 1997-09-10 DE DE69720481T patent/DE69720481T2/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| AU4339997A (en) | 1998-04-02 |
| EP0928335A2 (en) | 1999-07-14 |
| JP5265067B2 (ja) | 2013-08-14 |
| JP2001500511A (ja) | 2001-01-16 |
| CA2265917C (en) | 2008-07-08 |
| US5856462A (en) | 1999-01-05 |
| PT928335E (pt) | 2003-07-31 |
| WO1998011211A2 (en) | 1998-03-19 |
| CA2265917A1 (en) | 1998-03-19 |
| EP0928335B1 (en) | 2003-04-02 |
| ATE236248T1 (de) | 2003-04-15 |
| DK0928335T3 (da) | 2003-06-16 |
| ES2190541T3 (es) | 2003-08-01 |
| WO1998011211A3 (en) | 1998-04-16 |
| DE69720481D1 (de) | 2003-05-08 |
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